Coenzyme Q10 protects against amyloid beta-induced neuronal cell death by inhibiting oxidative stress and activating the P13K pathway

NeuroToxicology

Volumn 33, Issue 1, 2012, Pages 85-90

  Choi, Hojin ^a   Park, Hyun Hee ^a   Koh, Seong Ho ^a,b   Choi, Na Young ^a,b   Yu, Hyun Jeung ^c   Park, Jinse ^a   Lee, Young Joo ^a   Lee, Kyu Yong ^a  

^a Hanyang University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

^c Bundang Jesaeng Hospital   (South Korea)

Author keywords

Amyloid ; Coenzyme Q10; Neuroprotection; Oxidative stress; Phosphatidylinositol 3 kinase

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[25-35]; CYTOCHROME C; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK PROTEIN 70; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; UBIDECARENONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; CELLS, CULTURED; CEREBRAL CORTEX; CYTOCHROMES C; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; FREE RADICALS; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; IN SITU NICK-END LABELING; INDOLES; NEURONS; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UBIQUINONE; VITAMINS;

RATTUS;

EID: 84855249315     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2011.12.005     Document Type: Article

References (45)

1. Beal M.F. Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann NY Acad Sci 2003, 991:120-131.
2. Behl C., Davis J.B., Lesley R., Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 1994, 77:817-827.
3. Brion J.P., Anderton B.H., Authelet M., Dayanandan R., Leroy K., Lovestone S., et al. Neurofibrillary tangles and tau phosphorylation. Biochem Soc Symp 2001, 81-88.
4. Butterfield D.A. Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review. Free Radic Res 2002, 36:1307-1313.
5. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 2002, 296:1655-1657.
6. Cantrell D.A. Phosphoinositide 3-kinase signalling pathways. J Cell Sci 2001, 114:1439-1445.
7. Cenini G., Cecchi C., Pensalfini A., Bonini S.A., Ferrari-Toninelli G., Liguri G., et al. Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways. Amino Acids 2010, 38:1101-1106.
8. Christen Y. Oxidative stress and Alzheimer disease. Am J Clin Nutr 2000, 71:621S-629S.
9. Chyan Y.J., Poeggeler B., Omar R.A., Chain D.G., Frangione B., Ghiso J., et al. Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid. J Biol Chem 1999, 274:21937-21942.
10. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993, 262:689-695.
11. Dahlgren K.N., Manelli A.M., Stine W.B., Baker L.K., Krafft G.A., LaDu M.J. Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. J Biol Chem 2002, 277:32046-32053.
12. Filomeni G., Aquilano K., Rotilio G., Ciriolo M.R. Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide. Cancer Res 2003, 63:5940-5949.
13. Frame S., Cohen P., Biondi R.M. A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol Cell 2001, 7:1321-1327.
14. Huang X., Atwood C.S., Hartshorn M.A., Multhaup G., Goldstein L.E., Scarpa R.C., et al. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 1999, 38:7609-7616.
15. Huang X., Cuajungco M.P., Atwood C.S., Hartshorn M.A., Tyndall J.D., Hanson G.R., et al. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem 1999, 274:37111-37116.
16. Ill-Raga G., Ramos-Fernandez E., Guix F.X., Tajes M., Bosch-Morato M., Palomer E., et al. Amyloid-beta peptide fibrils induce nitro-oxidative stress in neuronal cells. J Alzheimers Diss 2010, 22:641-652.
17. Isaev N.K., Stelmashook E.V., Dirnagl U., Andreeva N.A., Manuhova L., Vorobjev V.S., et al. Neuroprotective effects of the antifungal drug clotrimazole. Neuroscience 2002, 113:47-53.
18. Jiang Q., Gu Z., Zhang G., Jing G. Diphosphorylation and involvement of extracellular signal-regulated kinases (ERK1/2) in glutamate-induced apoptotic-like death in cultured rat cortical neurons. Brain Res 2000, 857:71-77.
19. Kirschenbaum F., Hsu S.C., Cordell B., McCarthy J.V. Glycogen synthase kinase-3beta regulates presenilin 1 C-terminal fragment levels. J Biol Chem 2001, 276:30701-30707.
