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Volumn 176, Issue 5, 2010, Pages 2139-2149

Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: Potential clinical implications

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; PROGESTERONE RECEPTOR; PROTEIN KINASE B; SMALL INTERFERING RNA; TAMOXIFEN;

EID: 77952077124     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.090477     Document Type: Article
Times cited : (38)

References (59)
  • 1
    • 33646379862 scopus 로고    scopus 로고
    • Intranuclear 3′-phosphoinositide metabolism and Akt signaling: New mechanisms for tumorigenesis and protection against apoptosis?
    • Martelli AM, Faenza I, Billi AM, Manzoli L, Evangelisti C, Fala F, Cocco L: Intranuclear 3′-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis? Cell Signal 2006, 18:1101-1107
    • (2006) Cell Signal , vol.18 , pp. 1101-1107
    • Martelli, A.M.1    Faenza, I.2    Billi, A.M.3    Manzoli, L.4    Evangelisti, C.5    Fala, F.6    Cocco, L.7
  • 2
    • 33847314539 scopus 로고    scopus 로고
    • The phosphatidyl inositol 3-kinase signaling network: Implications for human breast cancer
    • Dillon RL, White DE, Muller WJ: The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Oncogene 2007, 26:1338-1345
    • (2007) Oncogene , vol.26 , pp. 1338-1345
    • Dillon, R.L.1    White, D.E.2    Muller, W.J.3
  • 3
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME: Cellular survival: a play in three Akts. Genes Dev 1999, 13:2905-2927
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 4
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM: Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005, 307:1098-1101
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 6
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC: AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 8
    • 27844526600 scopus 로고    scopus 로고
    • Akt-dependent transformation: There is more to growth than just surviving
    • DOI 10.1038/sj.onc.1209097, PII 1209097
    • Plas DR, Thompson CB: Akt-dependent transformation: there is more to growth than just surviving. Oncogene 2005, 24:7435-7442 (Pubitemid 41637983)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7435-7442
    • Plas, D.R.1    Thompson, C.B.2
  • 9
    • 33646759590 scopus 로고    scopus 로고
    • Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase
    • DOI 10.1038/sj.emboj.7601111, PII 7601111
    • Ahn JY, Liu X, Liu Z, Pereira L, Cheng D, Peng J, Wade PA, Hamburger AW, Ye K: Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. EMBO J 2006, 25:2083-2095 (Pubitemid 43756225)
    • (2006) EMBO Journal , vol.25 , Issue.10 , pp. 2083-2095
    • Ahn, J.-Y.1    Liu, X.2    Liu, Z.3    Pereira, L.4    Cheng, D.5    Peng, J.6    Wade, P.A.7    Hamburger, A.W.8    Ye, K.9
  • 12
    • 0034061694 scopus 로고    scopus 로고
    • The roles of gender, the menopause and hormone replacement on cardiovascular function
    • DOI 10.1016/S0008-6363(00)00005-5, PII S0008636300000055
    • Hayward CS, Kelly RP, Collins P: The roles of gender, the menopause and hormone replacement on cardiovascular function. Cardiovasc Res 2000, 46:28-49 (Pubitemid 30155943)
    • (2000) Cardiovascular Research , vol.46 , Issue.1 , pp. 28-49
    • Hayward, C.S.1    Kelly, R.P.2    Collins, P.3
  • 14
    • 58349104775 scopus 로고    scopus 로고
    • Oestrogen-receptor-positive breast cancer: Towards bridging histopathological and molecular classifications
    • Badve S, Nakshatri H: Oestrogen-receptor-positive breast cancer: towards bridging histopathological and molecular classifications. J Clin Pathol 2009, 62:6-12
    • (2009) J Clin Pathol , vol.62 , pp. 6-12
    • Badve, S.1    Nakshatri, H.2
  • 16
    • 34447130861 scopus 로고    scopus 로고
    • Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer
    • DOI 10.1158/0008-5472.CAN-07-0746
    • Eeckhoute J, Keeton EK, Lupien M, Krum SA, Carroll JS, Brown M: Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer. Cancer Res 2007, 67:6477-6483 (Pubitemid 47037533)
    • (2007) Cancer Research , vol.67 , Issue.13 , pp. 6477-6483
