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Volumn 2, Issue 3, 2012, Pages 345-356

Microglial physiopathology: How to explain the dual role of microglia after acute neural disorders?

Author keywords

Beneficial; CNS damage; Detrimental; Glial cells; Pattern recognition receptors; Spinal cord injury; Stroke

Indexed keywords

4 AMINOBUTYRIC ACID; ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOLAMINE; CD22 ANTIGEN; CD36 ANTIGEN; CD86 ANTIGEN; COMPLEMENT COMPONENT C3; FC RECEPTOR; FRACTALKINE; GLUTAMIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NERVE GROWTH FACTOR; NEUROMELANIN; PRION PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCAVENGER RECEPTOR A; SCAVENGER RECEPTOR BI; SECONDARY LYMPHOID TISSUE CHEMOKINE; SOMATOMEDIN C; THROMBIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

EID: 84880089425     PISSN: 21623279     EISSN: 21579032     Source Type: Journal    
DOI: 10.1002/brb3.51     Document Type: Article
Times cited : (90)

References (97)
  • 1
    • 0347364630 scopus 로고    scopus 로고
    • Migration and differentiation of neural precursor cells can be directed by microglia
    • Aarum, J., K. Sandberg, S. L. Haeberlein, and M. A. Persson. 2003. Migration and differentiation of neural precursor cells can be directed by microglia. Proc. Natl. Acad. Sci. U.S.A. 100:15983-15988.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 15983-15988
    • Aarum, J.1    Sandberg, K.2    Haeberlein, S.L.3    Persson, M.A.4
  • 2
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira, S., S. Uematsu, and O. Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 3
    • 0032737272 scopus 로고    scopus 로고
    • Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
    • Alliot, F., I. Godin, and B. Pessac. 1999. Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain. Brain Res. Dev. Brain Res. 117:145-152.
    • (1999) Brain Re. Dev. Brain Res. , vol.117 , pp. 145-152
    • Alliot, F.1    Godin, I.2    Pessac, B.3
  • 4
    • 0036470478 scopus 로고    scopus 로고
    • Neurogenesis in adult subventricular zone
    • Alvarez-Buylla, A., and J. M. Garcia-Verdugo. 2002. Neurogenesis in adult subventricular zone. J. Neurosci. 22:629-634.
    • (2002) J. Neurosci. , vol.22 , pp. 629-634
    • Alvarez-Buylla, A.1    Garcia-Verdugo, J.M.2
  • 5
    • 33644960523 scopus 로고    scopus 로고
    • Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus
    • Battista, D., C. C. Ferrari, F. H. Gage, and F. J. Pitossi. 2006. Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. Eur. J. Neurosci. 23:83-93.
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 83-93
    • Battista, D.1    Ferrari, C.C.2    Gage, F.H.3    Pitossi, F.J.4
  • 6
    • 33846887598 scopus 로고    scopus 로고
    • Microglial control of neuronal death and synaptic properties
    • Bessis, A., C. Bechade, D. Bernard, and A. Roumier. 2007. Microglial control of neuronal death and synaptic properties. Glia 55:233-238.
    • (2007) Glia , vol.55 , pp. 233-238
    • Bessis, A.1    Bechade, C.2    Bernard, D.3    Roumier, A.4
  • 7
    • 19544376505 scopus 로고    scopus 로고
    • Inflammation in areas of remote changes following focal brain lesion
    • Block, F., M. Dihne, and M. Loos. 2005. Inflammation in areas of remote changes following focal brain lesion. Prog. Neurobiol. 75:342-365.
    • (2005) Prog. Neurobiol , vol.75 , pp. 342-365
    • Block, F.1    Dihne, M.2    Loos, M.3
  • 8
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism
    • Block, M. L., and J. S. Hong. 2005. Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog. Neurobiol. 76:77-98.
    • (2005) Prog. Neurobiol , vol.76 , pp. 77-98
    • Block, M.L.1    Hong, F.S.2
  • 9
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
    • Block, M. L., L. Zecca, and J. S. Hong. 2007. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8:57-69.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, F.S.3
  • 11
    • 0036841128 scopus 로고    scopus 로고
    • Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis
    • Broderick, C., R. M. Hoek, J. V. Forrester, J. Liversidge, J. D. Sedgwick, and A. D. Dick. 2002. Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am. J. Pathol. 161:1669-1677.
