Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 2063-2074

  Suresh Kumar, G V ^a   Rajendraprasad, Y ^b   Mallikarjuna, B P ^c   Chandrashekar, S M ^a   Kistayya, C ^b  

^a St Johns Pharmacy College   (India)

^b ANDHRA UNIVERSITY   (India)

^c PES COLLEGE OF PHARMACY   (India)

Author keywords

4 Isopropylthiazole 2 carbohydrazide analogs; Antibacterial; Antifungal; Antitubercular; Broth dilution assay; Clubbed triazole thiazole derivatives; Cytotoxicity

Indexed keywords

1 [2 (4 BROMOPHENYL) 5 (4 ISOPROPYLTHIAZOL 2 YL) 2 METHYL 1,3,4 OXADIAZOL 3(2H)YL]ETHANONE; 1 [2 (4 CHLOROPHENYL) 5 ( 4 ISOPROPYLTHIAZOL 2 YL) 2 METHYL 1,3,4 OXADIAZOL 3 (2H) YL]ETHANONE; 1 [2 (4 HYDROXYPHENYL) 5 (4 ISOPROPYLTHIAZOL 2 YL) 2 METHYL 1,3,4 OXADIAZOL 3(2H)YL]ETHANONE; 1 [5 (4 ISOPROPYLTHIAZOL 2 YL) 2 (4 METHOXYPHENYL) 2 METHYL 1,3,4 OXADIAZOL 3(2H) YL]ETHANONE; 1 [5 (4 ISOPROPYLTHIAZOL 2 YL) 2 METHYL 2 (4 NITROPHENYL) 1,3,4 OXADIAZOL 3(2H)YL]ETHANONE; 1 [5 (4 ISOPROPYLTHIAZOL 2 YL) 2 METHYL 2 PARA TOLYL 1,3,4 OXADIAZOL 3(2H)YL]ETHANONE; 1 [5 (4 ISOPROPYLTHIAZOL 2 YL) 2 METHYL 2 PHENYL 1,3,4 OXADIAZOL 3(2H) YL]ETHANONE; 1 [5 (4 ISOPROPYLTHIAZOL 2 YL) 2,2 DIMETHYL 1,3,4 OXADIAZOL 3(2H) YL]ETHANONE; 2 (4 CHLOROPHENYL) 5 (4 ISOPROPYLTHIAZOL 2 YL) 1,3,4 OXADIAZOLE; 2 (4 ISOPROPYLTHIAZOL 2 YL) 5 (4 METHOXYPHENYL) 1,3,4 OXADIAZOLE; 2 (4 ISOPROPYLTHIAZOL 2 YL) 5 (4 NITROPHENYL) 1,3,4 OXADIAZOLE; 2 (4 ISOPROPYLTHIAZOL 2 YL) 5 PARA TOLYL 1,3,4 OXADIAZOLE; 2 (4 ISOPROPYLTHIAZOL 2 YL) 5 PHENOL 1,3,4 OXADIAZOLE; 2 (4 ISOPROPYLTHIAZOL 2 YL) 5 PHENYL 1,3,4 OXADIAZOLE; 3 (4 ISOPROPYLTHIAZOL 2 YL) 5 METHYL 4 PHENYL 4H 1,2,4 TRIAZOLE; 3 (4 ISOPROPYLTHIAZOL 2 YL) 6 ( 4 NITROPHENYL) [ 1,2,4 ]TRITRIAZOLO[ 3,4 B][ 1,3,4 ]THIADIAZOLE; 4 (2 CHLOROBENZYLIDENEAMINO) 5 (4 ISOPROPYLTHIAZOL 2 YL) 4H 1,2,4 TRIAZOLE 3 THIOL; 4 (2 HYDROXYBENZYLIDENEAMINO) 5 (4 ISOPROPYLTHIAZOL 2 YL) 4H 1,2,4 TRIAZOLE 3 THIOL; 4 (3 PHENYLALLYLIDENEAMINO) 5 (4 ISOPROPYLTHIAZOL 2 YL) 4H 1,2,4 TRIAZOLE 3 THIOL; 4 (3,4 DIMETHOXYBENZYLIDENEAMINO) 5 (4 ISOPROPYLTHIAZOL 2 YL) 4H 1,2,4 TRIAZOLE 3 THIOL; 4 (3,4,5 TRIMETHOXYBENZYLIDENEAMINO) 5 (4 ISOPROPYLTHIAZOL 2 YL) 4H 1,2,4 TRIAZOLE 3 THIOL; 4 (4 BROMOBENZYLIDENEAMINO) 5 (4 ISOPROPYLTHIAZOL 2 YL) 4H 1,2,4 TRIAZOLE 3 THIOL; 4 (4 DIMETHYLAMINEBENZYLIDENEAMINO) 5 (4 ISOISOPROPYLTHIAZOL 2 YL) 4H 1,2,4 TRIAZOLE 3 THIOL; 4 (4 METHOXYBENZYLIDENEAMINO) 5 (4 ISOPROPYLTHIAZOL 2 YL) 4H 1,2,4 TRIAZOLE 3 THIOL; 4 (BENZYLIDENEAMINO) 5 (4 ISOPROPYLTHIAZOL 2 YL) 4H 1,2,4 TRIAZOLE 3 THIOL; 5 (4 ISOPROPYLTHIAZOL 2 YL) 4 PHENYL 4H 1,2,4 TRIAZOLE 3 THIOL; ANTIFUNGAL AGENT; OXADIAZOLE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACILLUS SUBTILIS; BACTERIAL GROWTH; BACTERIAL STRAIN; BROTH DILUTION; CANDIDA TROPICALIS; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GROWTH INHIBITION; INFRARED SPECTROMETRY; KLEBSIELLA PNEUMONIAE; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; SACCHAROMYCES CEREVISIAE; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; ANTITUBERCULAR AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; OXADIAZOLES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRIAZOLES;

EID: 77949659737     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.045     Document Type: Article

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