Review of experimental animal models of acute pancreatitis

HPB

Volumn 8, Issue 4, 2006, Pages 264-286

  Su, Kim Hue ^a   Cuthbertson, Christine ^a   Christophi, Christopher ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Acute pancreatitis; Animal models

Indexed keywords

ALCOHOL; ALPHA 2 MACROGLOBULIN; ARGININE; CATHEPSIN B; CERULETIDE; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; CHYMOTRYPSINOGEN; COMPLEMENT COMPONENT C5A; CYTOKINE RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; ENZYME PRECURSOR; FIBRINOLYTIC AGENT; GLUTATHIONE PEROXIDASE; GLYCODEOXYCHOLIC ACID; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; MALONALDEHYDE; NEUROKININ 1 RECEPTOR; PHOSPHOLIPASE A2; SOMATOSTATIN; SUPEROXIDE DISMUTASE; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; TRYPSIN; TRYPSINOGEN; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

ACINAR CELL; ACUTE HEMORRHAGIC PANCREATITIS; ACUTE PANCREATITIS; DIET; DISEASE MODEL; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; INTERMETHOD COMPARISON; KNOCKOUT GENE; LUNG INJURY; MORTALITY; NON INVASIVE PROCEDURE; NONHUMAN; PANCREAS BLOOD FLOW; PANCREAS DUCT LIGATION; PANCREAS PERFUSION; PATHOGENESIS; PHENOTYPE; RELIABILITY; REPRODUCIBILITY; REVIEW; SIGNAL TRANSDUCTION; TISSUE NECROSIS;

EID: 33745890260     PISSN: 1365182X     EISSN: 14772574     Source Type: Journal    
DOI: 10.1080/13651820500467358     Document Type: Review

References (203)

1. Steinberg, SM and Gower, WR, Jr and Martin, D and Carey, LC and Cloutier, CT. (1983) Experimental pancreatitis does not produce pulmonary hypertension Surg Gynecol Obstet, 157, pp. 530-3.
2. Toouli, J and Brooke-Smith, M and Bassi, C and Carr-Locke, D and Telford, J and Freeny, P and (2002) Guidelines for the management of acute pancreatitis J Gastroenterol Hepatol, 17(Suppl), pp. S15-S39.
3. Bradley, EL 3rd. (1993) A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992 Arch Surg, 128, pp. 586-90.
4. Banks, PA. (1997) Practice guidelines in acute pancreatitis Am J Gastroenterol, 92, pp. 377-86.
5. Beger, HG and Bittner, R and Block, S and Buchler, M. (1986) Bacterial contamination of pancreatic necrosis. A prospective clinical study Gastroenterology, 91, pp. 433-8.
6. Steer, ML and Meldolesi, J. (1988) Pathogenesis of acute pancreatitis Annu Rev Med, 39, pp. 95-105.
7. Steer, ML. (1985) Workshop on experimental pancreatitis Dig Dis Sci, 30, pp. 575-81.
8. Frossard JL, Hadengue A. [Acute pancreatitis: New physiopathological concepts.] Gastroenterol Clin Biol 2001;25:164-76 (in French).
9. Frossard, JL and Hadengue, A and Pastor, CM. (2001) New serum markers for the detection of severe acute pancreatitis in humans Am J Respir Crit Care Med, 164, pp. 162-70.
10. Pastor, CM and Frossard, JL. (2001) Are genetically modified mice useful for the understanding of acute pancreatitis? FASEB J, 15, pp. 893-7.
11. Saluja, AK and Steer, MLP. (1999) Pathophysiology of pancreatitis. Role of cytokines and other mediators of inflammation Digestion, 60(Suppl 1), pp. 27-33.
12. Frossard, JL. (2001) Trypsin activation peptide (TAP) in acute pancreatitis: From pathophysiology to clinical usefulness JOP, 2, pp. 69-77.
13. Frossard, JL. (2000) Trypsinogen activation peptide in acute pancreatitis Lancet, 356, pp. 766-7.
14. Frossard, JL and Robert, J and Soravia, C and Mensi, N and Magnin, A and Hadengue, A and (2000) Early prediction in acute pancreatitis: The contribution of amylase and lipase levels in peritoneal fluid JOP, 1, pp. 36-45.
15. Robert, JH and Frossard, JL and Mermillod, B and Soravia, C and Mensi, N and Roth, M and (2002) Early prediction of acute pancreatitis: prospective study comparing computed tomography scans, Ranson, Glasgow, Acute Physiology and Chronic Health Evaluation II scores, and various serum markers World J Surg, 26, pp. 612-19.
16. Frossard, JL. (2003) Pathophysiology of acute pancreatitis: A multistep disease Acta Gastroenterol Belg, 66, pp. 166-73.
17. Norman, J. (1998) The role of cytokines in the pathogenesis of acute pancreatitis Am J Surg, 175, pp. 76-83.
18. Rinderknecht, H. (1988) Fatal pancreatitis, a consequence of excessive leukocyte stimulation? Int J Pancreatol, 3, pp. 105-12.
19. Demols, A and Le Moine, O and Desalle, F and Quertinmont, E and Van Laethem, JL and Deviere, J. (2000) CD4(+)T cells play an important role in acute experimental pancreatitis in mice Gastroenterology, 118, pp. 582-90.
20. Frossard, JL and Saluja, AK and Mach, N and Lee, HS and Bhagat, L and Hadenque, A and (2002) In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injury Am J Physiol Lung Cell Mol Physiol, 283, pp. L541-8.
21. Saluja, A and Hofbauer, B and Yamaguchi, Y and Yamanaka, K and Steer, M. (1996) Induction of apoptosis reduces the severity of caerulein-induced pancreatitis in mice Biochem Biophys Res Commun, 220, pp. 875-8.
22. Bhatia, M and Wallig, MA and Hofbauer, B and Lee, HS and Frossard, JL and Steer, ML and (1998) Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis Biochem Biophys Res Commun, 246, pp. 476-83.
23. Sweiry, JH and Mann, GE. (1996) Role of oxidative stress in the pathogenesis of acute pancreatitis Scand J Gastroenterol Suppl, 219, pp. 10-15.
24. Schoenberg, MH and Buchler, M and Gaspar, M and Stinner, A and Younes, M and Melzner, I and (1990) Oxygen free radicals in acute pancreatitis of the rat Gut, 31, pp. 1138-43.
25. Nonaka, A and Manabe, T and Kyogoku, T and Tamura, K and Tobe, T. (1990) Changes in lipid peroxide and oxygen radical scavengers in cerulein-induced acute pancreatitis. Imbalance between the offense and defense systems Digestion, 47, pp. 130-7.
26. Neuschwander-Tetri, BA and Ferrell, LD and Sukhabote, RJ and Grendell, JH. (1992) Glutathione monoethyl ester ameliorates caerulein-induced pancreatitis in the mouse J Clin Invest, 89, pp. 109-16.
27. Dabrowski, A and Gabryelewicz, A. (1992) Oxidative stress. An early phenomenon characteristic of acute experimental pancreatitis Int J Pancreatol, 12, pp. 193-9.
28. Lander, HM. (1997) An essential role for free radicals and derived species in signal transduction FASEB J, 11, pp. 118-24.
29. Fallon, MB and Gorelick, FS and Anderson, JM and Mennone, A and Saluja, A and Steer, ML. (1995) Effect of cerulein hyperstimulation on the paracellular barrier of rat exocrine pancreas Gastroenterology, 108, pp. 1863-72.
30. Schulz, HU and Niederau, C and Klonowski-Stumpe, H and Halangk, W and Luthen, R and Lippert, H. (1999) Oxidative stress in acute pancreatitis Hepatogastroenterology, 46, pp. 2736-50.
31. Lampel, M and Kern, HF. (1977) Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue Virchows Arch A Pathol Anat Histol, 373, pp. 97-117.
32. Watanabe, O and Baccino, FM and Steer, ML and Meldolesi, J. (1984) Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: Early morphological changes during development of experimental pancreatitis Am J Physiol, 246(4 Pt 1), pp. G457-67.
33. Niederau, C and Ferrell, LD and Grendell, JH. (1985) Caerulein-induced acute necrotizing pancreatitis in mice: Protective effects of proglumide, benzotript, and secretin Gastroenterology, 88(5 Pt 1), pp. 1192-204.
34. Renner IG, Wisner JR. Exogenous secretin ameliorates ceruletide induced acute pancreatitis in the dog. Dig Dis Sci 1983;28:946(abstract).
35. Adler, G and Kern, HF and Scheele, GA. (1986) Experimental models and concepts in acute pancreatitis. In The exocrine pancreas: Biology, pathobiology, diseases. New York: Raven.
36. Konturek, SJ and Dembinski, A and Konturek, PJ and Warzecha, Z and Jaworek, J and Gustaw, P and (1992) Role of platelet activating factor in pathogenesis of acute pancreatitis in rats Gut, 33, pp. 1268-74.
37. Lankisch, PG and Koop, H and Winckler, K and Folsch, UR and Creutzfeldt, W. (1977) Somatostatin therapy of acute experimental pancreatitis Gut, 18, pp. 713-16.
38. Adler, G and Gerhards, G and Schick, J and Rohr, G and Kern, HF. (1983) Effects of in vivo cholinergic stimulation of rat exocrine pancreas Am J Physiol, 244, pp. G623-9.
39. Kern, HF and Adler, G and Scheele, GA. (1985) Structural and biochemical characterization of maximal and supramaximal hormonal stimulation of rat exocrine pancreas Scand J Gastroenterol Suppl, 112, pp. 20-9.
40. Adler, G and Hupp, T and Kern, HF. (1979) Course and spontaneous regression of acute pancreatitis in the rat Virchows Arch A Pathol Anat Histol, 382, pp. 31-47.
41. Adler, G and Rohr, G and Kern, HF. (1982) Alteration of membrane fusion as a cause of acute pancreatitis in the rat Dig Dis Sci, 27, pp. 993-1002.
42. Guice, KS and Oldham, KT and Johnson, KJ and Kunkel, RG and Morganroth, ML and Ward, PA. (1988) Pancreatitis-induced acute lung injury. An ARDS model Ann Surg, 208, pp. 71-7.
43. Willemer, S and Feddersen, CO and Karges, W and Adler, G. (1987) Functional and morphological pulmonary changes in cerulein-induced pancreatitis in the rat Dig Dis Sci, 32, pp. 1190.
44. Kloppel, G and Dreyer, T and Willemer, S and Kern, HF and Adler, G. (1986) Human acute pancreatitis: Its pathogenesis in the light of immunocytochemical and ultrastructural findings in acinar cells Virchows Arch A Pathol Anat Histopathol, 409, pp. 791-803.
45. Willemer, S and Adler, G. (1989) Histochemical and ultrastructural characteristics of tubular complexes in human acute pancreatitis Dig Dis Sci, 34, pp. 46-55.
46. Willemer, S and Kloppel, G and Kern, HF and Adler, G. (1989) Immunocytochemical and morphometric analysis of acinar zymogen granules in human acute pancreatitis Virchows Arch A Pathol Anat Histopathol, 415, pp. 115-23.
47. Bartholomew, C. (1970) Acute scorpion pancreatitis in Trinidad Br Med J, 1, pp. 666-8.
48. Dressel, TD and Goodale, RL, Jr and Arneson, MA and Borner, JW. (1979) Pancreatitis as a complication of anticholinesterase insecticide intoxication Ann Surg, 189, pp. 199-204.
