-
1
-
-
23844438864
-
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity
-
Yoneyama M, Kikuchi M, Matsumoto K, Imaizumi T, Miyagishi M, et al. (2005) Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 175: 2851-2858.
-
(2005)
J Immunol
, vol.175
, pp. 2851-2858
-
-
Yoneyama, M.1
Kikuchi, M.2
Matsumoto, K.3
Imaizumi, T.4
Miyagishi, M.5
-
2
-
-
24144461689
-
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
-
Seth RB, Sun L, Ea CK, Chen ZJ, (2005) Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122: 669-682.
-
(2005)
Cell
, vol.122
, pp. 669-682
-
-
Seth, R.B.1
Sun, L.2
Ea, C.K.3
Chen, Z.J.4
-
3
-
-
27144440476
-
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
-
Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, et al. (2005) Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature 437: 1167-1172.
-
(2005)
Nature
, vol.437
, pp. 1167-1172
-
-
Meylan, E.1
Curran, J.2
Hofmann, K.3
Moradpour, D.4
Binder, M.5
-
4
-
-
24944538819
-
VISA is an adapter protein required for virus-triggered IFN-beta signaling
-
Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, et al. (2005) VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell 19: 727-740.
-
(2005)
Mol Cell
, vol.19
, pp. 727-740
-
-
Xu, L.G.1
Wang, Y.Y.2
Han, K.J.3
Li, L.Y.4
Zhai, Z.5
-
5
-
-
27144440523
-
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
-
Kawai T, Takahashi K, Sato S, Coban C, Kumar H, et al. (2005) IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6: 981-988.
-
(2005)
Nat Immunol
, vol.6
, pp. 981-988
-
-
Kawai, T.1
Takahashi, K.2
Sato, S.3
Coban, C.4
Kumar, H.5
-
6
-
-
51349108659
-
Negative regulation of cytoplasmic RNA-mediated antiviral signaling
-
Komuro A, Bamming D, Horvath CM, (2008) Negative regulation of cytoplasmic RNA-mediated antiviral signaling. Cytokine 43: 350-358.
-
(2008)
Cytokine
, vol.43
, pp. 350-358
-
-
Komuro, A.1
Bamming, D.2
Horvath, C.M.3
-
7
-
-
55249124522
-
Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors
-
Liang Y, Ishida H, Lenz O, Lin TI, Nyanguile O, et al. (2008) Antiviral suppression vs restoration of RIG-I signaling by hepatitis C protease and polymerase inhibitors. Gastroenterology 135: 1710-1718 e1712.
-
(2008)
Gastroenterology
, vol.135
, pp. 1710-1718
-
-
Liang, Y.1
Ishida, H.2
Lenz, O.3
Lin, T.I.4
Nyanguile, O.5
-
8
-
-
77954947887
-
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3
-
Kim H, Seed B, (2010) The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3. Nat Immunol 11: 743-750.
-
(2010)
Nat Immunol
, vol.11
, pp. 743-750
-
-
Kim, H.1
Seed, B.2
-
9
-
-
67650831470
-
Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection
-
Cronin SJ, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, et al. (2009) Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science 325: 340-343.
-
(2009)
Science
, vol.325
, pp. 340-343
-
-
Cronin, S.J.1
Nehme, N.T.2
Limmer, S.3
Liegeois, S.4
Pospisilik, J.A.5
-
10
-
-
77953423842
-
Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling
-
Valanne S, Myllymaki H, Kallio J, Schmid MR, Kleino A, et al. (2010) Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. J Immunol 184: 6188-6198.
-
(2010)
J Immunol
, vol.184
, pp. 6188-6198
-
-
Valanne, S.1
Myllymaki, H.2
Kallio, J.3
Schmid, M.R.4
Kleino, A.5
-
11
-
-
38749097018
-
NLRX1 is a regulator of mitochondrial antiviral immunity
-
Moore CB, Bergstralh DT, Duncan JA, Lei Y, Morrison TE, et al. (2008) NLRX1 is a regulator of mitochondrial antiviral immunity. Nature 451: 573-577.
-
(2008)
Nature
, vol.451
, pp. 573-577
-
-
Moore, C.B.1
Bergstralh, D.T.2
Duncan, J.A.3
Lei, Y.4
Morrison, T.E.5
-
12
-
-
34547809341
-
A new method with flexible and balanced control of false negatives and false positives for hit selection in RNA interference high-throughput screening assays
-
Zhang XD, (2007) A new method with flexible and balanced control of false negatives and false positives for hit selection in RNA interference high-throughput screening assays. J Biomol Screen 12: 645-655.
-
(2007)
J Biomol Screen
, vol.12
, pp. 645-655
-
-
Zhang, X.D.1
-
13
-
-
33947726050
-
CRM1-mediated nuclear export: to the pore and beyond
-
Hutten S, Kehlenbach RH, (2007) CRM1-mediated nuclear export: to the pore and beyond. Trends Cell Biol 17: 193-201.
-
(2007)
Trends Cell Biol
, vol.17
, pp. 193-201
-
-
Hutten, S.1
Kehlenbach, R.H.2
-
14
-
-
3042635320
-
CRM1-dependent, but not ARE-mediated, nuclear export of IFN-alpha1 mRNA
-
Kimura T, Hashimoto I, Nagase T, Fujisawa J, (2004) CRM1-dependent, but not ARE-mediated, nuclear export of IFN-alpha1 mRNA. J Cell Sci 117: 2259-2270.
-
(2004)
J Cell Sci
, vol.117
, pp. 2259-2270
-
-
Kimura, T.1
Hashimoto, I.2
Nagase, T.3
Fujisawa, J.4
-
15
-
-
0042658190
-
Nuclear mRNA export: insights from virology
-
Cullen BR, (2003) Nuclear mRNA export: insights from virology. Trends Biochem Sci 28: 419-424.
-
(2003)
Trends Biochem Sci
, vol.28
, pp. 419-424
-
-
Cullen, B.R.1
-
16
-
-
7044253474
-
Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function
-
Yedavalli VS, Neuveut C, Chi YH, Kleiman L, Jeang KT, (2004) Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function. Cell 119: 381-392.
-
(2004)
Cell
, vol.119
, pp. 381-392
-
-
Yedavalli, V.S.1
Neuveut, C.2
Chi, Y.H.3
Kleiman, L.4
Jeang, K.T.5
-
17
-
-
49149113373
-
Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation
-
Schroder M, Baran M, Bowie AG, (2008) Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation. EMBO J 27: 2147-2157.
-
(2008)
EMBO J
, vol.27
, pp. 2147-2157
-
-
Schroder, M.1
Baran, M.2
Bowie, A.G.3
-
18
-
-
49149114140
-
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
-
Soulat D, Burckstummer T, Westermayer S, Goncalves A, Bauch A, et al. (2008) The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J 27: 2135-2146.
-
(2008)
EMBO J
, vol.27
, pp. 2135-2146
-
-
Soulat, D.1
Burckstummer, T.2
Westermayer, S.3
Goncalves, A.4
Bauch, A.5
-
19
-
-
39349097864
-
Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen
-
Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, et al. (2008) Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen. Science 319: 921-926.
-
(2008)
Science
, vol.319
, pp. 921-926
-
-
Brass, A.L.1
Dykxhoorn, D.M.2
Benita, Y.3
Yan, N.4
Engelman, A.5
-
20
-
-
52949130695
-
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication
-
Konig R, Zhou Y, Elleder D, Diamond TL, Bonamy GM, et al. (2008) Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 135: 49-60.
-
(2008)
Cell
, vol.135
, pp. 49-60
-
-
Konig, R.1
Zhou, Y.2
Elleder, D.3
Diamond, T.L.4
Bonamy, G.M.5
-
21
-
-
55249088255
-
Genome-scale RNAi screen for host factors required for HIV replication
-
Zhou H, Xu M, Huang Q, Gates AT, Zhang XD, et al. (2008) Genome-scale RNAi screen for host factors required for HIV replication. Cell Host Microbe 4: 495-504.
-
(2008)
Cell Host Microbe
, vol.4
, pp. 495-504
-
-
Zhou, H.1
Xu, M.2
Huang, Q.3
Gates, A.T.4
Zhang, X.D.5
-
22
-
-
70349513508
-
A genome-wide genetic screen for host factors required for hepatitis C virus propagation
-
Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, et al. (2009) A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci U S A 106: 16410-16415.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 16410-16415
-
-
Li, Q.1
Brass, A.L.2
Ng, A.3
Hu, Z.4
Xavier, R.J.5
-
23
-
-
34547913440
-
Cellular cofactors affecting hepatitis C virus infection and replication
-
Randall G, Panis M, Cooper JD, Tellinghuisen TL, Sukhodolets KE, et al. (2007) Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci U S A 104: 12884-12889.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 12884-12889
-
-
Randall, G.1
Panis, M.2
Cooper, J.D.3
Tellinghuisen, T.L.4
Sukhodolets, K.E.5
-
24
-
-
76749090540
-
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication
-
Karlas A, Machuy N, Shin Y, Pleissner KP, Artarini A, et al. (2010) Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature 463: 818-822.
-
(2010)
Nature
, vol.463
, pp. 818-822
-
-
Karlas, A.1
Machuy, N.2
Shin, Y.3
Pleissner, K.P.4
Artarini, A.5
-
25
-
-
76749108989
-
Human host factors required for influenza virus replication
-
Konig R, Stertz S, Zhou Y, Inoue A, Hoffmann HH, et al. (2010) Human host factors required for influenza virus replication. Nature 463: 813-817.
-
(2010)
Nature
, vol.463
, pp. 813-817
-
-
Konig, R.1
Stertz, S.2
Zhou, Y.3
Inoue, A.4
Hoffmann, H.H.5
-
26
-
-
72249103485
-
A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection
-
Shapira SD, Gat-Viks I, Shum BO, Dricot A, de Grace MM, et al. (2009) A physical and regulatory map of host-influenza interactions reveals pathways in H1N1 infection. Cell 139: 1255-1267.
-
(2009)
Cell
, vol.139
, pp. 1255-1267
-
-
Shapira, S.D.1
Gat-Viks, I.2
Shum, B.O.3
Dricot, A.4
de Grace, M.M.5
-
27
-
-
51649095289
-
RNA interference screen for human genes associated with West Nile virus infection
-
Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, et al. (2008) RNA interference screen for human genes associated with West Nile virus infection. Nature 455: 242-245.
-
(2008)
Nature
, vol.455
, pp. 242-245
-
-
Krishnan, M.N.1
Ng, A.2
Sukumaran, B.3
Gilfoy, F.D.4
Uchil, P.D.5
-
28
-
-
79957962932
-
Non-apoptotic role of BID in inflammation and innate immunity
-
Yeretssian G, Correa RG, Doiron K, Fitzgerald P, Dillon CP, et al. (2011) Non-apoptotic role of BID in inflammation and innate immunity. Nature 474: 96-99.
-
(2011)
Nature
, vol.474
, pp. 96-99
-
-
Yeretssian, G.1
Correa, R.G.2
Doiron, K.3
Fitzgerald, P.4
Dillon, C.P.5
-
29
-
-
74549206702
-
How the noninflammasome NLRs function in the innate immune system
-
Ting JP, Duncan JA, Lei Y, (2010) How the noninflammasome NLRs function in the innate immune system. Science 327: 286-290.
-
(2010)
Science
, vol.327
, pp. 286-290
-
-
Ting, J.P.1
Duncan, J.A.2
Lei, Y.3
-
30
-
-
84863607133
-
Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection
-
Mgbemena V, Segovia JA, Chang TH, Tsai SY, Cole GT, et al. (2012) Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection. J Immunol 189: 606-615.
-
(2012)
J Immunol
, vol.189
, pp. 606-615
-
-
Mgbemena, V.1
Segovia, J.A.2
Chang, T.H.3
Tsai, S.Y.4
Cole, G.T.5
-
31
-
-
10744226053
-
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids
-
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, et al. (2004) CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids. J Biol Chem 279: 6305-6314.
-
(2004)
J Biol Chem
, vol.279
, pp. 6305-6314
-
-
Chuang, S.S.1
Helvig, C.2
Taimi, M.3
Ramshaw, H.A.4
Collop, A.H.5
-
32
-
-
8444251784
-
The Wnt signaling pathway in development and disease
-
Logan CY, Nusse R, (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20: 781-810.
-
(2004)
Annu Rev Cell Dev Biol
, vol.20
, pp. 781-810
-
-
Logan, C.Y.1
Nusse, R.2
-
33
-
-
37349025355
-
SnapShot: Noncanonical Wnt Signaling Pathways
-
Semenov MV, Habas R, Macdonald BT, He X, (2007) SnapShot: Noncanonical Wnt Signaling Pathways. Cell 131: 1378.
-
(2007)
Cell
, vol.131
, pp. 1378
-
-
Semenov, M.V.1
Habas, R.2
Macdonald, B.T.3
He, X.4
-
34
-
-
26944485185
-
WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity
-
Gordon MD, Dionne MS, Schneider DS, Nusse R, (2005) WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. Nature 437: 746-749.
-
(2005)
Nature
, vol.437
, pp. 746-749
-
-
Gordon, M.D.1
Dionne, M.S.2
Schneider, D.S.3
Nusse, R.4
-
35
-
-
84857372945
-
Wnt2 inhibits enteric bacterial-induced inflammation in intestinal epithelial cells
-
Liu X, Lu R, Wu S, Zhang YG, Xia Y, et al. (2011) Wnt2 inhibits enteric bacterial-induced inflammation in intestinal epithelial cells. Inflamm Bowel Dis 18: 418-29.
-
(2011)
Inflamm Bowel Dis
, vol.18
, pp. 418-429
-
-
Liu, X.1
Lu, R.2
Wu, S.3
Zhang, Y.G.4
Xia, Y.5
-
36
-
-
82455205826
-
Wingless homolog Wnt11 suppresses bacterial invasion and inflammation in intestinal epithelial cells
-
Liu X, Wu S, Xia Y, Li XE, Zhou ZD, et al. (2011) Wingless homolog Wnt11 suppresses bacterial invasion and inflammation in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 301: G992-G1003.
-
(2011)
Am J Physiol Gastrointest Liver Physiol
, vol.301
-
-
Liu, X.1
Wu, S.2
Xia, Y.3
Li, X.E.4
Zhou, Z.D.5
-
37
-
-
33646134826
-
Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells
-
Banziger C, Soldini D, Schutt C, Zipperlen P, Hausmann G, et al. (2006) Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells. Cell 125: 509-522.
-
(2006)
Cell
, vol.125
, pp. 509-522
-
-
Banziger, C.1
Soldini, D.2
Schutt, C.3
Zipperlen, P.4
Hausmann, G.5
-
38
-
-
33646123992
-
Secretion of Wnt ligands requires Evi, a conserved transmembrane protein
-
Bartscherer K, Pelte N, Ingelfinger D, Boutros M, (2006) Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell 125: 523-533.
-
(2006)
Cell
, vol.125
, pp. 523-533
-
-
Bartscherer, K.1
Pelte, N.2
Ingelfinger, D.3
Boutros, M.4
-
39
-
-
33846138014
-
Sprinter: a novel transmembrane protein required for Wg secretion and signaling
-
Goodman RM, Thombre S, Firtina Z, Gray D, Betts D, et al. (2006) Sprinter: a novel transmembrane protein required for Wg secretion and signaling. Development 133: 4901-4911.
-
(2006)
Development
, vol.133
, pp. 4901-4911
-
-
Goodman, R.M.1
Thombre, S.2
Firtina, Z.3
Gray, D.4
Betts, D.5
-
40
-
-
0344373791
-
Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements
-
Veeman MT, Slusarski DC, Kaykas A, Louie SH, Moon RT, (2003) Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Curr Biol 13: 680-685.
-
(2003)
Curr Biol
, vol.13
, pp. 680-685
-
-
Veeman, M.T.1
Slusarski, D.C.2
Kaykas, A.3
Louie, S.H.4
Moon, R.T.5
-
41
-
-
77952566304
-
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway
-
Yang P, An H, Liu X, Wen M, Zheng Y, et al. (2010) The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol 11: 487-494.
