DNA is a target of the photodynamic effects elicited in A2E-laden RPE by blue-light illumination

Investigative Ophthalmology and Visual Science

Volumn 44, Issue 5, 2003, Pages 2245-2251

  Sparrow, Janet R ^a   Zhou, Jilin ^b   Cai, Bolin ^b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; AVIDIN; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); DNA GLYCOSYLTRANSFERASE; ENDONUCLEASE; ENDONUCLEASE III; FLUORESCEIN; FORMAMIDOPYRIMIDINE N GLYCOSYLASE; GUANINE; PYRIDINIUM DERIVATIVE; RETINOID; SODIUM AZIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL DAMAGE; CELL DEATH; CELL VIABILITY; COMET ASSAY; CONTROLLED STUDY; DNA REPAIR; GENE TARGETING; HISTOCHEMISTRY; HUMAN; HUMAN CELL; ILLUMINATION; IMMUNOPEROXIDASE STAINING; OXIDATION; PHOTODYNAMICS; PIGMENT EPITHELIUM; PRIORITY JOURNAL;

CELL SURVIVAL; CELLS, CULTURED; COMET ASSAY; DEOXYGUANOSINE; DEOXYRIBONUCLEASE (PYRIMIDINE DIMER); DNA; DNA DAMAGE; DNA REPAIR; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; ENDODEOXYRIBONUCLEASES; ESCHERICHIA COLI PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; LIGHT; N-GLYCOSYL HYDROLASES; PHOTOCHEMOTHERAPY; PIGMENT EPITHELIUM OF EYE; PYRIDINIUM COMPOUNDS; RETINOIDS; VIRAL PROTEINS;

EID: 0037408428     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.02-0746     Document Type: Article

References (74)

