Inflammation in areas of remote changes following focal brain lesion

Progress in Neurobiology

Volumn 75, Issue 5, 2005, Pages 342-365

  Block, F ^a   Dihne M ^b   Loos, M ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ASTROCYTE; BRAIN CORTEX; BRAIN INJURY; BRAIN METABOLISM; CELL ACTIVATION; CORPUS STRIATUM; ENCEPHALITIS; EXCITOTOXICITY; HIPPOCAMPUS; MICROGLIA; NERVE INJURY; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SPINAL CORD; SUBSTANTIA NIGRA; THALAMUS;

ANIMALS; BRAIN; BRAIN ISCHEMIA; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION; MICE; NEUROGLIA; RATS;

EID: 19544376505     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2005.03.004     Document Type: Review

References (247)

1. W.C. Abraham, M. Dragunow, and W.P. Tate The role of immediate early genes in the stabilization of long-term potenziation Mol. Neurobiol. 5 1992 297 314
2. L. Acarin, B. Gonzalez, A.J. Castro, and B. Castellano Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: microglial/macrophage response and major histocompatibility complex class I and II expression Neuroscience 89 1999 549 565
3. L. Acarin, B. Gonzalez, J. Hidalgo, A.J. Castro, and B. Castellano Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: astroglial response and metallothionein expression Neuroscience 92 1999 827 839
4. K. Akagawa, M. Saji, N. Aoki, and T. Kanno Muscimol suppresses RCGU increase in the substantia nigra after destruction of the caudate nucleus Neuroreport 3 1992 441 444
5. D. Amaral, and M. Witter The three-dimensional organization of the hippocampal formation: a review of anatomical data Neuroscience 31 1989 571 591
6. D. Amaral, and M. Witter Hippocampal formation G. Paxinos The Rat Nervous System 1995 Academic Press 443 486
7. G. An, T.-N. Lin, J.-S. Liu, J.-J. Xue, Y.-Y. He, and C.Y. Hsu Expression of c-fos and c-jun family genes after focal cerebral ischemia Ann. Neurol. 33 1993 457 464
8. T. Asai, K. Kataoka, T. Tokuno, S. Chichibu, and M. Taneda Electrophysiological changes in substantia nigra after striatal infarction Neuroreport 7 1995 165 168
9. P.T. Atkins, P.K. Liu, and C.Y. Hsu Immediate early gene expression in response to cerebral ischemia. Friend or foe Stroke 27 1996 1682 11687
10. R.B. Banati, J. Gehrmann, P. Schubert, and G.W. Kreutzberg Cytotoxicity of microglia Glia 7 1993 111 118
11. J.C. Baron, M. Levasseur, B. Mazoyer, F. Legault-Demare, F. Mauguiere, S. Pappata, P. Jedynak, P. Derome, J. Cambier, S. Tran-Dinh, and H. Cambon Thalamocortical diaschisis: positron emission tomography in humans J. Neurol. Neurosurg. Psychiatr. 55 1992 935 942
12. F.C. Barone, B. Arvin, R.F. White, A. Miller, C.L. Webb, R.N. Willette, P.G. Lysko, and G.Z. Feuerstein Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury Stroke 28 1997 1233 1244
13. M.F. Beal, N.W. Kowall, D.W. Ellison, M.F. Mazurek, K.J. Swartz, and J.B. Martin Replication of the neurochemical characteristics of Hnutington's disease by quinolinic acid Nature 321 1986 168 171
14. N.B. Beamer, B.M. Coull, W.M. Clark, D.P. Briley, M. Wynn, and G. Sexton Persistent inflammatory response in stroke survivors Neurology 50 1998 1722 1728
15. L. Belayev, P. Busto, W. Zhao, and M.D. Ginsberg HU-211, a novel noncompetitive n-methyl-d-aspartate antagonist, improves neurological deficit and reduces infarct volume after reversible foval cerebral ischemia in the rat Stroke 26 1995 2313 2320
16. F.P. Bellinger, S. Madamba, and G.R. Siggins Interleukin-1beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus Brain Res. 628 1993 227 234
17. H. Benveniste, J. Drejer, A. Schousboe, and N.H. Diemer Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis J. Neurochem. 43 1984 1369 1374
18. H.-J. Bidmon, K. Kato, A. Schleicher, O.W. Witte, and K. Zilles Transient increase of manganese-superoxide dismutase in remote brain areas after focal photothrombotic cortical lesion Stroke 29 1998 203 211
19. H. Björklund, L. Olson, D. Dahl, and R. Schwarcz Short- and long-term consequences of intracranial injection of the excitotoxin, quinolinic acid, as evidenced by GFA immunohistochemistry of astrocytes Brain Res. 371 1986 267 277
20. K. Blinzinger, and G. Kreutzberg Displacement of synaptic terminals from regenerating motoneurons by microglial cells Zellforsch. Mikrosk. Anat. 85 1968 145 157
21. F. Block Stimulation of N-methyl-d-aspartate receptors in the rat nucleus reticularis thalami suppresses somatosensory evoked potentials Brain Res. 636 1994 143 146
22. F. Block, M. Loos, C. Frohn, and M. Schwarz Association between inflammation and nigral neuronal damage following striatal excitotoxic lesion Brain Res. 998 2004 29 35
23. F. Block, W. Schmidt, M. Nolden-Koch, and M. Schwarz Rolipram reduces excitotoxic neuronal damage Neuroreport 12 2001 1507 1511
24. F. Block, A. Tondar, W. Schmidt, and M. Schwarz Delayed treatment with rolipram protects against neuronal damage following global ischemia in rats Neuroreport 8 1997 3829 3832
25. F. Block, and M. Schwarz Expression of GFAP in the striatum and its projection areas in response to striatal quinolinic acid lesion in rats Neuroreport 5 1994 2237 2240
26. F. Block, and M. Schwarz Dextromethorphan reduces functional deficits and neuronal damage after global ischemia in rats Brain Res. 741 1996 153 159
27. F. Block, and M. Schwarz Neuroprotection for ischemic stroke Nervenarzt 70 1999 101 110
28. D.J. Bonthius, and O. Steward Induction of cortical spreading depression with potassium chloride upregulates levels of messenger RNA for glial fibrillarey acidic protein in cortex and hippocampus: inhibition by MK-9801 Brain Res. 618 1993 83 94
29. A receptor changes J. Chem. Neuroanat. 17 1999 75 97