    • (2002) Am. J. Pathol. , vol.161 , pp. 1669-1677
    • Broderick, C.1    Hoek, R.M.2    Forrester, J.V.3    Liversidge, J.4    Sedgwick, J.D.5    Dick, A.D.6
  • 14
    • 0035315852 scopus 로고    scopus 로고
    • Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7-2 (CD86) and prevention of cyst formation
    • Butovsky, O., E. Hauben, and M. Schwartz. 2001. Morphological aspects of spinal cord autoimmune neuroprotection: colocalization of T cells with B7-2 (CD86) and prevention of cyst formation. FASEB J. 15:1065-1067.
    • (2001) FASEB J , vol.15 , pp. 1065-1067
    • Butovsky, O.1    Hauben, E.2    Schwartz, M.3
  • 15
    • 20444364844 scopus 로고    scopus 로고
    • Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective
    • Butovsky, O., A. E. Talpalar, K. Ben-Yaakov, and M. Schwartz. 2005. Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol. Cell. Neurosci. 29:381-393.
    • (2005) Mol. Cell. Neurosci. , vol.29 , pp. 381-393
    • Butovsky, O.1    Talpalar, A.E.2    Ben-Yaakov, K.3    Schwartz, M.4
  • 17
    • 14944379101 scopus 로고    scopus 로고
    • The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia
    • Cho, S., E. M. Park, M. Febbraio, J. Anrather, L. Park, G. Racchumi, R. L. Silverstein, and C. Iadecola. 2005. The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. J. Neurosci. 25:2504-2512.
    • (2005) J. Neurosci. , vol.25 , pp. 2504-2512
    • Cho, S.1    Park, E.M.2    Febbraio, M.3    Anrather, J.4    Park, L.5    Racchumi, G.6    Silverstein, R.L.7    Iadecola, C.8
  • 19
    • 0030979469 scopus 로고    scopus 로고
    • Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain
    • Doetsch, F., J. M. Garcia-Verdugo, and A. Alvarez-Buylla. 1997. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J. Neurosci. 17:5046-5061.
    • (1997) J. Neurosci. , vol.17 , pp. 5046-5061
    • Doetsch, F.1    Garcia-Verdugo, J.M.2    Alvarez-Buylla, A.3
  • 20
    • 77954884148 scopus 로고    scopus 로고
    • Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS?
    • Downes, C. E., and P. J. Crack. 2010. Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS? Br. J. Pharmacol. 160:1872-1888.
    • (2010) Br. J. Pharmacol , vol.160 , pp. 1872-1888
    • Downes, C.E.1    Crack, P.J.2
  • 23
    • 59349110661 scopus 로고    scopus 로고
    • Brain inflammation and adult neurogenesis: the dual role of microglia
    • Ekdahl, C. T., Z. Kokaia, and O. Lindvall. 2009. Brain inflammation and adult neurogenesis: the dual role of microglia. Neuroscience 158:1021-1029.
    • (2009) Neuroscience , vol.158 , pp. 1021-1029
    • Ekdahl, C.T.1    Kokaia, Z.2    Lindvall, O.3
  • 25
    • 33847783428 scopus 로고    scopus 로고
    • Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene
    • Fendrick, S. E., Q. S. Xue, andW. J. Streit. 2007. Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene. J. Neuroinflammation 4:9.
    • (2007) J. Neuroinflammation , vol.4 , pp. 9
    • Fendrick, S.E.1    Xue, Q.S.2    Streit, W.J.3
  • 27
    • 29044451027 scopus 로고    scopus 로고
    • Systematic analysis of axonal damage and inflammatory response in different white matter tracts of acutely injured rat spinal cord
    • Gomes-Leal, W., D. J. Corkill, and C.W. Picanco-Diniz. 2005. Systematic analysis of axonal damage and inflammatory response in different white matter tracts of acutely injured rat spinal cord. Brain Res. 1066:57-70.
    • (2005) Brain Res , vol.1066 , pp. 57-70
    • Gomes-Leal, W.1    Corkill, D.J.2    Picanco-Diniz, C.W.3
  • 28
    • 0024255828 scopus 로고
    • Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells
    • Graeber, M. B., W. J. Streit, and G.W. Kreutzberg. 1988. Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells. J. Neurosci. Res. 21:18-24.
    • (1988) J. Neurosci. Res. , vol.21 , pp. 18-24
    • Graeber, M.B.1    Streit, W.J.2    Kreutzberg, G.W.3
  • 29
    • 34547519410 scopus 로고    scopus 로고
    • Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins
    • Griffiths, M., J.W. Neal, and P. Gasque. 2007. Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins. Int. Rev. Neurobiol. 82:29-55.
    • (2007) Int. Rev. Neurobiol. , vol.82 , pp. 29-55
    • Griffiths, M.1    Neal, J.W.2    Gasque, P.3
  • 30
    • 33846586015 scopus 로고    scopus 로고
    • Use of a poly(ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion
    • Hamby, A. M., S.W. Suh, T. M. Kauppinen, and R. A. Swanson. 2007. Use of a poly(ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion. Stroke 38:632-636.
    • (2007) Stroke , vol.38 , pp. 632-636
    • Hamby, A.M.1    Suh, S.W.2    Kauppinen, T.M.3    Swanson, R.A.4
  • 31
    • 41249088005 scopus 로고    scopus 로고
    • Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism
    • Hayakawa, K., K. Mishima, M. Nozako, M. Hazekawa, S. Mishima, M. Fujioka, K. Orito, N. Egashira, K. Iwasaki, andM. Fujiwara. 2008. Delayed treatment with minocycline ameliorates neurologic impairment through activated microglia expressing a high-mobility group box1-inhibiting mechanism. Stroke 39:951-958.
    • (2008) Stroke , vol.39 , pp. 951-958
    • Hayakawa, K.1    Mishima, K.2    Nozako, M.3    Hazekawa, M.4    Mishima, S.5    Fujioka, M.6    Orito, K.7    Egashira, N.8    Iwasaki, K.9    Fujiwara, M.10
  • 32
    • 79956152659 scopus 로고    scopus 로고
    • Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke
    • Heldmann, U., Y. Mine, Z. Kokaia, C. T. Ekdahl, and O. Lindvall. 2011. Selective depletion of Mac-1-expressing microglia in rat subventricular zone does not alter neurogenic response early after stroke. Exp. Neurol. 229:391-398.
    • (2011) Exp. Neurol. , vol.229 , pp. 391-398
    • Heldmann, U.1    Mine, Y.2    Kokaia, Z.3    Ekdahl, C.T.4    Lindvall, O.5
  • 33
    • 33749069319 scopus 로고    scopus 로고
    • Delayed minocycline treatment reduces long-term functional deficits and histological injury in a rodent model of focal ischemia
    • Hewlett, K. A., and D. Corbett. 2006. Delayed minocycline treatment reduces long-term functional deficits and histological injury in a rodent model of focal ischemia. Neuroscience 141:27-33.
    • (2006) Neuroscience , vol.141 , pp. 27-33
    • Hewlett, K.A.1    Corbett, D.2
  • 34
    • 33644671406 scopus 로고    scopus 로고
    • Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin
    • Hoehn, B. D., T. D. Palmer, and G. K. Steinberg. 2005. Neurogenesis in rats after focal cerebral ischemia is enhanced by indomethacin. Stroke 36:2718-2724.
    • (2005) Stroke , vol.36 , pp. 2718-2724
    • Hoehn, B.D.1    Palmer, T.D.2    Steinberg, G.K.3
  • 35
    • 0036847848 scopus 로고    scopus 로고
    • Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system
    • Husemann, J., J. D. Loike, R. Anankov, M. Febbraio, and S. C. Silverstein. 2002. Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system. Glia 40:195-205.
