The Akt-FoxO3a-manganese superoxide dismutase pathway is involved in the regulation of oxidative stress in diabetic nephropathy

Experimental Physiology

Volumn 98, Issue 4, 2013, Pages 934-945

  Lu, Qian ^a   Zhai, Yunpeng ^a   Cheng, Qian ^a   Liu, Yaowu ^a   Gao, Xing ^a   Zhang, Ting ^a   Wei, Yaqin ^a   Zhang, Fan ^a   Yin, Xiao Xing ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; GLUCOSE; MALONALDEHYDE; MANGANESE SUPEROXIDE DISMUTASE; MANNITOL; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR FKHRL1; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IN VITRO STUDY; KIDNEY CORTEX; KIDNEY FUNCTION; KIDNEY MASS; LIPID PEROXIDATION; MESANGIUM CELL; MOUSE; NONHUMAN; OSMOTIC PRESSURE; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84875542518     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2012.068361     Document Type: Article

References (37)

1. Accili D & Arden KC (2004). FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117, 421-426.
2. Brownlee M (2005). The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54, 1615-1625.
3. Garcia Z, Kumar A, Marques M, Cortes I & Carrera AC (2006). Phosphoinositide 3-kinase controls early and late events in mammalian cell division. EMBO J 25, 655-661.
4. Gaweł S, Wardas M, Niedworok E & Wardas P (2004). Malondialdehyde (MDA) as a lipid peroxidation marker. [Article in Polish.] Wiad Lek 57, 453-455.
5. Giacco F & Brownlee M (2010). Oxidative stress and diabetic complications. Circ Res 107, 1058-1070.
6. Holley AK, Bakthavatchalu V, Velez-Roman JM & St Clair DK (2011). Manganese superoxide dismutase: guardian of the powerhouse. Int J Mol Sci 12, 7114-7162.
7. Jaimes EA, Hua P, Tian RX & Raij L (2009). Human glomerular endothelium: interplay among glucose, free fatty acids, angiotensin II, and oxidative stress. Am J Physiol Renal Physiol 298, F125-F132.
8. Ji L, Yin XX, Wu ZM, Wang JY, Lu Q & Gao YY (2009). Ginkgo biloba extract prevents glucose-induced accumulation of ECM in rat mesangial cells. Phytother Res 23, 477-485.
9. Kanwar YS, Wada J, Sun L, Xie P, Wallner EI, Chen S, Chugh S & Danesh FR (2008). Diabetic nephropathy: mechanisms of renal disease progression. Exp Biol Med 233, 4-11.
10. Kashihara N, Haruna Y, Kondeti VK & Kanwar YS (2010). Oxidative stress in diabetic nephropathy. Curr Med Chem 17, 4256-4269.
11. Kato M, Yuan H, Xu ZG, Lanting L, Li SL, Wang M, Hu MC, Reddy MA & Natarajan R (2006). Role of the Akt/FoxO3a pathway in TGF-β1-mediated mesangial cell dysfunction: a novel mechanism related to diabetic kidney disease. J Am Soc Nephrol 17, 3325-3335.
12. Kattla JJ, Carew RM, Heljic M, Godson C & Brazil DP (2008). Protein kinase B/Akt activity is involved in renal TGF-β1-driven epithelial-mesenchymal transition in vitro and in vivo. Am J Physiol Renal Physiol 295, F215-F225.
13. Kim SH, Jang YW, Hwang P, Kim HJ, Han GY & Kim CW (2012). The reno-protective effect of a phosphoinositide 3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric renal disease rats. Exp Mol Med 44, 45-51.
14. Kiritoshi S, Nishikawa T, Sonoda K, Kukidome D, Senokuchi T, Matsuo T, Matsumura T, Tokunaga H, Brownlee M & Araki E (2003). Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells. Diabetes 52, 2570-2577.
15. Lee HS & Song CY (2009). Differential role of mesangial cells and podocytes in TGF-β-induced mesangial matrix synthesis in chronic glomerular disease. Histol Histopathol 24, 901-908.
16. +-dependent isocitrate dehydrogenase by hyperglycemia protects renal cells against oxidative stress. Mol Cells 29, 203-208.
