메뉴 건너뛰기




Volumn 9, Issue 5, 1996, Pages 882-890

Microsomal oxidation of N,N-diethylformamide and its effect on P450-dependent monooxygenases in rat liver

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; BETA NAPHTHOFLAVONE; CLOFIBRATE; CYTOCHROME P450; FORMAMIDE DERIVATIVE; PENTOXYRESORUFIN; PHENOBARBITAL; PYRAZOLE; UNSPECIFIC MONOOXYGENASE;

EID: 0029680494     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx950201u     Document Type: Article
Times cited : (23)

References (54)
  • 1
    • 0024822749 scopus 로고
    • Dimethylformamide
    • IARC
    • IARC (1989) Dimethylformamide. IARC Monogr. 47, 171-197.
    • (1989) IARC Monogr. , vol.47 , pp. 171-197
  • 2
    • 0029007649 scopus 로고
    • N-Formyl-benzotriazole: A stable and convenient N- And O-formylating agent
    • Katritzky, A. R., Chang, H. X., and Yang, B. (1995) N-Formyl-benzotriazole: a stable and convenient N- and O-formylating agent. Synthesis 5, 503-505.
    • (1995) Synthesis , vol.5 , pp. 503-505
    • Katritzky, A.R.1    Chang, H.X.2    Yang, B.3
  • 3
    • 0024477344 scopus 로고
    • Differences between rodents and human in the metabolic toxification of N,N-dimethylformamide
    • Mraz, J., Cross, H., Gescher, A., Threadgill, M. D., and Flek, J. (1989) Differences between rodents and human in the metabolic toxification of N,N-dimethylformamide. Toxicol. Appl. Pharmacol. 98, 507-516.
    • (1989) Toxicol. Appl. Pharmacol. , vol.98 , pp. 507-516
    • Mraz, J.1    Cross, H.2    Gescher, A.3    Threadgill, M.D.4    Flek, J.5
  • 4
    • 0023683248 scopus 로고
    • Cytotoxicity and metabolism of the hepatotoxin N-methylformamide and related formamides in mouse hepatocytes
    • Shaw A. J., Gescher, A., and Mraz, J. (1988) Cytotoxicity and metabolism of the hepatotoxin N-methylformamide and related formamides in mouse hepatocytes. Toxicol. Appl. Pharmacol. 95, 162-170.
    • (1988) Toxicol. Appl. Pharmacol. , vol.95 , pp. 162-170
    • Shaw, A.J.1    Gescher, A.2    Mraz, J.3
  • 5
    • 0022974128 scopus 로고
    • Biological effect of acetamide, formamide, and the monomethyl and dimethyl derivatives
    • Kennedy, G. L. (1985) Biological effect of acetamide, formamide, and the monomethyl and dimethyl derivatives. CRC Crit. Rev. Toxicol. 17, 129-182.
    • (1985) CRC Crit. Rev. Toxicol. , vol.17 , pp. 129-182
    • Kennedy, G.L.1
  • 6
    • 0027230877 scopus 로고
    • Metabolism of N,N-dimethylformamide: Key to understanding of its toxicity
    • Gescher, A. (1993) Metabolism of N,N-dimethylformamide: key to understanding of its toxicity. Chem. Res. Toxicol. 6, 245-251.
    • (1993) Chem. Res. Toxicol. , vol.6 , pp. 245-251
    • Gescher, A.1
  • 7
    • 0025963771 scopus 로고
    • Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities
    • Slatter, J. G., Hashed, M. S., Pearson, P. G., Han, D.-H., and Baillie, T. A. (1991) Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities. Chem. Res. Toxicol. 4, 157-161.