30. L.T. Brown Jr. Projections and termination of the corticospinal tract in rodents Exp. Brain Res. 13 1971 432 450
31. A.J. Bruce, W. Boling, M.S. Kindy, J. Peschon, P.J. Kraemer, M.K. Carpenter, F.W. Holtsberg, and M.P. Mattson Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors Nat. Med. 2 1996 788 794
32. A.M. Buchan Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted? Cerebrovasc. Brain Metab. Rev. 2 1990 1 26
33. R.E. Burke, A. Macaya, D. DeVivo, N. Kenyon, and E.M. Janec Neonatal hypoxic-ischemic or excitotoxic striatal injury results in a decreased adult number of substantia nigra neurons Neuroscience 50 1992 559 569
34. T.L. Butler, C.A. Kassed, P.R. Sanberg, A.E. Willing, and K.R. Pennypacker Neurodegeneration in the rat hippocampus and striatum after middle cerebral artery occlusion Brain Res. 929 2002 252 260
35. M. Caleo, M.C. Cenni, M. Costa, E. Menna, L. Zentilin, S. Giadrossi, M. Giacca, and L. Maffei Expression of BCL-2 via adeno-associated virus vectors rescues thalamic neurons after visual cortex lesion in the adult rat Eur. J. Neurosci. 15 2002 1271 1277
36. I.L. Campell, C.R. Abraham, E. Masliah, P. Kemper, J.D. Inglis, M.B. Oldstone, and L. Mucke Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6 Proc. Natl. Acad. Sci. U.S.A. 90 1993 1001 10065
37. P.H. Chan Role of oxidants in ischemic brain damage Stroke 27 1996 1124 1129
38. C.C. Chao, and S. Hu Tumor necrosis factor-alpha potentiates glutamate neurotoxicity in human fetal brain cell cultures Dev. Neurosci. 16 1994 172 179
39. V. Chaparro-Huerta, M.C. Rivera-Cervantes, B.M. Torres-Mendoza, and C. Beas-Zarate Neuronal death and tumor necrosis factor-alpha response to glutamate-induced excitotoxicity in the cerebral cortex of neonatal rats Neurosci. Lett. 333 2002 95 98
40. C.S. Chiang, A. Stalder, A. Samimi, and I.L. Campell Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice Dev. Neurosci. 16 1994 212 221
41. D.W. Choi Glutamate neurotoxicity and diseases of the nervous system Neuron 1 1988 623 634
42. D. Choi Methods for antagonizing glutamate neurotoxicity Cerebrovasc. Brain Metab. Rev. 2 1990 105 147
43. M. Chopp, R.L. Zhang, H. Chen, N. Jiang, and J.R. Rusch Postischemic administration of an anti-MAC-1 antibody reduces ischemic cells damage after transient middle cerebral artery occlusion in rats Stroke 25 1994 869 876
44. M.Y. Collaco, B.S. Aspey, J.S. Belleroche, and M.J. Harrison Focal ischemia causes an extensive induction of immediate early genes that are sensitive to MK-801 Stroke 25 1994 1855 1860
45. J. Cornwall, J.D. Cooper, and O.T. Phillipson Projections to the rostral reticular thalamic nucleus in the rat Exp. Brain Res. 80 1990 157 171
46. P. Coyle Vascular patterns of the rat hippocampal formation Exp. Neurol. 52 1976 447 458
47. F. Crespi, and C. Pietra Middle cerebral artery occlusion alters neurotransmitter activities in ipsilateral and contralateral brain regions: an ex vivo voltametric study Neurosci. Lett. 230 1997 77 80
48. F. Crick Function of the thalamic reticular complex: the searchlight hypothesis Proc. Natl. Acad. Sci. U.S.A. 81 1984 4586 4590
49. A. Czurko, and H. Nishino Collapsed" (argyrophilic, dark) neurons in rat model of transient focal cerebral ischemia Neurosci. Lett. 162 1993 71 74
50. C.A. Davies, S.A. Loddick, S. Toulmond, R.P. Stroemer, J. Hunt, and N.J. Rothwell The progression and topographic distribution of interleukin-1 beta expression after permanent middle cerebral artery occlusion in the rat J. Cereb. Blood Flow Metab. 19 1999 87 98
51. L.A. DeGiorgio, C. Dibinis, T.A. Milner, M. Saji, and B.T. Volpe Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury Brain Res. 795 1998 1 9
52. L.A. DeGiorgio, N. DeGiorgio, and B.T. Volpe Dizocilpine maleate, MK-801, but not 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline, NBQX, prevents transneuronal degeneration of nigral neurons after neurotoxic striatal-pallidal lesion Neuroscience 90 1999 79 85
53. J. DeKeyser, G. Sulter, and P.G. Luiten Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing? Trends Neurosci. 22 1999 535 540
54. G. Demeurisse, M. Verhas, and A. Capon Remote cortical dysfunction in aphasic stroke patients Stroke 22 1991 1015 1020
55. J. DeReuck, D. Decoo, I. Lemahieu, K. Strijckmans, P. Goethals, and G. van Maele Crossed cerebellar diaschisis after middle cerebral artery infarction Clin. Neurol. Neurosurg. 99 1997 11 16
56. R. De Simone, A. Giampaolo, B. Giometto, P. Gallo, G. Levi, C. Peschle, and F. Aloisi The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions J. Neuropathol. Exp. Neurol. 54 1995 175 187
57. N.H. Diemer, F.F. Johansen, H. Benveniste, T. Bruhn, M. Berg, E. Valente, and M.B. Jorgensen Ischemia as an excitotoxic lesion: protection against hippocampal nerve cell loss by denervation Acta Neurochir. Suppl. (Wien) 57 1993 94 101
58. D. Dietrich, B.D. Watson, R. Busto, M.D. Ginsberg, and J.R. Bethea Photocheimcally induced cerebral infarction. I. Early microvascular alterations Acta Neuropathol. 72 1987 315 325
59. D. Dietrich, R. Busto, B.D. Watson, P. Scheinberg, and M.D. Ginsberg Photochemically induced cerebral infarction. II. Edema and blood brain-barrier disruption Acta Neuropathol. 72 1987 326 334
60. M. Dihne, and F. Block Focal ischemia induces transient expression of IL-6 in the substantia nigra pars reticulata Brain Res. 889 2001 165 173
61. M. Dihne, F. Block, H. Korr, and R. Töpper Time course of glial proliferation and glial apoptosis following excitotoxic CNS injury Brain Res. 902 2001 178 189
62. M. Dihne, C. Grommes, M. Lutzenburg, O.W. Witte, and F. Block Different mechanisms of secondary neuronal damage in thalamic nuclei after focal cerebral ischemia in rats Stroke 33 2002 3006 3011