20. Koh S.H., Kim S.H., Kwon H., Kim J.G., Kim J.H., Yang K.H., et al. Phosphatidylinositol-3 kinase/Akt and GSK-3 mediated cytoprotective effect of epigallocatechin gallate on oxidative stress-injured neuronal-differentiated N18D3 cells. Neurotoxicology 2004, 25:793-802.
21. Koh S.H., Noh M.Y., Kim S.H. Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3. Brain Res 2008, 1188:254-262.
22. Kontush A., Berndt C., Weber W., Akopyan V., Arlt S., Schippling S., et al. Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma. Free Radic Biol Med 2001, 30:119-128.
23. Lee K.Y., Koh S.H., Noh M.Y., Kim S.H., Lee Y.J. Phosphatidylinositol-3-kinase activation blocks amyloid beta-induced neurotoxicity. Toxicology 2008, 243:43-50.
24. Lee Y.J., Park K.H., Park H.H., Kim Y.J., Lee K.Y., Kim S.H., et al. Cilnidipine mediates a neuroprotective effect by scavenging free radicals and activating the phosphatidylinositol 3-kinase pathway. J Neurochem 2009, 111:90-100.
25. Leevers S.J., Vanhaesebroeck B., Waterfield M.D. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol 1999, 11:219-225.
26. Lehninger A.L. The molecular organization of mitochondrial membranes. Adv Cytopharmacol 1971, 1:199-208.
27. Li J., Wang C., Zhang J.H., Cai J.M., Cao Y.P., Sun X.J. Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress. Brain Res 2010, 1328:152-161.
28. Mark R.J., Lovell M.A., Markesbery W.R., Uchida K., Mattson M.P. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide. J Neurochem 1997, 68:255-264.
29. Mark R.J., Pang Z., Geddes J.W., Uchida K., Mattson M.P. Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation. J Neurosci 1997, 17:1046-1054.
30. Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 1997, 23:134-147.
31. Markesbery W.R., Carney J.M. Oxidative alterations in Alzheimer's disease. Brain Pathol 1999, 9:133-146.
32. Mudher A., Chapman S., Richardson J., Asuni A., Gibb G., Pollard C., et al. Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. J Neurosci 2001, 21:4987-4995.
33. Noh M.Y., Koh S.H., Kim Y., Kim H.Y., Cho G.W., Kim S.H. Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death. J Neurochem 2009, 108:1116-1125.
34. Pap M., Cooper G.M. Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway. Mol Cell Biol 2002, 22:578-586.
35. Park H.H., Lee K.Y., Kim S.H., Lee Y.J., Koh S.H. L-DOPA-induced neurotoxicity is reduced by the activation of the PI3K signaling pathway. Toxicology 2009, 265:80-86.
36. Sang H., Lu Z., Li Y., Ru B., Wang W., Chen J. Phosphorylation of tau by glycogen synthase kinase 3beta in intact mammalian cells influences the stability of microtubules. Neurosci Lett 2001, 312:141-144.
37. Shim Y.S., Morris J.C. Biomarkers predicting Alzheimer's disease in cognitively normal aging. J Clin Neurol 2011, 7:60-68.
38. Shults C.W., Oakes D., Kieburtz K., Beal M.F., Haas R., Plumb S., et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002, 59:1541-1550.
39. Smith M.A., Rottkamp C.A., Nunomura A., Raina A.K., Perry G. Oxidative stress in Alzheimer's disease. Biochim Biophys Acta 2000, 1502:139-144.
40. Varadarajan S., Yatin S., Aksenova M., Review Butterfield D.A. Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol 2000, 130:184-208.
41. Wan L., Nie G., Zhang J., Luo Y., Zhang P., Zhang Z., et al. Beta-amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease. Free Radic Biol Med 2011, 50:122-129.
42. Xavier I.J., Mercier P.A., McLoughlin C.M., Ali A., Woodgett J.R., Ovsenek N. Glycogen synthase kinase 3beta negatively regulates both DNA-binding and transcriptional activities of heat shock factor 1. J Biol Chem 2000, 275:29147-29152.
43. Xu J., Zhou Z., Zeng L., Huang Y., Zhao W., Cheng C., et al. Cloning, expression and characterization of a novel human REPS1 gene. Biochim Biophys Acta 2001, 1522:118-121.
44. Yoganathan T.N., Costello P., Chen X., Jabali M., Yan J., Leung D., et al. Integrin-linked kinase (ILK): a hot therapeutic target. Biochem Pharmacol 2000, 60:1115-1119.
45. Zhao B. Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease. Neurochem Res 2009, 34:630-638.