    • (1991) Chem. Res. Toxicol. , vol.4 , pp. 157-161
    • Slatter, J.G.1    Hashed, M.S.2    Pearson, P.G.3    Han, D.-H.4    Baillie, T.A.5
  • 8
    • 0023185232 scopus 로고
    • Metabolism of N-methylformamide in mice: Primary kinetic deuterium isotope effect and identification of S-(N-methylcarbamoyl)glutathione as a metabolite
    • Threadgill, M. D., Axworthy, D. B., Baillie, T. A., Farmer, P. B., Farrow, K. C., Gescher, A., Kestell, P., Pearson, P., and Shaw, A. J. (1987) Metabolism of N-methylformamide in mice: primary kinetic deuterium isotope effect and identification of S-(N-methylcarbamoyl)glutathione as a metabolite. J. Pharmacol. Exp. Ther. 242, 312-319.
    • (1987) J. Pharmacol. Exp. Ther. , vol.242 , pp. 312-319
    • Threadgill, M.D.1    Axworthy, D.B.2    Baillie, T.A.3    Farmer, P.B.4    Farrow, K.C.5    Gescher, A.6    Kestell, P.7    Pearson, P.8    Shaw, A.J.9
  • 9
    • 0027461642 scopus 로고
    • Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterate isotopomers by cytochrome P4502E1
    • Mraz, J., Jheeta, P., Gescher, A., Hyland, R., Thummel, K., and Threadgill, M. D. (1993) Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterate isotopomers by cytochrome P4502E1. Chem. Res. Toxicol. 6, 197-207.
    • (1993) Chem. Res. Toxicol. , vol.6 , pp. 197-207
    • Mraz, J.1    Jheeta, P.2    Gescher, A.3    Hyland, R.4    Thummel, K.5    Threadgill, M.D.6
  • 10
    • 0026573524 scopus 로고
    • Metabolie oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1
    • Hyland, R., Gescher, A., Thummel, K., Schiller, C., Jheeta, P., Mynett, K., Smith, A. W., and Mraz, J. (1992) Metabolie oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1. Mol. Pharmacol. 41, 259-266.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 259-266
    • Hyland, R.1    Gescher, A.2    Thummel, K.3    Schiller, C.4    Jheeta, P.5    Mynett, K.6    Smith, A.W.7    Mraz, J.8
  • 11
    • 0026035519 scopus 로고
    • Role of human cytochrome P4502E1 in the oxidation of many low molecular weight cancer suspects
    • Guengerich, F. P., Kim, D. H., and Iwasaki, M. (1991) Role of human cytochrome P4502E1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4, 168-179.
    • (1991) Chem. Res. Toxicol. , vol.4 , pp. 168-179
    • Guengerich, F.P.1    Kim, D.H.2    Iwasaki, M.3
  • 13
    • 0025091145 scopus 로고
    • N-Alkylformamides are metabolized to N-alkylcarbamoylating species by hepatic microsomes from rodents and humans
    • Cross, H., Dayal, R., Hyland, R., and Gescher, A. (1990) N-Alkylformamides are metabolized to N-alkylcarbamoylating species by hepatic microsomes from rodents and humans. Chem. Res. Toxicol. 3, 357-362.
    • (1990) Chem. Res. Toxicol. , vol.3 , pp. 357-362
    • Cross, H.1    Dayal, R.2    Hyland, R.3    Gescher, A.4
  • 14
    • 0015054054 scopus 로고
    • Etude toxicologique de la formamide et de ser dérivés N. Méthylés et N. Ethylés
    • Chann, P. H., Xuong, N. D., and Arnn-Gelade, M. C. (1971) Etude toxicologique de la formamide et de ser dérivés N. Méthylés et N. Ethylés. Thérapie 26, 409-429.
    • (1971) Thérapie , vol.26 , pp. 409-429
    • Chann, P.H.1    Xuong, N.D.2    Arnn-Gelade, M.C.3
  • 15
    • 0021253492 scopus 로고
    • An alternative 7-ethoxyresorufin assay: A continuous visible spectrophotometric method for measurement of cytochrome P450 monooxygenase activity
    • Klotz, A. V., Stogeman, J. J., and Walsh, C. (1984) An alternative 7-ethoxyresorufin assay: a continuous visible spectrophotometric method for measurement of cytochrome P450 monooxygenase activity. Anal. Biochem. 140, 138-145.
