A point mutation at F1737 of the human Nav1.7 sodium channel decreases inhibition by local anesthetics

Journal of Neurogenetics

Volumn 25, Issue 4, 2011, Pages 134-139

  Panigel, Jacqueline ^a   Cook, Sean Peter ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Ion sodium channel gating drug effects; Local anesthetic binding site; SCN9a; Voltage gated sodium channel subtype 9a

Indexed keywords

ALANINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; PHENYLALANINE; SODIUM CHANNEL NAV1.7; TETRACAINE; VOLTAGE GATED SODIUM CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; ELECTRIC POTENTIAL; GENE ACTIVATION; GENE INACTIVATION; HUMAN; HUMAN CELL; HYPOTHESIS; IC 50; MUTANT; NERVE CELL; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE POTENTIAL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANESTHETICS, LOCAL; BINDING SITES; BINDING, COMPETITIVE; DRUG RESISTANCE; HEK293 CELLS; HUMANS; ION CHANNEL GATING; NEURAL INHIBITION; NOCICEPTORS; POINT MUTATION; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 81555218164     PISSN: 01677063     EISSN: 15635260     Source Type: Journal    
DOI: 10.3109/01677063.2011.629702     Document Type: Article

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