Modulation of cytochrome P450 enzymes in response to continuous or intermittent high-fat diet in pigs

Xenobiotica

Volumn 43, Issue 8, 2013, Pages 686-698

  Puccinelli, Emanuela ^a   Gervasi, Pier Giovanni ^a   Pelosi, Gualtiero ^a   Puntoni, Mariarita ^a   Longo, Vincenzo ^b  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^b Institute of Agricultural Biology and Biotechnology   (Italy)

Author keywords

Adaptive response; Cholesterol; CYP3A; Liver; Nuclear receptors

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; CYTOCHROME P450; CYTOCHROME P450 2C11; CYTOCHROME P450 2C9; CYTOCHROME P450 2E1; CYTOCHROME P450 4A1; DICLOFENAC; ETHOXYRESORUFIN DEETHYLASE; LIPID; PACLITAXEL; TOLBUTAMIDE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNSPECIFIC MONOOXYGENASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BODY WEIGHT; CELL STRESS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS REACTION; DRUG HYDROXYLATION; DUODENUM; ENZYME ACTIVITY; EXPERIMENTAL PIG; HEART; INFLAMMATION; KUPFFER CELL; LIPID BLOOD LEVEL; LIVER; LIVER CELL; LIVER HISTOLOGY; LIVER MICROSOME; LIVER TOXICITY; MALE; MODULATION; MOLECULAR WEIGHT; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; CYTOCHROME P-450 ENZYME SYSTEM; DIET, HIGH-FAT; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; LIPIDS; LIVER; MALE; MICROSOMES, LIVER; REAL-TIME POLYMERASE CHAIN REACTION; SUS SCROFA; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; SUIDAE;

EID: 84879986411     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2012.756558     Document Type: Article

References (76)

