메뉴 건너뛰기




Volumn 54, Issue 7, 2013, Pages 1106-1112

Comparison of 18F-fluoroazomycin-arabinofuranoside and 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) in preclinical models of cancer

Author keywords

18F FAZA; 64Cu ATSM; PET imaging; Tumor hypoxia

Indexed keywords

CARBONATE DEHYDRATASE IX; COPPER EXPORTING ADENOSINE TRIPHOSPHATASE; DIACETYL BIS(N4 METHYLTHIOSEMICARBAZONE) C 64; FLUOROAZOMYCIN ARABINOFURANOSIDE F 18; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; COPPER; COPPER (II) DIACETYL DI(N(4) METHYLTHIOSEMICARBAZONE); COPPER (II) DIACETYL-DI(N(4)-METHYLTHIOSEMICARBAZONE); DIAGNOSTIC AGENT; FLUOROAZOMYCIN ARABINOSIDE; NITROIMIDAZOLE DERIVATIVE; ORGANOMETALLIC COMPOUND; THIOSEMICARBAZONE DERIVATIVE;

EID: 84879990817     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.112.111120     Document Type: Article
Times cited : (23)

References (40)
  • 1
    • 79958191830 scopus 로고    scopus 로고
    • Hypoxia-mediated drug resistance: Novel insights on the functional interaction of hifs and cell death pathways
    • Rohwer N, Cramer T. Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways. Drug Resist Updat. 2011;14:191-201.
    • (2011) Drug Resist Updat , vol.14 , pp. 191-201
    • Rohwer, N.1    Cramer, T.2
  • 2
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
    • Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci. 2012;33:207-214.
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 3
    • 34547103992 scopus 로고    scopus 로고
    • Hypoxia and radiotherapy: Opportunities for improved outcomes in cancer treatment
    • Moeller BJ, Richardson RA, Dewhirst MW. Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment. Cancer Metastasis Rev. 2007;26:241-248.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 241-248
    • Moeller, B.J.1    Richardson, R.A.2    Dewhirst, M.W.3
  • 4
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Significance and impact on clinical outcome
    • Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 2007;26:225-239.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 5
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996;56:4509-4515.
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 6
    • 10644270846 scopus 로고    scopus 로고
    • Tumor hypoxia: Causative factors, compensatory mechanisms, and cellular response
    • Vaupel P, Harrison L. Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Oncologist. 2004;9(suppl 5):4-9.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 5 , pp. 4-9
    • Vaupel, P.1    Harrison, L.2
  • 7
    • 79953865922 scopus 로고    scopus 로고
    • Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma
    • Tafani M, Di Vito M, Frati A, et al. Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma. J Neuroinflammation. 2011;8:32-47.
    • (2011) J Neuroinflammation , vol.8 , pp. 32-47
    • Tafani, M.1    Di Vito, M.2    Frati, A.3
  • 8
    • 79953870540 scopus 로고    scopus 로고
    • Targeting hif1a eliminates cancer stem cells in hematological malignancies
    • Wang Y, Liu Y, Malek SN, Zheng P. Targeting HIF1a eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 2011;8:399-411.
    • (2011) Cell Stem Cell , vol.8 , pp. 399-411
    • Wang, Y.1    Liu, Y.2    Malek, S.N.3    Zheng, P.4
  • 9
    • 84857407549 scopus 로고    scopus 로고
    • Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia
    • Conley SJ, Gheordunescu E, Kakarala P, et al. Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia. Proc Natl Acad Sci USA. 2012;109:2784-2789.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2784-2789
    • Conley, S.J.1    Gheordunescu, E.2    Kakarala, P.3
  • 10
    • 0018635742 scopus 로고
    • Hypoxic sensitizers: Implications for radiation therapy
    • Chapman JD. Hypoxic sensitizers: implications for radiation therapy. N Engl J Med. 1979;301:1429-1432.
    • (1979) N Engl J Med , vol.301 , pp. 1429-1432
    • Chapman, J.D.1
  • 11
    • 15044349250 scopus 로고    scopus 로고
    • Hypoxia-specific tumor imaging with 18f-fluoroazomycin arabinoside
    • Piert M, Machulla HJ, Picchio M, et al. Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside. J Nucl Med. 2005;46:106-113.