49. Pantoja, JL and Renner, IG and Abramson, SB and Edmondson, HA. (1983) Production of acute hemorrhagic pancreatitis in the dog using venom of the scorpion, Buthus quinquestriatus Dig Dis Sci, 28, pp. 429-39.
50. Dressel, TD and Goodale, RL, Jr and Zweber, B and Borner, JW. (1982) The effect of atropine and duct decompression on the evolution of Diazinon-induced acute canine pancreatitis Ann Surg, 195, pp. 424-34.
51. Siech, M and Heinrich, P and Letko, G. (1991) Development of acute pancreatitis in rats after single ethanol administration and induction of a pancreatic juice edema Int J Pancreatol, 8, pp. 169-75.
52. Andrzejewska, A and Dlugosz, JW and Jurkowska, G. (1998) The effect of antecedent acute ethanol ingestion on the pancreas ultrastructure in taurocholate pancreatitis in rats Exp Mol Pathol, 65, pp. 64-77.
53. Foitzik, T and Lewandrowski, KB and Fernandez-del Castillo, C and Rattner, DW and Klar, E and Warshaw, AL. (1994) Exocrine hyperstimulation but not pancreatic duct obstruction increases the susceptibility to alcohol-related pancreatic injury Arch Surg, 129, pp. 1081-5.
54. Letko, G and Nosofsky, T and Lessel, W and Siech, M. (1991) Transition of rat pancreatic juice edema into acute pancreatitis by single ethanol administration Pathol Res Pract, 187, pp. 247-50.
55. Luthen, RE and Niederau, C and Grendell, JH. (1994) Glutathione and ATP levels, subcellular distribution of enzymes, and permeability of duct system in rabbit pancreas following intravenous administration of alcohol and cerulein Dig Dis Sci, 39, pp. 871-9.
56. Quon, MG and Kugelmas, M and Wisner, JR, Jr and Chandrasoma, P and Valenzuela, JE. (1992) Chronic alcohol consumption intensifies caerulein-induced acute pancreatitis in the rat Int J Pancreatol, 12, pp. 31-9.
57. Schneider, A and Whitcomb, DC and Singer, MV. (2002) Animal models in alcoholic pancreatitis - what can we learn? Pancreatology, 2, pp. 189-203.
58. Katz, M and Carangelo, R and Miller, LJ and Gorelick, F. (1996) Effect of ethanol on cholecystokinin-stimulated zymogen conversion in pancreatic acinar cells Am J Physiol, 270(1 Pt 1), pp. G171-5.
59. Saluja, AK and Lu, L and Yamaguchi, Y and Hofbauer, B and Runzi, M and Dawra, R and (1997) A cholecystokinin-releasing factor mediates ethanol-induced stimulation of rat pancreatic secretion J Clin Invest, 99, pp. 506-12.
60. Lerch, MM and Albrecht, E and Ruthenburger, M and Mayerle, J and Halangk, W and Kruger, B. (2003) Pathophysiology of alcohol-induced pancreatitis Pancreas, 27, pp. 291-6.
61. Pandol, SJ and Periskic, S and Gukovsky, I and Zaninovic, V and Jung, Y and Zong, Y and (1999) Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide Gastroenterology, 117, pp. 706-16.
62. Ponnappa, BC and Marciniak, R and Schneider, T and Hoek, JB and Rubin, E. (1997) Ethanol consumption and susceptibility of the pancreas to cerulein-induced pancreatitis Pancreas, 14, pp. 150-7.
63. Ramo, OJ. (1987) Antecedent long term ethanol consumption in combination with different diets alters the severity of experimental acute pancreatitis in rats Gut, 28, pp. 64-9.
64. Siech, M and Weber, H and Letko, G and Dummler, W and Schoenberg, MH and Beger, HG. (1997) Similar morphological and intracellular biochemical changes in alcoholic acute pancreatitis and ischemic acute pancreatitis in rats Pancreas, 14, pp. 32-8.
65. Wedgwood, KR and Adler, G and Kern, H and Reber, HA. (1986) Effects of oral agents on pancreatic duct permeability. A model of acute alcoholic pancreatitis Dig Dis Sci, 31, pp. 1081-8.
66. Friedman, HS and Lowery, R and Shaughnessy, E and Scorza, J. (1983) The effects of ethanol on pancreatic blood flow in awake and anesthetized dogs Proc Soc Exp Biol Med, 174, pp. 377-82.
67. Lu, Z and Karne, S and Kolodecik, T and Gorelick, FS. (2002) Alcohols enhance caerulein-induced zymogen activation in pancreatic acinar cells Am J Physiol Gastrointest Liver Physiol, 282, pp. G501-7.
68. Weber, H and Merkord, J and Jonas, L and Wagner, A and Schroder, H and Kading, U and (1995) Oxygen radical generation and acute pancreatitis: effects of dibutyltin dichloride/ethanol and ethanol on rat pancreas Pancreas, 11, pp. 382-8.
69. Werner, J and Laposata, M and Fernandez-del Castillo, C and Saghir, M and Iozzo, RV and Lewandrowski, KB and (1997) Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol Gastroenterology, 113, pp. 286-94.
70. Abcouwer SF, Norman J, Fink G, Carter G, Lustig RJ, Souba WW. Tissue-specific regulation of glutamine synthetase gene expression in acute pancreatitis is confirmed by using interleukin-1 receptor knockout mice. Surgery 1996;120:255-63; discussion 263-4.
71. Norman, JG and Fink, GW and Sexton, C and Carter, G. (1996) Transgenic animals demonstrate a role for the IL-1 receptor in regulating IL-1beta gene expression at steady-state and during the systemic stress induced by acute pancreatitis J Surg Res, 63, pp. 231-6.
72. Denham W, Yang J, Norman J. Evidence for an unknown component of pancreatic ascites that induces adult respiratory distress syndrome through an interleukin-1 and tumor necrosis factor-dependent mechanism. Surgery 1997;122:295-301; discussion 301-2.
