Synthesis of 4-benzyl-1,3-thiazole derivatives as potential anti-inflammatory agents: An analogue-based drug design approach

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 24, Issue 3, 2009, Pages 890-897

  Sharma, Ritesh N ^a   Xavier, Franklin P ^b   Vasu, Kamala K ^b   Chaturvedi, Subhash C ^c   Pancholi, Shyam S ^a  

^a GANPAT UNIVERSITY   (India)

^b B V PATEL PHARMACEUTICAL EDUCATION AND RESEARCH DEVELOPMENT PERD CENTRE   (India)

^c DEVI AHILYA UNIVERSITY   (India)

Author keywords

4 benzyl 1,3 thiazole; Analogue design; Anti inflammatory; Bioisosterism; Darbufelone; Romazarit

Indexed keywords

((Z) 5 [[3,5 BIS(1,1 DIMETHYLETHYL) 4 HYDROXYPHENYL]METHYLLENE] 2 IMINO 4 THIAZOLIDINONE; 4 BENZYL 1,3 THIAZOLE; AMINO ACID DERIVATIVE; ANTIINFLAMMATORY AGENT; CARBONYL DERIVATIVE; MOLECULAR SCAFFOLD; ROMAZARIT; THIAZOLE DERIVATIVE; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG; ANALGESIC AGENT; BENZYL DERIVATIVE; CARRAGEENAN; DARBUFELONE; OXAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; MALE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RAT; SUBSTITUTION REACTION; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; DOSE RESPONSE; EDEMA; HINDLIMB; PATHOLOGY; PLETHYSMOGRAPHY; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZYL COMPOUNDS; CARRAGEENAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; EDEMA; FEMALE; HINDLIMB; MALE; OXAZOLES; PLETHYSMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIAZOLIDINES;

EID: 70749097429     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360802519558     Document Type: Article

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