State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain

Pain

Volumn 110, Issue 1-2, 2004, Pages 166-174

  Wang, Ging Kuo ^a   Russell, Corinna ^a   Wang, Sho Ya ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Amitriptyline; Local anesthetics; Neuropathic pain; State dependent block; Voltage gated Na + channel

Indexed keywords

5 HYDROXY 2 (N PHENETHYL N PROPYLAMINO)TETRALIN; AMITRIPTYLINE; ANESTHETIC AGENT; DRUG RECEPTOR; DRUG RESIDUE; SODIUM CHANNEL;

ALPHA CHAIN; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING; EMBRYO; HUMAN; HUMAN CELL; IC 50; KIDNEY CELL; MUTANT; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; VOLTAGE CLAMP; WILD TYPE;

AMITRIPTYLINE; ANALGESICS, NON-NARCOTIC; ANESTHESIA, LOCAL; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; EMBRYO; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUSCLE PROTEINS; MUTAGENESIS, SITE-DIRECTED; PAIN; PATCH-CLAMP TECHNIQUES; SODIUM CHANNELS; TIME FACTORS; TRANSFECTION;

EID: 3242668020     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2004.03.018     Document Type: Article

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