    • (1984) Anal. Biochem. , vol.140 , pp. 138-145
    • Klotz, A.V.1    Stogeman, J.J.2    Walsh, C.3
  • 16
    • 0022763719 scopus 로고
    • Metabolism of diethylnitrosamine by nasal mucosa and hepatic microsomes from hamster and rat: Species specificity of nasal mucosa
    • Longo, V., Citti, L., and Gervasi, P. G. (1986) Metabolism of diethylnitrosamine by nasal mucosa and hepatic microsomes from hamster and rat: species specificity of nasal mucosa. Carcinogenesis 7, 1323-1328.
    • (1986) Carcinogenesis , vol.7 , pp. 1323-1328
    • Longo, V.1    Citti, L.2    Gervasi, P.G.3
  • 18
    • 78651165715 scopus 로고
    • The carbon-monoxide binding protein of liver microsomes. I. Evidences for its hemoprotein nature
    • Omura, T., and Sato, R. (1964) The carbon-monoxide binding protein of liver microsomes. I. Evidences for its hemoprotein nature. J. Biol. Chem. 293, 2370-2378.
    • (1964) J. Biol. Chem. , vol.293 , pp. 2370-2378
    • Omura, T.1    Sato, R.2
  • 19
    • 0023216022 scopus 로고
    • Monoclonal antibodies to ethanol-induced rat liver cytochrome P450 that metabolize aniline and nitrosamines
    • Ko, I. Y., Park, S. S., Song, B. J., Patten, C., Tan, Y., Han, Y. C., Yang, C. S., and Gelboin, H. V. (1987) Monoclonal antibodies to ethanol-induced rat liver cytochrome P450 that metabolize aniline and nitrosamines. Cancer. Res. 47, 3101-3109.
    • (1987) Cancer. Res. , vol.47 , pp. 3101-3109
    • Ko, I.Y.1    Park, S.S.2    Song, B.J.3    Patten, C.4    Tan, Y.5    Han, Y.C.6    Yang, C.S.7    Gelboin, H.V.8
  • 20
    • 0020664888 scopus 로고
    • High-affinity nitrosamine dealkylase system in rat liver microsomes and its induction by fasting
    • Tu, Y. Y., and Yang, C. S. (1983) High-affinity nitrosamine dealkylase system in rat liver microsomes and its induction by fasting. Cancer. Res. 43, 623-629.
    • (1983) Cancer. Res. , vol.43 , pp. 623-629
    • Tu, Y.Y.1    Yang, C.S.2
  • 21
    • 0021140128 scopus 로고
    • Selective induction of renal microsomal cytochrome P450-linked monooxygenases by 1,1-dichloroethylene in mice
    • Krijgsheld, K. R., and Gram, T. E. (1984) Selective induction of renal microsomal cytochrome P450-linked monooxygenases by 1,1-dichloroethylene in mice. Biochem. Pharmacol. 33, 1901-1956.
    • (1984) Biochem. Pharmacol. , vol.33 , pp. 1901-1956
    • Krijgsheld, K.R.1    Gram, T.E.2
  • 22
    • 0026176952 scopus 로고
    • Drug metabolizing enzymes in liver olfactory and respiratory epithelium of cattle
    • Longo, V., Mazzaccaro, A., Naldi, F., and Gervasi, P. G. (1991) Drug metabolizing enzymes in liver olfactory and respiratory epithelium of cattle. J. Biochem. Toxicol. 6, 123-128.
    • (1991) J. Biochem. Toxicol. , vol.6 , pp. 123-128
    • Longo, V.1    Mazzaccaro, A.2    Naldi, F.3    Gervasi, P.G.4
  • 23
    • 0024625072 scopus 로고
    • Genetically engineered V79 Chinese hamster cell expression of purified cytochrome P450IIB1 monooxygenase activity
    • Platt, K. L., Molitor, E., Dohemer, J., Dogra, S., and Oesch, F. (1989) Genetically engineered V79 Chinese hamster cell expression of purified cytochrome P450IIB1 monooxygenase activity. J. Biochem. Toxicol. 4, 1-6.
