Bioactivation of diclofenac in vitro and in vivo: Correlation to electrochemical studies

Chemical Research in Toxicology

Volumn 21, Issue 5, 2008, Pages 1107-1119

  Madsen, Kim G ^a   Skonberg, Christian ^a   Jurva, Ulrik ^b   Cornett, Claus ^a   Hansen, Steen H ^a   Johansen, Tommy N ^a   Olsen, Jørgen ^c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b ASTRAZENECA R AND D   (Sweden)

^c NOVO NORDISK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

4' HYDROXYDICLOFENAC; 5 HYDROXYDICLOFENAC; DICLOFENAC; DICLOFENAC DERIVATIVE; GLUTATHIONE; IMINE; PARACETAMOL; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; AUTOOXIDATION; CELL ISOLATION; CORRELATION ANALYSIS; CYCLIC POTENTIOMETRY; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; ELECTROCHEMICAL ANALYSIS; ELECTROCHEMISTRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER MICROSOME; MALE; MASS SPECTROMETRY; METABOLITE; METHODOLOGY; MOLECULAR WEIGHT; NONHUMAN; OXIDATION REDUCTION POTENTIAL; RAT; ANIMAL; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION REACTION; SYNTHESIS; TANDEM MASS SPECTROMETRY;

RATTUS;

ANIMALS; CELLS, CULTURED; DICLOFENAC; ELECTROCHEMISTRY; GLUTATHIONE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; RATS; TANDEM MASS SPECTROMETRY;

EID: 47549117734     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx700419d     Document Type: Article

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