1. Agellon LB, Drover VAB, Cheema SK, et al. (2002). Dietary cholesterol fails to stimulate the human cholesterol 7-alpha-hydroxylase gene (CYP7A1) in transgenic mice. J Biol Chem 277:20131-4.
2. Aitken RJ, Wingate JK, De Iuliis GN, et al. (2006). Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa. J Clin Endocrinol Metab 91:4154-63.
3. Amato G, Longo V, Mazzaccaro A, Gervasi PG. (1996). Microsomal oxidation of N,N-diethylformamide and its effect on P450-dependent monooxygenases in rat liver. Chem Res Toxicol 9:882-90.
4. Anzenbacherová E, Baranová J, Zuber R, et al. (2005). Model systems based on experimental animals for studies on drug metabolism in man: (mini)pig cytochrome P450 3A29 and 2E1. Basic Clin Pharmacol Toxicol 96:244-5.
5. Baranová J, Anzenbacherová E, Anzenbacher P, Soucek P. (2005). Minipig cytochrome P450 2E1: comparison with human enzyme. Drug Metab Dispos 33:862-65.
6. Bode G, Clausing P, Gervais F, et al. and under the auspices of the steering group of the RETHINK project. (2010). The utility of minipig as an animal model in regulatory toxicology. J Pharmacol Toxicol Meth 62:196-220.
7. Bodin K, Andersson U, Rystedt E, et al. (2002). Metabolism of 4betahydroxycholesterol in humans. J Biol Chem 277:31534-40.
8. Brunius C, Rasmussen MK, Lacoutière H, et al. (2012). Expression and activities of hepatic cytochrome P450 (CYP1A, CYP2A and CYP2E1) in entire and castrated male pigs. Animal 6:271-7.
9. Cheung O, Sanyal AJ. (2009). Recent advances in non-alcoholic fatty liver disease. Curr Opin Gastroenterol 25:230-7.
10. Chiang JY. (1998). Regulation of bile acid synthesis. Front Biosci 15:76-93.
11. Chiang JYL. (2004). Regulation of bile acid synthesis: pathway, nuclear receptors, and mechanisms. J Hepatol 40:539-51.
12. Chiang JYL, Kimmel R, Stroup D. (2001). Regulation of cholesterol 7ahydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRa). Gene 262:257-65.
13. Chirulli V, Marvasi L, Zaghini A, et al. (2007). Inducibility of AhRregulated CYP genes by beta-naphthoflavone in the liver, lung, kidney and heart of the pig. Toxicology 240:25-37.
14. Donato MT, Lahoz A, Jiménez N, et al. (2006). Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated form fatty liver grafts. Drug Metab Dispos 34:1556-62.
15. Donato MT, Jiménez N, Serralta A, et al. (2007). Effects of steatosis on drug-metabolizing capability of primary human hepatocytes. Toxicol In Vitro 21:271-6.
16. Dussault I, Yoo HD, Lin M, et al. (2003). Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. Proc Natl Acad Sci USA 100:833-8.
17. Ekins S, VandenBranden M, Ring BJ, Wrighton SA. (1997). Examination of purported probes of human CYP2B6. Pharmacogenomics 7:165-79.
18. Emery MG, Fisher JM, Chien JY, et al. (2003). CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease. Hepatol 38:428-35.
19. Enriquez A, Leclercq I, Farrell GC, Robertson G. (1999). Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. Biochem Biophys Res Commun 255:300-6.
20. Finn RD, Henderson CJ, Scott CL, Wolf CR. (2009). Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. Biochem J 417:43-54.
21. Forster R, Ancian P, Fredholm M, et al. under the auspices of the steering group of the RETHINK project. (2010). The minipig as a platform for new technologies in toxicology. J Pharmacol Toxicol Meth 62:227-35.
22. Gao J, Xie W. (2010). Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism. Drug Metab Dispos 38:2091-5.
23. Ghose R, Omoluabi O, Gandhi A, et al. (2011). Role of high-fat diet in regulation of gene expression of grug metabolizing enzymes and transporters. Life Sci 89:57-64.
24. Gómez-Lechón MJ, Jover R, Donato MT. (2009). Cytochrome P450 and steatosis. Curr Drug Metab 10:692-9.
25. Guengerich FP. (2005). Human cytochrome P450 enzymes. In: Ortiz de Montellano PR, ed. Cytochrome P450. 3rd ed. Dordrecht: Kluwer Academic/Plenum Publishers, 377-530.
26. Hanagama M, Inoue H, Kamiya M, et al. (2008). Gene expression on liver toxicity induced by administration of haloperidol in rats with severe fatty liver. Legal Med 10:177-84.
27. Irizar A, Ioannides C. (1998). Marked inhibition of hepatic cytochrome P450 activity in cholesterol-induced atherosclerosis in rabbits. Toxicology 126:179-93.
28. Kim HK, Jeong TS, Lee MK, et al. (2003). Lipid-lowering efficacy of esperetin metabolites in high-cholesterol fed rats. Clin Chim Acta 327:129-37.
29. Ko IY, Park SS, Song BJ, et al. (1987). Monoclonal antibodies to ethanol-induced rat liver cytochrome P450 that metabolize aniline and nitrosamines. Cancer Res 47:3101-9.
30. Köhler CU, Welge P, Roos PH. (2007). Regulation of CYP2E1 at the protein and activity level in minipigs. Naunyn-Schmiedeberg's Arch Pharmacol, Mainz 375:37.
31. Koopmans SJ, Dekker R, Ackermans MT, et al. (2011). Dietary saturated fat/cholesterol, but not unsaturated fat or starch, induces C-reactive protein associated early atherosclerosis and ectopic fat deposition in diabetic pigs. Cardiovasc Diabetol 14:10-64.
32. Laemmli UK. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-5.
33. Leclercq I, Horsmans Y, Desager JP, et al. (1999). Dietary restriction of energy and sugar results in a reduction in human cytochrome P450 2E1 activity. Br J Nutr 82:257-62.
34. Lieber CS, Leo MA, Mak KM, et al. (2004). Model of nonalcoholic steatohepatitis. Am J Clin Nutr 79:502-9.
35. Longo V, Mazzaccaro A, Naldi F, Gervasi PG. (1991). Drugmetabolizing enzymes in liver, olfactory, and respiratory epithelium of cattle. J Biochem Toxicol 6:123-8.
36. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-75.
37. Lubet RA, Nims RW, Mayer RT, et al. (1985). Measurement of cytochrome P450 dependent dealkylation of alkoxyphenoxazones in hepatic S9s and hepatocyte homogenates: effects of dicumarol. Mut Res 142:127-31.
38. Mancy A, Antignac M, Minoletti C, et al. (1999). Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry 38:14264-70.
39. Marini S, Grasso E, Longo V, et al. (2003). 4-Biphenylaldehyde and 9- anthraldehyde: two fluorescent substrates for determining P450 enzyme activities in rat and human. Xenobiotica 33:1-11.
