Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 8, 1999, Pages 1171-1174

  Carter, Jeffery S ^a,b   Kramer, Steven ^a,b   Talley, John J ^a,b   Penning, Thomas ^a,b   Collins, Paul ^a,b   Graneto, Matthew J ^a,b   Seibert, Karen ^a,b   Koboldt, Carol M ^a,b   Masferrer, Jaime ^a,b   Zweifel, Ben ^a,b  

^a PFIZER INC   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; SULFONAMIDE; THIAZOLE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; INFLAMMATION; PHARMACOPHORE; PROSTAGLANDIN SYNTHESIS INHIBITION; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MODELS, CHEMICAL; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; SULFONAMIDES; THIAZOLES;

EID: 0033583501     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00157-2     Document Type: Article

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