    • (2005) J Nucl Med , vol.46 , pp. 106-113
    • Piert, M.1    Machulla, H.J.2    Picchio, M.3
  • 12
    • 22144449210 scopus 로고    scopus 로고
    • Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent cu-atsm
    • Burgman P, O'Donoghue JA, Lewis JS, Welch MJ, Humm JL, Ling CC. Cell line-dependent differences in uptake and retention of the hypoxia-selective nuclear imaging agent Cu-ATSM. Nucl Med Biol. 2005;32:623-630.
    • (2005) Nucl Med Biol , vol.32 , pp. 623-630
    • Burgman, P.1    O'Donoghue, J.A.2    Lewis, J.S.3    Welch, M.J.4    Humm, J.L.5    Ling, C.C.6
  • 13
    • 34548485457 scopus 로고    scopus 로고
    • Tumour hypoxia imaging with [18f] faza pet in head and neck cancer patients: A pilot study
    • Souvatzoglou M, Grosu AL, Roper B, et al. Tumour hypoxia imaging with [18F] FAZA PET in head and neck cancer patients: a pilot study. Eur J Nucl Med Mol Imaging. 2007;34:1566-1575.
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , pp. 1566-1575
    • Souvatzoglou, M.1    Grosu, A.L.2    Roper, B.3
  • 14
    • 34249313652 scopus 로고    scopus 로고
    • Imaging of tumor hypoxia with [124i] iaza in comparison with [18f]fmiso and [18f]faza-first small animal pet results
    • Reischl G, Dorow DS, Cullinane C, et al. Imaging of tumor hypoxia with [124I] IAZA in comparison with [18F]FMISO and [18F]FAZA-first small animal PET results. J Pharm Pharm Sci. 2007;10:203-211.
    • (2007) J Pharm Pharm Sci , vol.10 , pp. 203-211
    • Reischl, G.1    Dorow, D.S.2    Cullinane, C.3
  • 15
    • 0038376175 scopus 로고    scopus 로고
    • In vivo assessment of tumor hypoxia in lung cancer with 60cu-atsm
    • Dehdashti F, Mintun MA, Lewis JS, et al. In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM. Eur J Nucl Med Mol Imaging. 2003;30:844-850.
    • (2003) Eur J Nucl Med Mol Imaging , vol.30 , pp. 844-850
    • Dehdashti, F.1    Mintun, M.A.2    Lewis, J.S.3
  • 16
    • 80052338025 scopus 로고    scopus 로고
    • Assessment of tumor hypoxia by 62cu-atsm pet/ct as a predictor of response in head and neck cancer: A pilot study
    • Minagawa Y, Shizukuishi K, Koike I, et al. Assessment of tumor hypoxia by 62Cu-ATSM PET/CT as a predictor of response in head and neck cancer: a pilot study. Ann Nucl Med. 2011;25:339-345.
    • (2011) Ann Nucl Med , vol.25 , pp. 339-345
    • Minagawa, Y.1    Shizukuishi, K.2    Koike, I.3
  • 17
    • 34548151815 scopus 로고    scopus 로고
    • Comparison of molecular markers of hypoxia and imaging with 60cu-atsm in cancer of the uterine cervix
    • Grigsby PW, Malyapa RS, Higashikubo R, et al. Comparison of molecular markers of hypoxia and imaging with 60Cu-ATSM in cancer of the uterine cervix. Mol Imaging Biol. 2007;9:278-283.
    • (2007) Mol Imaging Biol , vol.9 , pp. 278-283
    • Grigsby, P.W.1    Malyapa, R.S.2    Higashikubo, R.3
  • 18
    • 79551681223 scopus 로고    scopus 로고
    • Internal radiotherapy with copper-64- diacetyl-bis (n4- methylthiosemicarbazone) reduces cd1331 highly tumorigenic cells and metastatic ability of mouse colon carcinoma
    • Yoshii Y, Furukawa T, Kiyono Y, et al. Internal radiotherapy with copper-64- diacetyl-bis (N4-methylthiosemicarbazone) reduces CD1331 highly tumorigenic cells and metastatic ability of mouse colon carcinoma. Nucl Med Biol. 2011;38:151-157.