63. U. Dirnagl, C. Iadecola, and M.A. Moskowitz Pathobiology of ischaemic stroke: an integrated view Trends Neurosci. 22 1999 391 397
64. M. Dragunow, R.L.M. Faul, and K.L.P. Jansen MK-801, an antagonist of NMDA receptors, inhibits injury-induced c-fos protein accumulation in rat brain Neurosci. Lett. 109 1990 128 133
65. M. Edwards, T.A. Kent, H.C. Rea, J. Wei, M. Quast, T. Izumi, S. Mitra, and J.R. Perez-Polo APE/Ref-1 responses to ischemia in rat brain Neuroreport 9 1998 4015 4018
66. G.S. Emch, G.E. Hermann, and R.C. Rogers TNF-alpha-induced c-fos generation in the nucleus of the solitary tract is blocked by NBQX and MK-801 Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 2001 1394 1400
67. M. Endres, S. Namura, M. Shimizu-Sasamata, C. Waeber, L. Zhang, T. Gomez-Isla, B.T. Hyman, and M.A. Moskowitz Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family J. Cereb. Blood Flow Metab. 18 1998 238 247
68. S. Estus, W.J. Zaks, R.S. Freeman, M. Gruda, R. Bravo, and E.M. Johnson Jr. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis J. Cell Biol. 127 1994 1717 1727
69. E. Fattori, D. Lazzaro, P. Musiani, A. Modesti, T. Alonzi, and G. Ciliberto IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage Eur. J. Neurosci. 7 1995 2441 2449
70. S.M. Fine, R.A. Angel, S.W. Perry, L.G. Epstein, J.P. Rothstein, S. Dewhurst, and H.A. Gelbard Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes: implications for pathogenesis of HIV-1 dementia J. Biol. Chem. 271 1996 15303 15306
71. T. Freyaldenhoven, S. Ali, and L. Schmued Systemic administration of MPTP induces thalamic neuronal degeneration in mice Brain Res. 759 1997 9 17
72. G.Z. Feuerstein, T. Liu, and F.C. Barone Cytokines, inflammation, and brain injury: role of tumor necrosis factor-α Cerebrovasc. Brain Metab. Rev. 6 1994 341 360
73. F. Gallyas, F.H. Guldner, G. Zoltay, and J.R. Wolff Golgi-like demonstration of "dark" neurons with an argyrophil III method for experimental neuropahology Acta Neuropathol. (Berl.) 79 1990 620 628
74. F. Gallyas, G. Zoltay, and W. Dames Formation of "dark" (argyrophilic) neurons of arious origin proceeds with a common mechanism of biophysical nature (a novel hypothesis) Acta Neuropathol. (Berl.) 83 1992 504 509
75. J.A. Gandia, H.S. De Las, M. Garcia, and J.M. Gimenez-Amaya Afferent projections to the reticular thalamic nucleus from the globus pallidus and the substantia nigra in the rat Brain Res. Bull. 32 1993 351 358
76. J.H. Garcia, K.-F. Liu, Z.-R. Ye, and J.A. Gutierrez Incomplete infarct and delayed neuronal death after transient middle cerebral artery occlusion in rats Stroke 28 1997 2303 2310
77. D.S. Gary, A.J. Bruce-Keller, M.S. Kindy, and M.P. Mattson Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor J. Cereb. Blood Flow Metab. 18 1998 1283 1287
78. 11C]PK11195 and positron emission tomography in patients after ischemic stroke Neuroreport 11 2000 2957 2960
79. C.D. Gimmi, G.J. Frexxeman, J.G. Gribben, G. Gray, and L.M. Nadler Human T-cell clonal anergy is induced by antigen presentation on the absence of B7 costimulation Proc. Natl. Acad. Sci. U.S.A. 90 1993 6586 6590
80. R. Giuffrida, and A. Rustioni Glutamate and aspartate immunoreactivity in corticospinal tract neurons of rats J. Comp. Neurol. 288 1989 154 164
81. D. Giulian, J. Li, B. Leara, and C. Keenen Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture Neurochem. Int. 25 1994 227 233
82. D. Giulian, and M.J. Tapscott Immunoregulation of cells within the central nervous system Brain Behav. Immun. 2 1988 352 358
83. M.B. Graeber, K. Bise, and P. Mehrain CR3/43, a marker for activated human microglia: application to diagnostic neuropathology Neuropathol. Appl. Neurobiol. 20 1994 406 408
84. J. Ham, C. Babij, J. Whitfield, C.M. Pfarr, D. Lallemand, M. Yaniv, and L.L. Rubin A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death Neuron 14 1995 927 939
85. K. Hara, D.L. Kong, F.R. Sharp, and P.R. Weistein Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats Neurosci. Lett. 256 1998 53 56
86. D.M. Hermann, G. Mies, R. Hata, and K.-A. Hossmann Microglial and astrocytic reactions prior to onset of thalamic cell death after traumatic lesion of the rat sensorimotor cortex Acta Neuropathol. 99 2000 147 153
87. D.G. Herrera, and H.A. Robertson Application of potassium chloride to the brain surface induces the c-fos proto-oncogene: reversal by MK-801 Brain Res. 610 1990 166 170
88. S. Holmin, and T. Mathiesen Intracerebral administration of interleukin-1 beta and induction of inflammation, apoptosis, and vasogenic edema J. Neurosurg. 92 2000 108 120
89. I.K. Hwang, K.Y. Yoo, S.K. Park, S.J. An, J.Y. Lee, S.Y. Choi, J.H. Kang, Y.G. Kwai, T.C. Kang, and M.H. Won Expression and changes of endogenous insulin-like growth factor-1 in neurons and glia in the gerbil hippocampus and dentate gyrus after ischemic insult Neurochem. Int. 45 2004 149 156
90. H. Iizuka, K. Sakatani, and W. Young Neural damage in the rat thalamus after cortical infarcts Stroke 21 1990 790 794
91. M. Inagaki, T. Koeda, and K. Takeshita Prognosis and MRI after ischemic stroke of the basal ganglia Pediatr. Neurol. 8 1992 104 108
92. O. Isacson, W. Fischer, K. Wictorin, D. Dawbarn, and A. Björklund Astroglial response in the excitoxically lesioned neostriatum and its projection areas in the rat Neuroscience 20 1987 1043 1056
93. S. Jander, M. Schroeter, O. Peters, O.W. Witte, and G. Stoll Cortical spreading depression induces proinflammatory cytokine gene expression in the rat brain J. Cereb. Blood Flow Metab. 21 2001 218 225
94. S. Jander, M. Schroeter, and G. Stoll Role of NMDA receptor signaling in the regulation of inflammatory gene expression after focal brain ischemia J. Neuroimmunol. 109 2000 181 187
