Effects of steatosis on drug-metabolizing capability of primary human hepatocytes

Toxicology in Vitro

Volumn 21, Issue 2, 2007, Pages 271-276

  Donato, M T ^a,b   Jimenez N ^b   Serralta, A ^b   Mir, J ^b   Castell, J V ^a,b   Gomez Lechon M J ^b  

^a UNIVERSITY OF VALENCIA   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

Human hepatocytes; P450 enzymes; Steatosis

Indexed keywords

7 ETHOXYCOUMARIN DEETHYLASE; CYTOCHROME P450; LONG CHAIN FATTY ACID; MESSENGER RNA; TESTOSTERONE;

ARTICLE; CELL CULTURE; CELL ISOLATION; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; DOSE RESPONSE; DOWN REGULATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ANALYSIS; FATTY LIVER; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; LIPID STORAGE; LIVER CELL; LIVER GRAFT; OXIDATION; TRANSPLANTATION;

CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; HEPATOCYTES; HUMANS; OXIDATION-REDUCTION; TESTOSTERONE;

EID: 33846820161     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2006.07.008     Document Type: Article

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