Analysis of the ligand binding site in Fas (CD95) by site-directed mutagenesis and comparison with TNFR and CD40

Biochemistry

Volumn 37, Issue 11, 1998, Pages 3723-3726

  Starling, Gary C ^a   Kiener, Peter A ^a   Aruffo, Alejandro ^a   Bajorath, Jürgen ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; FAS ANTIGEN; LIGAND; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; HUMAN; IMMUNOMODULATION; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO ACIDS; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; ANTIGENS, CD95; BINDING SITES; FAS LIGAND PROTEIN; HUMANS; LIGANDS; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, TUMOR NECROSIS FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032539963     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972959d     Document Type: Article

References (16)

1. Nagata, S., and Golstein, P. (1995) Science 267, 1449-1456.
2. Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A., and Nagata, S. (1992) Nature 356, 314-317.
3. Takahashi, T., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Suda, T., and Nagata, S. (1994) Cell 76, 969-976.
4. Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., and Nagata, S. (1993) Nature 364, 806-809.
5. Galle, P. R., Hofmann, W. J., Walczak, H., Schaller, H., Otto, G., Stremmel, W., Krammer, P. H., and Runkel, L. (1995) J. Exp. Med. 182, 1223-1230.
6. Dowling, P., Shang, G., Raval, S., Menonna, J., Cook, S., and Husar, W. (1996) J. Exp. Med. 184, 1513-1518.
7. Giordano, C., Stassi, G., De Maria, R., Todaro, M., Richiusa, P., Papoff, G., Ruberti, G., Bagnasco, M., Testi, R., and Galluzzo, A. (1997) Science 275, 960-963.
8. Lues, W. C., Kiener, P. A., Ledbetter, J. A., Aruffo, A., and Klebanoff, S. J. (1996) J. Exp. Med. 184, 429-440.
9. Bajorath, J., and Aruffo, A. (1997) J. Computer-Aided Mol. Des. 11, 3-8.
10. Starling, G. C., Bajorath, J., Emswiler, J., Ledbetter, J. A., Aruffo, A, and Kiener P. A. (1997) J. Exp. Med. 185, 1487-1492.
11. Banner, D. W., D'Arcy, A., Janes, W., Gentz, R., Schoenfeld, H.-J., Broger, C., Loetscher, H., and Lesslauer, W. (1993) Cell 73, 431-445.
12. Bajorath, J., Chalupny, N. J., Marken, J. S., Siadak, A. W., Skonier, J., Gordon, M., Hollenbaugh, D., Noelle, R. J., Ochs, H. D., and Aruffo A. (1995) Biochemistry 34, 1833-1840.
13. Bajorath, J., Marken, J. S., Chalupny, N. J., Spoon, T. L., Siadak, A. W., Gordon, M., Noelle, R. J., Hollenbaugh, D., and Aruffo, A. (1995) Biochemists 34, 9884-9892.
14. Kiener, P. A., Davis, P. M., Starling, G. C., Mehlin, C., Klebanoff, S. J., Ledbetter, J. A., and Liles, W. C. (1997) J. Exp. Med. 185, 1511-1516.
15. Starling, G. C., Llewellyn, M. C., Whitney, G. S., and Aruffo, A. (1997) Tissue Antigens 49, 1-6.
16. Takahashi, T., Tanaka, M., Inazawa, J., Abe, T., Suda, T., and Nagata, S. (1994) Int. Immunol. 6, 1567-1574.