Design, Synthesis and Evaluation of Antiinflammatory, Analgesic and Ulcerogenicity studies of Novel S-Substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of Diclofenac acid as Nonulcerogenic Derivatives

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 4, 2008, Pages 1822-1831

  Bhandari, Shashikant V ^a   Bothara, Kailash G ^a   Raut, Mayuresh K ^a   Patil, Ajit A ^a   Sarkate, Aniket P ^a   Mokale, Vinod J ^a  

^a AISSMS COLLEGE OF PHARMACY   (India)

Author keywords

1,3,4 Oxadiazole; Analgesic; Anti inflammatory; Diclofenac; Ulcerogenicity

Indexed keywords

5 [2 (2,6 DICHLOROANILINO)BENZYL] (3 METHOXYPHENACYL) 1,3,4 OXADIAZOLE 2 THIOL; 5 [2 (2,6 DICHLOROANILINO)BENZYL] (3,4 DIMETHOXYPHENACYL) 1,3,4 OXADIAZOLE 2 THIOL; 5 [2 (2,6 DICHLOROANILINO)BENZYL] (4 BROMOPHENACYL) 1,3,4 OXADIAZOLE 2 THIOL; 5 [2 (2,6 DICHLOROANILINO)BENZYL] (4 HYDROXYPHENACYL) 1,3,4 OXADIAZOLE 2 THIOL; ACETIC ACID; ANTIINFLAMMATORY AGENT; DICLOFENAC; DICLOFENAC ACID; N (2 HYDROXYBENZYLIDENYL) [2 (2,6 DICHLOROANILINO)BENZYL CARBAZIDE]; N (4 BROMO BENZYLIDENYL) [2 (2,6 DICHLOROANILINO)BENZYL CARBAZIDE]; N (4 METHOXYBENZYLIDENYL) [2 (2,6 DICHLOROANILINO)BENZYL CARBAZIDE]; N (CINNAMALDENYL) [2 (2,6 DICHLOROANILINO)BENZYL CARBAZIDE]; PHENACYL 1,3,4 OXADIAZOLE 2 THIOL; SCHIFF BASE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EDEMA; HISTOPATHOLOGY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SYNTHESIS; THIN LAYER CHROMATOGRAPHY; ULCEROGENESIS; WRITHING TEST;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; OXADIAZOLES; RATS; SCHIFF BASES; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

RATTUS;

EID: 39049103420     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.014     Document Type: Article

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