-
1
-
-
0344813769
-
Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human samples
-
Anzenbacher P, Soucek P, Anzenbacherová E, Gut I, Hrabý K, Svoboda Z, and Kvetina J (1998) Presence and activity of cytochrome P450 isoforms in minipig liver microsomes. Comparison with human samples. Drug Metab Dispos 26:90-93.
-
(1998)
Drug Metab Dispos
, vol.26
, pp. 90-93
-
-
Anzenbacher, P.1
Soucek, P.2
Anzenbacherová, E.3
Gut, I.4
Hrabý, K.5
Svoboda, Z.6
Kvetina, J.7
-
2
-
-
15244357333
-
Model systems based on experimental animals for studies on drug metabolism in man: (Mini)pig cytochromes P450 3A29 and 2E1
-
Anzenbacherova E, Baranova J, Zuber R, Pechova A, Anzenbacher P, Soucek P, and Martínkova J (2005) Model systems based on experimental animals for studies on drug metabolism in man: (mini)pig cytochromes P450 3A29 and 2E1. Basic Clin Pharmacol Toxicol 96:244-245.
-
(2005)
Basic Clin Pharmacol Toxicol
, vol.96
, pp. 244-245
-
-
Anzenbacherova, E.1
Baranova, J.2
Zuber, R.3
Pechova, A.4
Anzenbacher, P.5
Soucek, P.6
Martínkova, J.7
-
3
-
-
0034454016
-
Determining the best animal model for human cytochrome P450 activities: A comparison of mouse, rat, rabbit, dog, micropig, monkey and man
-
Bogaards JJP, Bertrand M, Jackson P, Oudshoorn MJ, Weavers RJ, van Bladeren PJ, and Walther B (2000) Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica 30:1131-1152.
-
(2000)
Xenobiotica
, vol.30
, pp. 1131-1152
-
-
Bogaards, J.J.P.1
Bertrand, M.2
Jackson, P.3
Oudshoorn, M.J.4
Weavers, R.J.5
Van Bladeren, P.J.6
Walther, B.7
-
4
-
-
0027438967
-
Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone
-
Carriere V, Goasduff T, Ratanasavanh D, Morel F, Gautier JC, Guillouzo A, Beaune P, and Berthou F (1993) Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone. Chem Res Toxicol 6:852-857.
-
(1993)
Chem Res Toxicol
, vol.6
, pp. 852-857
-
-
Carriere, V.1
Goasduff, T.2
Ratanasavanh, D.3
Morel, F.4
Gautier, J.C.5
Guillouzo, A.6
Beaune, P.7
Berthou, F.8
-
5
-
-
0642284630
-
Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation
-
Chang TKH, Crespi CL, and Waxman DJ (1998) Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. Methods Mol Biol 127:147-152.
-
(1998)
Methods Mol Biol
, vol.127
, pp. 147-152
-
-
Chang, T.K.H.1
Crespi, C.L.2
Waxman, D.J.3
-
6
-
-
0030812882
-
In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat and horse
-
Chauret N, Gauthier A, Martin J, and Nicol-Griffith DA (1997) In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat and horse. Drug Metab Dispos 25:1130-1135.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 1130-1135
-
-
Chauret, N.1
Gauthier, A.2
Martin, J.3
Nicol-Griffith, D.A.4
-
7
-
-
0030894106
-
Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species
-
Court MH, von Moltke LL, Shader RI, and Greenblatt DJ (1997) Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. Biopharm Drug Dispos 18:213-226.
-
(1997)
Biopharm Drug Dispos
, vol.18
, pp. 213-226
-
-
Court, M.H.1
Von Moltke, L.L.2
Shader, R.I.3
Greenblatt, D.J.4
-
8
-
-
0037039785
-
Wanted: Pig transplants that work
-
Couzin J (2002) Wanted: pig transplants that work. Science (Wash DC) 295:1108.
-
(2002)
Science (Wash DC)
, vol.295
, pp. 1108
-
-
Couzin, J.1
-
9
-
-
0033610626
-
Detoxifying activity in pig livers and hepatocytes intended for xenotherapy
-
Desille M, Corcos L, L'Helgoualch A, Frémond B, Campion JP, Guillouzo A, and Clément B (1999) Detoxifying activity in pig livers and hepatocytes intended for xenotherapy. Transplantation 68:1437-1443.
-
(1999)
Transplantation
, vol.68
, pp. 1437-1443
-
-
Desille, M.1
Corcos, L.2
L'Helgoualch, A.3
Frémond, B.4
Campion, J.P.5
Guillouzo, A.6
Clément, B.7
-
10
-
-
0033199820
-
Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices
-
Donato MT, Castell JV, and Gomez-Lechon MJ (1999) Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices. J Hepatol 31:542-549.
-
(1999)
J Hepatol
, vol.31
, pp. 542-549
-
-
Donato, M.T.1
Castell, J.V.2
Gomez-Lechon, M.J.3
-
11
-
-
0030895593
-
Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone
-
Gorski JC, Jones DR, Wrighton SA, and Hall SD (1997) Contribution of human CYP3A subfamily members to the 6-hydroxylation of chlorzoxazone. Xenobiotica 27:243-256.
-
(1997)
Xenobiotica
, vol.27
, pp. 243-256
-
-
Gorski, J.C.1
Jones, D.R.2
Wrighton, S.A.3
Hall, S.D.4
-
12
-
-
0026542989
-
Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences
-
Gotoh O (1992) Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. J Biol Chem 267:83-90.
-
(1992)
J Biol Chem
, vol.267
, pp. 83-90
-
-
Gotoh, O.1
-
13
-
-
0030735150
-
Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species
-
Guengerich FP (1997) Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species. Chem-Biol Interact 106:161-182.
-
(1997)
Chem-Biol Interact
, vol.106
, pp. 161-182
-
-
Guengerich, F.P.1
-
14
-
-
0026035519
-
Role of human cytochrome P450 in the oxidation of many low molecular weight cancer suspects
-
Guengerich FP, Kim DH, and Iwasaki M (1991) Role of human cytochrome P450 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 4:168-179.
-
(1991)
Chem Res Toxicol
, vol.4
, pp. 168-179
-
-
Guengerich, F.P.1
Kim, D.H.2
Iwasaki, M.3
-
15
-
-
26844581769
-
Catalytic and immunochemical characterization of cytochrome P450 isoenzyme induction in dog liver
-
Jayyosi Z, Muc M, Erick J, Thomas PE, and Kelley M (1996) Catalytic and immunochemical characterization of cytochrome P450 isoenzyme induction in dog liver. Fundam Appl Toxicol 31:95-101.
-
(1996)
Fundam Appl Toxicol
, vol.31
, pp. 95-101
-
-
Jayyosi, Z.1
Muc, M.2
Erick, J.3
Thomas, P.E.4
Kelley, M.5
-
16
-
-
0141519338
-
Human hepatic CYP2E expression during development
-
Johnsrud EK, Koukouritaki SB, Divakaran K, Brunengraber LL, Hines RN, and McCarver DG (2003) Human hepatic CYP2E expression during development. J Pharmacol Exp Ther 307:402-407.
-
(2003)
J Pharmacol Exp Ther
, vol.307
, pp. 402-407
-
-
Johnsrud, E.K.1
Koukouritaki, S.B.2
Divakaran, K.3
Brunengraber, L.L.4
Hines, R.N.5
McCarver, D.G.6
-
17
-
-
0003122802
-
Preparation and characterization of microsomal fractions for studies on xenobiotic metabolism
-
Snell K and Mullock BJ eds, IRL Press, Oxford, UK
-
Lake BG (1990) Preparation and characterization of microsomal fractions for studies on xenobiotic metabolism, in Biochemical Toxicology. A Practical Approach (Snell K and Mullock BJ eds) pp 183-215, IRL Press, Oxford, UK.
-
(1990)
Biochemical Toxicology. A Practical Approach
, pp. 183-215
-
-
Lake, B.G.1
-
18
-
-
0031588947
-
Molecular modelling of CYP2E1 enzymes from rat, mouse and man: An explanation for species differences in butadiene metabolism and potential carcinogenicity and rationalization of CYP2E substrate specificity
-
Lewis DFV, Bird MG, and Parke DV (1997) Molecular modelling of CYP2E1 enzymes from rat, mouse and man: an explanation for species differences in butadiene metabolism and potential carcinogenicity and rationalization of CYP2E substrate specificity. Toxicology 118:93-113.
-
(1997)
Toxicology
, vol.118
, pp. 93-113
-
-
Lewis, D.F.V.1
Bird, M.G.2
Parke, D.V.3
-
19
-
-
12244291252
-
Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: Investigation of enzyme-substrate and enzyme-inhibitor interactions
-
Lewis DFV, Lake BG, Bird MG, Loizou GD, Dickins M, and Goldfarb PS (2003) Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: investigation of enzyme-substrate and enzyme-inhibitor interactions. Toxicol In Vitro 17:93-105.