1. Burkle A. Mechanisms of aging. Eye 2001;15:371-375.
2. Baynes JW. The Maillard hypothesis on aging: time to focus on DNA. Ann NY Acad Sci. 2002;959:360-367.
3. Olshansky SJ, Hayflick L, Carnes BA. No truth to the fountain of youth. Sci Am. 2002;286:92-95.
4. Kawanishi S, Hiraku Y, Oikawa S. Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging. Mutat Res. 2001;488:65-76.
5. Hasty P, Vijg J. Genomic priorities in aging. Science. 2002;296: 1248-1251.
6. Harmon D. Aging: a theory based on free radical and radiation chemistry. Gerontology. 1956;11:298-300.
7. De Zwart LL, Meerman JHN, Commandeur JNN, Vermeulen NPE. Biomarkers of free radical damage applications in experimental animals and in humans. Free Radic Biol Med. 1999;26:202-226.
8. Dizdaroglu M. Chemical determination of free radical-induced damage to DNA. Free Radic Biol Med. 1991;10:225-242.
9. Kasai H. Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat Res. 1997;387:147-163.
10. Zhang Y, Herman B. Apoptosis and successful aging. Mech Ageing Dev. 2002;123:563-565.
11. Kennedy CJ, Rakoczy PE, Constable IJ. Lipofuscin of the retinal pigment epithelium: a review. Eye. 1995;9:763-771.
12. Eldred GE. Lipofuscin and other lysosomal storage deposits in the retinal pigment epithelium. In: Marmor MF, Wolfensberger TJ, eds. The Retinal Pigment Epithelium: Function and Disease. New York: Oxford University Press; 1998:651-668.
13. Sparrow JR, Nakanishi K, Parish CA. The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci. 2000;41:1981-1989.
14. Schutt F, Davies S, Kopitz J, Holz FG, Boulton ME. Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci. 2000;41:2303-2308.
15. Sparrow JR, Cai B. Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2. Invest Ophthalmol Vis Sci. 2001;42:1356-1362.
16. Liu IY, White L, LaCroix AZ. The association of age-related macular degeneration and lens opacities in the aged. Am J Public Health. 1989;79:765-769.
17. Pollack A, Marcovich A, Bukelman A, Oliver M. Age-related macular degeneration after extracapsular cataract extraction with intraocular lens implantation. Ophthalmology. 1996;103:1546-1554.
18. Taylor HR, West S, Munoz B, Rosenthal FS, Bressler SB, Bressler NM. The long-term effects of visible light on the eye. Arch Ophthalmol. 1992;110:99-104.
19. Mata NL, Weng J, Travis GH. Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration. Proc Natl Acad Sci USA. 2000;97:7154-7159.
20. Mata NL, Tzekov RT, Liu X, Weng J, Birch DG, Travis GH. Delayed dark adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2001;42:1685-1690.
21. Allikmets R, Singh N, Sun H, et al. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet. 1997;15:236-246.
22. Martinez-Mir A, Paloma E, Allikmets R, et al. Retinitis pigmentosa caused by a homozygous mutation in the Stargardt disease gene ABCR. Nat Genet. 1998;18:11-12.
23. Cremers FP, van de Pol DJ, van Driel M, et al. Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt's disease gene ABCR. Hum Mol Genet. 1998;7:355-362.
24. Maugeri A, Klevering BJ, Rohrschneider K, et al. Mutations in the ABCA4 (ABCR) gene are the major cause of autosomal recessive cone-rod dystrophy. Am J Hum Genet. 2000;67:960-966.
25. Allikmets R. Further evidence for an association of ABCR alleles with age-related macular degeneration: the International ABCR Screening Consortium. Am J Hum Genet. 2000;67:487-491.
26. Allikmets R, Shroyer NF, Singh N, et al. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science. 1997;277:1805-1807.
27. Stone EM, Webster AR, Vandenburgh K, et al. Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration (Letter). Nat Genet. 1998;20:328-329.
28. De La Paz MA, Guy VK, Abou-Donia S, et al. Analysis of the Stargardt disease gene (ABCR) in age-related macular degeneration. Ophthalmology. 1999;106:1531-1536.
29. Bernstein PS, Leppert M, Singh N, et al. Genotype-phenotype analysis of ABCR variants in macular degeneration probands and siblings. Invest Ophthalmol Vis Sci. 2002;43:466-473.
30. Boulton M, Dontsov A, Jarvis-Evans J, Ostrovsky M, Svistunenko D. Lipofuscin is a photoinducible free radical generator. J Photochem Photobiol B. 1993;19:201-204.
31. Gaillard ER, Atherton SJ, Eldred G, Dillon J. Photophysical studies on human retinal lipofuscin. Photochem Photobiol. 1995;61:448-453.
32. Rozanowska M, Jarvis-Evans J, Korytowski W, Boulton ME, Burke JM, Sarna T. Blue light-induced reactivity of retinal age pigment: in vitro generation of oxygen-reactive species. J Biol Chem. 1995; 270:18825-18830.
33. Ben-Shabat S, Itagaki Y, Jockusch S, Sparrow JR, Turro NJ, Nakanishi K. Formation of a nona-oxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement. Angew Chem Int Ed. 2002;41:814-817.
34. Sparrow JR, Zhou J, Ben-Shabat S, Vollmer H, Itagaki Y, Nakanishi K. Involvement of oxidative mechanisms in blue light induced damage to A2E-laden RPE. Invest Ophthalmol Vis Sci. 2002;43: 1222-1227.
35. Moor ACE. Signaling pathways in cell death and survival after photodynamic therapy. J Photochem Photobiol B. 2000;57:1-13.
36. Oleinick NL, Evans HH. The photobiology of photodynamic therapy: cellular targets and mechanisms. Radiat Res. 1998; 150(suppl 5):S146-S156.
37. Lin CP, Lynch MC, Kochevar IE. Reactive oxidizing species produced near the plasma membrane induce apoptosis in bovine aorta endothelial cells. Exp Cell Res. 2000;259:351-359.
38. Sparrow JR, Parish CA, Hashimoto M, Nakanishi K. A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture. Invest Ophthalmol Vis Sci. 1999;40:2988-2995.