40. Meier UT, Kronbach T, Meyer UA. (1985). Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography. Anal Biochem 151:286-91.
41. Messina A, Nannelli A, Fiorio R, et al. (2009). Expression and inducibility of CYP1A1, 1A2m 1B1 by b-naphthoflavone and CYP2B22, 3A22, 3A29, 3A46 by rifampicin in the respiratory and olfactory mucosa of pig. Toxicology 260:47-52.
42. Miners JO, Birkett DJ. (1998). Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. Br J Clin Pharmacol 45:525-38.
43. Murray M. (2006). Altered CYP expression and function in response to dietary factors: potential roles in disease pathogenesis. Curr Drug Metab 7:67-81.
44. Myant NB, Mitropoulos KA. (1977). Cholesterol 7a-hydroxylase. J Lipid Res 18:135-53.
45. Myers MJ, Farrell DE, Howard KD, Kawalek JC. (2001). Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine. Drug Metab Dispos 29:908-15.
46. Orellana M, Rodrigo R, Varela N, et al. (2006). Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients. Hepatol Res 34:57-63.
47. Orolin J, Vecera R, Markova I, et al. (2009). Differences in hepatic expression of genes involved in lipid homeostasis between hereditary hypertriglyceridemic rats and healthy Wistar rats and in their response to dietary cholesterol. Food Chem Toxicol 47:2624-30.
48. Osabe M, Sugatani J, Fukuyama T, et al. (2008). Expression of hepatic UDP-glucoronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator- activated receptor a in male rats fed a highfat and high-sucrose diet. Drug Metab Dispos 36:294-302.
49. Pascussi JM, Gerbal-Chaloin S, Pichard-Garcia L, et al. (2000). Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem Biophys Res Commun 274:707-13.
50. Puccinelli E, Gervasi PG, La Marca M, et al. (2010). Expression and inducibility by phenobarbital of CYP2C33, CYP2C42, CYP2C49 and CYP3As in porcine liver, kidney, small intestine and nasal tissues. Xenobiotica 40:525-35.
51. Puccinelli E, Gervasi PG, Longo V. (2011). Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model. Curr Drug Metab 12:507-25.
52. Radonjic M, Van Erk MJ, Pasman WJ, et al. (2009). Effect of body fat distribution on the transcription response to dietary fat interventions. Genes Nutr 4:143-9.
53. Raucy JL, Lasker JM, Kraner JC, et al. (1991). Induction of cytochrome CYP4502IIE1 in the obese overfed rat. Mol Pharmacol 39:275-80.
54. Reinke LA, Moyer MJ. (1985). p-Nitrophenol hydroxylation, a microsomal oxidation which is highly inducible by ethanol. Drug Metab Dispos 13:548-52.
55. Rezen T, Rozman D, Pascussi JM, Monostory K. (2011). Interplay between cholesterol and drug metabolism. Biochim Biophys Acta 1814:146-60.
56. Robertson G, Leclercq I, Farrell GC. (2001). Nonalcoholic steatosis and steatohepatitis II. Cytochrome P450 enzymes and oxidative stress. Am J Physiol Gastrointest Liver Physiol 281:G1135-9.
57. Ryan DE, Lewin W. (1990). Purification and characterization of hepatic microsomal cytochrome P-450. Pharmacol Ther 45:153-239.
58. Skaanild MT, Friis C. (1999). Cytochrome P450 sex differences in minipigs and conventional pigs. Pharmacol Toxicol 85:174-80.
59. Stresser DM, Blanchard AP, Turner SD, et al. (2000). Substratedependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates. Drug Metab Dispos 28:1440-8.
60. Sugatani J, Wada T, Osabe M, et al. (2006). Dietary inulin alleviates hepatic steatosis and xenobiotics-induced liver injury in rats fed a high-fat and high-sucrose diet: association with the suprression of hepatic cytochrome P450 and hepatocyte nuclear factor 4a expression. Drug Metab Dispos 34:1677-87.
61. Tharp DL, Masseau I, Ivey J, et al. (2009). Endogenous testosterone attenuates neointima formation after moderate coronary balloon injury in male swine. Cardiovasc Res 82:152-60.
62. Towbin H, Staehelin T, Gordon J. (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4.
63. Vaclavikova R, Soucek P, Svobodova L, et al. (2004). Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs. Drug Metab Dispos 32:666-74.
64. Varela NM, Quinones LA, Orellana M, et al. (2008). Study of cytochrome P450 2E1 and its allele variants in liver injury of nondiabetic, nonalcoholic steatohepatitis obese women. Biol Res 41:81-92.
65. Vilahur G, Padro T, Badimon L. (2011). Atherosclerosis and thrombosis: insights from large animal models. J Biomed Biothechnol 22:1069-75.
66. Villeneuve J, Pichette V. (2004). Cytochrome P450 and liver diseases. Curr Drug Metab 5:273-82.
67. Weltman MD, Farrell GC, Hall P, et al. (1998). Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 27:128-33.
68. Yao M, Dai M, Liu Z, et al. (2011). Comparison of the substrate kinetics of pig CYP3A29 with pig liver microsomes and human CYP3A4. Biosci Rep 31:211-20.
69. Yao M, Dai M, Liu Z, et al. (2012). mRNA expression profiles of P450 3A enzyme in the liver and small intestine of the domestic pig. Res Vet Sci 93:360-5.
70. Yoo JS, Hong JY, Ning SM, Yang CS. (1990). Roles of dietary corn oil in the regulation of cytochromes P450 and glutathione S-transferases in rat liver. J Nutr 120:1718-26.
71. Yoo JS, Ning SM, Pantuck CB, et al. (1991). Regulation of hepatic microsomal cytochrome P450IIE1 level by dietary lipids and carbohydrates in rats. J Nutr 121:959-65.
72. Zamaratskaia G, Zlabek V, Chen G, Madej A. (2009). Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration. Animal 3:1124-32.
73. Zaragoza C, Gomez-Guerrero C, Martin-Ventura JL, et al. (2011). Animal models of Cardiovascular diseases. J Biomed Biothechnol 2011:497841.
74. Zhou J, Zhai Y, Mu Y, et al. (2006). A novel pregnane X receptormediated and sterol regulatory element-binding protein-independent lipogenic pathway. J Biol Chem 281:15013-20.
75. Zhou J, Febbraio M, Wada T, et al. (2008). Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARg in promoting steatosis. Gastroenterology 134:556-67.
76. Zhou C, King N, Chen KY, Breslow JL. (2009). Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in ApoE deficient mice. J Lipid Res 50:2004-13.