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Volumn 52, Issue 3, 2013, Pages 1077-1087

Trans-epithelial transport of the betalain pigments indicaxanthin and betanin across Caco-2 cell monolayers and influence of food matrix

Author keywords

Betalainic food; Betalains; Betanin; Caco 2 cells; Indicaxanthin; Intestinal absorption

Indexed keywords

BETALAIN; BETANIN; INDICAXANTHIN; UNCLASSIFIED DRUG;

EID: 84879552165     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-012-0414-5     Document Type: Article
Times cited : (74)

References (56)
  • 2
    • 77949754615 scopus 로고    scopus 로고
    • Antioxidant activity of olive polyphenols in humans: A review
    • 10.1024/0300-9831.79.3.152 1:CAS:528:DC%2BC3cXktFOhtbc%3D
    • Raederstorff D (2009) Antioxidant activity of olive polyphenols in humans: a review. Int J Vitam Nutr Res 79:152-165
    • (2009) Int J Vitam Nutr Res , vol.79 , pp. 152-165
    • Raederstorff, D.1
  • 3
    • 77953744137 scopus 로고    scopus 로고
    • Dietary constituents of broccoli and other cruciferous vegetables: Implications for prevention and therapy of cancer
    • 10.1016/j.ctrv.2010.01.002 1:CAS:528:DC%2BC3cXpt1Ont78%3D
    • Herr I, Buchler MW (2010) Dietary constituents of broccoli and other cruciferous vegetables: implications for prevention and therapy of cancer. Cancer Treat Rev 36:377-383
    • (2010) Cancer Treat Rev , vol.36 , pp. 377-383
    • Herr, I.1    Buchler, M.W.2
  • 4
    • 0000197026 scopus 로고
    • The betalains: Structure, biosynthesis and chemical taxonomy
    • E.E. Conn (eds) 7 Academic Press New York
    • Piattelli M (1981) The betalains: structure, biosynthesis and chemical taxonomy. In: Conn EE (ed) The biochemistry of plants: a comprehensive treatise, vol 7. Academic Press, New York, pp 557-575
    • (1981) The Biochemistry of Plants: A Comprehensive Treatise , pp. 557-575
    • Piattelli, M.1
  • 6
    • 33745252561 scopus 로고    scopus 로고
    • Betalain stability and degradation. Structural and chromatic aspects
    • 10.1111/j.1750-3841.2006.00022.x 1:CAS:528:DC%2BD28Xms1Wluro%3D
    • Herbach KM, Stintzing FC, Carle R (2006) Betalain stability and degradation. Structural and chromatic aspects. J Food Sci 71:R41-R50
    • (2006) J Food Sci , vol.71
    • Herbach, K.M.1    Stintzing, F.C.2    Carle, R.3
  • 7
    • 0000647197 scopus 로고    scopus 로고
    • Stability of betalain pigments from a cactacea fruit
    • 10.1021/jf960804r 1:CAS:528:DyaK2sXlsVOhs74%3D
    • Reynoso R, Garcia FA, Morales D, Gonzalez de Mejia E (1997) Stability of betalain pigments from a cactacea fruit. J Agric Food Chem 45:2884-2889
    • (1997) J Agric Food Chem , vol.45 , pp. 2884-2889
    • Reynoso, R.1    Garcia, F.A.2    Morales, D.3    Gonzalez De Mejia, E.4
  • 8
    • 0037951635 scopus 로고    scopus 로고
    • Increased resistance to oxidation of betalain-enriched human low density lipoproteins
    • 10.1080/1071576031000097490 1:CAS:528:DC%2BD3sXjslOmsbw%3D
    • Tesoriere L, Butera D, D'Arpa D, Di Gaudio F, Allegra M, Gentile C, Livrea MA (2003) Increased resistance to oxidation of betalain-enriched human low density lipoproteins. Free Radic Res 37:689-696
    • (2003) Free Radic Res , vol.37 , pp. 689-696