    • (2002) Glia , vol.40 , pp. 195-205
    • Husemann, J.1    Loike, J.D.2    Anankov, R.3    Febbraio, M.4    Silverstein, S.C.5
  • 36
    • 0031866386 scopus 로고    scopus 로고
    • Focal ischaemia of the rat brain elicits an unusual inflammatory response: early appearance of CD8+ macrophages/microglia
    • Jander, S., M. Schroeter, D. D'Urso, C. Gillen, O.W.Witte, and G. Stoll. 1998. Focal ischaemia of the rat brain elicits an unusual inflammatory response: early appearance of CD8+ macrophages/microglia. Eur. J. Neurosci. 10:680-688.
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 680-688
    • Jander, S.1    Schroeter, M.2    D'Urso, D.3    Gillen, C.4    Witte, O.W.5    Stoll, G.6
  • 37
    • 32944474237 scopus 로고    scopus 로고
    • Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer
    • Karin, M., T. Lawrence, and V. Nizet. 2006. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell 124:823-835.
    • (2006) Cell , vol.124 , pp. 823-835
    • Karin, M.1    Lawrence, T.2    Nizet, V.3
  • 38
    • 39849083520 scopus 로고    scopus 로고
    • Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra
    • Kaushal, V., and L. C. Schlichter. 2008. Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J. Neurosci. 28:2221-2230.
    • (2008) J. Neurosci. , vol.28 , pp. 2221-2230
    • Kaushal, V.1    Schlichter, L.C.2
  • 39
    • 70350558453 scopus 로고    scopus 로고
    • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    • Kigerl, K. A., J. C.Gensel, D. P. Ankeny, J. K. Alexander, D. J. Donnelly, and P. G. Popovich. 2009. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J. Neurosci. 29:13435-13444.
    • (2009) J. Neurosci. , vol.29 , pp. 13435-13444
    • Kigerl, K.A.1    Gensel, J.C.2    Ankeny, D.P.3    Alexander, J.K.4    Donnelly, D.J.5    Popovich, P.G.6
  • 40
    • 57549088119 scopus 로고    scopus 로고
    • Minocycline and neurodegenerative diseases. Behav
    • Kim, H. S., and Y. H. Suh. 2009. Minocycline and neurodegenerative diseases. Behav. Brain Res. 196:168-179.
    • (2009) Brain Res , vol.196 , pp. 168-179
    • Kim, H.S.1    Suh, Y.H.2
  • 41
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg, G.W. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 42
    • 33847785649 scopus 로고    scopus 로고
    • Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
    • Lalancette-Hebert, M, G. Gowing, A. Simard, Y. C.Weng, and J. Kriz. 2007. Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J. Neurosci. 27:2596-2605.
    • (2007) J. Neurosci. , vol.27 , pp. 2596-2605
    • Lalancette-Hebert, M.1    Gowing, G.2    Simard, A.3    Weng, Y.C.4    Kriz, J.5
  • 45
    • 75849151435 scopus 로고    scopus 로고
    • Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury
    • Lehnardt, S. 2010. Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury. Glia 58:253-263.
    • (2010) Glia , vol.58 , pp. 253-263
    • Lehnardt, S.1
  • 47
    • 40449097556 scopus 로고    scopus 로고
    • A vicious cycle involving release of heat shock protein 60 from injured cells and activation of Toll-like receptor 4 mediates neurodegeneration in the CNS
    • Lehnardt, S., E. Schott, T. Trimbuch, D. Laubisch, C. Krueger, G. Wulczyn, R. Nitsch, and J. R.Weber. 2008. A vicious cycle involving release of heat shock protein 60 from injured cells and activation of Toll-like receptor 4 mediates neurodegeneration in the CNS. J. Neurosci. 28:2320-2331.
    • (2008) J. Neurosci. , vol.28 , pp. 2320-2331
    • Lehnardt, S.1    Schott, E.2    Trimbuch, T.3    Laubisch, D.4    Krueger, C.5    Wulczyn, G.6    Nitsch, R.7    Weber, J.R.8
  • 48
    • 0030769136 scopus 로고    scopus 로고
    • Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion
    • Lehrmann, E., T. Christensen, J. Zimmer, N. H. Diemer, and B. Finsen. 1997. Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion. J. Comp. Neurol. 386:461-476.