73. Denham, W and Yang, J and Fink, G and Denham, D and Carter, G and Ward, K and (1997) Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis Gastroenterology, 113, pp. 1741-6.
74. Suzuki, S and Miyasaka, K and Jimi, A and Funakoshi, A. (2000) Induction of acute pancreatitis by cerulein in human IL-6 gene transgenic mice Pancreas, 21, pp. 86-92.
75. Gloor, B and Todd, KE and Lane, JS and Rigberg, DA and Reber, HA. (1998) Mechanism of increased lung injury after acute pancreatitis in IL-10 knockout mice J Surg Res, 80, pp. 110-14.
76. Gerard, C and Frossard, JL and Bhatia, M and Saluja, A and Gerard, NP and Lu, B and (1997) Targeted disruption of the beta-chemokine receptor CCR1 protects against pancreatitis-associated lung injury J Clin Invest, 100, pp. 2022-7.
77. Bhatia, M and Saluja, AK and Hofbauer, B and Frossard, JL and Lee, HS and Castagliuolo, I and (1998) Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury Proc Natl Acad Sci U S A, 95, pp. 4760-5.
78. Grady, EF and Yoshimi, SK and Maa, J and Valeroso, D and Vartanian, RK and Rahim, S and (2000) Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice Br J Pharmacol, 130, pp. 505-12.
79. Frossard, JL and Saluja, A and Bhagat, L and Lee, HS and Bhatia, M and Hofbauer, B and (1999) The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis-associated lung injury Gastroenterology, 116, pp. 694-701.
80. Kaufmann, P and Tilz, GP and Smolle, KH and Demel, U and Krejs, GJ. (1996) Increased plasma concentrations of circulating intercellular adhesion molecule-1 (cICAM-1) in patients with necrotizing pancreatitis Immunobiology, 195, pp. 209-19.
81. Werner J, Z'Graggen K, Fernandez-del Castillo C, Lewandrowski KB, Compton CC, Warshaw AL. Specific therapy for local and systemic complications of acute pancreatitis with monoclonal antibodies against ICAM-1. Ann Surg 1999;229:834-40; discussion 841-2.
82. Fu, K and Tomita, T and Sarras, MP, Jr and De Lisle, RC and Andrews, GK. (1998) Metallothionein protects against cerulein-induced acute pancreatitis: Analysis using transgenic mice Pancreas, 17, pp. 238-46.
83. Halangk, W and Lerch, MM and Brandt-Nedelev, B and Roth, W and Ruthenbuerger, M and Reinheckel, T and (2000) Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis J Clin Invest, 106, pp. 773-81.
84. Umans, L and Serneels, L and Overbergh, L and Stas, L and Van Leuven, F. (1999) alpha2-macroglobulin- and murinoglobulin-1-deficient mice. A mouse model for acute pancreatitis Am J Pathol, 155, pp. 983-93.
85. Bhatia, M and Saluja, AK and Singh, VP and Frossard, JL and Lee, HS and Bhagat, L and (2001) Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injury Am J Physiol Gastrointest Liver Physiol, 280, pp. G974-8.
86. Merriam, LT and Webster, C and Joehl, RJ. (1997) Complement component C5 deficiency reduces edema formation in murine ligation-induced acute pancreatitis J Surg Res, 67, pp. 40-5.
87. Mizuma, K and Schroder, T and Kaarne, M and Korpela, H and Lempinen, M. (1984) Serum phospholipase A2 in diet-induced pancreatitis Eur Surg Res, 16, pp. 156-61.
88. Thal, A and Brackney, E. (1954) Acute hemorrhagic pancreatic necrosis produced by local Shwartzman reaction: Experimental study on pancreatitis JAMA, 155, pp. 569-74.
89. Thal, A. (1955) Studies on pancreatitis. II. Acute pancreatic necrosis produced experimentally by the arthus sensitization reaction Surgery, 37, pp. 911-17.
90. Janigan, DT and Nevalainen, TJ and MacAulay, MA and Vethamany, VG. (1975) Foreign serum-induced pancreatitis in mice. I. A new model of acute pancreatitis Lab Invest, 33, pp. 591-607.
91. Nevalainen, TJ and Fowlie, FE and Janigan, DT. (1977) Foreign serum-induced pancreatitis in mice. II. Secretory disturbances of acinar cells Lab Invest, 36, pp. 469-73.
92. Nevalainen, TJ. (1978) Pancreatic injury caused by intraductal injection of foreign serum in rat Virchows Arch B Cell Pathol, 27, pp. 89-98.
93. Letko, G and Mantke, R and Sokolowski, A and Spormann, H. (1990) Enzymatic and histologic investigations into the course of pancreatic alterations induced by anti-acinar-cell-antiserum Int Surg, 75, pp. 254-8.
94. Jancar, S and De Giaccobi, G and Mariano, M and Mencia-Huerta, JM and Sirois, P and Braquet, P. (1988) Immune complex induced pancreatitis: effect of BN 52021, a selective antagonist of platelet-activating factor Prostaglandins, 35, pp. 757-70.
95. Kanno, H and Nose, M and Itoh, J and Taniguchi, Y and Kyogoku, M. (1992) Spontaneous development of pancreatitis in the MRL/Mp strain of mice in autoimmune mechanism Clin Exp Immunol, 89, pp. 68-73.
96. Waldner, H. (1992) Vascular mechanisms to induce acute pancreatitis Eur Surg Res, 24(Suppl 1), pp. 62-7.
97. Banerjee, AK and Galloway, SW and Kingsnorth, AN. (1994) Experimental models of acute pancreatitis Br J Surg, 81, pp. 1096-103.
98. Lombardi, B and Estes, LW and Longnecker, DS. (1975) Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet Am J Pathol, 79, pp. 465-80.
99. Lombardi, B and Rao, NK. (1975) Acute hemorrhagic pancreatic necrosis in mice. Influence of the age and sex of the animals and of dietary ethionine, choline, methionine, and adenine sulfate Am J Pathol, 81, pp. 87-99.