95. E.G. Jones Some aspects of the organization of the thalamic reticular complex J. Comp. Neurol. 162 1975 285 308
96. H. Kanemitsu, T. Nakagomi, A. Tamura, T. Tsuchiya, G. Kono, and K. Sano Differences in the extent of primary ischemic damage between middle cererbal artery coagulation and intraluminal occlusion models J. Cereb. Blood Flow Metab. 22 2002 1196 1204
97. H. Kettenmann, R. Banati, and W. Walz Elektrophysiological behavior of microglia Glia 7 1993 93 101
98. J.S. Kim, S.S. Yoon, Y.H. Kim, and J.S. Ryu Serial measurement of interleukin-6, transforming growth factor-β, and S-100 protein in patients with acute stroke Stroke 27 1996 1553 1557
99. H. Kinouchi, F.R. Sharp, P.H. Chan, J. Koistinaho, S.M. Sagar, and T. Yoshimoto Induction of c-fos, junB, c-jun, and hsp70 mRNA in cortex, thalamus, basal ganglia, and hippocampus following middle cerebral artery occlusion J. Cereb. Blood Flow Metab. 14 1994 808 817
100. H. Kinouchi, F.R. Sharp, P.H. Chan, S. Mikawa, H. Kamii, S. Arai, and T. Yoshimoto MK-801 inhibits the induction of immediate early genes in cortex, thalamus, and hippocampus, but not in the substantia nigra following middle cerebral artery occlusion Neurosci. Lett. 179 1994 111 114
101. H. Kinouchi, H. Huang, S. Arai, K. Mizoi, and T. Yoshimoto Induction of cyclooxygenase-2 messenger RNA after transient and permanent middle cerebral artery occlusion in rats: comparison with c-fos messenger RNA by using in situ hybridization J. Neurosurg. 91 1999 1005 1012
102. T. Kirino Delayed neuronal death in the gerbil hippocampus following ischemia Brain Res. 239 1982 57 69
103. J. Koizumi, Y. Yoshida, and T. Nakazawa Experimental studies of ischemic brain edema: a new experimental model in which recirculation can be reintroduced Jpn. J. Stroke 8 1986 1 8
104. Z. Kokaia, Q. Zhao, M. Kokaia, E. Elmer, M. Metsis, B. Siesjo, and O. Lindvall Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage Exp. Neurol. 136 1995 73 88
105. K. Korematsu, S. Goto, S. Nagahiro, N. Inoue, T. Oyama, K. Yamada, and Y. Ushio Change of phosphotyrosine immunoreactivity on microglia in the rat substantia nigra following striatal ischemic injury Glia 13 1995 147 153
106. E.B. Krammer Anterograde and transsynaptic degeneration "en cascade" in basal ganglia induced by intrastriatal injection of kainic aicd: an animal analogue of Huntington's disease Brain Res. 196 1980 209 221
107. R.Z. Kuang, and K. Kalil Branching patterns of corticospinal axon arbors in the rodent J. Comp. Neurol. 292 1990 585 598
108. Y. Kumon, S. Sakaki, H. Watanabe, K. Nakano, S. Ohta, S. Matsuda, H. Yoshimura, and M. Sakanaka Ciliary neurotrophic factor attenuates spatial cognition impairment, cortical infarction and thalamic degeneration in spontaneously hypertensive rats with focal cerebral ischemia Neurosci. Lett. 206 1996 141 144
109. A. Ledeboer, J.J. Breve, A. Wierinckx, S. van der Jagt, A.F. Bristow, J.E. Leysen, F.J. Tilders, and A.M. Van Dam Expression and regulation ofinterleukin-10 and interleukin-10 receptor in rat astroglial and microglial cells Eur. J. Neurosci. 16 2002 1175 1185
110. X.G. Li, S.L. Florence, and J.H. Kass Areal distributions of cortical neurons projecting to different levels of the caudal brain stem and spinal cord in rats Somatosens. Motor Res. 7 1990 315 335
111. Y. Li, M. Chopp, J.H. Garcia, Y. Yoshida, Z.G. Zhang, and S.R. Levine Distribution of the 72-kD heat-shock-protein as a function of transient focal cerebral ischemia in rats Stroke 23 1992 1292 1298
112. Y. Li, M. Chopp, N. Jiang, F. Yao, and C. Zaloga Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat J. Cereb. Blood Flow Metab. 15 1995 389 397
113. Y. Li, M. Chopp, N. Jiang, and C. Zaloga In situ dection of DNA fragmentation after focal cerebral ischemia in mice Mol. Brain Res. 28 1995 164 168
114. Y. Li, M. Chopp, N. Jiang, Z.G. Zhang, and C. Zaloga Induction of DNA fragmentation after 10 to 120 minutes of focal cerebral ischemia in rats Stroke 26 1995 1252 1257
115. F.Y. Liang, V. Moret, M. Wiesendanger, and E.M. Rouiller Corticomotoneuronal connections in the rat: evidence from double-labeling of motoneurons and corticospinal axon arborizations J. Comp. Neurol. 311 1991 356 366
116. M.D. Linnik, R.H. Zobrist, and M.D. Hatfield Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats Stroke 24 1993 2002 2008
117. J. Liu, I. Ginis, M. Spatz, and J.M. Hallenbeck Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide Am. J. Physiol. Cell Physiol. 278 2000 144 153
118. S.A. Loddick, and N.J. Rothwell Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat J. Cereb. Blood Flow Metab. 16 1996 932 940
119. M. Loos, M. Dihne, and F. Block Tumor necrosis factor - expression in areas of remote degeneration following middle cerebral artery occlusion of the rat Neuroscience 122 2003 373 380
120. M.A. Lynch Age-related impairment in long-term potentiation in hippocampus: a role for the cytokine interleukin-1beta? Progr. Neurobiol. 56 1998 571 589
121. A. Macaya, F. Munell, R.M. Gubits, and R.E. Burke Apoptosis in substantia nigra following developmental striatal excitotoxic injury Proc. Natl. Acad. Sci. U.S.A. 91 1994 8117 8121
122. J.P. MacManus, I.E. Hill, Z.G. Huang, I. Rasquinha, D. Xue, and A.M. Buchan DNA damage consistent with apoptosis in transient focal ischaemic neocortex Neuroreport 5 1994 493 496
123. C.G. Markgraf, E.J. Green, B.E. Hurwitz, E. Morikawa, W.D. Dietrich, P.M. McCabe, M.D. Ginsberg, and N. Schneiderman Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats Brain Res. 575 1992 238 246
