Comparison of molecular markers of hypoxia and imaging with 60Cu-ATSM in cancer of the uterine cervix

Molecular Imaging and Biology

Volumn 9, Issue 5, 2007, Pages 278-283

  Grigsby, Perry W ^a,c   Malyapa, Robert S ^a,d   Higashikubo, Ryuji ^a   Schwarz, Julie K ^a,c   Welch, Michael J ^a   Huettner, Phyllis C ^b   Dehdashti, Farrokh ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c USA   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

Cervical cancer; Hypoxia PET imaging; Prognostic markers

Indexed keywords

CARBONATE DEHYDRATASE IX; CISPLATIN; CYCLOOXYGENASE 2; DIACETYL BIS(N4 METHYLTHIOSEMICARBAZONE) CU 60; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUORODEOXYGLUCOSE F 18; TRACER; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; AGED; APOPTOSIS; ARTICLE; BRACHYTHERAPY; CANCER ADJUVANT THERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE MARKER; EXTERNAL BEAM RADIOTHERAPY; FEMALE; HUMAN; HUMAN TISSUE; HYPOXIA; INTERMETHOD COMPARISON; ISOTOPE LABELING; PILOT STUDY; POSITRON EMISSION TOMOGRAPHY; PREDICTION; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR RECURRENCE; UTERINE CERVIX CANCER;

ADULT; AGED; AGED, 80 AND OVER; ANOXIA; BIOLOGICAL MARKERS; COPPER RADIOISOTOPES; CYCLOOXYGENASE 2; FEMALE; HUMANS; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; ORGANOMETALLIC COMPOUNDS; PILOT PROJECTS; PROSPECTIVE STUDIES; RADIOPHARMACEUTICALS; RECEPTOR, EPIDERMAL GROWTH FACTOR; THIOSEMICARBAZONES; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34548151815     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-007-0095-2     Document Type: Article

References (35)