-
(2003)
Toxicol In Vitro
, vol.17
, pp. 93-105
-
-
Lewis, D.F.V.1
Lake, B.G.2
Bird, M.G.3
Loizou, G.D.4
Dickins, M.5
Goldfarb, P.S.6
-
20
-
-
0030935567
-
Cytochrome P450 2E1: Its physiological and pathological role
-
Lieber CS (1997) Cytochrome P450 2E1: its physiological and pathological role. Physiol Rev 77:517-544.
-
(1997)
Physiol Rev
, vol.77
, pp. 517-544
-
-
Lieber, C.S.1
-
21
-
-
0029775813
-
Chlorzoxazone: An in vitro and in vivo substrate probe for liver CYP2E1
-
Lucas D, Menez JF, and Berthou F (1996) Chlorzoxazone: an in vitro and in vivo substrate probe for liver CYP2E1. Methods Enzymol 272:115-123.
-
(1996)
Methods Enzymol
, vol.272
, pp. 115-123
-
-
Lucas, D.1
Menez, J.F.2
Berthou, F.3
-
22
-
-
18844395887
-
Cytochrome P450 activities in hepatic microsomes from the mini pig
-
Madden S, Gentile DM, Crawford GA, Simpson AG, and Johnston AM (1998) Cytochrome P450 activities in hepatic microsomes from the mini pig. ISSX Proc 13:73.
-
(1998)
ISSX Proc
, vol.13
, pp. 73
-
-
Madden, S.1
Gentile, D.M.2
Crawford, G.A.3
Simpson, A.G.4
Johnston, A.M.5
-
23
-
-
2342504526
-
Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors
-
Monostory K, Hazai E, and Vereczkey L (2004) Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors. Chem-Biol Interact 147:331-340.
-
(2004)
Chem-Biol Interact
, vol.147
, pp. 331-340
-
-
Monostory, K.1
Hazai, E.2
Vereczkey, L.3
-
24
-
-
0031732210
-
Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes
-
Monshouwer M, van't Klooster GAE, Nijmeijer SM, Witkamp RF, and van Miert AS (1998) Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes. Toxicol In Vitro 12:715-723.
-
(1998)
Toxicol In Vitro
, vol.12
, pp. 715-723
-
-
Monshouwer, M.1
Van't Klooster, G.A.E.2
Nijmeijer, S.M.3
Witkamp, R.F.4
Van Miert, A.S.5
-
25
-
-
0035006985
-
Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine
-
Myers MJ, Farrell DE, Howard KD, and Kawalek JC (2001) Identification of multiple constitutive and inducible hepatic cytochrome P450 enzymes in market weight swine. Drug Metab Dispos 29:908-915.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 908-915
-
-
Myers, M.J.1
Farrell, D.E.2
Howard, K.D.3
Kawalek, J.C.4
-
26
-
-
0037464481
-
Construction and assessment of models of CYP2E1: Predictions of metabolism from docking, molecular dynamics and density functional theoretical calculations
-
Park JY and Harris D (2003) Construction and assessment of models of CYP2E1: predictions of metabolism from docking, molecular dynamics and density functional theoretical calculations. J Med Chem 46:1645-1660.
-
(2003)
J Med Chem
, vol.46
, pp. 1645-1660
-
-
Park, J.Y.1
Harris, D.2
-
27
-
-
0030056594
-
Specificity of substrate and inhibitor probes for cytochrome P450s: Evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes
-
Sai Y, Dai R, Yang TJ, Krausz KW, Gonzalez FJ, Gelboin HV, and Shou M (2000) Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes. Xenobiotica 26:681-693.
-
(2000)
Xenobiotica
, vol.26
, pp. 681-693
-
-
Sai, Y.1
Dai, R.2
Yang, T.J.3
Krausz, K.W.4
Gonzalez, F.J.5
Gelboin, H.V.6
Shou, M.7
-
28
-
-
0027420580
-
Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity
-
Sandhu P, Baba T, and Guengerich FP (1993) Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity, Arch Biochem Biophys 306:443-450.