    • (1997) J. Comp. Neurol. , vol.386 , pp. 461-476
    • Lehrmann, E.1    Christensen, T.2    Zimmer, J.3    Diemer, N.H.4    Finsen, B.5
  • 50
    • 33745243255 scopus 로고    scopus 로고
    • Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally
    • Ling, Z., Y. Zhu, C. Tong, J. A. Snyder, J.W. Lipton, and P.M. Carvey. 2006. Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally. Exp. Neurol. 199:499-512.
    • (2006) Exp. Neurol. , vol.199 , pp. 499-512
    • Ling, Z.1    Zhu, Y.2    Tong, C.3    Snyder, J.A.4    Lipton, J.W.5    Carvey, P.M.6
  • 51
    • 33845938979 scopus 로고    scopus 로고
    • Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia
    • Liu, Z., Y. Fan, S. J. Won, M. Neumann, D.Hu, L. Zhou, P. R. Weinstein, and J. Liu. 2007. Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia. Stroke 38:146-152.
    • (2007) Stroke , vol.38 , pp. 146-152
    • Liu, Z.1    Fan, Y.2    Won, S.J.3    Neumann, M.4    Hu, D.5    Zhou, L.6    Weinstein, P.R.7    Liu, J.8
  • 52
    • 34547680192 scopus 로고    scopus 로고
    • CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4
    • Lyons, A., E. J. Downer, S. Crotty, Y. M. Nolan, K. H. Mills, and M. A. Lynch. 2007. CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4. J. Neurosci. 27:8309-8313.
    • (2007) J. Neurosci. , vol.27 , pp. 8309-8313
    • Lyons, A.1    Downer, E.J.2    Crotty, S.3    Nolan, Y.M.4    Mills, K.H.5    Lynch, M.A.6
  • 54
    • 0345189366 scopus 로고    scopus 로고
    • Inflammatory blockade restores adult hippocampal neurogenesis
    • Monje, M. L., H. Toda, and T. D. Palmer. 2003. Inflammatory blockade restores adult hippocampal neurogenesis. Science 302:1760-1765.
    • (2003) Science , vol.302 , pp. 1760-1765
    • Monje, M.L.1    Toda, H.2    Palmer, T.D.3
  • 55
    • 44849093806 scopus 로고    scopus 로고
    • Microglia inhibition is a target of mild hypothermic treatment after the spinal cord injury
    • Morino, T., T. Ogata, J. Takeba, and H. Yamamoto. 2008. Microglia inhibition is a target of mild hypothermic treatment after the spinal cord injury. Spinal Cord 46:425-431.
    • (2008) Spinal Cord , vol.46 , pp. 425-431
    • Morino, T.1    Ogata, T.2    Takeba, J.3    Yamamoto, H.4
  • 56
    • 0027386940 scopus 로고
    • Characterization of microglial reaction after middle cerebral artery occlusion in rat brain
    • Morioka, T., A. N. Kalehua, andW. J. Streit. 1993. Characterization of microglial reaction after middle cerebral artery occlusion in rat brain. J. Comp. Neurol. 327:123-132.
    • (1993) J. Comp. Neurol. , vol.327 , pp. 123-132
    • Morioka, T.1    Kalehua, A.N.2    Streit, W.J.3
  • 57
    • 2542421703 scopus 로고    scopus 로고
    • Neuronal expression of CD22: novelmechanism for inhibiting microglial proinflammatory cytokine production
    • Mott, R. T., G. Ait-Ghezala, T. Town, T. Mori, M. Vendrame, J. Zeng, J. Ehrhart, M. Mullan, and J. Tan. 2004. Neuronal expression of CD22: novelmechanism for inhibiting microglial proinflammatory cytokine production. Glia 46:369-379.