124. C.G. Markgraf, E.J. Green, B. Watson, P.M. McCabe, N. Schneidermann, and M.D. Ginsberg Recovery of sensorimotor function after distal middle cerebral artery photothrombotic occlusion in rats Stroke 25 1994 153 159
125. W.R. Martin, W.J. Powers, and M.E. Raichle Cerebral blood volume measured with inhaled C150 and positron emission tomography J. Cereb. Blood Flow Metab. 7 1987 421 426
126. J.C. Martinou, M. Dubois-Dauphin, J.K. Staple, I. Rodriguez, H. Frankowski, M. Missotten, P. Albertini, D. Talabot, S. Catsicas, and C. Pietra Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia Neuron 13 1994 1017 1030
127. M.K. Matyszak Inflammation in the CNS: balance between immunological privilege and immune responses Prog. Neurobiol. 56 1998 19 35
128. P.L. McGeer, S. Itagaki, and E.G. McGeer Expression of the histocompatibility glycoprotein HLA-DR in neurological disease Acta Neuropathol. 76 1988 550 557
129. M.E. Meistrell 3rd, G.I. Botchkina, H. Wang, E. Di Santo, K.M. Cockroft, O. Bloom, J.M. Vishnubhakat, P. Ghezzi, and K.J. Tracey Tumor necrosis factor is a brain damaging cytokine in cerebral ischemia Shock 8 1997 341 348
130. B. Meldrum, and J. Garthwaite Excitatory amino acid neurotoxicity and neurodegenerative diseases Top. Pharm. Sci. 11 1990 379 387
131. H. Memezawa, H. Minamisawa, M.-L. Smith, and B.K. Siesjö Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat Exp. Brain Res. 89 1992 67 78
132. H. Memezawa, M.-L. Smith, and B.K. Siesjö Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats Stroke 23 1992 552 559
133. S. Miettinen, F.R. Fusco, J. Yrjanheikki, R. Keinanen, T. Hirvonen, R. Roivainen, M. Narhi, T. Hokfelt, and J. Koistinaho Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through M-methyl-d-aspartic acid-receptors and phospholipase A2 Proc. Natl. Acad. Sci. U.S.A. 94 1997 6500 6505
134. A. Mitani, H. Kubo, K. Iga, H. Imon, F. Kadoya, and K. Kataoka A new enzymatic cycling technique for glutamate determination in brain microdialysates J. Neurochem. 54 1990 709 711
135. I. Miyai, A.D. Blau, M.J. Reding, and B.T. Volpe Patients with stroke confined to the basal ganglia have diminished response to rehabilitation efforts: implications for basal ganglia-cortical interactions Neurology 48 1997 95 101
136. K. Miyashita, H. Abe, T. Nakajima, A. Ishikawa, M. Nishiura-Suzuki, H. Naritomi, R. Tanaka, and T. Sawada Glutamate release in the gerbil hippocampus after middle cerebral artery occlusion Neuroreport 5 1994 945 948
137. H. Mizushima, C.J. Zhou, K. Dohi, R. Horai, M. Asano, Y. Iwakura, T. Hirabayashi, S. Arata, S. Nakajo, A. Takaki, H. Ohtaki, and S. Shioda Reduced postischemic apoptosis in the hippocampus of mice deficient in interleukin-1 J. Comp. Neurol. 448 2002 203 216
138. T. Morioka, A.N. Kalehua, and W.J. Streit Characterization of microglial reaction after middle cerebral artery occlusion in rat brain J. Comp. Neurol. 327 1993 123 132
139. M.J. Muessel, N.E. Berman, and R.M. Klein Early and specific expression of monocyte chemoattractant protein-1 in the thalamus induced by cortical injury Brain Res. 870 2000 211 221
140. N.J. Mulcahy, J. Ross, N.J. Rothwell, and S.A. Loddick Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat Br. J. Pharmacol. 140 2003 471 476
141. H. Nagasawa, and K. Kogure Exo-focal postischemic neuronal death in the rat brain Brain Res. 524 1990 196 202
142. H. Nagasawa, K. Kogure, T. Fujiwara, M. Itoh, and T. Ido Metabolic disturbances in exo-focal brain areas after cortical stroke studied by positron emission tomography J. Neurol. Sci. 123 1994 147 153
143. T. Nakagomi, H. Kanemistu, K. Narita, H. Nakayama, T. Ishii, and A. Tamura Enhanced synthesis in the ipsilateral substantia nigra following middle cerebral artery occlusion in the rat Acta Neuropathol. 95 1998 565 570
144. M. Nakane, A. Tamura, T. Miyasaka, T. Nagaoka, and T. Kuroiwa Astrocytic swelling in the ipsilateral substantia nigra after occlusion of the middle cerebral artery in rats AJNR Am. J. Neuroradiol. 22 2001 660 663
145. M. Nakane, A. Tamura, Y. Sasaki, and A. Teraoka MRI of secondary changes in the thalamus following a cerebral infarct Neuroradiology 44 2002 915 920
146. M. Nakane, A. Teraoka, R. Asato, and A. Tamura Degeneration of the ipsilateral substantia nigra following cerebral infarction in the striatum Stroke 23 1992 328 332
147. P.W. Nathan, M.C. Smith, and P. Deacon The corticospinal tract in man. Course and location of fibers at different segmental levels Brain 113 1990 303 324
148. H. Nawashiro, K. Tasaki, C.A. Ruetzler, and J.M. Hallenbeck TNF-α pretreatment induces protective effects against focal cerebral ischemia in mice J. Cereb. Blood Flow Metab. 17 1997 483 490
149. M. Nedergaard, and A.J. Hansen Spreading depression is not associated with neuronal injury in the normal brain Brain Res. 449 1988 395 398
150. H. Nishino, A. Czurko, A. Fukuda, T. Hashitani, H. Hida, Z. Karadi, and L. Lenard Pathophysiological process after transient ischemia of the middle cerebral artery in the rat Brain Res. Bull. 35 1994 51 56
151. T. Nitatori, N. Sato, S. Waguri, Y. Karasawa, H. Araki, K. Shibanai, E. Kominami, and Y. Uchiyama Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis J. Neurosci. 15 1995 1001 1011
152. M. Nolden-Koch, E. Breuer, and F. Block Expression of IL-1β in the hippocampus following focal ischemia J. Neurol. 247 Suppl. 3 2000 129
153. C. Nordborg, and B.B. Johansson Secondary thalamic lesions after ligation of the middle cerebral artery: an ultrastructural study Acta Neuropathol. (Berl.) 91 1996 61 66
154. P.T. Ohara, and A.R. Lieberman The thalamic reticular nucleus of the adult rat: experimental anatomical studies J. Neurocytol. 14 1985 365 411