    • Eeckhoute, J.1    Keeton, E.K.2    Lupien, M.3    Krum, S.A.4    Carroll, J.S.5    Brown, M.6
  • 20
    • 30944442856 scopus 로고    scopus 로고
    • The Akt pathway in human breast cancer: A tissue-array-based analysis
    • DOI 10.1038/modpathol.3800525, PII 3800525
    • Bose S, Chandran S, Mirocha JM, Bose N: The Akt pathway in human breast cancer: a tissue-array-based analysis. Mod Pathol 2006, 19:238-245 (Pubitemid 43117608)
    • (2006) Modern Pathology , vol.19 , Issue.2 , pp. 238-245
    • Bose, S.1    Chandran, S.2    Mirocha, J.M.3    Bose, N.4
  • 21
    • 0036169031 scopus 로고    scopus 로고
    • Genesis: Cluster analysis of microarray data
    • Sturn A, Quackenbush J, Trajanoski Z: Genesis: cluster analysis of microarray data. Bioinformatics 2002, 18:207-208 (Pubitemid 34145055)
    • (2002) Bioinformatics , vol.18 , Issue.1 , pp. 207-208
    • Sturn, A.1    Quackenbush, J.2    Trajanoski, Z.3
  • 25
    • 0035971181 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance
    • DOI 10.1074/jbc.M010840200
    • Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Ali S, Nakshatri H: Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J Biol Chem 2001, 276:9817-9824 (Pubitemid 37391881)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.13 , pp. 9817-9824
    • Campbell, R.A.1    Bhat-Nakshatri, P.2    Patel, N.M.3    Constantinidou, D.4    Ali, S.5    Nakshatri, H.6
  • 26
    • 0033104495 scopus 로고    scopus 로고
    • Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation
    • Asada M, Yamada T, Ichijo H, Delia D, Miyazono K, Fukumuro K, Mizutani S: Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J 1999, 18:1223-1234 (Pubitemid 29110307)
    • (1999) EMBO Journal , vol.18 , Issue.5 , pp. 1223-1234
    • Asada, M.1    Yamada, T.2    Ichijo, H.3    Delia, D.4    Miyazono, K.5    Fukumuro, K.6    Mizutani, S.7
  • 29
    • 27844445642 scopus 로고    scopus 로고
    • Perturbations of the AKT signaling pathway in human cancer
    • DOI 10.1038/sj.onc.1209085, PII 1209085
    • Altomare DA, Testa JR: Perturbations of the AKT signaling pathway in human cancer. Oncogene 2005, 24:7455-7464 (Pubitemid 41637985)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7455-7464
    • Altomare, D.A.1    Testa, J.R.2
  • 30
    • 19944398464 scopus 로고    scopus 로고
    • High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB
    • DOI 10.1002/path.1760
    • Van de Sande T, Roskams T, Lerut E, Joniau S, Van Poppel H, Verhoeven G, Swinnen JV: High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB. J Pathol 2005, 206:214-219 (Pubitemid 40754025)
    • (2005) Journal of Pathology , vol.206 , Issue.2 , pp. 214-219
    • Van De Sande, T.1    Roskams, T.2    Lerut, E.3    Joniau, S.4    Van Poppel, H.5    Verhoeven, G.6    Swinnen, J.V.7
  • 32
    • 33745316089 scopus 로고    scopus 로고
    • Identification of a tumour suppressor network opposing nuclear Akt function
    • DOI 10.1038/nature04809, PII NATURE04809
    • Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP: Identification of a tumour suppressor network opposing nuclear Akt function. Nature 2006, 441:523-527 (Pubitemid 44050155)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 523-527
    • Trotman, L.C.1    Alimonti, A.2    Scaglioni, P.P.3    Koutcher, J.A.4    Cordon-Cardo, C.5    Pandolfi, P.P.6
  • 34
    • 23144442026 scopus 로고    scopus 로고
    • The TCL1 family of oncoproteins: Co-activators of transformation
    • Teitell MA: The TCL1 family of oncoproteins: co-activators of transformation. Nat Rev Cancer 2005, 5:640-648
    • (2005) Nat Rev Cancer , vol.5 , pp. 640-648
    • Teitell, M.A.1
  • 37
    • 0025062215 scopus 로고
    • Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti- Oestrogen 4-hydroxytamoxifen
    • Berry M, Metzger D, Chambon P: Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti- oestrogen 4-hydroxytamoxifen. EMBO J 1990, 9:2811-2818
    • (1990) EMBO J , vol.9 , pp. 2811-2818
    • Berry, M.1    Metzger, D.2    Chambon, P.3
  • 42
    • 34047127470 scopus 로고    scopus 로고
    • Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer
    • Blanco-Aparicio C, Perez-Gallego L, Pequeno B, Leal JF, Renner O, Carnero A: Mice expressing myrAKT1 in the mammary gland develop carcinogen-induced ER-positive mammary tumors that mimic human breast cancer. Carcinogenesis 2007, 28:584-594
    • (2007) Carcinogenesis , vol.28 , pp. 584-594
    • Blanco-Aparicio, C.1    Perez-Gallego, L.2    Pequeno, B.3    Leal, J.F.4    Renner, O.5    Carnero, A.6
  • 44
    • 27944446105 scopus 로고    scopus 로고
    • Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
    • Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A: Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 2005, 20:539-550
    • (2005) Mol Cell , vol.20 , pp. 539-550
    • Yoeli-Lerner, M.1    Yiu, G.K.2    Rabinovitz, I.3    Erhardt, P.4    Jauliac, S.5    Toker, A.6
  • 48
    • 33846416534 scopus 로고    scopus 로고
    • Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice
    • Maroulakou IG, Oemler W, Naber SP, Tsichlis PN: Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res 2007, 67:167-177
    • (2007) Cancer Res , vol.67 , pp. 167-177
    • Maroulakou, I.G.1    Oemler, W.2    Naber, S.P.3    Tsichlis, P.N.4
  • 49
    • 56849118516 scopus 로고    scopus 로고
    • Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
    • Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Unterman T, Hay N: Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 2008, 14:458-470
    • (2008) Cancer Cell , vol.14 , pp. 458-470
    • Nogueira, V.1    Park, Y.2    Chen, C.C.3    Xu, P.Z.4    Chen, M.L.5    Tonic, I.6    Unterman, T.7    Hay, N.8
  • 50
    • 45549104364 scopus 로고    scopus 로고
    • p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK
    • Boehme KA, Kulikov R, Blattner C: p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK. Proc Natl Acad Sci U S A 2008, 105:7785-7790
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 7785-7790
    • Boehme, K.A.1    Kulikov, R.2    Blattner, C.3
  • 52
    • 33751552134 scopus 로고    scopus 로고
    • Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity
    • Likhite VS, Stossi F, Kim K, Katzenellenbogen BS, Katzenellenbogen JA: Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity. Mol Endocrinol 2006, 20:3120-3132
    • (2006) Mol Endocrinol , vol.20 , pp. 3120-3132
    • Likhite, V.S.1    Stossi, F.2    Kim, K.3    Katzenellenbogen, B.S.4    Katzenellenbogen, J.A.5
  • 53
    • 35348904493 scopus 로고    scopus 로고
    • Phosphorylation of estrogen receptor-{alpha} at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients
    • Jiang J, Sarwar N, Peston D, Kulinskaya E, Shousha S, Coombes RC, Ali S: Phosphorylation of estrogen receptor-{alpha} at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients. Clin Cancer Res 2007, 13:5769-5776
    • (2007) Clin Cancer Res , vol.13 , pp. 5769-5776
    • Jiang, J.1    Sarwar, N.2    Peston, D.3    Kulinskaya, E.4    Shousha, S.5    Coombes, R.C.6    Ali, S.7
  • 55
    • 34248369435 scopus 로고    scopus 로고
    • Rare cancer-specific mutations in PIK3CA show gain of function
    • Gymnopoulos M, Elsliger MA, Vogt PK: Rare cancer-specific mutations in PIK3CA show gain of function. Proc Natl Acad Sci U S A 2007, 104:5569-5574
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5569-5574
    • Gymnopoulos, M.1    Elsliger, M.A.2    Vogt, P.K.3
  • 58
    • 32944482243 scopus 로고    scopus 로고
    • Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy
    • Cui X, Schiff R, Arpino G, Osborne CK, Lee AV: Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy. J Clin Oncol 2005, 23:7721-7735
    • (2005) J Clin Oncol , vol.23 , pp. 7721-7735
    • Cui, X.1    Schiff, R.2    Arpino, G.3    Osborne, C.K.4    Lee, A.V.5
  • 59
    • 18244391514 scopus 로고    scopus 로고
    • Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
    • Perez-Tenorio G, Stal O: Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br J Cancer 2002, 86:540-545
    • (2002) Br J Cancer , vol.86 , pp. 540-545
    • Perez-Tenorio, G.1    Stal, O.2


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