    • (2011) Nucl Med Biol , vol.38 , pp. 151-157
    • Yoshii, Y.1    Furukawa, T.2    Kiyono, Y.3
  • 19
    • 0141592797 scopus 로고    scopus 로고
    • Enhancing targeted radiotherapy by copper(ii)diacetyl- bis(n4-methylthiosemicarbazone) using 2-deoxy-d-glucose
    • Aft RL, Lewis JS, Zhang F, Kim J, Welch MJ. Enhancing targeted radiotherapy by copper(II)diacetyl- bis(N4-methylthiosemicarbazone) using 2-deoxy-D-glucose. Cancer Res. 2003;63:5496-5504.
    • (2003) Cancer Res , vol.63 , pp. 5496-5504
    • Aft, R.L.1    Lewis, J.S.2    Zhang, F.3    Kim, J.4    Welch, M.J.5
  • 20
    • 20144387807 scopus 로고    scopus 로고
    • Assessment of regional tumor hypoxia using 18f-fluoromisonidazole and 64cu(ii)-diacetyl-bis(n4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring micropet imaging, po2 probe measurement, autoradiography, and fluorescent microscopy in the r3327-at and fadu rat tumor models
    • O'Donoghue JA, Zanzonico P, Pugachev A, et al. Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4- methylthiosemicarbazone) positron emission tomography: comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent microscopy in the R3327-AT and FaDu rat tumor models. Int J Radiat Oncol Biol Phys. 2005;61:1493-1502.
    • (2005) Int J Radiat Oncol Biol Phys , vol.61 , pp. 1493-1502
    • O'Donoghue, J.A.1    Zanzonico, P.2    Pugachev, A.3
  • 21
    • 48249146505 scopus 로고    scopus 로고
    • Autoradiographic and smallanimal pet comparisons between 18f-fmiso, 18f-fdg, 18f-flt and the hypoxic selective 64cu-atsm in a rodent model of cancer
    • Dence CS, Ponde DE, Welch MJ, Lewis JS. Autoradiographic and smallanimal PET comparisons between 18F-FMISO, 18F-FDG, 18F-FLT and the hypoxic selective 64Cu-ATSM in a rodent model of cancer. Nucl Med Biol. 2008;35:713-720.
    • (2008) Nucl Med Biol , vol.35 , pp. 713-720
    • Dence, C.S.1    Ponde, D.E.2    Welch, M.J.3    Lewis, J.S.4
  • 22
    • 77950299410 scopus 로고    scopus 로고
    • Some thoughts on the mechanism of cellular trapping of cu(ii)-atsm
    • Dearling JL, Packard AB. Some thoughts on the mechanism of cellular trapping of Cu(II)-ATSM. Nucl Med Biol. 2010;37:237-243.
    • (2010) Nucl Med Biol , vol.37 , pp. 237-243
    • Dearling, J.L.1    Packard, A.B.2
  • 24
    • 13844305880 scopus 로고    scopus 로고
    • Investigation into 64cu-labeled bis (selenosemicarbazone) and bis(thiosemicarbazone) complexes as hypoxia imaging agents
    • McQuade P, Martin KE, Castle TC, et al. Investigation into 64Cu-labeled Bis (selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents. Nucl Med Biol. 2005;32:147-156.
    • (2005) Nucl Med Biol , vol.32 , pp. 147-156
    • McQuade, P.1    Martin, K.E.2    Castle, T.C.3
  • 25
    • 84856009969 scopus 로고    scopus 로고
    • An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis (4-methylthiosemicarbazonato)copperii
    • Donnelly PS, Liddell JR, Lim S, et al. An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis (4-methylthiosemicarbazonato)copperII. Proc Natl Acad Sci USA. 2012;109: 47-52.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 47-52
    • Donnelly, P.S.1    Liddell, J.R.2    Lim, S.3
  • 26
    • 15944397653 scopus 로고    scopus 로고
    • Preparation of the hypoxia imaging pet tracer [18f]faza: Reaction parameters and automation
    • Reischl G, Ehrlichmann W, Bieg C, et al. Preparation of the hypoxia imaging PET tracer [18F]FAZA: reaction parameters and automation. Appl Radiat Isot. 2005;62:897-901.