155. W.Y. Ong, S.K. Leong, L.J. Garey, R. Reynolds, and A.W. Liang An immunocytochemical study of glutamate receptors and glutamine synthetase in the hippocampus of rats injected with kainate Exp. Brain Res. 109 1996 251 267
156. T. Ohtsuki, C.A. Ruetzler, K. Tasaki, and J.M. Hallenbeck Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal CA1 neurons J. Cereb. Blood Flow Metab. 16 1996 1137 1142
157. M. Okada, H. Nakanishi, A. Tamura, A. Urae, K. Mine, K. Yamamoto, and M. Fujiwara Long-term spatial cognitive impairment after middle cerebral artery occlusion in rats: no involvement of the hippocampus J. Cereb. Blood Flow Metab. 15 1995 1012 1021
158. Y.G. Özdemir, H. Bolay, E. Erdem, and T. Dalkara Occlusion of the MCA by an intraluminal filament may cause disturbances in the hippocampal blood flow due to anomalies of circle of Willis and filament thickness Brain Res. 822 1999 260 264
159. 11C]PK11195 Neurology 55 2000 1052 1054
160. G.M. Pasinetti, D.G. Morgan, and C.E. Finch Disappearance of GAD-mRNA and tyrosine hydroxylase in substantia nigra following striatal ibotenic acid lesions: evidence for transneuronal regression Exp. Neurol. 112 1991 131 139
161. K.R. Pennypacker, S. Eidizadeh, C.A. Kassed, J.P. O'Callaghan, P.R. Sanberg, and A.E. Willing Expression of fos-related antigen-2 in rat hippocampus after middle cerebral arterial occlusion Neurosci. Lett. 289 2000 1 4
162. V.H. Perry, and M.C. Brown Macrophages and nerve regeneration Curr. Opin. Neurobiol. 2 1992 679 682
163. V.H. Perry, M.C. Brown, and S. Gordon The macrophage response to central and peripheral nerve injury. A possible role for macrophages in regeneration J. Exp. Med. 165 1987 1218 1223
164. R.S. Petralia, Y.X. Wang, and R.J. Wenthold The NMDA receptor subunits NR2A and NR 2B show histological and ultrastructural localization patterns similar to those of NR1 J. Neurosci. 14 1994 6102 6120
165. D. Plenz, M. Herrera-Marschitz, and S.T. Kitai Morphological organization of the globus pallidus-subthalamic nucleus system studied in organotypic cultures J. Comp. Neurol. 397 1998 437 457
166. P.G. Popovich, B.T. Stokes, and C.C. Whitacre Concept of autoimmunity following spinal cord injury: possible role for T-lymphocytes in the traumatized central nervous system J. Neurosci. Res. 45 1996 349 363
167. C.J.S. Price, D.K. Menon, A.M. Peters, J.R. Ballinger, R.W. Barber, K.K. Balan, A. Lynch, J.H. Xuereb, T. Fryer, J.V. Guadagno, and E.A. Warburton Cerebral neutrophil recruitment, histology, and outcome in actue ischemic stroke Stroke 35 2004 1659 1664
168. A.K. Pringle, N. Niyadurupola, P. Johns, D.C. Anthony, and F. Iannotti
169. B. Puig, and I. Ferrer Caspase-3-associated apoptotic cell death in excitotoxic necrosis of the entorhinal cortex following intraperitoneal injection of kainic aicd in the rat Neurosci. Lett. 321 2002 182 186
170. O. Rapalino, O. Lazarov-Spiegler, E. Agranov, G.J. Velan, E. Yoles, M. Fraidakis, A. Solomon, R. Gepstein, A. Katz, M. Belkin, M. Hadani, and M. Schwartz Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats Nat. Med. 4 1998 814 821
171. J.K. Relton, and N.J. Rothwell Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat Brain Res. Bull. 29 1992 243 246
172. D.T. Ross, and F.F. Ebner Thalamic retrograde degeneration following cortical injury: an excitotoxic process? Neuroscience 35 1990 525 550
173. D.T. Ross, and D.I. Graham Selective loss and selective sparing of neurons in the thalamic reticular nucleus following human cardiac arrest J. Cereb. Blood Flow Metab. 13 1993 558 567
174. D.T. Ross, D.I. Graham, and J.H. Adams Selective loss of neurons from the thalamic reticular nucleus following severe human head injury J. Neurotrauma 10 1993 151 165
175. S.M. Rothman, and J.W. Olney Glutamate and the pathophysiology of hypoxic-ischemic brain damage Ann. Neurol. 19 1986 106 111
176. S.M. Rothman, and J.W. Olney Excitotoxicity and NMDA receptor Trends Neurosci. 19 1987 339 345
177. K. Rupalla, P.R. Allegrini, D. Sauer, and C. Wiessner Time course of microglia activation and apoptosis in various brain regions after permanent focal cerebral ischemia in mice Acta Neuropathol. 96 1998 172 178
178. M. Saji, A.D. Blau, and B.T. Volpe Prevention of transneuronal degeneration of neurons in the substantia nigra reticulata by ablation of the subthalamic nucleus Exp. Neurol. 141 1996 120 129
179. M. Saji, M. Cohen, A.D. Blau, T.C. Wessel, and B.T. Volpe Transient forebrain ischemia induces delayed injury in the substantia nigra reticulata: degeneration of GABA neurons, compensatory expression of GAD mRNA Brain Res. 643 1994 234 244
180. M. Saji, Y. Endo, T. Miyanishi, B.T. Volpe, and K. Ohno Behavioral correlates of transneuronal degeneration of substantia nigra pars reticulata neurons are reversed by ablation of the subthalamic nucleus Behav. Brain Res. 84 1997 63 71
181. M. Saji, M. Kimura, G. Ishida, and K. Ohno Deafferentation-induced c-fos gene expression in subthalamic nucleus and substantia nigra reticulata is reduced by non-NMDA receptor antagonist Brain Res. 703 1995 165 174
182. M. Saji, and D.J. Reis Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist Science 235 1987 66 68
183. P. Sanberg, S.F. Calderon, M. Giordano, J.M. Tew, and A.B. Norman The quinoilinic acid model of Huntington's disease: locomotor abnormalities Exp. Neurol. 105 1989 45 53
184. T. Sasaki, T. Nakagomi, and T. Kirino Indomethacin ameliorates ischemic neuronal damage in the gerbil hippocampal CA1 sector Stroke 19 1988 1399 1403
185. S. Sastry, and G.W. Arendash Time-depedent changes in iron levels and associated neuronal loss within the substantia nigra following lesions within the neostriatum/globus pallidus complex Neuroscience 67 1995 649 666