    • (1989) J. Biochem. Toxicol. , vol.4 , pp. 1-6
    • Platt, K.L.1    Molitor, E.2    Dohemer, J.3    Dogra, S.4    Oesch, F.5
  • 24
    • 0028048628 scopus 로고
    • Microsomal metabolism of N,N-diethylacetamide and N,N-dimethylacetamide and their effects on drug-metabolizing enzymes of rat liver
    • Menicagli, S., Longo, V., Mazzaccaro, A., and Gervasi, P. G. (1994) Microsomal metabolism of N,N-diethylacetamide and N,N-dimethylacetamide and their effects on drug-metabolizing enzymes of rat liver. Biochem. Pharmacol. 48, 717-726.
    • (1994) Biochem. Pharmacol. , vol.48 , pp. 717-726
    • Menicagli, S.1    Longo, V.2    Mazzaccaro, A.3    Gervasi, P.G.4
  • 25
    • 0025635625 scopus 로고
    • Roles of cytochrome P450IIE1 in the dealkylation and denitrosation of N-nitrosodimethylamine and N-nitrosodiethylamine in rat liver
    • Yoo, J. N., Ishizaki, H. and Yang, C. S. (1990) Roles of cytochrome P450IIE1 in the dealkylation and denitrosation of N-nitrosodimethylamine and N-nitrosodiethylamine in rat liver. Carcinogenesis 11, 2239-2243.
    • (1990) Carcinogenesis , vol.11 , pp. 2239-2243
    • Yoo, J.N.1    Ishizaki, H.2    Yang, C.S.3
  • 26
    • 0001818451 scopus 로고
    • Microsomal enzymes involved in toxicology-analysis and separation
    • Hayes, W., Ed., Raven Press, New York
    • Guengerich, F. P. (1982) Microsomal enzymes involved in toxicology-analysis and separation. In Principles and Methods of Toxicology (Hayes, W., Ed.), pp 609-634, Raven Press, New York.
    • (1982) Principles and Methods of Toxicology , pp. 609-634
    • Guengerich, F.P.1
  • 27
    • 0026490252 scopus 로고
    • Purification and characterization of an acetone-inducible cytochrome P450 from hamster liver microsomes
    • Puccini, P., Menicagli, S., Longo, V., Santucci, A., and Gervasi, P. G. (1992) Purification and characterization of an acetone-inducible cytochrome P450 from hamster liver microsomes. Biochem. J. 287, 863-870.
    • (1992) Biochem. J. , vol.287 , pp. 863-870
    • Puccini, P.1    Menicagli, S.2    Longo, V.3    Santucci, A.4    Gervasi, P.G.5
  • 28
    • 0025335593 scopus 로고
    • Effects of vanadate on hepatic cytochrome P450 expression in streptozotocin-diabetic rats
    • Donahue, B. S., and Morgan, E. T. (1990). Effects of vanadate on hepatic cytochrome P450 expression in streptozotocin-diabetic rats. Drug Metab. Dispos. 18, 519-526.
    • (1990) Drug Metab. Dispos. , vol.18 , pp. 519-526
    • Donahue, B.S.1    Morgan, E.T.2
  • 29
    • 0027219708 scopus 로고
    • Combined effects of streptozotocin-induced diabetes plus 4-methylpyrazole treatment on rat liver cytochrome P4502E1
    • Wu, D., and Cederbaum, A. I. (1993) Combined effects of streptozotocin-induced diabetes plus 4-methylpyrazole treatment on rat liver cytochrome P4502E1. Arch. Biochem. Biophys. 302, 175-182.