-
(1993)
Arch Biochem Biophys
, vol.306
, pp. 443-450
-
-
Sandhu, P.1
Baba, T.2
Guengerich, F.P.3
-
29
-
-
0642315132
-
Cytochrome P450 reconstitution systems
-
Shimada T and Yamazaki H (1998) Cytochrome P450 reconstitution systems. Methods Mol Biol 107:85-93.
-
(1998)
Methods Mol Biol
, vol.107
, pp. 85-93
-
-
Shimada, T.1
Yamazaki, H.2
-
30
-
-
0032825471
-
Cytochrome P450 sex differences in minipig and conventional pig
-
Skaanild M and Friis C (1999) Cytochrome P450 sex differences in minipig and conventional pig. Pharmacol Toxicol 85:174-180.
-
(1999)
Pharmacol Toxicol
, vol.85
, pp. 174-180
-
-
Skaanild, M.1
Friis, C.2
-
31
-
-
2442708468
-
Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs
-
Soucek P, Zuber R, Anzenbacherová E, Anzenbacher P, and Guengerich FP (2001) Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs. BMC Pharmacol 1:19.
-
(2001)
BMC Pharmacol
, vol.1
, pp. 19
-
-
Soucek, P.1
Zuber, R.2
Anzenbacherová, E.3
Anzenbacher, P.4
Guengerich, F.P.5
-
32
-
-
0027253618
-
High-performance liquid chromatographic assay for 4-nitrophenol hydroxylation, putative cytochrome P450 2E1 activity, in human liver microsomes
-
Tassaneeyakul W, Veronese ME, Birkett DJ, and Miners JO (1993) High-performance liquid chromatographic assay for 4-nitrophenol hydroxylation, putative cytochrome P450 2E1 activity, in human liver microsomes. J Chromatogr 616:73-78.
-
(1993)
J Chromatogr
, vol.616
, pp. 73-78
-
-
Tassaneeyakul, W.1
Veronese, M.E.2
Birkett, D.J.3
Miners, J.O.4
-
33
-
-
0033958619
-
Cytochrome P4502E (CYP2E) in brain: Constitutive expression, induction by ethanol and localization by fluorescence in situ hybridization
-
Upadhya SC, Tirumalai PS, Boyd MR, Mori T, and Ravindranath V (2000) Cytochrome P4502E (CYP2E) in brain: constitutive expression, induction by ethanol and localization by fluorescence in situ hybridization. Arch Biochem Biophys 373:23-34.
-
(2000)
Arch Biochem Biophys
, vol.373
, pp. 23-34
-
-
Upadhya, S.C.1
Tirumalai, P.S.2
Boyd, M.R.3
Mori, T.4
Ravindranath, V.5
-
34
-
-
2442719015
-
Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs
-
Vaclavikova R, Soucek P, Svobodova L, Anzenbacher P, Simek P, Guengerich FP, and Gut I (2004) Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs. Drug Metab Dispos 32:666-674.
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 666-674
-
-
Vaclavikova, R.1
Soucek, P.2
Svobodova, L.3
Anzenbacher, P.4
Simek, P.5
Guengerich, F.P.6
Gut, I.7
-
35
-
-
0017088267
-
Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P450) reductase purified by biospecific affinity chromatography
-
Yasukochi Y and Masters BSS (1976) Some properties of a detergent-solubilized NADPH-cytochrome c (cytochrome P450) reductase purified by biospecific affinity chromatography. J Biol Chem 251:5337-5344.
-
(1976)
J Biol Chem
, vol.251
, pp. 5337-5344
-
-
Yasukochi, Y.1
Masters, B.S.S.2
-
36
-
-
0030830029
-
Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1
-
Zerilli A, Ratanasavanh D, Lucas D, Goasduff T, Dréano Y, Menard C, Picart D, and Berthou F (1997) Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1. Chem Res Toxicol 10:1205-1212.
-
(1997)
Chem Res Toxicol
, vol.10
, pp. 1205-1212
-
-
Zerilli, A.1
Ratanasavanh, D.2
Lucas, D.3
Goasduff, T.4
Dréano, Y.5
Menard, C.6
Picart, D.7
Berthou, F.8
-
37
-
-
0036548404
-
Cytochromes P450 and experimental models of drug metabolism
-
Zuber R, Anzenbacherová E, and Anzenbacher P (2002) Cytochromes P450 and experimental models of drug metabolism. J Cell Mol Med 6:189-198.
-
(2002)
J Cell Mol Med
, vol.6
, pp. 189-198
-
-
Zuber, R.1
Anzenbacherová, E.2
Anzenbacher, P.3
|