    • (2004) Glia , vol.46 , pp. 369-379
    • Mott, R.T.1    Ait-Ghezala, G.2    Town, T.3    Mori, T.4    Vendrame, M.5    Zeng, J.6    Ehrhart, J.7    Mullan, M.8    Tan, J.9
  • 58
    • 0032510798 scopus 로고    scopus 로고
    • Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor
    • Neumann, H., T. Misgeld, K. Matsumuro, and H.Wekerle. 1998. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc. Natl. Acad. Sci. U.S.A. 95:5779-5784.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 5779-5784
    • Neumann, H.1    Misgeld, T.2    Matsumuro, K.3    Wekerle, H.4
  • 60
    • 44949248404 scopus 로고    scopus 로고
    • Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege
    • Neumann, J., S. Sauerzweig, R. Ronicke, F. Gunzer, K. Dinkel, O. Ullrich, M. Gunzer, and K. G. Reymann. 2008. Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege. J. Neurosci. 28:5965-5975.
    • (2008) J. Neurosci. , vol.28 , pp. 5965-5975
    • Neumann, J.1    Sauerzweig, S.2    Ronicke, R.3    Gunzer, F.4    Dinkel, K.5    Ullrich, O.6    Gunzer, M.7    Reymann, K.G.8
  • 61
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn, A., F. Kirchhoff, and F. Helmchen. 2005. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 62
    • 4644232615 scopus 로고    scopus 로고
    • Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
    • Olson, J. K., and S. D. Miller. 2004. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173:3916-3924.
    • (2004) J. Immunol. , vol.173 , pp. 3916-3924
    • Olson, J.K.1    Miller, S.D.2
  • 63
    • 34548213150 scopus 로고    scopus 로고
    • MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity
    • Pei, Z., H. Pang, L. Qian, S. Yang, T.Wang, W. Zhang, X.Wu, S. Dallas, B.Wilson, J. M. Reece, et al. 2007. MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity. Glia 55:1362-1373.
    • (2007) Glia , vol.55 , pp. 1362-1373
    • Pei, Z.1    Pang, H.2    Qian, L.3    Yang, S.4    Wang, T.5    Zhang, W.6    Wu, X.7    Dallas, S.8    Wilson, B.9    Reece, J.M.10
  • 64
    • 0023553325 scopus 로고
    • Modulation of CD4 antigen on macrophages and microglia in rat brain
    • Perry, V. H., and S. Gordon. 1987.Modulation of CD4 antigen on macrophages and microglia in rat brain. J. Exp. Med. 166:1138-1143.
    • (1987) J. Exp. Med , vol.166 , pp. 1138-1143
    • Perry, V.a.1    Gordon, S.2
  • 65
    • 33846585119 scopus 로고    scopus 로고
    • Systemic infections and inflammation affect chronic neurodegeneration
    • Perry, V. H., C. Cunningham, and C. Holmes. 2007. Systemic infections and inflammation affect chronic neurodegeneration. Nat. Rev. Immunol. 7:161-167.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 161-167
    • Perry, V.H.1    Cunningham, C.2    Holmes, C.3
  • 66
  • 67
    • 0032838089 scopus 로고    scopus 로고
    • Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury
    • Popovich, P. G., Z.Guan, P. Wei, I. Huitinga, N. van Rooijen, and B. T. Stokes. 1999. Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp. Neurol. 158:351-365.
    • (1999) Exp. Neurol. , vol.158 , pp. 351-365
    • Popovich, P.G.1    Guan, Z.2    Wei, P.3    Huitinga, I.4    van Rooijen, N.5    Stokes, B.T.6
  • 70
    • 33847759064 scopus 로고    scopus 로고
    • Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    • Qin, L., X.Wu, M. L. Block, Y. Liu, G. R. Breese, J. S. Hong, D. J. Knapp, and F. T. Crews. 2007. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55:453-462.
    • (2007) Glia , vol.55 , pp. 453-462
    • Qin, L.1    Wu, X.2    Block, M.L.3    Liu, Y.4    Breese, G.R.5    Hong, J.S.6    Knapp, D.J.7    Crews, F.T.8
  • 71
    • 0031022698 scopus 로고    scopus 로고
    • Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth
    • Rabchevsky, A. G., andW. J. Streit. 1997. Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth. J. Neurosci. Res. 47:34-48.
    • (1997) J. Neurosci. Res. , vol.47 , pp. 34-48
    • Rabchevsky, A.G.1    Streit, W.J.2
  • 72
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: unique stimuli, specialized responses
    • Ransohoff, R. M., and V. H. Perry. 2009. Microglial physiology: unique stimuli, specialized responses. Annu. Rev. Immunol. 27:119-145.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 74
    • 0033836315 scopus 로고    scopus 로고
    • Regulation of the adhesion versus cytotoxic functions of the Mac-1/CR3/alphaMbeta2-integrin glycoprotein
    • Ross, G. D. 2000. Regulation of the adhesion versus cytotoxic functions of the Mac-1/CR3/alphaMbeta2-integrin glycoprotein. Crit. Rev. Immunol. 20:197-222.
    • (2000) Crit. Rev. Immunol. , vol.20 , pp. 197-222
    • Ross, G.D.1
  • 75
    • 66949172845 scopus 로고    scopus 로고
    • Minocycline treatment in acute stroke: an open-label, evaluator-blinded study
    • Schabitz, W. R., A. Schneider, and R. Laage. 2008. Minocycline treatment in acute stroke: an open-label, evaluator-blinded study. Neurology 71:1461.
    • (2008) Neurology , vol.71 , pp. 1461
    • Schabitz, W.R.1    Schneider, A.2    Laage, R.3
  • 76
    • 0028597088 scopus 로고
    • Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion
    • Schroeter, M., S. Jander, O.W.Witte, and G. Stoll. 1994. Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion. J. Neuroimmunol. 55:195-203.
    • (1994) J. Neuroimmunol. , vol.55 , pp. 195-203
    • Schroeter, M.1    Jander, S.2    Witte, O.W.3    Stoll, G.4
  • 78
    • 0035884948 scopus 로고    scopus 로고
    • Astrocytes give rise to new neurons in the adult mammalian hippocampus
    • Seri, B., J.M.Garcia-Verdugo, B. S. McEwen, and A. Alvarez-Buylla. 2001. Astrocytes give rise to new neurons in the adult mammalian hippocampus. J. Neurosci. 21:7153-7160.
    • (2001) J. Neurosci. , vol.21 , pp. 7153-7160
    • Seri, B.1    Garcia-Verdugo, J.M.2    McEwen, B.S.3    Alvarez-Buylla, A.4
  • 80
    • 79960776760 scopus 로고    scopus 로고
    • Ion channels on microglia: therapeutic targets for neuroprotection
    • Skaper, S. D. 2011. Ion channels on microglia: therapeutic targets for neuroprotection. CNS Neurol. Disord. Drug Targets 10:44-56.
    • (2011) CNS Neurol. Disord. Drug Targets , vol.10 , pp. 44-56
    • Skaper, S.D.1
  • 81
    • 0035101188 scopus 로고    scopus 로고
    • Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices
    • Stence, N., M.Waite, and M. E. Dailey. 2001. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33:256-266.
    • (2001) Glia , vol.33 , pp. 256-266
    • Stence, N.1    Waite, M.2    Dailey, M.E.3
  • 82
    • 1542376941 scopus 로고    scopus 로고
    • Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury
    • Stirling, D. P., K. Khodarahmi, J. Liu, L. T. McPhail, C. B. McBride, J. D. Steeves, M. S. Ramer, andW. Tetzlaff. 2004. Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. J. Neurosci. 24:2182-2190.
    • (2004) J. Neurosci. , vol.24 , pp. 2182-2190
    • Stirling, D.P.1    Khodarahmi, K.2    Liu, J.3    McPhail, L.T.4    McBride, C.B.5    Steeves, J.D.6    Ramer, M.S.7    Tetzlaff, W.8
  • 83
    • 0036847816 scopus 로고    scopus 로고
    • Microglia as neuroprotective, immunocompetent cells of the CNS
    • Streit, W. J. 2002. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40:133-139.
    • (2002) Glia , vol.40 , pp. 133-139
    • Streit, W.J.1
  • 85
    • 34247880267 scopus 로고    scopus 로고
    • Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18
    • Sugama, S., M. Fujita, M. Hashimoto, and B. Conti. 2007. Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18. Neuroscience 146:1388-1399.
    • (2007) Neuroscience , vol.146 , pp. 1388-1399
    • Sugama, S.1    Fujita, M.2    Hashimoto, M.3    Conti, B.4
  • 87
    • 67649838794 scopus 로고    scopus 로고
    • Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke
    • Thored, P., U. Heldmann, W. Gomes-Leal, R. Gisler, V. Darsalia, J. Taneera, J. M. Nygren, S. E. Jacobsen, C. T. Ekdahl, Z. Kokaia, et al. 2009. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke. Glia 57:835-849.
    • (2009) Glia , vol.57 , pp. 835-849
    • Thored, P.1    Heldmann, U.2    Gomes-Leal, W.3    Gisler, R.4    Darsalia, V.5    Taneera, J.6    Nygren, J.M.7    Jacobsen, S.E.8    Ekdahl, C.T.9    Kokaia, Z.10
  • 88
    • 33846590145 scopus 로고    scopus 로고
    • Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats
    • Tian, D. S., M. J. Xie, Z. Y. Yu, Q. Zhang, Y. H.Wang, B. Chen, C. Chen, andW.Wang. 2007. Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. Brain Res. 1135:177-185.
    • (2007) Brain Res , vol.1135 , pp. 177-185
    • Tian, D.S.1    Xie, M.J.2    Yu, Z.Y.3    Zhang, Q.4    Wang, Y.H.5    Chen, B.6    Chen, C.W.Wang.7
  • 89
    • 27744464859 scopus 로고    scopus 로고
    • The microglial "activation" continuum: from innate to adaptive responses
    • Town, T., V. Nikolic, and J. Tan. 2005. The microglial "activation" continuum: from innate to adaptive responses. J. Neuroinflammation 2:24.
    • (2005) J. Neuroinflammation , vol.2 , pp. 24
    • Town, T.1    Nikolic, V.2    Tan, J.3
  • 92
    • 62549144445 scopus 로고    scopus 로고
    • Minocycline reduces intracerebral hemorrhage-induced brain injury
    • Wu, J., S. Yang, G. Xi, G. Fu, R. F. Keep, and Y. Hua. 2009. Minocycline reduces intracerebral hemorrhage-induced brain injury. Neurol. Res. 31:183-188.
    • (2009) Neurol. Res. , vol.31 , pp. 183-188
    • Wu, J.1    Yang, S.2    Xi, G.3    Fu, G.4    Keep, R.F.5    Hua, Y.6
  • 93
    • 33745900796 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation
    • Yan, Y. P., K. A. Sailor, R. Vemuganti, and R. J. Dempsey. 2006. Insulin-like growth factor-1 is an endogenous mediator of focal ischemia-induced neural progenitor proliferation. Eur. J. Neurosci. 24:45-54.
    • (2006) Eur. J. Neurosci. , vol.24 , pp. 45-54
    • Yan, Y.P.1    Sailor, K.A.2    Vemuganti, R.3    Dempsey, R.J.4
  • 95
    • 0033539522 scopus 로고    scopus 로고
    • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window
    • Yrjanheikki, J., T. Tikka, R. Keinanen, G. Goldsteins, P. H. Chan, and J. Koistinaho. 1999. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc. Natl. Acad. Sci. U.S.A. 96:13496-13500.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 13496-13500
    • Yrjanheikki, J.1    Tikka, T.2    Keinanen, R.3    Goldsteins, G.4    Chan, P.H.5    Koistinaho, J.6
  • 96
    • 34247560648 scopus 로고    scopus 로고
    • Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages
    • Zhao, X., G. Sun, J. Zhang, R. Strong, W. Song, N. Gonzales, J. C. Grotta, and J. Aronowski. 2007. Hematoma resolution as a target for intracerebral hemorrhage treatment: role for peroxisome proliferator-activated receptor gamma in microglia/macrophages. Ann. Neurol. 61: 352-362.
    • (2007) Ann. Neurol. , vol.61 , pp. 352-362
    • Zhao, X.1    Sun, G.2    Zhang, J.3    Strong, R.4    Song, W.5    Gonzales, N.6    Grotta, J.C.7    Aronowski, J.8


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