100. Gilliland, L and Steer, ML. (1980) Effects of ethionine on digestive enzyme synthesis and discharge by mouse pancreas Am J Physiol, 239, pp. G418-26.
101. Lombardi, B. (1976) Influence of dietary factors on the pancreatotoxicity of ethionine Am J Pathol, 84, pp. 633-48.
102. Coelle, EF and Adham, N and Elashoff, J and Lewin, K and Taylor, IL. (1983) Effects of prostaglandin and indomethacin on diet-induced acute pancreatitis in mice Gastroenterology, 85, pp. 1307-12.
103. Buchler, M and Friess, H and Uhl, W and Beger, HG. (1992) Clinical relevance of experimental acute pancreatitis Eur Surg Res, 24(Suppl 1), pp. 85-8.
104. Niederau, C and Luthen, R and Niederau, MC and Grendell, JH and Ferrell, LD. (1992) Acute experimental hemorrhagic-necrotizing pancreatitis induced by feeding a choline-deficient, ethionine-supplemented diet. Methodology and standards Eur Surg Res, 24(Suppl 1), pp. 40-54.
105. Rao, KN and Eagon, PK and Okamura, K and Van Thiel, DH and Gavaler, JS and Kelly, RH and (1982) Acute hemorrhagic pancreatic necrosis in mice. Induction in male mice treated with estradiol Am J Pathol, 109, pp. 8-14.
106. Mizunuma, T and Kawamura, S and Kishino, Y. (1984) Effects of injecting excess arginine on rat pancreas J Nutr, 114, pp. 467-71.
107. Hegyi, P and Rakonczay, Z, Jr and Sari, R and Gog, C and Lonovics, J and Takacs, T and (2004) L-arginine-induced experimental pancreatitis World J Gastroenterol, 10, pp. 2003-9.
108. Varga, IS and Matkovics, B and Hai, DQ and Kotorman, M and Takacs, T and Sasvari, M. (1997) Lipid peroxidation and antioxidant system changes in acute L-arginine pancreatitis in rats Acta Physiol Hung, 85, pp. 129-38.
109. Czako, L and Takacs, T and Varga, IS and Tiszlavicz, L and Hai, DQ and Hegyi, P and (1998) Involvement of oxygen-derived free radicals in L-arginine-induced acute pancreatitis Dig Dis Sci, 43, pp. 1770-7.
110. Czako, L and Takacs, T and Varga, IS and Tiszlavicz, L and Hai, DQ and Hegyi, P and (2000) Oxidative stress in distant organs and the effects of allopurinol during experimental acute pancreatitis Int J Pancreatol, 27, pp. 209-16.
111. Czako, L and Takacs, T and Varga, IS and Hai, DQ and Tiszlavicz, L and Hegyi, P and (2000) The pathogenesis of L-arginine-induced acute necrotizing pancreatitis: Inflammatory mediators and endogenous cholecystokinin J Physiol Paris, 94, pp. 43-50.
112. Varga, IS and Matkovics, B and Czako, L and Hai, DQ and Kotorman, M and Takacs, T and (1997) Oxidative stress changes in L-arginine-induced pancreatitis in rats Pancreas, 14, pp. 355-9.
113. Takacs, T and Czako, L and Morschl, E and Laszlo, F and Tiszlavicz, L and Rakonczay, Z, Jr and (2002) The role of nitric oxide in edema formation in L-arginine-induced acute pancreatitis Pancreas, 25, pp. 277-82.
114. Takacs, T and Czako, L and Jarmay, K and Farkas, G, Jr and Mandi, Y and Lonovics, J. (1996) Cytokine level changes in L-arginine-induced acute pancreatitis in rat Acta Physiol Hung, 84, pp. 147-56.
115. Rakonczay, Z, Jr and Jarmay, K and Kaszaki, J and Mandi, Y and Duda, E and Hegyi, P and (2003) NF-kappaB activation is detrimental in arginine-induced acute pancreatitis Free Radic Biol Med, 34, pp. 696-709.
116. Takacs, T and Rakonczay, Z, Jr and Varga, IS and Ivanyi, B and Mandi, Y and Boros, I and (2002) Comparative effects of water immersion pretreatment on three different acute pancreatitis models in rats Biochem Cell Biol, 80, pp. 241-51.
117. Kishino, Y and Kawamura, S. (1984) Pancreatic damage induced by injecting a large dose of arginine Virchows Arch B Cell Pathol Incl Mol Pathol, 47, pp. 147-55.
118. Tani, S and Itoh, H and Okabayashi, Y and Nakamura, T and Fujii, M and Fujisawa, T and (1990) New model of acute necrotizing pancreatitis induced by excessive doses of arginine in rats Dig Dis Sci, 35, pp. 367-74.
119. Weaver, C and Bishop, AE and Polak, JM. (1994) Pancreatic changes elicited by chronic administration of excess L-arginine Exp Mol Pathol, 60, pp. 71-87.
120. Delaney, CP and McGeeney, KF and Dervan, P and Fitzpatrick, JM. (1993) Pancreatic atrophy: A new model using serial intra-peritoneal injections of L-arginine Scand J Gastroenterol, 28, pp. 1086-90.
121. Steinberg, W and Tenner, S. (1994) Acute pancreatitis N Engl J Med, 330, pp. 1198-210.
122. Renner, IG and Savage, WT 3rd and Pantoja, JL and Renner, VJ. (1985) Death due to acute pancreatitis. A retrospective analysis of 405 autopsy cases Dig Dis Sci, 30, pp. 1005-18.
123. Karimgani, I and Porter, KA and Langevin, RE and Banks, PA. (1992) Prognostic factors in sterile pancreatic necrosis Gastroenterology, 103, pp. 1636-40.