    • (2005) Appl Radiat Isot , vol.62 , pp. 897-901
    • Reischl, G.1    Ehrlichmann, W.2    Bieg, C.3
  • 27
    • 80455132113 scopus 로고    scopus 로고
    • Evaluation of the role of tumorassociated macrophages in an experimental model of peritoneal carcinomatosis using 18f-fdg pet
    • Cottone L, Valtorta S, Capobianco A, et al. Evaluation of the role of tumorassociated macrophages in an experimental model of peritoneal carcinomatosis using 18F-FDG PET. J Nucl Med. 2011;52:1770-1777.
    • (2011) J Nucl Med , vol.52 , pp. 1770-1777
    • Cottone, L.1    Valtorta, S.2    Capobianco, A.3
  • 28
    • 70449707196 scopus 로고    scopus 로고
    • Automated production of copper radioisotopes and preparation of high specific activity [64cu]cu-atsm for pet studies
    • Matarrese M, Bedeschi P, Scardaoni R, et al. Automated production of copper radioisotopes and preparation of high specific activity [64Cu]Cu-ATSM for PET studies. Appl Radiat Isot. 2010;68:5-13.
    • (2010) Appl Radiat Isot , vol.68 , pp. 5-13
    • Matarrese, M.1    Bedeschi, P.2    Scardaoni, R.3
  • 29
    • 77952888155 scopus 로고    scopus 로고
    • High levels of carbonic anhydrase ix in tumour tissue and plasma are biomarkers of poor prognostic in patients with nonsmall cell lung cancer
    • Ilie M, Mazure NM, Hofman V, et al. High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with nonsmall cell lung cancer. Br J Cancer. 2010;102:1627-1635.
    • (2010) Br J Cancer , vol.102 , pp. 1627-1635
    • Ilie, M.1    Mazure, N.M.2    Hofman, V.3
  • 30
    • 33847649279 scopus 로고    scopus 로고
    • Hif-1a and ca ix staining in invasive breast carcinomas: Prognosis and treatment outcome
    • Trastour C, Benizri E, Ettore F, et al. HIF-1a and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Int J Cancer. 2007;120:1451-1458.
    • (2007) Int J Cancer , vol.120 , pp. 1451-1458
    • Trastour, C.1    Benizri, E.2    Ettore, F.3
  • 31
    • 79957832643 scopus 로고    scopus 로고
    • An experimental study of dendritic cells transfected with cancer stem-like cells rna against 9l brain tumors
    • Xiao ZY, Tang H, Xu ZM, et al. An experimental study of dendritic cells transfected with cancer stem-like cells RNA against 9L brain tumors. Cancer Biol Ther. 2011;11:974-980.
    • (2011) Cancer Biol Ther , vol.11 , pp. 974-980
    • Xiao, Z.Y.1    Tang, H.2    Xu, Z.M.3
  • 32
    • 0037187390 scopus 로고    scopus 로고
    • Studies on the mechanism of hypoxic selectivity in copper bis(thiosemicarbazone) radiopharmaceuticals
    • Maurer RI, Blower PJ, Dilworth JR, Reynolds CA, Zheng Y, Mullen GE. Studies on the mechanism of hypoxic selectivity in copper bis(thiosemicarbazone) radiopharmaceuticals. J Med Chem. 2002;45:1420-1431.
    • (2002) J Med Chem , vol.45 , pp. 1420-1431
    • Maurer, R.I.1    Blower, P.J.2    Dilworth, J.R.3    Reynolds, C.A.4    Zheng, Y.5    Mullen, G.E.6
  • 33
    • 63649085984 scopus 로고    scopus 로고
    • In vitro kinetic studies on the mechanism of oxygen-dependent cellular uptake of copper radiopharmaceuticals
    • Holland JP, Giansiracusa JH, Bell SG, Wong LL, Dilworth Jr. In vitro kinetic studies on the mechanism of oxygen-dependent cellular uptake of copper radiopharmaceuticals. Phys Med Biol. 2009;54:2103-2119.