1. Hockel M, Horn LC, Fritsch H (2005) Association between the mesenchymal compartment of uterovaginal organogenesis and local tumour spread in stage IB-IIB cervical carcinoma: A prospective study. Lancet Oncol 6:751-756
2. Graeber TG, Osmanian C, Jacks T, et al. (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379:88-91
3. Ausserer WA, Bourrat-Floeck B, Green CJ, Laderoute KR, Sutherland RM (1994) Regulation of c-jun expression during hypoxic and low-glucose stress. Mol Cell Biol 14:5032-5042
4. Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353-364
5. Loncaster JA, Cooper RA, Logue JP, Davidson SE, Hunter RD, West CM (2000) Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix. Br J Cancer 83:620-625
6. Lee CM, Shrieve DC, Zempolich KA, et al. (2005) Correlation between human epidermal growth factor receptor family (EGFR, HER2, HER3, HER4), phosphorylated Akt (P-Akt), and clinical outcomes after radiation therapy in carcinoma of the cervix. Gynecol Oncol 99:415-421
7. Lopez-Ocejo O, Viloria-Petit A, Bequet-Romero M, Mukhopadhyay D, Rak J, Kerbel RS (2000) Oncogenes and tumor angiogenesis: The HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner. Oncogene 19:4611-4620
8. Dassonville O, Formento JL, Francoual M, et al. (1993) Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer. J Clin Oncol 11:1873-1878
9. Kulkarni S, Rader JS, Zhang F, et al. (2001) Cyclooxygenase-2 is overexpressed in human cervical cancer. Clin Cancer Res 7:429-434
10. Gaffney DK, Holden J, Davis M, Zempolich K, Murphy KJ, Dodson M (2001) Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy. Int J Radiat Oncol Biol Phys 49:1213-1217
11. Loncaster JA, Harris AL, Davidson SE, et al. (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 61:6394-6399
12. Nunn A, Linder K, Strauss HW (1995) Nitroimidazoles and imaging hypoxia. Eur J Nucl Med 22:265-280
13. Rasey JS, Koh WJ, Evans ML, et al. (1996) Quantifying regional hypoxia in human tumors with positron emission tomography of [18F]fluoromisonidazole: A pretherapy study of 37 patients. Int J Radiat Oncol Biol Phys 36:417-428
14. Thorwarth D, Eschmann SM, Scheiderbauer J, Paulsen F, Alber M (2005) Kinetic analysis of dynamic 18F-fluoromisonidazole PET correlates with radiation treatment outcome in head-and-neck cancer. BMC Cancer 5:152
15. Fujibayashi Y, Taniuchi H, Yonekura Y, Ohtani H, Konishi J, Yokoyama A (1997) Copper-62-ATSM: A new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med 38:1155-1160
16. Lewis JS, McCarthy DW, McCarthy TJ, Fujibayashi Y, Welch MJ (1999) Evaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model. J Nucl Med 40:177-183
17. Lewis JS, Sharp TL, Laforest R, Fujibayashi Y, Welch MJ (2001) Tumor uptake of copper-diacetyl-bis(N (4)-methylthiosemicarbazone): Effect of changes in tissue oxygenation. J Nucl Med 42:655-661
18. Lewis JS, Herrero P, Sharp TL, et al. (2002) Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N (4)-methylthiosemicarbazone). J Nucl Med 43:1557-1569
19. Dehdashti F, Grigsby PW, Mintun MA, Lewis JS, Siegel BA, Welch MJ (2003) Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: Relationship to therapeutic response - a preliminary report. Int J Radiat Oncol Biol Phys 55:1233-1238
20. Grigsby PW, Siegel BA, Dehdashti F (2001) Lymph node staging by positron emission tomography in patients with carcinoma of the cervix. J Clin Oncol 19:3745-3749
21. Perez CA, Brady LW (1998) Principles and Practice of Radiation Oncology, 3rd ed. Philadelphia: Lippincott-Raven
22. Grigsby PW (1999) Modification of the radiation response of patients with carcinoma of the uterine cervix. Cancer Control 6:343-351
23. Chiarotto JA, Hill RP (1999) A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines. Br J Cancer 80:1518-1524
24. Laderoute KR, Alarcon RM, Brody MD, et al. (2000) Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Clin Cancer Res 6:2941-2950
25. Cheng WF, Chen CA, Lee CN, Wei LH, Hsieh FJ, Hsieh CY (2000) Vascular endothelial growth factor and prognosis of cervical carcinoma. Obstet Gynecol 96:721-726
26. Ueda M, Ueki M, Terai Y, et al. (1999) Biological implications of growth factors on the mechanism of invasion in gynecological tumor cells. Gynecol Obstet Investig 48:221-218
27. Laderoute KR, Grant TD, Murphy BJ, Sutherland RM (1992) Enhanced epidermal growth factor receptor synthesis in human squamous carcinoma cells exposed to low levels of oxygen. Int J Cancer 52:428-432
28. Kim HJ, Wu HG, Park IA, Ha SW (2003) High cyclooxygenase-2 expression is related with distant metastasis in cervical cancer treated with radiotherapy. Int J Radiat Oncol Biol Phys 55:16-20
29. Tran BN, Grigsby PW, Dehdashti F, Herzog TJ, Siegel BA (2003) Occult supraclavicular lymph node metastasis identified by FDG-PET in patients with carcinoma of the uterine cervix. Gynecol Oncol 90:572-576
30. Amit A, Beck D, Lowenstein L, et al. (2005, 2006) The role of hybrid PET/ CT in the evaluation of patients with cervical cancer. Gynecol Oncol 100:65-69
31. Clavo AC, Brown RS, Wahl RL (1995) Fluorodeoxyglucose uptake in human cancer cell lines is increased by hypoxia. J Nucl Med 36:1625-1632
32. Burgman P, Odonoghue JA, Humm JL, Ling CC (2001) Hypoxia-Induced increase in FDG uptake in MCF7 cells. J Nucl Med 42:170-175
33. Levine EL, Renehan A, Gossiel R, et al. (1995) Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma. Radiother Oncol 37:1-9
34. Kim CY, Tsai MH, Osmanian C, et al. (1997) Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Cancer Res 57:4200-4204
35. Lyng H, Sundfor K, Trope C, Rofstad EK (2000) Disease control of uterine cervical cancer: Relationships to tumor oxygen tension, vascular density, cell density, and frequency of mitosis and apoptosis measured before treatment and during radiotherapy. Clin Cancer Res 6:1104-1112