124. Pfeffer, RB and Stasior, O and Hinton, JW. (1957) The clinical picture of the sequential development of acute hemorrhagic pancreatitis in the dog Surg Forum, 8, pp. 248-51.
125. Byrne, JJ and Joison, J. (1964) Bacterial regurgitation in experimental pancreatitis Am J Surg, 107, pp. 317-20.
126. Nance, FC and Cain, JL. (1968) Studies of hemorrhagic pancreatitis in germ-free dogs Gastroenterology, 55, pp. 368-74.
127. Johnson, RH and Doppman, J. (1967) Duodenal reflux and the etiology of pancreatitis Surgery, 62, pp. 462-7.
128. Nevalainen, TJ and Seppa, A. (1975) Acute pancreatitis caused by closed duodenal loop in the rat Scand J Gastroenterol, 10, pp. 521-7.
129. Chetty, U and Gilmour, HM and Taylor, TV. (1980) Experimental acute pancreatitis in the rat - a new model Gut, 21, pp. 115-17.
130. Ferrie, MM and O'Hare, R and Joffe, SN. (1978) Acute and chronic pancreatitis in the rat caused by a closed duodenal loop Digestion, 18, pp. 280-5.
131. Orda, R and Hadas, N and Orda, S and Wiznitzer, T. (1980) Experimental acute pancreatitis. Inducement by taurocholate sodium-trypsin injection into a temporarily closed duodenal loop in the rat Arch Surg, 115, pp. 327-9.
132. Murakami, H and Togawa, M and Takahashi, S and Kasahara, N and Yamamoto, J and Matsuura, N and (1990) Pharmacological studies of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate. Effects on experimental pancreatitis Arzneimittelforschung, 40, pp. 1352-8.
133. Kagugawa, Y and Takeda, K and Sunamura, M and Kawaguchi, S and Kobari, M and Matsuno, S. (1990) Effect of continuous arterial infusion of protease inhibitor on experimental acute pancreatitis induced by closed duodenal loop obstruction Nippon Shokakibyo Gakkai Zasshi, 87, pp. 1444-50.
134. Ono, H and Hayakawa, T and Kondo, T and Shibata, T and Kitagawa, M and Sakai, Y and (1990) Prevention of experimental acute pancreatitis by intraduodenal trypsin inhibitor in rat Dig Dis Sci, 35, pp. 787-92.
135. Ohnishi, H and Kosuzume, H and Ashida, Y and Kato, K and Honjo, I. (1984) Effects of urinary trypsin inhibitor on pancreatic enzymes and experimental acute pancreatitis Dig Dis Sci, 29, pp. 26-32.
136. Takasugi, S and Yonezawa, H and Ikei, N and Kanno, T. (1982) Prevention of acute experimental pancreatitis in rats and dogs by intraduodenal infusion of a synthetic trypsin inhibitor Digestion, 24, pp. 36-41.
137. De Rai, P and Franciosi, C and Confalonieri, GM and Biffi, R and Andreoni, B and Uggeri, F and (1988) Effects of somatostatin on acute pancreatitis induced in rats by injection of taurocholate and trypsin into a temporarily closed duodenal loop Int J Pancreatol, 3, pp. 367-73.
138. Crocket, KV and Brackett, K and Crocket, A and Jacobson, ED and Rao, SS and Joffe, SN. (1984) Prostaglandin E1 treatment in experimental acute pancreatitis in the rat Eur Surg Res, 16, pp. 265-73.
139. Schapiro, H and McDougal, HD and Morrison, EJ and Wan, AT. (1976) Acute hemorrhagic pancreatitis in the dog. IV. Treatment with vasopressin Am J Dig Dis, 21, pp. 286-9.
140. Crocket, KV and Reising, JR and Wirman, JA and Gau, N and Joffe, SN. (1984) Effect of Dextran 40 and aprotinin on experimental acute pancreatitis J Surg Res, 36, pp. 256-64.
141. Weber, A and Friess, H and Sill, U and Buchler, M. (1992) The closed duodenal loop technique Eur Surg Res, 24(Suppl 1), pp. 24-8.
142. Farmer, RC and Maslin, SC and Reber, HA. (1983) Acute pancreatitis: The role of duct permeability Surg Forum, 34, pp. 224-7.
143. Wedgwood, KR and Farmer, RC and Reber, HA. (1986) A model of hemorrhagic pancreatitis in cats - role of 16,16-dimethyl prostaglandin E2 Gastroenterology, 90, pp. 32-9.
144. Widdison, AL and Alvarez, C and Reber, HA. (1992) The low-pressure duct perfusion model of acute pancreatitis Eur Surg Res, 24(Suppl 1), pp. 55-61.
145. Olazabal, A. (1983) Effect of prostaglandins E2 and I2 and of indomethacin on deoxycholic acid-induced damage to the rat bile-pancreatic duct Gastroenterology, 84(5 Pt 1), pp. 928-34.
146. Bilchik, AJ and Leach, SD and Zucker, KA and Modlin, IM. (1990) Experimental models of acute pancreatitis J Surg Res, 48, pp. 639-47.
147. Aho, HJ and Koskensalo, SM and Nevalainen, TJ. (1980) Experimental pancreatitis in the rat. Sodium taurocholate-induced acute haemorrhagic pancreatitis Scand J Gastroenterol, 15, pp. 411-16.
148. Beck, IT and Kahn, DS and Solymar, J and McKenna, RD and Zylberszac, B. (1964) The role of pancreatic enzymes in the pathogenesis of acute pancreatitis. III. Comparison of the pathologic and biochemical changes in the canine pancreas to intraductal injection with bile and with trypsin Gastroenterology, 46, pp. 531-42.
149. Opie, EL. (1901) The etiology of acute hemorrhagic pancreatitis Johns Hopkins Hosp Bull, 12, pp. 182-90.
150. Papp, M and Makara, GB and Hajtman, B and Csaki, L. (1966) A quantitative study of pancreatic blood flow in experimental pancreatitis Gastroenterology, 51, pp. 524-8.
