Aroylpropionic acid based 2,5-disubstituted-1,3,4-oxadiazoles: Synthesis and their anti-inflammatory and analgesic activities

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2372-2378

  Akhter, Mymoona ^a   Husain, Asif ^a   Azad, Bismillah ^a   Ajmal, Mohd ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

1,3,4 Oxadiazoles; Anti inflammatory agents; Aroylpropionic acid

Indexed keywords

2 (3 PHENYL PROPANE 3 ONE) 5 (1 NAPHTHOXYMETHYL) 1,3,4 OXADIAZOLE; 2 (3 PHENYL PROPANE 3 ONE) 5 (2 CHLOROPHENYL) 1,3,4 OXADIAZOLE; 2 (3 PHENYL PROPANE 3 ONE) 5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOLE; 2 (3 PHENYL PROPANE 3 ONE) 5 (4 NITROPHENYL) 1,3,4 OXADIAZOLE; 2 (3 PHENYL PROPANE 3 ONE) 5 PHENYL 1,3,4 OXADIAZOLE; 2 [3 (2,4 DIMETHYLPHENYL) PROPANE 3 ONE] 5 (2 CHLOROPHENYL) 1,3,4 OXADIAZOLE; 2 [3 (2,4 DIMETHYLPHENYL) PROPANE 3 ONE] 5 (3,4 DIMETHOXYPHENYL) 1,3,4 OXADIAZOLE; 2 [3 (2,4 DIMETHYLPHENYL) PROPANE 3 ONE] 5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOLE; 2 [3 (2,4 DIMETHYLPHENYL) PROPANE 3 ONE] 5 (4 METHOXYPHENYL) 1,3,4 OXADIAZOLE; 2 [3 (2,4 DIMETHYLPHENYL) PROPANE 3 ONE] 5 (4 NITROPHENYL) 1,3,4 OXADIAZOLE; 2 [3 (2,4 DIMETHYLPHENYL) PROPANE 3 ONE] 5 BENZYL 1,3,4 OXADIAZOLE; 2 [3 (2,4 DIMETHYLPHENYL) PROPANE 3 ONE] 5 PHENOXYMETHYL 1,3,4 OXADIAZOLE; 2 [3 (2,4 DIMETHYLPHENYL) PROPANE 3 ONE] 5 PHENYL 1,3,4 OXADIAZOLE; 2 [3 (4 METHYLPHENYL) PROPANE 3 ONE] 5 (1 NAPHTHOXYMETHYL) 1,3,4 OXADIAZOLE; 2 [3 (4 METHYLPHENYL) PROPANE 3 ONE] 5 (2 CHLOROPHENYL) 1,3,4 OXADIAZOLE; 2 [3 (4 METHYLPHENYL) PROPANE 3 ONE] 5 (2 NAPHTHOXYMETHYL) 1,3,4 OXADIAZOLE; 2 [3 (4 METHYLPHENYL) PROPANE 3 ONE] 5 (3,4 DIMETHOXYPHENYL) 1,3,4 OXADIAZOLE; 2 [3 (4 METHYLPHENYL) PROPANE 3 ONE] 5 (4 CHLOROPHENYL) 1,3,4 OXADIAZOLE; 2 [3 (4 METHYLPHENYL) PROPANE 3 ONE] 5 (4 METHOXYPHENYL) 1,3,4 OXADIAZOLE DERIVATIVE; 2 [3 (4 METHYLPHENYL) PROPANE 3 ONE] 5 (4 NITROPHENYL) 1,3,4 OXADIAZOLE; 2 [3 (4 METHYLPHENYL) PROPANE 3 ONE] 5 BENZYL 1,3,4 OXADIAZOLE; 2 [3 (4 METHYLPHENYL) PROPANE 3 ONE] 5 PHENOXYMETHYL 1,3,4 OXADIAZOLE; 2 [3 (4 METHYLPHENYL) PROPANE 3 ONE] 5 PHENYL 1,3,4 OXADIAZOLE; ACETIC ACID; IBUPROFEN; MALONALDEHYDE; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VIVO STUDY; LIPID PEROXIDATION; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PAW EDEMA; RAT;

ACUTE DISEASE; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CYCLIZATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; EDEMA; IBUPROFEN; LIPID PEROXIDATION; MICE; MOLECULAR STRUCTURE; OXADIAZOLES; PROPIONIC ACIDS; RATS; RATS, WISTAR; STEREOISOMERISM; STOMACH ULCER;

EID: 64249110012     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.005     Document Type: Article

References (23)

1. Guyton C.A., and Hall J.E. Textbook of Medical Physiology. ninth ed. (1998), Harcourt Asia Pte. Ltd. p. 846
2. Vane J.R., Bakhle Y.S., and Bolting R.M. Annu. Rev. Pharmacol. Toxicol. 38 (1998) 97
3. Guslandi M. Drugs 53 (1997) 1
4. Khan M.S.Y., and Akhter M. Eur. J. Med. Chem. 40 (2005) 371
5. Amir M., and Kumar S. Pharmazie 60 (2005) 175
6. Khan M.S.Y., Husain A., Hasan S.M., and Akhter M. Sci. Pharm. 70 (2002) 277
7. Bhandari S.V., Bothara K.G., Raut M.K., Patil A.A., Sarkate A.P., and Mokale V.J. Bioorg. Med. Chem. 16 (2008) 1822
8. Amir M., Kumar H., and Javed S.A. Arch. Pharm. (Weinheim) 340 (2007) 577
9. Abdel K.M., Mohga M.E., and Nasser S.A. Molecules 8 (2003) 744
10. Liu Z.M., Yang G.F., and Qing X.H. J. Chem. Technol. Biotechnol. 76 (2001) 1154
11. Narayana B., Ashalatha B.V., Vijay Raj K.K., Fernandes J., and Sarojini B.K. Biorg. Med. Chem. Lett. 13 (2005) 4638
12. Khan M.S.Y., and Akhter M. Ind. J. Chem. 42B (2003) 900
13. Abdel el-Samii Z.K. J. Chem. Technol. Biotechnol. 53 (1992) 143
14. Kadi A.A., El-Brollosy N.R., Al-Deeb O.A., Habib E.E., Ibrahim T.M., and El-Emam A.A. Eur. J. Med. Chem. 42 (2007) 235
15. Santagati M., Modica M., Santagati A., Russo F., Caruso A., Cutuli V., Di Pietro E., and Amico-Roxas M. Pharmazie 49 (1994) 880
16. Boschelli D.H., Connor D.T., Bornemeier D.A., Dyer R.D., Kennedy J.A., Kuipers P.J., Okonkwo G.C., Schrier D.J., and Wright C.D. J. Med. Chem. 36 (1993) 1802
17. Mullican M.D., Wilson M.W., Connor D.T., Kostlan C.R., Schrier D.J., and Dyer R.D. J. Med. Chem. 36 (1993) 1090
18. Somerville L.F., and Allen C.H.F. In: Blatt A.H. (Ed). Organic Synthesis Collective Volume II (Jan 1943), Wiley 81
19. Amir M., and Kumar S. Eur. J. Med. Chem. 39 (2004) 535
20. Winter C., Risley E., and Nuss G. Proc. Soc. Exp. Biol. Med. 111 (1962) 544
21. Seigmund E., Cadmus R., and Lu G. Proc. Soc. Exp. Biol. Med. 95 (1957) 729
22. Cioli V., Putzolu S., Rossi V., Corza B.P., and Corradino C. Toxicol. Appl. Pharmacol. 50 (1979) 283
23. Ohkawa H., Ohishi N., and Yagi K. Anal. Biochem. 95 (1979) 351