Synthesis, antimicrobial and cytotoxic activities of some novel thiazole clubbed 1,3,4-oxadiazoles

European Journal of Medicinal Chemistry

Volumn 67, Issue , 2013, Pages 54-59

  Desai, N C ^a   Bhatt, Nayan ^a   Somani, Hardik ^a   Trivedi, Amit ^a  

^a BHAVNAGAR UNIVERSITY   (India)

Author keywords

1,3,4 Oxadiazole; Antibacterial activity; Antifungal activity; Cytotoxicity; Thiazole; Thiazole clubbed 1,3,4 oxadiazoles

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; CHLORAMPHENICOL; N (4 METHYL 5 (4 (((2 NITROPHENYL)AMINO)METHYL) 5 THIOXO 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)THIAZOL 2 YL)ACETAMIDE; N (4 METHYL 5 (4 (((3 NITROPHENYL)AMINO)METHYL) 5 THIOXO 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)THIAZOL 2 YL)ACETAMIDE; N (4 METHYL 5 (4 (((4 NITROPHENYL)AMINO)METHYL) 5 THIOXO 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)THIAZOL 2 YL)ACETAMIDE; N (4 METHYL 5 (5 THIOXO 4 ((M TOLYLAMINO)METHYL) 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)THIAZOL 2 YL)ACETAMIDE; N (4 METHYL 5 (5 THIOXO 4 ((O TOLYLAMINO)METHYL) 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)THIAZOL 2 YL)ACETAMIDE; N (4 METHYL 5 (5 THIOXO 4 ((P TOLYLAMINO)METHYL) 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL)THIAZOL 2 YL)ACETAMIDE; N (5 (4 (((2 FLUOROPHENYL)AMINO)METHYL) 5 THIOXO 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL) 4 METHYLTHIAZOL 2 YL)ACETAMIDE; N (5 (4 (((2 METHOXYPHENYL)AMINO)METHYL) 5 THIOXO 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL) 4 METHYLTHIAZOL 2 YL)ACETAMIDE; N (5 (4 (((3 FLUOROPHENYL)AMINO)METHYL) 5 THIOXO 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL) 4 METHYLTHIAZOL 2 YL)ACETAMIDE; N (5 (4 (((3 METHOXYPHENYL)AMINO)METHYL) 5 THIOXO 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL) 4 METHYLTHIAZOL 2 YL)ACETAMIDE; N (5 (4 (((4 FLUOROPHENYL)AMINO)METHYL) 5 THIOXO 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL) 4 METHYLTHIAZOL 2 YL)ACETAMIDE; N (5 (4 (((4 METHOXYPHENYL)AMINO)METHYL) 5 THIOXO 4,5 DIHYDRO 1,3,4 OXADIAZOL 2 YL) 4 METHYLTHIAZOL 2 YL)ACETAMIDE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ELECTRON; ESCHERICHIA COLI; FEMALE; HUMAN; HUMAN CELL; INFRARED RADIATION; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; STRUCTURE ACTIVITY RELATION; UTERINE CERVIX CANCER;

1,3,4-OXADIAZOLE; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; CYTOTOXICITY; THIAZOLE; THIAZOLE CLUBBED 1,3,4-OXADIAZOLES;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ESCHERICHIA COLI; FUNGI; HELA CELLS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXADIAZOLES; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84880182646     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.06.029     Document Type: Article

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