186. U. Scherbel, R. Raghupathi, M. Nakamura, K.E. Saatman, J.Q. Trojanowski, E. Neugebauer, M.W. Marino, and T.K. McIntosh Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury Proc. Natl. Acad. Sci. U.S.A. 96 1999 8721 8726
187. G.P. Schielke, G.Y. Yang, B.D. Shivers, and A.L. Betz Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice J. Cereb. Blood Flow Metab. 18 1998 180 185
188. R. Schmidt-Kastner, H. Fliss, and A.M. Hakim Subtle neuronal death in striatum after short forebrain ischemia in rats detected by in situ end-labeling for DANN damage Stroke 28 1997 163 170
189. A.B. Schmitt, G.A. Brook, A. Buss, W. Nacimiento, J. Noth, and G.W. Kreutzberg Dynamics of microglial activation in the spinal cord after cerebral infarction are revealed by expression of MHC class II antigen Neuropathol. Appl. Neurobiol. 24 1998 167 176
190. A.B. Schmitt, A. Buss, S. Breuer, G.A. Brook, K. Pech, D. Martin, J. Schoenen, S. Love, J.M. Schroeder, G.W. Kreutzberg, and W. Nacimiento Major histocompatibility class II expression by activated microglia caudal to lesions of descending tracts in the human spinal cord is not associated wit a T cell response Acta Neuropathol. (Berl.) 100 2000 528 536
191. L.C. Schmued, C. Albertson, and W.J. Slikker Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration Brain Res. 751 1997 37 46
192. L.C. Schmued, and K.J. Hopkins Fluoro-Jade: novel fluorochromes for detecting toxicant-induced neuronal degeneration Toxicol. Pathol. 28 2000 91 99
193. R.H. Schwartz A cell culture model for T lymphocyte clonal anergy Science 248 1990 1349 1356
194. O.U. Scremin Cerebral vascular system G. Paxinos The Rat Nervous System 2nd ed. 1995 Academic Press San Diego 3 35
195. J.D. Sedgwick, S. Schwender, R. Gregersen, R. Doerries, and V. ter Meulen Resident macrophages (ramified microglia) of the adult brown norway rat central nervous system are constitutively major histocompatibility class II positive J. Exp. Med. 177 1993 1145 1152
196. R.J. Seitz, N.P. Azari, U. Knorr, F. Binkofski, H. Herzog, and H.-J. Freund The role of diaschisis in stroke recovery Stroke 30 1999 1844 1850
197. M.J. Serou, M.A. DeCoster, and N.G. Bazan Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression J. Neurosci. Res. 58 1999 593 598
198. M. Shimizu-Sasamata, T. Kano, J. Rogowska, G.L. Wolf, M.A. Moskowitz, and E.H. Lo YM872, a highly water-soluble AMPA receptor antagonist, preserves the hemodynamic penumbra and reduces brain injury after permanent focal ischemia in rats Stroke 29 1998 2141 2148
199. B.K. Siesjö, C.D. Agardh, and F. Bengtsson Free radicals and brain damage Cerebrovasc. Brain Metab. Rev. 1 1989 165 211
200. R.S. Sloviter, C.A. Zappone, B.D. Harvey, A.V. Bumanglag, R.A. Bender, and M. Frotscher Dormant basket cell" hypothesis revisited: relative vulnerabilities of dentate gyrus mossy cells and inhibitory interneurons after hippocampal status epilepticus in the rat J. Comp. Neurol. 459 2003 44 76
201. A.M. Smetanka, K.T. Yee, and R.D. Lund Differential induction of class I and II MHC antigen expression by degenerating myelinated and unmyelinated axons Brain Res. 521 1990 343 346
202. M. Sopala, T. Frankiewicz, C. Parsons, and W. Danysz Middle cerebral artery occlusion produces secondary, remote impairment in hippocampal plasticity of rats - involvement of N-methyl-d-aspartate receptors? Neurosci. Lett. 281 2000 143 146
203. J.C. Sorensen, I. Dalmau, J. Zimmer, and B. Finsen Microglial reactions to retrograde degeneration of tracer-identified thalamic neurons after frontal sensorimotor cortex lesions in adult rats Exp. Brain Res. 112 1996 203 212
204. M.A. Soriano, I. Ferrer, E. Rodriguez-Farre, and A.M. Planas Apoptosis and c-Jun in the thalamus of the rat following cortical infarction Neuroreport 7 1996 425 428
205. M.A. Soriano, C. Justicia, I. Ferrer, E. Rodriguez-Farre, and A.M. Planas Striatal infarction in the rat causes a transient reduction of tyrosine hydroxylase immunoreactivity in the ipsilateral substantia nigra Neurobiol. Dis. 4 1997 376 385
206. R. Sornas, H. Ostlund, and R. Muller Cerebrospinal fluid cytology after stroke Arch. Neurol. 26 1972 489 501
207. D. Srinivasan, J.H. Yen, D.J. Joseph, and W. Friedman Cell type-specific interleukin-1beta signalling in the CNS J. Neurosci. 24 2004 6482 6488
208. B.A. States, J. Honkaniemi, P.R. Weinstein, and F.R. Sharp DNA fragmentation and hsp70 protein induction in hippocampus and cortex occurs in separate neurons following permanent middle cerebral artery occlusions J. Cereb. Blood Flow Metab. 16 1996 1165 1175
209. C. Steinhaeuser, and V. Gallo News on glutamate receptors in glial cells Trends Neurosci. 19 1996 339 345
210. L. Stefanis, and R.E. Burke Transneuronal degeneration in substantia nigra pars reticulata following striatal excitotoxic injury in adult rat: time-course, distribution and morphology of cell death Neuroscience 74 1996 997 1008
211. W.J. Streit, M.B. Graeber, and G.W. Kreutzberg Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury Exp. Neurol. 105 1989 115 126
212. W.J. Streit, T. Morioka, and A.N. Kalehua MK-801 prevents microglial reaction in rat hippocampus after forebrain ischemia Neuroreport 3 1992 146 148
213. J.L. Takahashi, F. Giuliani, C. Power, Y. Imai, and V.W. Yong Interleukin-1 beta promotes oligodendrocyte death through glutamate excitotoxicity Ann. Neurol. 53 2003 588 595
214. A. Tamura, D.I. Graham, J. McCulloch, and G.M. Teasdale Focal cerebral ischaemia in the rat: description of technique and early neuropathological consequences following middle cerebral artery occlusion J. Cereb. Blood Flow Metab. 1 1981 53 60
215. A. Tamura, Y. Tahira, H. Nagashima, T. Kirino, O. Gotoh, S. Hojo, and K. Sano Thalamic atrophy following cerebral infarction in the territory of the middle cerebral artery Stroke 22 1991 615 618