    • (1993) Arch. Biochem. Biophys. , vol.302 , pp. 175-182
    • Wu, D.1    Cederbaum, A.I.2
  • 30
    • 0024310194 scopus 로고
    • Evaluation of the involvement of a male specific cytochrome P450 isozyme in a senescence-associated decline of hepatic drug metabolism in male rats
    • Fujita, S., Morimoto, R., Chiba, M., Kitani, K., and Suzuki, T. (1989) Evaluation of the involvement of a male specific cytochrome P450 isozyme in a senescence-associated decline of hepatic drug metabolism in male rats. Biochem. Pharmacol. 38, 3225-3231.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 3225-3231
    • Fujita, S.1    Morimoto, R.2    Chiba, M.3    Kitani, K.4    Suzuki, T.5
  • 31
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 32
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin, H., Stachelin, P., and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 76, 4350-4354.
    • (1979) Proc. Natl. Acad. Sci. U.S.A. , vol.76 , pp. 4350-4354
    • Towbin, H.1    Stachelin, P.2    Gordon, J.3
  • 33
    • 0019741894 scopus 로고
    • Production and application of antibodies to rat liver cytochrome P-450
    • Kaminsky, L. S., Fasco, M. J., and Guengerich, F. P. (1981) Production and application of antibodies to rat liver cytochrome P-450. Methods Enzymol. 74, 262-272.
    • (1981) Methods Enzymol. , vol.74 , pp. 262-272
    • Kaminsky, L.S.1    Fasco, M.J.2    Guengerich, F.P.3
  • 34
    • 0023147728 scopus 로고
    • A simple, non Chromatographic procedure to purify immunoglobins from serum and ascites fluid
    • McKinney, M. M., and Parkinson, A. (1987) A simple, non Chromatographic procedure to purify immunoglobins from serum and ascites fluid. J. Immunol. Methods 96, 271-278.
    • (1987) J. Immunol. Methods , vol.96 , pp. 271-278
    • McKinney, M.M.1    Parkinson, A.2
  • 35
    • 33645551503 scopus 로고
    • Istituto Editoriale Universitario, Milano
    • Dixon, M., and Webb, E. C. (1972) In Enzimi, pp 85, Istituto Editoriale Universitario, Milano.
    • (1972) Enzimi , pp. 85
    • Dixon, M.1    Webb, E.C.2
  • 36
    • 0023150082 scopus 로고
    • Dimethylformamide (DMF) hepatotoxicity
    • Scailteur, V., and Lauwerys, R. R. (1987) Dimethylformamide (DMF) hepatotoxicity. Toxicology 43, 231-238.
    • (1987) Toxicology , vol.43 , pp. 231-238
    • Scailteur, V.1    Lauwerys, R.R.2
  • 37
    • 0021950192 scopus 로고
    • Comparison of ethanol and imidazole pretreatments on hepatic monooxygenase activities in the rat
    • Reinke, L. A., Sexter, S. H., and Rikans, L. E. (1985) Comparison of ethanol and imidazole pretreatments on hepatic monooxygenase activities in the rat. Res. Commun. Chem. Pathol. Pharmacol. 47, 97-106.
    • (1985) Res. Commun. Chem. Pathol. Pharmacol. , vol.47 , pp. 97-106
    • Reinke, L.A.1    Sexter, S.H.2    Rikans, L.E.3
  • 38
    • 0022350885 scopus 로고
    • Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P450 by phenobarbital and other xenobiotic in rat
    • Lubet, R. A., Mayer, R. T., Cameron, J. W., Nims, R. W., Burke, M. D., Wolf, T., and Guengerich, F. P. (1985) Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P450 by phenobarbital and other xenobiotic in rat. Arch. Biochem. Biophys. 238, 43-48.
