P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 302, Issue 10, 2012, Pages

  Hoque, Rafaz ^a   Sohail, Muhammed Adnan ^a   Salhanick, Steven ^b   Malik, Ahsan F ^a   Ghani, Ayaz ^a   Robson, Simon C ^c   Mehal, Wajahat Z ^a,c  

^a YALE UNIVERSITY   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

Caspase 1; CD39; Damage associated molecular pattern; Inflammasome; Nod like receptor family; Pryin domain containing 3

Indexed keywords

A 438079; ADENOSINE TRIPHOSPHATE; APYRASE; CD39 ANTIGEN; CYTOCHROME P450 2E1; ETHENO NAD; INFLAMMASOME; INTERLEUKIN 1BETA; PARACETAMOL; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL LEVEL; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; GENE DELETION; HISTOPATHOLOGY; KUPFFER CELL; LIVER HEMORRHAGE; LIVER NECROSIS; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOXIC HEPATITIS; WILD TYPE;

ACETAMINOPHEN; ANIMALS; ANTIGENS, CD; ANTIPYRETICS; APYRASE; CELLS, CULTURED; DRUG-INDUCED LIVER INJURY; HEMORRHAGE; INFLAMMASOMES; INTERLEUKIN-1BETA; KUPFFER CELLS; MALE; MICE; MICE, INBRED C57BL; NAD; NECROSIS; PYRIDINES; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION; TETRAZOLES;

EID: 84861123734     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00352.2011     Document Type: Article

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