151. Sum, PT and Bencosme, SA and Beck, IT. (1970) Pathogenesis of bile-induced acute pancreatitis in the dog. Experiments with detergents Am J Dig Dis, 15, pp. 637-46.
152. Musa, BE and Nelson, AW and Gillette, EL and Ferguson, HL and Lumb, WV. (1976) A model to study acute pancreatitis in the dog J Surg Res, 21, pp. 51-6.
153. Aho, HJ and Nevalainen, TJ. (1980) Experimental pancreatitis in the rat. Ultrastructure of sodium taurocholate-induced pancreatic lesions Scand J Gastroenterol, 15, pp. 417-24.
154. Aho, HJ and Nevalainen, TJ and Aho, AJ. (1983) Experimental pancreatitis in the rat. Development of pancreatic necrosis, ischemia and edema after intraductal sodium taurocholate injection Eur Surg Res, 15, pp. 28-36.
155. Schmidt, J and Rattner, DW and Lewandrowski, K and Compton, CC and Mandavilli, U and Knoefel, WT and (1992) A better model of acute pancreatitis for evaluating therapy Ann Surg, 215, pp. 44-56.
156. Hietaranta, AJ and Aho, HJ and Gronroos, JM and Hua, ZY and Nevalainen, TJ. (1992) Pancreatic phospholipase A2 in proximal tubules of rat kidney in experimental acute pancreatitis and after intravenous injection of the enzyme Pancreas, 7, pp. 326-33.
157. Elliott DW, Williams RD, Zollinger RM. Alterations in the pancreatic resistance to bile in the pathogenesis of acute pancreatitis. Ann Surg 1957;146:669-81; discussion 681-2.
158. Arendt, T. (1993) Bile-induced acute pancreatitis in cats. Roles of bile, bacteria, and pancreatic duct pressure Dig Dis Sci, 38, pp. 39-44.
159. Condon, RE and Woods, JH and Poulin, TL and Wagner, WG and Pissiotis, CA. (1974) Experimental pancreatitis treated with glucagon or lactated Ringer solution Arch Surg, 109, pp. 154-8.
160. Bockman, DE and Schiller, WR and Anderson, MC. (1971) Route of retrograde flow in the exocrine pancreas during ductal hypertension Arch Surg, 103, pp. 321-9.
161. Klar, E and Messmer, K and Warshaw, AL and Herfarth, C. (1990) Pancreatic ischaemia in experimental acute pancreatitis: Mechanism, significance and therapy Br J Surg, 77, pp. 1205-10.
162. Beger, HG and Rau, B and Mayer, J and Pralle, U. (1997) Natural course of acute pancreatitis World J Surg, 21, pp. 130-5.
163. Bassi, D and Kollias, N and Fernandez-del Castillo, C and Foitzik, T and Warshaw, AL and Rattner, DW. (1994) Impairment of pancreatic microcirculation correlates with the severity of acute experimental pancreatitis J Am Coll Surg, 179, pp. 257-63.
164. Gullo, A and Berlot, G. (1996) Ingredients of organ dysfunction or failure World J Surg, 20, pp. 430-6.
165. Pfeffer, RB and Lazzarini-Robertson, A, Jr and Safadi, D and Mixter, G, Jr and Secoy, CF and Hinton, JW. (1962) Gradations of pancreatitis, edematous, through hemorrhagic, experimentally produced by controlled injection of microspheres into blood vessels in dogs Surgery, 51, pp. 764-9.
166. Lefer, AM and Spath, JA, Jr. (1974) Pancreatic hypoperfusion and the production of a myocardial depressant factor in hemorrhagic shock Ann Surg, 179, pp. 868-76.
167. Barzilai, A and Ryback, BJ and Medina, JA and Toth, L and Dreiling, DA. (1987) The morphological changes of the pancreas in hypovolemic shock and the effect of pretreatment with steroids Int J Pancreatol, 2, pp. 23-32.
168. Warshaw, AL and O'Hara, PJ. (1978) Susceptibility of the pancreas to ischemic injury in shock Ann Surg, 188, pp. 197-201.
169. Eibl, G and Buhr, HJ and Foitzik, T. (2002) Therapy of microcirculatory disorders in severe acute pancreatitis: What mediators should we block? Intensive Care Med, 28, pp. 139-46.
170. Spormann, H and Sokolowski, A and Birkigt, HG and Letko, G. (1986) Contribution of pancreatic edema and short-term ischemia to experimental acute pancreatitis in the rat. I. Procedure and pathomorphological investigations Z Exp Chir Transplant Kunstliche Organe, 19, pp. 323-30.
171. Redha, F and Uhlschmid, G and Ammann, RW and Freiburghaus, AU. (1990) Injection of microspheres into pancreatic arteries causes acute hemorrhagic pancreatitis in the rat: A new animal model Pancreas, 5, pp. 188-93.
172. Sjovall, S and Holmin, T and Evander, A and Stenram, U. (1988) Splenic and gastro-duodenal vein occlusion - influence on the pancreatic gland and on the outcome of experimental pancreatitis Int J Pancreatol, 3, pp. 143-9.
173. Shibayama, Y. (1987) Pancreatic venous stasis and endotoxaemia as aetiologic factors in acute haemorrhagic pancreatitis J Pathol, 152, pp. 177-82.
174. Freiburghaus AU, Redha F, Ammann RW. Acute pancreatitis after microembolism of the rat pancreas progresses into chronic pancreatitis. Digestion 1993;54:277 (abstract).
175. Fernandez-del Castillo, C and Harringer, W and Warshaw, AL and Vlahakes, GJ and Koski, G and Zaslavsky, AM and (1991) Risk factors for pancreatic cellular injury after cardiopulmonary bypass N Engl J Med, 325, pp. 382-7.