39. Parish CA, Hashimoto M, Nakanishi K, Dillon J, Sparrow JR. Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium. Proc Natl Acad Sci USA. 1998;95:14609-14613.
40. Rojas E, Lopez MC, Valverde M. Single cell electrophoresis assay: methodology and applications. J Chromat B. 1999;722:225-254.
41. Collins AR, Duthie SJ, Dobson VL. Direct enzymatic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis. 1993;14:1733-1735.
42. Gedik CM, Ewen SWB, Collins AR. Single-cell gel electrophoresis applied to the analysis of UV-C damage and its repair in human cells. Int J Radiat Biol. 1992;62:313-320.
43. Koppen G, Angelis KJ. Repair of X-ray induced DNA damage measured by the comet assay in roots of Viciafaba. Environ Mol Mutagen. 1998;32:281-285.
44. Green MHL, Lowe JE, Delaney CA, Green IC. Comet assay to detect nitric oxide-dependent DNA damage in mammalian cells. Methods Enzymol. 1996;269:243-265.
45. Struthers L, Patel R, Clark J, Thomas S. Direct detection of 8-oxodeoxyguanosine and 8-oxoguanine by avidin and its analogues. Anal Biochem. 1998;255:20-31.
46. Kochevar IE, Redmond RW. Photosensitized production of singlet oxygen. Methods Enzymol. 2000;319:20-28.
47. Fairbairn DW, Olive PL, O'Neill KL. The comet assay: a comprehensive review. Mutat Res. 1995;339:37-59.
48. McCarthy PJ, Sweetman SFS, Mckenna PG, McKelvey-Martin VJ. Evaluation of manual and image analysis quantification of DNA damage in the alkaline comet assay. Mutagenesis. 1997;12:209-214.
49. Kielbassa C, Epe B. DNA damage induced by ultraviolet and visible light and its wavelength dependence. Methods Enzymol. 2000; 319:436-445.
50. Boiteux S, Gajewski E, Laval J, Dizdaroglu M. Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Biochemistry. 1992;31:106-110.
51. Didier C, Pouget J-P, Cadet J, Favier A, Beani J-C, Richard M-J. Modulation of exogenous and endogenous levels of thioredoxin in human skin fibroblasts prevents DNA damaging effect of ultraviolet A radiation. Free Radic Biol Med. 2001;30:537-546.
52. Davies RJH. Purines as targets for DNA photodamage. Biochem Soc Trans. 1997;25:323-326.
53. Alapetite C, Wachter T, Sage E. Moustacchi E. Use of the alkaline comet assay to detect DNA repair deficiencies in human fibroblasts exposed to UVC, UVB, UVA and γ-rays. Int J Radiat Biol. 1996; 69:359-369.
54. 1-treated rat liver and human oral mucosal cells. Cancer Res. 1996;56:683-688.
55. Collins AR. Oxidative DNA damage, antioxidants and cancer. Bioessays. 1999;21:238-246.
56. Kasselouri A, Bourdon O, Demore D, et al. Fluorescence and mass spectroscopy studies of meta-tetra(hydroxyphenyl)chlorin photoproducts. Photochem Photobiol. 1999;70:275-279.
57. Collins AR, Horvathova E. Biochemical and biomedical aspects of oxidative modification. Biochem Soc Trans. 2001;29:337-341.
58. Arlett CF, Lowe JE, Harcourt SA, et al. Hypersensitivity of human lymphocytes to UV-B and solar irradiation. Cancer Res. 1993;53: 609-614.
59. Smela ME, Hamm ML, Henderson PT, Harris CM, Harris TM, Essigmann JM. The aflatoxin B1 formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma. Proc Natl Acad Sci USA. 2002;99:6655-6660.
60. Laffon B, Pasaro E, Mendez J. DNA damage and repair in human leukocytes exposed to styrene-7,8-oxide measured by the comet assay. Toxicol Lett. 2002;126:61-68.
61. Koskinen M, Plna K. Specific DNA adducts induced by some mono-substituted epoxides in vitro and in vivo. Chem Biol Interact. 2000;129:209-229.
62. Horvathova E, Slamenova D, Hlincikova L, Mandal TK, Gabelova A, Collins AR. The nature and origin of DNA single-strand breaks determined with the comet assay. Mutat Res. 1998;409:163-171.
63. McKelvey-Martin VJ, Green MHL, Schmezer P, Pool-Zobel BL, De Meo MP, Collins A. The single cell gel electrophoresis assay (comet assay): a European review. Mutat Res. 1993;288:47- 63.
64. Bohr VA. Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells. Free Radic Biol Med. 2002;32:804-812.
65. Gonzalez C, Najera O, Cortes E, et al. Hydrogen peroxide-induced DNA damage and DNA repair in lymphocytes from malnourished children. Environ Mol Mutagen. 2002;39:33-42.
66. Jaiswal M, LaRusso NF, Shapiro RA, Billiar TR, Gores GJ. Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. Gastroenterology. 2001;120:190-199.
67. Marnett LJ. Oxyradicals and DNA damage. Carcinogenesis. 2000; 21:361-370.
68. Collins AR, Dusinska M, Horvathova E, Munro E, Savio M, Stetina R. Inter-individual differences in repair of DNA base oxidation, measured in vitro with the comet assay. Mutagenesis. 2001;16:297-301.
69. Kohno T, Shinmura K, Tosaka M, et al. Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA. Oncogene. 1998;16: 3219-3225.
70. Hamilton ML, Van Remmen H, Drake JA, et al. Does oxidative damage to DNA increase with age? Proc Natl Acad Sci USA. 2001;98:10469-10474.
71. Cabelof DC, Raffoul JJ, Yanamadala S, Ganir C, Guo ZM, Heydari AR. Attenuation of DNA polymerase β-dependent base excision repair and increased DMS-induced mutagenicity in aged mice. Mutat Res. 2002;500:135-145.
72. Sohal RS, Agarwal S, Candas M, Forster MJ, Lal H. Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev. 1994;76:215-224.
73. Vijg J, Giese H, Dolle MET. Models for studying genomic instability during aging. In: Gilchrest BA, Bohr VA, eds. Advances in Cell Aging and Gerontology. Amsterdam: Elsevier, 2001:73-90.
74. Bohr VA. DNA damage and its processing with aging: human premature aging syndromes as model systems. In: Gilchrest BA, Bohr VA, eds. Advances in Cell Aging and Gerontology. Amsterdam: Elsevier, 2001:191-205.