Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562

Phytomedicine

Volumn 14, Issue 11, 2007, Pages 739-746

  Sreekanth, Devalraju ^a   Arunasree, M K ^a   Roy, Karnati R ^a   Chandramohan Reddy, T ^a   Reddy, Gorla V ^a   Reddanna, Pallu ^a  

^a UNIVERSITY OF HYDERABAD   (India)

Author keywords

Apoptosis; Betanin; Chronic myeloid leukemia; Opuntia ficus indica

Indexed keywords

BETACYANIN; BETANIN; CYTOCHROME C; GENOMIC DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CHROMATIN CONDENSATION; CHRONIC MYELOID LEUKEMIA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ELECTROPHORESIS; FLOW CYTOMETRY; FRUIT; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; MEMBRANE POTENTIAL; MITOCHONDRION; NUTRITION; OPUNTIA FICUS INDICA; PLANT; PRIORITY JOURNAL; PROTEIN DEGRADATION; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BETACYANINS; CELL CYCLE; CELL PROLIFERATION; COLORING AGENTS; FRUIT; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; OPUNTIA; PHYTOTHERAPY; PLANT EXTRACTS;

CARYOPHYLLALES; OPUNTIA FICUS-INDICA;

EID: 35148837739     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2007.03.017     Document Type: Article

References (37)