176. Fernandez-Cruz, L and Sabater, L and Gilabert, R and Ricart, MJ and Saenz, A and Astudillo, E. (1993) Native and graft pancreatitis
177. Takahasi, TYN. (1985) Ischemic injury of the human pancreas. Its basic patterns correlated with the pancreatic microvasculature Pathol Res Pract, 179, pp. 645-51.
178. Menger, MD and Vollmar, B and Glasz, J and Post, S and Messmer, K. (1993) Microcirculatory manifestations of hepatic ischemia/reperfusion injury Prog Appl Microcirc, 19, pp. 106-24.
179. Hoffmann, TF and Leiderer, R and Waldner, H and Arbogast, S and Messmer, K. (1995) Ischemia reperfusion of the pancreas: A new in vivo model for acute pancreatitis in rats Res Exp Med (Berl), 195, pp. 125-44.
180. Broe, PJ and Zuidema, GD and Cameron, JL. (1982) The role of ischemia in acute pancreatitis: Studies with an isolated perfused canine pancreas Surgery, 91, pp. 377-82.
181. Gress, TM and Arnold, R and Adler, G. (1990) Structural alterations of pancreatic microvasculature in cerulein-induced pancreatitis in the rat Res Exp Med (Berl), 190, pp. 401-12.
182. Busing, M and Hopt, UT and Schareck, WD and Quacken, M and Morgenroth, K. (1990) Ultrastructural changes of human pancreatic allografts after cold ischemia and reperfusion Transplant Proc, 22, pp. 612-13.
183. Busing, M and Hopt, UT and Quacken, M and Becker, HD and Morgenroth, K. (1993) Morphological studies of graft pancreatitis following pancreas transplantation Br J Surg, 80, pp. 1170-3.
184. Anderson, MC and Schiller, WR. (1968) Microcirculatory dynamics in the normal and inflamed pancreas Am J Surg, 115, pp. 118-27.
185. Becker, H and Vinten-Johansen, J and Buckberg, GD and Bugyi, HI. (1982) Correlation of pancreatic blood flow and high-energy phosphates during experimental pancreatitis Eur Surg Res, 14, pp. 203-10.
186. Kelly, DM and McEntee, GP and McGeeney, KF and Fitzpatrick, JM. (1993) Microvasculature of the pancreas, liver, and kidney in cerulein-induced pancreatitis Arch Surg, 128, pp. 293-5.
187. Baxter, JN and Jenkins, SA and Day, DW and Roberts, NB and Cowell, DC and Mackie, CR and (1985) Effects of somatostatin and a long-acting somatostatin analogue on the prevention and treatment of experimentally induced acute pancreatitis in the rat Br J Surg, 72, pp. 382-5.
188. Walker, NI. (1987) Ultrastructure of the rat pancreas after experimental duct ligation. I. The role of apoptosis and intraepithelial macrophages in acinar cell deletion Am J Pathol, 126, pp. 439-51.
189. Lerch, MM and Adler, G. (1994) Experimental animal models of acute pancreatitis Int J Pancreatol, 15, pp. 159-70.
190. Lerch, M and Adler, G. (1993) Experimental pancreatitis Current opinion in gastroenterology, 9, pp. 752-9.
191. Vasilescu, C and Tasca, C. (1991) Acute experimental pancreatitis - morphological evidence for the development of a multiple organ failure syndrome Rom J Morphol Embryol, 37, pp. 25-9.
192. Popper, HL and Necheles, H. (1942) Edema of the pancreas Surg Gynecol Obstet, 74, pp. 123.
193. Popper, HL and Necheles, H and Russell, KC. (1948) Transition of pancreatic edema into pancreatic necrosis Surg Gynecol Obstet, 87, pp. 79.
194. Lerch, MM and Saluja, AK and Dawra, R and Ramarao, P and Saluja, M and Steer, ML. (1992) Acute necrotizing pancreatitis in the opossum: earliest morphological changes involve acinar cells Gastroenterology, 103, pp. 205-13.
195. Lerch, MM and Saluja, AK and Runzi, M and Dawra, R and Saluja, M and Steer, ML. (1993) Pancreatic duct obstruction triggers acute necrotizing pancreatitis in the opossum Gastroenterology, 104, pp. 853-61.
196. Cavuoti, OP and Moody, FG and Martinez, G. (1988) Role of pancreatic duct occlusion with prolamine (Ethibloc) in necrotizing pancreatitis Surgery, 103, pp. 361-6.
197. Senninger, N and Moody, FG and Coelho, JC and Van Buren, DH. (1986) The role of biliary obstruction in the pathogenesis of acute pancreatitis in the opossum Surgery, 99, pp. 688-93.
198. Acosta, JM and Ledesma, CL. (1974) Gallstone migration as a cause of acute pancreatitis N Engl J Med, 290, pp. 484-7.
199. Gukovskaya, AS and Perkins, P and Zaninovic, V and Sandoval, D and Rutherford, R and Fitzsimmons, T and (1996) Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat Gastroenterology, 110, pp. 875-84.
200. Chen, JW and Saccone, GT and Toouli, J. (1998) Sphincter of Oddi dysfunction and acute pancreatitis Gut, 43, pp. 305-8.
201. Chen, JW and Thomas, A and Woods, CM and Schloithe, AC and Toouli, J and Saccone, GT. (2000) Sphincter of Oddi dysfunction produces acute pancreatitis in the possum Gut, 47, pp. 539-45.
202. Liu, YF and Saccone, GT and Thune, A and Baker, RA and Harvey, JR and Toouli, J. (1992) Sphincter of Oddi regulates flow by acting as a variable resistor to flow Am J Physiol, 263(5 Pt 1), pp. G683-9.
203. Toouli, J and Baker, RA. (1991) Innervation of the sphincter of Oddi: physiology and considerations of pharmacological intervention in biliary dyskinesia Pharmacol Ther, 49, pp. 269-81.