A 175 Million Year History of T Cell Regulatory Molecules Reveals Widespread Selection, with Adaptive Evolution of Disease Alleles

Immunity

Volumn 38, Issue 6, 2013, Pages 1129-1141

  Forni, Diego ^a   Cagliani, Rachele ^a   Pozzoli, Uberto ^a   Colleoni, Marta ^a   Riva, Stefania ^a   Biasin, Mara ^b   Filippi, Giulia ^c   DeGioia, Luca ^c   Gnudi, Federica ^b   Comi, GiacomoP ^b   Bresolin, Nereo ^a,b   Clerici, Mario ^b,d   Sironi, Manuela ^a  

^a SCIENTIFIC INSTITUTE   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS ANTIGEN; GAMMA INTERFERON; GENOMIC DNA; INDUCIBLE T CELL COSTIMULATOR LIGAND; PROGRAMMED DEATH 1 LIGAND 1; TUMOR NECROSIS FACTOR RECEPTOR;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; BALANCING SELECTION; CROHN DISEASE; DIVERSIFYING SELECTION; DNA FLANKING REGION; EVOLUTIONARY ADAPTATION; GENE EXPRESSION REGULATION; GENE FLOW; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAPLOTYPE; HOMOZYGOSITY; HUMAN; HUMAN GENOME; LIGAND BINDING; LOCAL ADAPTATION; MUTAGENESIS; NATURAL SELECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PAN TROGLODYTES; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPIC VARIATION; PHYLOGENETIC TREE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PURIFYING SELECTION; REGULATOR GENE; SELECTIVE SWEEP; SPECIES DIVERSITY; T LYMPHOCYTE ACTIVATION;

ADAPTATION, PHYSIOLOGICAL; ALLELES; ANIMALS; AUTOIMMUNE DISEASES; BIOLOGICAL EVOLUTION; GENE FLOW; GENETIC PREDISPOSITION TO DISEASE; GENETICS, POPULATION; HUMANS; LYMPHOCYTE ACTIVATION; NEANDERTHALS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGRAMMED CELL DEATH 1 RECEPTOR; RISK; SELECTION, GENETIC; SELF TOLERANCE; T-LYMPHOCYTES, REGULATORY;

EID: 84879593719     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2013.04.008     Document Type: Article

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