1. Bomser J., Madhavi D.L., Singletary K., and Smith M.A. In vitro anticancer activity of fruit extracts from Vaccinium species. Planta Med. 62 (1996) 212-216
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
3. Desagher S., and Martinou J.C. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 20 (2000) 369-377
4. Galati E.M., Monforte M.T., Tripodo M.M., Aquino A.D., and Mondello M.R. Anti-ulcer activity of Opuntia ficus-indica (L.) Mill. (Cactaceae): ultrastructural study. J. Ethanopharmacol. 76 (2001) 1-9
5. Gentile C., Tessoriere L., Allegra M., Livrea M.A., and Alessio P.D. Antioxidant betalins from Cactus pear (O. ficus-indica) inhibit endothelial ICAM-1 expression. Ann. NY Acad. Sci. 1028 (2004) 481-486
6. Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
7. Hong W.K., and Sporn M.B. Recent advances in chemoprevention of cancer. Science 278 (1997) 1073-1077
8. Hou D.-X., Fukuda M., Johnson J.A., Miyamori K., Ushikai M., and Fujii M. Fisetin induces transcription of NADPH: quinone oxidoreductase gene through an antioxidant responsive element involved activation. Int. J. Oncol. 18 (2001) 1175-1179
9. Jiang M.C., Yang-Yen H.F., Lin J., and Yen J.J. Differential regulation of p53, c-Myc, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells. Oncogene 13 (1996) 609-616
10. Kamei H., Kojima T., Hasegawa M., Koide T., Umeda T., Yukawa T., and Terabe K. Suppression of tumor cell growth by anthocyanins in vitro. Cancer Invest. 13 (1995) 590-594
11. Kanner J., Harel S., and Granit R. Betalains - a new class of dietary cationized antioxidants. J. Agric. Food Chem. 49 (2001) 5178-5185
12. Kapadia G., Tokuda H., Konoshima T., and Nishino H. Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract. Cancer Lett. 100 (1996) 211-214
13. Katdare M., Osborne M.P., and Telang N.T. Inhibition of aberrant proliferation and induction of apoptosis in pre-neoplastic human mammary epithelial cells by natural phytochemicals. Oncol. Rep. 5 (1998) 311-315
14. Kroemer G., and Reed J.C. Mitochondrial control of cell death. Nat. Med. 6 (2000) 513-519
15. Kuo M.L., Huang T.S., and Lin J.K. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochim. Biophys. Acta 1317 (1996) 95-100
16. Matsumoto H., Inaba H., Kishi M., Tominanga S., Hirayama M., and Tusda T. Orally administrated delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. J. Agric. Food Chem. 49 (2001) 1546-1551
17. Meiers S., Kemeny M., Weyand U., Gastpar R., von Angerer E., and Marko D. The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. J. Agric. Food Chem. 49 (2001) 958-962
18. Mossman T. Rapid colorimetric assay for cellular growth and survival; application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
19. Muntha Reddy K., Ruby L., Alexander Lindo, and Muraleedharan Nair G. Relative inhibition of lipid peroxidation, cyclooxygenase enzymes and human tumor cell proliferation by natural food colors. J. Agric. Food Chem. 53 (2005) 9268-9273
20. Nagasawa H., Nagura F., Mohamad S.B., Uto Y., Zhu J.W., Tsukuda T., Hashimoto T., Asakawa Y., and Hori H. Apoptosis induction in HCT116 cells by cytochalasins isolated from the fungus Daldinia vernicosa. Phytomedicine 6 6 (2000) 403-409
21. Nagase H., Sasaki K., Kito H., Haga A., and Sato T. Inhibitory effect of delphinidin from Solanum melongena on human fibrosarcoma HT-1080 invasiveness in vitro. Planta Med. 64 (1998) 216-219
22. Netzel M., Stinzing F.C., Quaas D., Strab G., Carle R., Bitsch R., Bitsch I., and Frank T. Renal excretion of antioxidative constituents from red beet in humans. Food Res. Int. 38 (2005) 1051-1058
23. Pardhasaradhi B.V.V., Mubarak Ali A., Leela Kumari A., Reddanna P., and Ashok K. Phycocyanin mediated apoptosis in AK-5 tumor cells involves down regulation of Bcl-2 and generation of ROS. Mol. Cancer Ther. 2 (2003) 1165-1170
24. Pardhasaradhi B.V.V., Madhurima Reddy, Mubarak Ali A., Leela kumari A., and Ashok K. Differential cytotoxic effects of Annona squamosa seed extracts on human tumor cell lines: role of reactive oxygen species and glutathione. J. Biosci. 30 (2005) 237-244
25. Park E.H., and Chun M.J. Wound healing activity of Opuntia ficus-indica. Fitoterapia 72 (2001) 165-167
26. Park E.H., Kahng J.H., Lee S.H., and Shin K.H. An anti-inflammatory principles from cactus. Fitoterapia 72 (2001) 288-290
27. Reddy M.C., Vadiraja B.B., Kiranmai G., Reddy M.N., Reddanna P., and Madyastha K.M. Selective inhibition of cyclooxygenase-2 by C-Phycocyanin, a biliprotein from Spirulina platensis. Biochem. Biophys. Res. Commun. 277 (2000) 599-603
28. Reddy M.C., Subhashini J., Mahipal S.V.K., Bhat V.B., Srinivas Reddy P., and Kiranmai G. C-Phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW264.7 macrophages. Biochem. Biophys. Res. Commun. 304 (2003) 385-392
29. Seuduto R.C., and Grotyohann L.W. Measurement of mitochondrial membrane potential using fluorescent Rhodamine derivatives. Biophys. J. 76 (1999) 469-477
30. Sies H., and Stahl W. Non-nutritive bioactive constituents of plants: lycopene, lutein, and zeaxanthin. Int. J. Vit. Nutr. Res. 73 (2003) 95-100
31. Stinzing, F.C., 1999. Partialsynthese und Analytik von Betaxanthinen und Untersuchungen zum Vorkommen von Betalainen in Fruchten von Opunti ficus-indica. Diploma Thesis, Hohnheim University, Institute of Food Technology, Hohenheim.
32. Strack D., Engel U., and Wray V. Neobetanin: a new natural plant constituent. Phytochemistry 26 (1987) 2399-2400
33. Strack D., Vogt T., and Schliemann W. Recent advances in betalain research. Photochemistry 62 (2003) 247-269
34. Subhashini J., Mahipal S.V.K., Reddy M.C., Mallikarjuna Reddy M., Rachamallu A., and Reddanna P. Molecular mechanisms in C-Phycocyanin induced apoptosis in human chronic myeloid leukemia cell line -K 562. Biochem. Pharmacol. 68 (2004) 453-462
35. Tesoriere L., Butera D., D'Arpa D., Di Gaudio F., Allegra M., Gentile C., and Livrea M.A. Increased resistance to oxidation of betalain-enriched human low density lipoproteins. Free Radic. Res. 37 (2003) 689-696
36. Vaux D.L., and Korsmeyer S.J. Cell death in development. Cell 96 (1999) 245-254
37. Zakharova N., and Petrova T. Relationships between the structure and antioxidant activity of certain betalains. Appl. Biochem. Microbiol. 34 (1998) 182-185