17. Lekli I, Mukherjee S, Ray D, Gurusamy N, Kim YH, Tosaki A, Engelman RM, Ho YS & Das DK (2010). Functional recovery of diabetic mouse hearts by glutaredoxin-1 gene therapy: role of Akt-FoxO-signaling network. Gene Ther 17, 478-485.
18. Li J, Lee YS, Choi JS, Sung HY, Kim JK, Lim SS & Kang YH (2010). Roasted licorice extracts dampen high glucose-induced mesangial hyperplasia and matrix deposition through blocking Akt activation and TGF-beta signaling. Phytomedicine 17, 800-810.
19. Li M, Chiu JF, Mossman BT & Fukagawa NK (2006). Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats. J Biol Chem 281, 40429-40439.
20. Likidlilid A, Patchanans N, Peerapatdit T & Sriratanasathavorn C (2010). Lipid peroxidation and antioxidant enzyme activities in erythrocytes of type 2 diabetic patients. J Med Assoc Thai 93, 682-693.
21. Lu Q, Yin XX, Wang JY, Gao YY & Pan YM (2007). Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats. Acta Pharmacol Sin 28, 818-828.
22. Lustgarten MS, Jang YC, Liu Y, Qi W, Qin Y, Dahia PL, Shi Y, Bhattacharya A, Muller FL, Shimizu T, Shirasawa T, Richardson A & Van Remmen H (2011). MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging. Aging Cell 10, 493-505.
23. Ma J, Ding Y, Fang X, Wang R & Sun Z (2012). Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway. J Immunol 188, 5337-5347.
24. Najafian B, Alpers CE & Fogo AB (2011). Pathology of human diabetic nephropathy. Contrib Nephrol 170, 36-47.
25. Noh H & Ha H (2010). Reactive oxygen species and oxidative stress. Contrib Nephrol 170, 102-112.
26. Pantsulaia T (2006). Role of TGF-beta in pathogenesis of diabetic nephropathy. Georgian Med News 131, 13-18.
27. Rossing P (2006). Diabetic nephropathy: worldwide epidemic and effects of current treatment on natural history. Curr Diab Rep 6, 479-483.
28. Sharma K, McCue P & Dunn SR (2003). Diabetic kidney disease in the db/db mouse. Am J Physiol Renal Physiol 284, F1138-F1144.
29. Sinuani I, Beberashvili I, Averbukh Z, Cohn M, Gitelman I & Weissgarten J (2010). Mesangial cells initiate compensatory tubular cell hypertrophy. Am J Nephrol 31, 326-331.
30. Skurk C, Maatz H, Kim HS, Yang J, Abid MR, Aird WC & Walsh K (2004). The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP. J Biol Chem 279, 1513-1525.
31. Sunters A, Fernandez de Mattos S, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA, Coffer PJ, Medema RH, Coombes RC & Lam EW (2003). FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem 278, 49795-49805.
32. Suwanabol PA, Seedial SM, Zhang F, Shi X, Si Y, Liu B & Kent KC (2012). TGF-β and Smad3 modulate PI3K/Akt signaling pathway in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 302, H2211-H2219.
33. Tang WH, Martin KA & Hwa J (2012). Aldose reductase, oxidative stress, and diabetic mellitus. Front Pharmacol 3, 87.
34. Wang AB, Li HL, Zhang R, She ZG, Chen HZ, Huang Y, Liu DP & Liang CC (2007). A20 attenuates vascular smooth muscle cell proliferation and migration through blocking PI3k/Akt singling in vitro and in vivo. J Biomed Sci 14, 357-371.
35. Wang JY, Yin XX, Wu YM, Tang DQ, Gao Y, Wan MR, Hou XY & Zhang B (2006). Ginkgo biloba extract prevents against glomerulosclerosis in rat mesangial cells. Acta Pharmacol Sin 27, 1222-1230.
36. Yin XX, Zhang YD, Yu JX, Zhang B, Shen JP & Qiu J (2006). The antioxidative effects of Astragalus saponin I protect against development of early diabetic nephropathy. J Pharmacol Sci 101, 166-173.
37. Zhang H, Zhang HM, Wu LP, Tan DX, Kamat A, Li YQ, Katz MS, Abboud HE, Reiter RJ & Zhang BX (2011). Impaired mitochondrial complex III and melatonin responsive reactive oxygen species generation in kidney mitochondria of db/db mice. J Pineal Res 51, 338-344.