    • Tesoriere, L.1    Butera, D.2    D'Arpa, D.3    Di Gaudio, F.4    Allegra, M.5    Gentile, C.6    Livrea, M.A.7
  • 9
    • 13944257662 scopus 로고    scopus 로고
    • Distribution of betalain pigments in red blood cells after consumption of cactus pear fruits and increased resistance of the cells to ex vivo-induced oxidative hemolysis in humans
    • 10.1021/jf048134+ 1:CAS:528:DC%2BD2MXnsVCktg%3D%3D
    • Tesoriere L, Butera D, Allegra M, Fazzari M, Livrea MA (2005) Distribution of betalain pigments in red blood cells after consumption of cactus pear fruits and increased resistance of the cells to ex vivo-induced oxidative hemolysis in humans. J Agric Food Chem 53:1266-1270
    • (2005) J Agric Food Chem , vol.53 , pp. 1266-1270
    • Tesoriere, L.1    Butera, D.2    Allegra, M.3    Fazzari, M.4    Livrea, M.A.5
  • 10
    • 33749319474 scopus 로고    scopus 로고
    • Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells
    • 10.1080/10715760600554228 1:CAS:528:DC%2BD28XntFWltLg%3D
    • Tesoriere L, Allegra M, Butera D, Gentile C, Livrea MA (2006) Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells. Free Radic Res 40:753-761
    • (2006) Free Radic Res , vol.40 , pp. 753-761
    • Tesoriere, L.1    Allegra, M.2    Butera, D.3    Gentile, C.4    Livrea, M.A.5
  • 11
    • 34247588311 scopus 로고    scopus 로고
    • Kinetics of the lipoperoxyl radical-scavenging activity of indicaxanthin in solution and unilamellar liposomes
    • 10.1080/10715760601026614 1:CAS:528:DC%2BD2sXhs1yitrY%3D
    • Tesoriere L, Allegra M, Butera D, Gentile C, Livrea MA (2007) Kinetics of the lipoperoxyl radical-scavenging activity of indicaxanthin in solution and unilamellar liposomes. Free Radic Res 41:226-233
    • (2007) Free Radic Res , vol.41 , pp. 226-233
    • Tesoriere, L.1    Allegra, M.2    Butera, D.3    Gentile, C.4    Livrea, M.A.5
  • 12
    • 67650917704 scopus 로고    scopus 로고
    • Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoproxyl radical scavenging activity in solution and liposomes
    • 10.1080/10715760903037681 1:CAS:528:DC%2BD1MXotlagsL8%3D
    • Tesoriere L, Allegra M, Gentile C, Livrea MA (2009) Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoproxyl radical scavenging activity in solution and liposomes. Free Radic Res 43:706-717
    • (2009) Free Radic Res , vol.43 , pp. 706-717
    • Tesoriere, L.1    Allegra, M.2    Gentile, C.3    Livrea, M.A.4
  • 13
    • 14944378075 scopus 로고    scopus 로고
    • Antioxidant betalains from cactus pear (Opuntia ficus indica) inhibit endothelial ICAM-1 expression
    • 10.1196/annals.1322.057 1:CAS:528:DC%2BD2MXivFWns7Y%3D
    • Gentile C, Tesoriere L, Allegra M, Livrea MA, D'Alessio P (2004) Antioxidant betalains from cactus pear (Opuntia ficus indica) inhibit endothelial ICAM-1 expression. Ann NY Acad Sci 1028:481-486
    • (2004) Ann NY Acad Sci , vol.1028 , pp. 481-486
    • Gentile, C.1    Tesoriere, L.2    Allegra, M.3    Livrea, M.A.4    D'Alessio, P.5
  • 14
    • 28444440307 scopus 로고    scopus 로고
    • Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors
    • 10.1021/jf051399j 1:CAS:528:DC%2BD2MXhtFegs7%2FJ
    • Reddy MK, Alexander-Lindo RL, Nair MG (2005) Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. J Agric Food Chem 53:9268-9273
    • (2005) J Agric Food Chem , vol.53 , pp. 9268-9273
    • Reddy, M.K.1    Alexander-Lindo, R.L.2    Nair, M.G.3
  • 15
    • 35148837739 scopus 로고    scopus 로고
    • Betanin a betacyanin pigment purified from fruits of Opuntia ficus indica induces apoptosis in human chronic myeloid leukemia cell line-K562
    • 10.1016/j.phymed.2007.03.017
    • Sreekantah D, Arunasree MK, Roy KR, Reddy TC, Reddy GV, Reddanna P (2007) Betanin a betacyanin pigment purified from fruits of Opuntia ficus indica induces apoptosis in human chronic myeloid leukemia cell line-K562. Phytomedicine 14:739-746
    • (2007) Phytomedicine , vol.14 , pp. 739-746
    • Sreekantah, D.1    Arunasree, M.K.2    Roy, K.R.3    Reddy, T.C.4    Reddy, G.V.5    Reddanna, P.6
  • 16
    • 79954542344 scopus 로고    scopus 로고
    • Cytotoxic effect of the red beetroot (Beta vulgaris, L9 extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines
    • 10.2174/187152011795347504 1:CAS:528:DC%2BC3MXltlKnsr8%3D
    • Kapadia GJ, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H (2011) Cytotoxic effect of the red beetroot (Beta vulgaris, L9 extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancer cell lines. Anticancer Agents Med Chem 11:280-284
    • (2011) Anticancer Agents Med Chem , vol.11 , pp. 280-284
    • Kapadia, G.J.1    Azuine, M.A.2    Rao, G.S.3    Arai, T.4    Iida, A.5    Tokuda, H.6
  • 17
    • 5144227379 scopus 로고    scopus 로고
    • Absorption, excretion, and distribution in low density lipoproteins of dietary antioxidant betalains. Potential health effects of betalains in humans
    • 1:CAS:528:DC%2BD2cXotFGhsrg%3D
    • Tesoriere L, Allegra M, Butera D, Livrea MA (2004) Absorption, excretion, and distribution in low density lipoproteins of dietary antioxidant betalains. Potential health effects of betalains in humans. Am J Clin Nutr 80:941-945
    • (2004) Am J Clin Nutr , vol.80 , pp. 941-945
    • Tesoriere, L.1    Allegra, M.2    Butera, D.3    Livrea, M.A.4
  • 18
    • 23844473854 scopus 로고    scopus 로고
    • Urinary pharmacokinetics of betalains following consumption of red beet juice in healthy humans
    • 10.1016/j.phrs.2005.04.005 1:CAS:528:DC%2BD2MXos1aiu7Y%3D
    • Frank T, Stintzing FC, Carle R, Bitsch I, Quaas D, Strass G, Bitsch R, Netzel M (2005) Urinary pharmacokinetics of betalains following consumption of red beet juice in healthy humans. Pharmacol Res 52:290-297
    • (2005) Pharmacol Res , vol.52 , pp. 290-297
    • Frank, T.1    Stintzing, F.C.2    Carle, R.3    Bitsch, I.4    Quaas, D.5    Strass, G.6    Bitsch, R.7    Netzel, M.8
  • 19
    • 0035181508 scopus 로고    scopus 로고
    • Betalains-a new class of dietary cationized antioxidants
    • 10.1021/jf010456f 1:CAS:528:DC%2BD3MXnsFyhsr0%3D
    • Kanner J, Harel S, Granit R (2001) Betalains-a new class of dietary cationized antioxidants. J Agric Food Chem 49:5178-5185
    • (2001) J Agric Food Chem , vol.49 , pp. 5178-5185
    • Kanner, J.1    Harel, S.2    Granit, R.3
  • 22
    • 57849091384 scopus 로고    scopus 로고
    • In vitro digestion of betalainic foods. Stability and bioaccessibility of betaxanthins and betacyanins and antioxidative potential of food digesta
    • 10.1021/jf8017172 1:CAS:528:DC%2BD1cXhtlSlsrnL
    • Tesoriere L, Fazzari M, Angileri F, Gentile C, Livrea MA (2008) In vitro digestion of betalainic foods. Stability and bioaccessibility of betaxanthins and betacyanins and antioxidative potential of food digesta. J Agric Food Chem 56:10487-10492
    • (2008) J Agric Food Chem , vol.56 , pp. 10487-10492
    • Tesoriere, L.1    Fazzari, M.2    Angileri, F.3    Gentile, C.4    Livrea, M.A.5
  • 23
    • 0034950281 scopus 로고    scopus 로고
    • Induction of UDP-glucuronyltransferase UGT1A1 by the flavonoid chrysin in Caco2 cells- potential role in carcinogen bioactivation
    • 10.1023/A:1011019417236 1:CAS:528:DC%2BD3MXltVSktrw%3D
    • Galijatovic A, Otake Y, Walle UK, Walle T (2001) Induction of UDP-glucuronyltransferase UGT1A1 by the flavonoid chrysin in Caco2 cells- potential role in carcinogen bioactivation. Pharm Res 18:374-379
    • (2001) Pharm Res , vol.18 , pp. 374-379
    • Galijatovic, A.1    Otake, Y.2    Walle, U.K.3    Walle, T.4
  • 24
    • 0036805724 scopus 로고    scopus 로고
    • Comparison of human duodenum and Caco2 gene expression profiles for 12,000 gene sequence tags and correlation with permeability of 26 drugs
    • 10.1023/A:1020483911355 1:CAS:528:DC%2BD38XnsFSgsLg%3D
    • Sun DX, Lennernas H, Welage LS, Barnett JL, Landowski CP, Foster D, Fleischer D, Lee KD, Amidon JL (2002) Comparison of human duodenum and Caco2 gene expression profiles for 12,000 gene sequence tags and correlation with permeability of 26 drugs. Pharm Res 19:1400-1416
    • (2002) Pharm Res , vol.19 , pp. 1400-1416
    • Sun, D.X.1    Lennernas, H.2    Welage, L.S.3    Barnett, J.L.4    Landowski, C.P.5    Foster, D.6    Fleischer, D.7    Lee, K.D.8    Amidon, J.L.9
  • 25
    • 0037032250 scopus 로고    scopus 로고
    • Antioxidant activities of sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: Betanin and indicaxanthin
    • 10.1021/jf025696p 1:CAS:528:DC%2BD38XntlaitLY%3D
    • Butera D, Tesoriere L, Di Gaudio F, Bongiorno A, Allegra M, Pintaudi AM, Kohen R, Livrea MA (2002) Antioxidant activities of sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: betanin and indicaxanthin. J Agric Food Chem 50:6895-6901
    • (2002) J Agric Food Chem , vol.50 , pp. 6895-6901
    • Butera, D.1    Tesoriere, L.2    Di Gaudio, F.3    Bongiorno, A.4    Allegra, M.5    Pintaudi, A.M.6    Kohen, R.7    Livrea, M.A.8
  • 26
    • 0037051509 scopus 로고    scopus 로고
    • Identification of betalains from yellow beet (Beta vulgaris, L) and cactus pear (Opuntia ficus indica, L Mill) by high performance liquid chromatography-electrospray ionization mass spectrometry
    • 10.1021/jf011305f 1:CAS:528:DC%2BD38XhsF2isL0%3D
    • Stintzing FC, Schieber A, Carle R (2002) Identification of betalains from yellow beet (Beta vulgaris, L) and cactus pear (Opuntia ficus indica, L Mill) by high performance liquid chromatography-electrospray ionization mass spectrometry. J Agric Food Chem 50:2302-2307
    • (2002) J Agric Food Chem , vol.50 , pp. 2302-2307
    • Stintzing, F.C.1    Schieber, A.2    Carle, R.3
  • 27
    • 0001728908 scopus 로고    scopus 로고
    • Quantum-chemical descriptors in QSAR/QSPR studies
    • 10.1021/cr950202r
    • Katritzky AR, Lobanov VS, Karelson M (1996) Quantum-chemical descriptors in QSAR/QSPR studies. Chem Rev 96:1027-1043
    • (1996) Chem Rev , vol.96 , pp. 1027-1043
    • Katritzky, A.R.1    Lobanov, V.S.2    Karelson, M.3
  • 28
    • 33750530838 scopus 로고    scopus 로고
    • Betanin, the main pigment of red beet: Molecular origin of its exceptionally high free radical-scavenging activity
    • 10.1080/02652030600986032 1:CAS:528:DC%2BD28Xht1GktLvK
    • Gliszczynska-Swiglo A, Szymusiak H, Malinowska P (2006) Betanin, the main pigment of red beet: molecular origin of its exceptionally high free radical-scavenging activity. Food Addit Contam 23:1079-1087
    • (2006) Food Addit Contam , vol.23 , pp. 1079-1087
    • Gliszczynska-Swiglo, A.1    Szymusiak, H.2    Malinowska, P.3
  • 29
    • 0024593744 scopus 로고
    • Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
    • 1:STN:280:DyaL1M7itFeqsg%3D%3D
    • Hidalgo IJ, Raub TJ, Borchardt RT (1989) Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96:736-749
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 30
    • 0034807847 scopus 로고    scopus 로고
    • Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells
    • 10.1023/A:1010974909998 1:CAS:528:DC%2BD3MXnt1ekt70%3D
    • Behrens I, Stenberg P, Artusson P, Kissel T (2001) Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells. Pharmacol Res 18:1138-1145
    • (2001) Pharmacol Res , vol.18 , pp. 1138-1145
    • Behrens, I.1    Stenberg, P.2    Artusson, P.3    Kissel, T.4
  • 31
    • 0025311288 scopus 로고
    • Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal (Caco-2) absorptive cells
    • 10.1002/jps.2600790604 1:CAS:528:DyaK3cXkvFSru74%3D
    • Artursson P (1990) Epithelial transport of drugs in cell culture. I: a model for studying the passive diffusion of drugs over intestinal (Caco-2) absorptive cells. J Pharm Sci 79:476-482
    • (1990) J Pharm Sci , vol.79 , pp. 476-482
    • Artursson, P.1
  • 32
    • 0025329248 scopus 로고
    • Epithelial transport of drugs in cell culture. II: Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells
    • 10.1002/jps.2600790710 1:CAS:528:DyaK3cXkvFSqsrY%3D
    • Artursson P, Magnusson C (1990) Epithelial transport of drugs in cell culture. II: effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of intestinal epithelial (Caco-2) cells. J Pharm Sci 79:595-600
    • (1990) J Pharm Sci , vol.79 , pp. 595-600
    • Artursson, P.1    Magnusson, C.2
  • 33
    • 0041318875 scopus 로고    scopus 로고
    • Transepithelial transport of ferulic acid by monocarboxylic acid transporter in Caco-2 cell monolayers
    • 10.1271/bbb.67.856 1:CAS:528:DC%2BD3sXjslOmtbg%3D
    • Konishi Y, Shimizu M (2003) Transepithelial transport of ferulic acid by monocarboxylic acid transporter in Caco-2 cell monolayers. Biosci Biotechnol Biochem 67:856-862
    • (2003) Biosci Biotechnol Biochem , vol.67 , pp. 856-862
    • Konishi, Y.1    Shimizu, M.2
  • 34
    • 34347379290 scopus 로고    scopus 로고
    • H + -coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
    • 10.1113/expphysiol.2005.029959 1:CAS:528:DC%2BD2sXptFGrsbc%3D
    • Thwaites DT, Anderson CMH (2007) H + -coupled nutrient, micronutrient and drug transporters in the mammalian small intestine. Exp Physiol 92:603-619
    • (2007) Exp Physiol , vol.92 , pp. 603-619
    • Thwaites, D.T.1    Anderson, C.M.H.2
  • 35
    • 68149170038 scopus 로고    scopus 로고
    • The role of transporters in the pharmacokinetics of orally administered drugs
    • 10.1007/s11095-009-9924-0 1:CAS:528:DC%2BD1MXnvFKgu7w%3D
    • Shugarts S, Benet LZ (2009) The role of transporters in the pharmacokinetics of orally administered drugs. Pharm Res 26:2039-2045
    • (2009) Pharm Res , vol.26 , pp. 2039-2045
    • Shugarts, S.1    Benet, L.Z.2
  • 36
    • 33747154211 scopus 로고    scopus 로고
    • Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes
    • 10.1016/j.eplepsyres.2006.05.016 1:CAS:528:DC%2BD28XosVOgsbc%3D
    • Ogawa K, Yumoto R, Hamada N, Nagai J, Takano M (2006) Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes. Epilepsy Res 71:76-87
    • (2006) Epilepsy Res , vol.71 , pp. 76-87
    • Ogawa, K.1    Yumoto, R.2    Hamada, N.3    Nagai, J.4    Takano, M.5
  • 37
    • 0033846534 scopus 로고    scopus 로고
    • Cellular uptake of dietary flavonoid quercetin 4′-β-glucoside by sodium-dependent glucose transporter SLGT1
    • 1:CAS:528:DC%2BD3cXmtFCnsb8%3D
    • Walgren RA, Lin J-T, Kinne RK-H, Walle T (2000) Cellular uptake of dietary flavonoid quercetin 4′-β-glucoside by sodium-dependent glucose transporter SLGT1. J Pharmacol Experim Therap 294:837-843
    • (2000) J Pharmacol Experim Therap , vol.294 , pp. 837-843
    • Walgren, R.A.1    Lin, J.-T.2    Kinne, R.-H.3    Walle, T.4
  • 39
    • 0020613211 scopus 로고
    • Determination of acid surface pH in vivo in rat proximal jejunum
    • 10.1136/gut.24.8.734 1:CAS:528:DyaL3sXkvVGrtro%3D
    • Lucas M (1983) Determination of acid surface pH in vivo in rat proximal jejunum. Gut 24:734-739
    • (1983) Gut , vol.24 , pp. 734-739
    • Lucas, M.1
  • 41
    • 34247588533 scopus 로고    scopus 로고
    • Spectrophotometric evidence for the solubilization site of betalain pigments in membrane biomimetic systems
    • 10.1021/jf0632536
    • Turco Liveri ML, Sciascia L, Lombardo R, Tesoriere L, Passante E, Livrea MA (2007) Spectrophotometric evidence for the solubilization site of betalain pigments in membrane biomimetic systems. J Agric Food Chem 55:2836-2840
    • (2007) J Agric Food Chem , vol.55 , pp. 2836-2840
    • Turco Liveri, M.L.1    Sciascia, L.2    Lombardo, R.3    Tesoriere, L.4    Passante, E.5    Livrea, M.A.6
  • 42
    • 72449141707 scopus 로고    scopus 로고
    • Partition of indicaxanthin in membrane biomimetic systems. A kinetic and modeling approach
    • 10.1021/jf902266m 1:CAS:528:DC%2BD1MXhtlWlsr%2FP
    • Turco Liveri ML, Sciascia L, Allegra M, Tesoriere L, Livrea MA (2009) Partition of indicaxanthin in membrane biomimetic systems. A kinetic and modeling approach. J Agric Food Chem 57:10959-10963
    • (2009) J Agric Food Chem , vol.57 , pp. 10959-10963
    • Turco Liveri, M.L.1    Sciascia, L.2    Allegra, M.3    Tesoriere, L.4    Livrea, M.A.5
  • 43
    • 0028080058 scopus 로고
    • Quantitative approach to delineate paracellular diffusion in cultured epithelial cell monolayer
    • 10.1002/jps.2600831103 1:CAS:528:DyaK2cXmtlyht7k%3D
    • Adson A, Raub TJ, Burton PS, Barshun CL, Hilgers AR, Audus KL, Ho NF (1994) Quantitative approach to delineate paracellular diffusion in cultured epithelial cell monolayer. J Pharm Sci 83:1529-1536
    • (1994) J Pharm Sci , vol.83 , pp. 1529-1536
    • Adson, A.1    Raub, T.J.2    Burton, P.S.3    Barshun, C.L.4    Hilgers, A.R.5    Audus, K.L.6    Ho, N.F.7
  • 44
    • 0011351116 scopus 로고
    • Effect of an oral rehydration solution on paracellular drug transport in intestinal epithelial cells and tissues: Assessment of charge and tissue selectivity
    • Karlsson J, Ungell AL, Artursson P (1994) Effect of an oral rehydration solution on paracellular drug transport in intestinal epithelial cells and tissues: assessment of charge and tissue selectivity. Pharm Res 11:S248
    • (1994) Pharm Res , vol.11 , pp. 248
    • Karlsson, J.1    Ungell, A.L.2    Artursson, P.3
  • 45
    • 0030792730 scopus 로고    scopus 로고
    • Estimation of the relative contribution of the transcellular and paracellular pathway to the transport of passively absorbed drugs in the Caco-2 cell culture model
    • 10.1023/A:1012111008617 1:CAS:528:DyaK2sXmsFehurY%3D
    • Pade V, Stavchansky S (1997) Estimation of the relative contribution of the transcellular and paracellular pathway to the transport of passively absorbed drugs in the Caco-2 cell culture model. Pharm Res 14:1210-1215
    • (1997) Pharm Res , vol.14 , pp. 1210-1215
    • Pade, V.1    Stavchansky, S.2
  • 46
    • 0030931449 scopus 로고    scopus 로고
    • Paracellular diffusion in Caco-2 cell monolayers: Effect of perturbation on the transport of hydrophilic compounds that vary in charge and size
    • 10.1021/js9700309 1:CAS:528:DyaK2sXlvVygsb8%3D
    • Knipp GT, Ho NF, Barsuhn CL, Borchardt R (1997) Paracellular diffusion in Caco-2 cell monolayers: effect of perturbation on the transport of hydrophilic compounds that vary in charge and size. J Pharm Sci 86:1105-1110
    • (1997) J Pharm Sci , vol.86 , pp. 1105-1110
    • Knipp, G.T.1    Ho, N.F.2    Barsuhn, C.L.3    Borchardt, R.4
  • 47
    • 0027134778 scopus 로고
    • Mechanism of intestinal absorption of ranitidine and ondansetron: Transport across Caco-2 cell monolayer
    • 10.1023/A:1018965929419 1:CAS:528:DyaK2cXmvVyhsg%3D%3D
    • Gan LS, Hsyu PH, Pritchard JF, Thakker D (1993) Mechanism of intestinal absorption of ranitidine and ondansetron: transport across Caco-2 cell monolayer. Pharm Res 10:1722-1725
    • (1993) Pharm Res , vol.10 , pp. 1722-1725
    • Gan, L.S.1    Hsyu, P.H.2    Pritchard, J.F.3    Thakker, D.4
  • 48
    • 0031942688 scopus 로고    scopus 로고
    • PH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs
    • 10.1023/A:1011954332221 1:CAS:528:DyaK1cXhsFCnt7o%3D
    • Avdeef A, Box KJ, Comer JEA, Hibbert C, Tam KY (1998) pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs. Pharm Res 15:209-215
    • (1998) Pharm Res , vol.15 , pp. 209-215
    • Avdeef, A.1    Box, K.J.2    Comer, J.E.A.3    Hibbert, C.4    Tam, K.Y.5
  • 49
    • 0032696606 scopus 로고    scopus 로고
    • Effect of molecular charge on intestinal epithelial drug transport: PH-dependent transport of cationic drugs
    • 1:CAS:528:DyaK1MXntFChtr8%3D
    • Palm K, Luthman K, Ros J, Grasjo J, Artursson P (1999) Effect of molecular charge on intestinal epithelial drug transport: pH-dependent transport of cationic drugs. J Pharmacol Exp Ther 291:435-443
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 435-443
    • Palm, K.1    Luthman, K.2    Ros, J.3    Grasjo, J.4    Artursson, P.5
  • 50
    • 33847123621 scopus 로고    scopus 로고
    • Intestinal absorption of miltefosine: Contribution of passive paracellular transport
    • 10.1007/s11095-006-9170-7 1:CAS:528:DC%2BD2sXhslWisrc%3D
    • Menez C, Buyse M, Dugave C, Farinotti R, Barratt G (2007) Intestinal absorption of miltefosine: contribution of passive paracellular transport. Pharm Res 24:546-554
    • (2007) Pharm Res , vol.24 , pp. 546-554
    • Menez, C.1    Buyse, M.2    Dugave, C.3    Farinotti, R.4    Barratt, G.5
  • 51
    • 0028859318 scopus 로고
    • In vitro systems for studying intestinal drug absorption
    • 10.1002/med.2610150202 1:CAS:528:DyaK2MXltlCrtb0%3D
    • Hillgren KM, Kato A, Borchardt RT (1995) In vitro systems for studying intestinal drug absorption. Med Res Rev 15:83-109
    • (1995) Med Res Rev , vol.15 , pp. 83-109
    • Hillgren, K.M.1    Kato, A.2    Borchardt, R.T.3
  • 52
    • 0025804183 scopus 로고
    • Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells
    • 10.1016/0006-291X(91)91647-U 1:CAS:528:DyaK3MXhslOrt7c%3D
    • Artursson P, Karlsson J (1991) Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem Biophys Res Commun 175:880-885
    • (1991) Biochem Biophys Res Commun , vol.175 , pp. 880-885
    • Artursson, P.1    Karlsson, J.2
  • 53
    • 8444226748 scopus 로고    scopus 로고
    • Uptake of quercetin 3-glucoside from whole onion and apple peel extracts by Caco-2 cell monolayers
    • 10.1021/jf030733d 1:CAS:528:DC%2BD2cXosVOkt74%3D
    • Boyer J, Brown D, Liu RH (2004) Uptake of quercetin 3-glucoside from whole onion and apple peel extracts by Caco-2 cell monolayers. J Agric Food Chem 52:7172-7179
    • (2004) J Agric Food Chem , vol.52 , pp. 7172-7179
    • Boyer, J.1    Brown, D.2    Liu, R.H.3
  • 54
    • 0019876875 scopus 로고
    • The specificity of proanthocyanidin-protein interactions
    • 1:CAS:528:DyaL3MXktlOmsr4%3D
    • Hagerman AE, Butler LG (1981) The specificity of proanthocyanidin-protein interactions. J Biol Chem 256:4494-4497
    • (1981) J Biol Chem , vol.256 , pp. 4494-4497
    • Hagerman, A.E.1    Butler, L.G.2
  • 55
    • 79960087686 scopus 로고    scopus 로고
    • From herb to kitchen and bedside: Food factors are pharmacological molecules with antioxidant activity
    • 10.3109/10715762.2011.579826 1:CAS:528:DC%2BC3MXosFehsb0%3D
    • Konishi T (2011) From herb to kitchen and bedside: food factors are pharmacological molecules with antioxidant activity. Free Radic Res 45:863-864
    • (2011) Free Radic Res , vol.45 , pp. 863-864
    • Konishi, T.1
  • 56
    • 4344637798 scopus 로고    scopus 로고
    • Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: A comparative study with vitamin C
    • 1:CAS:528:DC%2BD2cXmtFKisrk%3D
    • Tesoriere L, Butera D, Pintaudi AM, Allegra M, Livrea MA (2004) Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: a comparative study with vitamin C. Am J Clin Nutr 80:391-395
    • (2004) Am J Clin Nutr , vol.80 , pp. 391-395
    • Tesoriere, L.1    Butera, D.2    Pintaudi, A.M.3    Allegra, M.4    Livrea, M.A.5


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