216. K. Tasaki, C.A. Ruetzler, T. Ohtsuki, D. Martin, H. Nawashiro, and J.M. Hallenbeck Lipopolysaccharide pretreatment induces resistance against focal cerebral ischemic damage in spontaneously hypertensive rats Brain Res. 748 1997 267 270
217. V. Taupin, S. Toulmond, A. Serrano, J. Benavides, and F. Zavala Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand J. Neuroimmunol. 42 1993 177 185
218. W.E. Thomas Brain macrophages: evaluation of microglia and their function Brain Res. Rev. 17 1992 61 74
219. H. Togashi, K. Mori, Y. Itoh, M. Matsumoto, K. Ueno, S. Ohashi, Otan, and M. Yoshioka Involvement of interleukin-1 beta/nitric oxide pathway in the postischemic impairment of long-term potentiation of the rat hippocampus Neurosci. Lett. 313 2001 133 136
220. T. Tominaga, and S.T. Ohnishi Interrelationship of brain edema, motor deficits and memory impairment in rats exposed to focal ischemia Stroke 20 1989 513 518
221. R. Töpper, J. Gehrmann, M. Schwarz, F. Block, J. Noth, and G.W. Kreutzberg Remote microglial activation in the quinolinic acid model of Huntington's disease Exp. Neurol. 123 1993 271 283
222. S. Toulmond, X. Vige, D. Fage, and J. Benavides Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons Neurosci. Lett. 144 1992 49 52
223. D.J. Tracey Ascending and descending pathways in the spinal cord G. Paxinos The Rat Nervous System 1995 Academic Press 67 75
224. L. Tveten Spinal cord vascularity. II. Extraspinal sources of spinal cord arteries in the rat Acta Radiol. Diagn. 17 1976 167 179
225. L. Tveten Spinal cord vascularity. IV. The spinal cord arteries in the rat Acta Radiol Diagn 17 1976 385 398
226. A. Uchino, A. Sawada, Y. Takase, R. Egashira, and S. Kudo Transient detection of early wallerian degeneration on diffusion-weighted MRI after an acute cerebrovascular accident Neuroradiology 46 2004 183 188
227. J.G. Valtschanoff, R.J. Weinberg, and A. Rustioni Amino acid immunoreactivity in corticospinal terminals Exp. Brain Res. 93 1993 95 103
228. A. Van Harreveld, and E. Fifkova Glutamate release from the retina during spreading depression J. Neurobiol. 2 1970 13 29
229. C. Von Monakow Aphasie und diaschisis Neurol. Centralbl. 25 1906 1026 1038
230. P.Y. Wang, C.H. Kao, M.Y. Mui, and S.J. Wang Leukocyte infiltration in acute hemispheric ischemic stroke Stroke 24 1993 236 240
231. H. Watanabe, Y. Kumon, S. Ohta, K. Nakano, S. Sakaki, S. Matsuda, and M. Sakanaka Protein synthesis inhibitor transiently reduces neuronal death in the thalamus of spontaneously hypertensive rats following cortical infarction Neurosci. Lett. 233 1997 25 28
232. B.D. Watson, D. Dietrich, R. Busto, M.S. Wachtel, and M.D. Ginsberg Induction of reproducible brain infarction by photochemically initiated thrombosis Ann. Neurol. 17 1985 497 504
233. Y.P. Wu, and E.A. Ling Induction of microglial and astrocytic response in the adult rat lumbar spinal cord following middle cerebral artery occlusion Exp. Brain Res. 118 1998 235 242
234. Y.P. Wu, and E.A. Ling Expression of Fos in the spinal motoneurons labelled by horseradish peroxidase following middle cerebral artery occlusion in rats Brain Res. Bull. 45 1998 571 576
235. Y.P. Wu, and E.A. Ling Transsynaptic changes of neurons and associated microglial reaction in the spinal cord of rats following middle cerebral artery occlusion Neurosci. Lett. 256 1998 41 44
236. Y.P. Wu, C.K. Tan, and E.A. Ling Expression of Fos-like immunoreactivity in the brain and spinal cord of rats following middle cerebral artery occlusion Exp. Brain Res. 115 1997 129 136
237. K. Yamada, A. Kinoshita, E. Kohmura, T. Sakaguchi, J. Taguchi, K. Kataoka, and T. Hayakawa Basic fibroblast growth factor prevents thalamic degeneration after cortical infarction J. Cereb. Blood Flow Metab. 11 1991 472 478
238. M. Yamada, and H. Hatanaka Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death Brain Res. 643 1994 173 180
239. K. Yamagata, K.I. Andreasson, and W.E. Kaufmann Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids Neuron 11 1993 371 386
240. Z.C. Ye, and H. Sontheimer Cytokine modulation of glial glutamate uptake: a possible involvement of nitric oxide Neuroreport 7 1996 2181 2185
241. A.B. Young, J.B. Penney, G.W. Dauth, M.B. Bramberg, and S. Gilman Glutamate or aspartate as a possible neurotransmitter of the cerebral cortico-fugal fibres in the monkey Neurology 33 1983 1513 1516
242. M. Yoshioka, Y. Itoh, K. Mori, K. Ueno, M. Matsumoto, and H. Togashi Effects of an interleukin-1 beta analogue (Lys-D-Pro-Thr) on incomplete cerebral ischemia-induced inhibition of long-term potentiation in rat hippocampal neurons in vivo Neurosci. Lett. 261 1999 171 174
243. Z. Yu, G. Cheng, X. Wen, G.D. Wu, W.-T. Lee, and D. Pleasure Tumor necrosis factor α increases neuronal vulnerability to excitotoxic necrosis by inducing expression of the AMPA-glutamate receptor subunit GluR1 via an acid sphingomyelinase and NF-κB dependent mechanism Neurobiol. Dis. 11 2002 199 213
244. E. Zea-Longa, P.R. Weinstein, S. Carlson, and R. Cummings Reversible cerebral artery occlusion without craniectomy in rats Stroke 20 1989 84 91
245. F. Zhao, T. Kuroiwa, N. Miyasaka, T. Nagaoka, M. Nakane, A. Tamura, and H. Mizusawa Characterisctic changes in T(2)-value, apparent diffusion coefficient, and ultrastructure of substantia nigra evolving exofocal postischemic neuronal death in rats Brain Res. 895 2001 238 244
246. C.Z. Zhu, and R.L. Auer Graded hypotension and MCA occlusion duration: effect in transient focal ischemia J. Cereb. Blood Flow Metab. 15 1995 980 988
247. K. Zilles, and A. Wree Cortex: areal and laminar structure G. Paxinos The Rat Nervous System 1985 Academic Press Sydney 375 415