Human Rad17 is phosphorylated upon DNA damage and also overexpressed in primary non-small cell lung cancer tissues

Cancer Research

Volumn 61, Issue 20, 2001, Pages 7417-7421

  Wang, X ^a   Wang, L ^a   Callister, M D ^a   Putnam, J B ^a   Mao, L ^a   Li, L ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN RAD17; REGULATOR PROTEIN; REPLICATION FACTOR C; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IONIZING RADIATION; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ULTRAVIOLET RADIATION;

CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE PROTEINS; COLORECTAL NEOPLASMS; DNA DAMAGE; HUMANS; LUNG NEOPLASMS; PHOSPHORYLATION; TUMOR CELLS, CULTURED;

EID: 0035886873     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Cell cycle checkpoints: Preventing an identity crisis
2. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae
3. The DNA damage response: Putting checkpoints in perspective
4. Cell cycle control and cancer
5. Cancer-susceptibility genes. Gatekeepers and caretakers
6. Fission yeast rad17: A homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins
7. hRAD17, a structural homolog of the Schizosaccharomyces pombe RAD17 cell cycle checkpoint gene, stimulates p53 accumulation
8. The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint
9. Human and mouse RAD17 genes: Identification, localization, genomic structure and histological expression pattern in normal testis and seminoma
10. Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene
11. Substrate specificities and identification of putative substrates of ATM kinase family members
12. A Rad3-Rad26 complex responds to DNA damage independently of other checkpoint proteins
13. ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation
14. G2/M checkpoint genes of Saccharomyces cerevisiae: Further evidence for roles in DNA replication and/or repair
15. Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways
16. A novel Rad24 checkpoint protein complex closely related to replication factor C
17. Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpoints
18. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9
19. Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage-responsive checkpoint complex
20. A sliding clamp model for the Rad1 family of cell cycle checkpoint proteins
21. Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
22. HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma
23. Determination of the genotype of a panel of human tumor cell lines for the human homologues of yeast cell cycle checkpoint control genes: Identification of cell lines carrying homoallelic missense base substitutions
24. Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering
25. Identification of novel regions of allelic loss from a genomewide scan of esophageal squamous-cell carcinoma in a high-risk Chinese population
26. Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis
27. ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses