Evolutionary and Functional Analysis of Celiac Risk Loci Reveals SH2B3 as a Protective Factor against Bacterial Infection

American Journal of Human Genetics

Volumn 86, Issue 6, 2010, Pages 970-977

  Zhernakova, Alexandra ^a,b,i   Elbers, Clara C ^a,i   Ferwerda, Bart ^c,i   Romanos, Jihane ^d,i   Trynka, Gosia ^d,i   Dubois, Patrick C ^e,i   de Kovel, Carolien G F ^a,i   Franke, Lude ^d,e,i   Oosting, Marije ^c,i   Barisani, Donatella ^f,i   Bardella, Maria Teresa ^g,h,i   Joosten, Leo A B ^c,i   Saavalainen, Paivi ^i,j   van Heel, David A ^e,i   Catassi, Carlo ^i,k,l   Netea, Mihai G ^c,i   Wijmenga, Cisca ^d,i  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^f UNIVERSITY OF MILANO BICOCCA   (Italy)

^g FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^h UNIVERSITY OF MILAN   (Italy)

ⁱ TAMPERE UNIVERSITY HOSPITAL   (Finland)

^j UNIVERSITY OF HELSINKI   (Finland)

^k UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^l UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

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Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; INTERLEUKIN 12P35; INTERLEUKIN 18 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN 18 RECEPTOR BETA; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; MURAMYL DIPEPTIDE; SH2B3 PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BACTERIAL INFECTION; CELIAC DISEASE; CONTROLLED STUDY; EUROPE; EVOLUTIONARY ADAPTATION; GENE FREQUENCY; GENE FUNCTION; GENE LOCUS; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MOLECULAR RECOGNITION; NORTH AFRICA; PRIORITY JOURNAL; RISK ASSESSMENT; SCORING SYSTEM; SIGNAL TRANSDUCTION;

AFRICA, NORTHERN; BACTERIAL INFECTIONS; CELIAC DISEASE; DISEASE SUSCEPTIBILITY; EUROPE; EVOLUTION, MOLECULAR; GENETICS, POPULATION; HUMANS; NOD2 SIGNALING ADAPTOR PROTEIN; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; SELECTION, GENETIC;

BACTERIA (MICROORGANISMS); HORDEUM; SECALE CEREALE; TRITICUM AESTIVUM;

EID: 77953231426     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajhg.2010.05.004     Document Type: Article

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