    • (2009) Phys Med Biol , vol.54 , pp. 2103-2119
    • Holland, J.P.1    Giansiracusa, J.H.2    Bell, S.G.3    Wong, L.L.4    Dilworth, J.R.5
  • 34
    • 0036277755 scopus 로고    scopus 로고
    • Understanding copper uptake at the molecular level
    • Wessling-Resnick M. Understanding copper uptake at the molecular level. Nutr Rev. 2002;60:177-179.
    • (2002) Nutr Rev , vol.60 , pp. 177-179
    • Wessling-Resnick, M.1
  • 35
    • 0041341920 scopus 로고    scopus 로고
    • The copper export pump atp7b modulates the cellular pharmacology of carboplatin in ovarian carcinoma cells
    • Katano K, Safaei R, Samimi G, Holzer A, Rochdi M, Howell SB. The copper export pump ATP7B modulates the cellular pharmacology of carboplatin in ovarian carcinoma cells. Mol Pharmacol. 2003;64:466-473.
    • (2003) Mol Pharmacol , vol.64 , pp. 466-473
    • Katano, K.1    Safaei, R.2    Samimi, G.3    Holzer, A.4    Rochdi, M.5    Howell, S.B.6
  • 36
    • 65649088246 scopus 로고    scopus 로고
    • Increased levels of copper efflux transporter atp7b are associated with poor outcome in colorectal cancer patients receiving oxaliplatin-based chemotherapy
    • Martinez-Balibrea E, Martinez-Cardus A, Musulen E, et al. Increased levels of copper efflux transporter ATP7B are associated with poor outcome in colorectal cancer patients receiving oxaliplatin-based chemotherapy. Int J Cancer. 2009;124: 2905-2910.
    • (2009) Int J Cancer , vol.124 , pp. 2905-2910
    • Martinez-Balibrea, E.1    Martinez-Cardus, A.2    Musulen, E.3
  • 37
    • 84859954148 scopus 로고    scopus 로고
    • A novel role for copper in ras/mitogenactivated protein kinase signaling
    • Turski ML, Brady DC, Kim HJ, et al. A novel role for copper in Ras/mitogenactivated protein kinase signaling. Mol Cell Biol. 2012;32:1284-1295.
    • (2012) Mol Cell Biol , vol.32 , pp. 1284-1295
    • Turski, M.L.1    Brady, D.C.2    Kim, H.J.3
  • 38
    • 0034916544 scopus 로고    scopus 로고
    • Copper-62 atsm as a hypoxic tissue tracer in myocardial ischemia
    • Takahashi N, Fujibayashi Y, Yonekura Y, et al. Copper-62 ATSM as a hypoxic tissue tracer in myocardial ischemia. Ann Nucl Med. 2001;15:293-296.
    • (2001) Ann Nucl Med , vol.15 , pp. 293-296
    • Takahashi, N.1    Fujibayashi, Y.2    Yonekura, Y.3
  • 39
    • 84856333052 scopus 로고    scopus 로고
    • Radiolabeled cu-atsm as a novel indicator of overreduced intracellular state due to mitochondrial dysfunction: Studies with mitochondrial dna-less r0 cells and cybrids carrying melas mitochondrial dna mutation
    • Yoshii Y, Yoneda M, Ikawa M, et al. Radiolabeled Cu-ATSM as a novel indicator of overreduced intracellular state due to mitochondrial dysfunction: studies with mitochondrial DNA-less r0 cells and cybrids carrying MELAS mitochondrial DNA mutation. Nucl Med Biol. 2012;39:177-185.
    • (2012) Nucl Med Biol , vol.39 , pp. 177-185
    • Yoshii, Y.1    Yoneda, M.2    Ikawa, M.3
  • 40
    • 57449097020 scopus 로고    scopus 로고
    • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    • Sonveaux P, Vegran F, Schroeder T, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest. 2008;118: 3930-3942.
    • (2008) J Clin Invest , vol.118 , pp. 3930-3942
    • Sonveaux, P.1    Vegran, F.2    Schroeder, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.