    • (1985) Arch. Biochem. Biophys. , vol.238 , pp. 43-48
    • Lubet, R.A.1    Mayer, R.T.2    Cameron, J.W.3    Nims, R.W.4    Burke, M.D.5    Wolf, T.6    Guengerich, F.P.7
  • 39
    • 0023510268 scopus 로고
    • Studies on the pregnenolone-16α-carbomtrile-inducible of rat liver microsomal cytochrome P450 and UDP-glucuronyl-transferase
    • Arlotto, M. P., Sonderfan, A. J., Klassen, C. D., and Parkinson, A. (1987) Studies on the pregnenolone-16α-carbomtrile-inducible of rat liver microsomal cytochrome P450 and UDP-glucuronyl-transferase. Biochem. Pharmacol. 36, 3859-3866.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 3859-3866
    • Arlotto, M.P.1    Sonderfan, A.J.2    Klassen, C.D.3    Parkinson, A.4
  • 40
    • 0025139447 scopus 로고
    • Purification and characterization of hepatic microsomal cytochrome P450 Pharmacol
    • Ryan, D. E., and Levin, W. (1990) Purification and characterization of hepatic microsomal cytochrome P450 Pharmacol. Ther. 45, 153-239.
    • (1990) Ther. , vol.45 , pp. 153-239
    • Ryan, D.E.1    Levin, W.2
  • 41
    • 0025305212 scopus 로고
    • Changes in the amount of cytochrome P450s in rat hepatic microsomes with starvation
    • Imaoka, S., Terano, Y., and Funae, Y. (1990) Changes in the amount of cytochrome P450s in rat hepatic microsomes with starvation. Arch. Biochem. Biophys. 278, 168-178.
    • (1990) Arch. Biochem. Biophys. , vol.278 , pp. 168-178
    • Imaoka, S.1    Terano, Y.2    Funae, Y.3
  • 42
    • 0023900010 scopus 로고
    • Ethanol-fasting and acetone-inducible cytochrome P450 in rat liver: Replication and characterization of enzymes belonging to the IIB and IIE gene subfamilies
    • Johansson, I., Ekstrom, G., Sholte, B., Puzycki, D., Jornvall, H., and Ingelman-Sundberg, M. (1988) Ethanol-fasting and acetone-inducible cytochrome P450 in rat liver: replication and characterization of enzymes belonging to the IIB and IIE gene subfamilies. Biochemistry 27, 1925-1934.
    • (1988) Biochemistry , vol.27 , pp. 1925-1934
    • Johansson, I.1    Ekstrom, G.2    Sholte, B.3    Puzycki, D.4    Jornvall, H.5    Ingelman-Sundberg, M.6
  • 43
    • 0026828953 scopus 로고
    • Regulation of two electrophoretically distinct proteins recognized by antibody against rat liver cytochrome P4503A1
    • Gemzik, B., Greenway, D., Nevins, C., and Parkinson, A. (1992) Regulation of two electrophoretically distinct proteins recognized by antibody against rat liver cytochrome P4503A1. J. Biochem. Toxicol. 7, 43-52.
    • (1992) J. Biochem. Toxicol. , vol.7 , pp. 43-52
    • Gemzik, B.1    Greenway, D.2    Nevins, C.3    Parkinson, A.4
  • 44
    • 0026512675 scopus 로고
    • Phenobarbital induction of P450 gene expression
    • Waxman, D. J., and Azaroff, L. (1992)Phenobarbital induction of P450 gene expression. Biochem. J. 281, 577-592.
    • (1992) Biochem. J. , vol.281 , pp. 577-592
    • Waxman, D.J.1    Azaroff, L.2
  • 45
    • 0025323155 scopus 로고
    • Selectivity in the inhibition of mammalian cytochromes P450 by chemical agents
    • Murray, M., and Reidy, G. F. (1990) Selectivity in the inhibition of mammalian cytochromes P450 by chemical agents. Pharmacol. Rev. 42, 85-101.
