Synthesis and QSAR studies of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives as potential antimicrobial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 16, 2004, Pages 4185-4190

  Sharma, Pratibha ^a   Rane, Nilesh ^a   Gurram, V K ^a  

^a DEVI AHILYA UNIVERSITY   (India)

Author keywords

Antibacterial; Antifungal; Molar refractivity; Pyrimido 4,5 d pyrimidine; QSAR; Synthesis

Indexed keywords

4 (2 CHLOROPHENYL) 3 (4 CHLOROPHENYLAZO) 6 ETHOXY 2 OXO 1,2,3,4 TETRAHYDRO 5 ETHYLCARBOXYLATOPYRIMIDINE; ANTIINFECTIVE AGENT; ETHYL 4 (2 CHLOROPHENYL) 6 ETHOXY 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROSCOPY; NONHUMAN; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTI-INFECTIVE AGENTS; MODELS, MOLECULAR; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3142698398     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.06.014     Document Type: Article

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27. Important structural data for compound 5h. Bond length (Å), C17-C12, 1.51, N21-C29, 1.43, N19-N8, 1.35, N8-N7, 1.24, N7-C1, 1.43, C6-Cl34, 1.70, C14-Cl35, 1.70; Bond angles (deg), C17-N19-N8, 114.51, N19-N8-N7, 120.64, N8-N7-C1, 119.91, C15-C17-C12, 117.72, C23-N21-C29, 118.80; Torsion angle (Å), N19-N8-N7-C1, 178.25, N8-N7-C1-C3, -3.78, C22-N21-C29-C27, 91.82, C15-C17-C12-C14, -141.20