    • (1990) Pharmacol. Rev. , vol.42 , pp. 85-101
    • Murray, M.1    Reidy, G.F.2
  • 46
  • 47
  • 48
    • 0027281051 scopus 로고
    • Formation of ligand and metabolite complexes as a means for selective quantitation of cytochrome P450 isozymes
    • Roos, P. H., Golub-Ciosk, B., Kallweit, P., Kauczinski, D., and Hanstein, W. B. (1993) Formation of ligand and metabolite complexes as a means for selective quantitation of cytochrome P450 isozymes. Biochem. Pharmacol. 45, 2239-2250.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 2239-2250
    • Roos, P.H.1    Golub-Ciosk, B.2    Kallweit, P.3    Kauczinski, D.4    Hanstein, W.B.5
  • 49
    • 0025989135 scopus 로고
    • Effects of disulfiram on hepatic P4502E1, other microsomal enzymes and hepatotoxicity in rats
    • Brady, J. F., Xiao, F., Wang, M. H., Li, Y., Ning, S. H., Gapac, J. M., and Yang, C. S. (1991) Effects of disulfiram on hepatic P4502E1, other microsomal enzymes and hepatotoxicity in rats. Toxicol. Appl. Pharmacol. 108, 366-373.
    • (1991) Toxicol. Appl. Pharmacol. , vol.108 , pp. 366-373
    • Brady, J.F.1    Xiao, F.2    Wang, M.H.3    Li, Y.4    Ning, S.H.5    Gapac, J.M.6    Yang, C.S.7
  • 50
    • 0023230514 scopus 로고
    • Increased sensitivity of the microsomal oxidation of ethanol to inhibition by pyrazole and 4-methylpyrazole after chronic ethanol treatment
    • Feierman, D. E., and Cederbaum, A. I. (1987) Increased sensitivity of the microsomal oxidation of ethanol to inhibition by pyrazole and 4-methylpyrazole after chronic ethanol treatment. Biochem. Pharmacol. 36, 3277-3283.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 3277-3283
    • Feierman, D.E.1    Cederbaum, A.I.2
  • 51
    • 0026504543 scopus 로고
    • A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene, and trichloroethylene in rat liver
    • Nakajima, T., Wang, R. S., Elovaara, E., Park, S. S., Gelboin, H. V., and Vainio, H. (1992) A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene, and trichloroethylene in rat liver. Biochem. Pharmacol. 43, 251-257.
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 251-257
    • Nakajima, T.1    Wang, R.S.2    Elovaara, E.3    Park, S.S.4    Gelboin, H.V.5    Vainio, H.6
  • 52
    • 0024466834 scopus 로고
    • High affinity diethylnitrosamine-deethylase in liver microsomes from acetone-induced rats
    • Puccini, P., Fiorio, R., Longo, V., and Gervasi, P. G. (1989) High affinity diethylnitrosamine-deethylase in liver microsomes from acetone-induced rats. Carcinogenesis. 10, 1629-1634.
    • (1989) Carcinogenesis , vol.10 , pp. 1629-1634
    • Puccini, P.1    Fiorio, R.2    Longo, V.3    Gervasi, P.G.4
  • 53
    • 0025790277 scopus 로고
    • Pyridine effects on P4502E1, 2B and IVB expression in rabbit liver: Characterization of high- And low-affinity pyridine N-oxygenases
    • Km, S. G., Philpot, R. M., and Novak, R. F. (1991) Pyridine effects on P4502E1, 2B and IVB expression in rabbit liver: characterization of high- and low-affinity pyridine N-oxygenases. J. Pharmacol. Exp. Ther. 259, 470-477.
    • (1991) J. Pharmacol. Exp. Ther. , vol.259 , pp. 470-477
    • Km, S.G.1    Philpot, R.M.2    Novak, R.F.3
  • 54
    • 0026549715 scopus 로고
    • Effects of dimethylformamide on hepatic microsomal monooxygenase system and glutathione metabolism in rats
    • Imasu, K., Fujishiro, K., and Inoue, N. (1992) Effects of dimethylformamide on hepatic microsomal monooxygenase system and glutathione metabolism in rats. Toxicology 72, 41-50.
    • (1992) Toxicology , vol.72 , pp. 41-50
    • Imasu, K.1    Fujishiro, K.2    Inoue, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.