-
(2010)
Nat Immunol
, vol.11
, pp. 487-494
-
-
Yang, P.1
An, H.2
Liu, X.3
Wen, M.4
Zheng, Y.5
-
42
-
-
33744821869
-
Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening
-
Trosset JY, Dalvit C, Knapp S, Fasolini M, Veronesi M, et al. (2006) Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins 64: 60-67.
-
(2006)
Proteins
, vol.64
, pp. 60-67
-
-
Trosset, J.Y.1
Dalvit, C.2
Knapp, S.3
Fasolini, M.4
Veronesi, M.5
-
43
-
-
80055110944
-
Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production
-
Chatel-Chaix L, Melancon P, Racine ME, Baril M, Lamarre D, (2011) Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production. J Virol 85: 11022-11037.
-
(2011)
J Virol
, vol.85
, pp. 11022-11037
-
-
Chatel-Chaix, L.1
Melancon, P.2
Racine, M.E.3
Baril, M.4
Lamarre, D.5
-
44
-
-
0037329247
-
Wnt2b controls retinal cell differentiation at the ciliary marginal zone
-
Kubo F, Takeichi M, Nakagawa S, (2003) Wnt2b controls retinal cell differentiation at the ciliary marginal zone. Development 130: 587-598.
-
(2003)
Development
, vol.130
, pp. 587-598
-
-
Kubo, F.1
Takeichi, M.2
Nakagawa, S.3
-
45
-
-
73149097234
-
Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)
-
Beurel E, Michalek SM, Jope RS, (2010) Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3). Trends Immunol 31: 24-31.
-
(2010)
Trends Immunol
, vol.31
, pp. 24-31
-
-
Beurel, E.1
Michalek, S.M.2
Jope, R.S.3
-
46
-
-
84870708787
-
Hepatitis C Virus Induces Epithelial Mesenchymal Transition in Primary Human Hepatocytes
-
Bose SK, Meyer K, Di Bisceglie AM, Ray RB, Ray R, (2012) Hepatitis C Virus Induces Epithelial Mesenchymal Transition in Primary Human Hepatocytes. J Virol 86: 13621-8.
-
(2012)
J Virol
, vol.86
, pp. 13621-13628
-
-
Bose, S.K.1
Meyer, K.2
Di Bisceglie, A.M.3
Ray, R.B.4
Ray, R.5
-
47
-
-
78650177936
-
Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1
-
Lei CQ, Zhong B, Zhang Y, Zhang J, Wang S, et al. (2010) Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity 33: 878-889.
-
(2010)
Immunity
, vol.33
, pp. 878-889
-
-
Lei, C.Q.1
Zhong, B.2
Zhang, Y.3
Zhang, J.4
Wang, S.5
-
48
-
-
23944486750
-
Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
-
Martin M, Rehani K, Jope RS, Michalek SM, (2005) Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6: 777-784.
-
(2005)
Nat Immunol
, vol.6
, pp. 777-784
-
-
Martin, M.1
Rehani, K.2
Jope, R.S.3
Michalek, S.M.4
-
49
-
-
58149234278
-
Glycogen synthase kinase 3 inhibition protects the heart from acute ischemia-reperfusion injury via inhibition of inflammation and apoptosis
-
Gao HK, Yin Z, Zhou N, Feng XY, Gao F, et al. (2008) Glycogen synthase kinase 3 inhibition protects the heart from acute ischemia-reperfusion injury via inhibition of inflammation and apoptosis. J Cardiovasc Pharmacol 52: 286-292.
-
(2008)
J Cardiovasc Pharmacol
, vol.52
, pp. 286-292
-
-
Gao, H.K.1
Yin, Z.2
Zhou, N.3
Feng, X.Y.4
Gao, F.5
-
50
-
-
77249158055
-
3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis
-
Gurrieri C, Piazza F, Gnoato M, Montini B, Biasutto L, et al. (2010) 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis. J Pharmacol Exp Ther 332: 785-794.
-
(2010)
J Pharmacol Exp Ther
, vol.332
, pp. 785-794
-
-
Gurrieri, C.1
Piazza, F.2
Gnoato, M.3
Montini, B.4
Biasutto, L.5
-
51
-
-
0038044650
-
Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling
-
Sanchez JF, Sniderhan LF, Williamson AL, Fan S, Chakraborty-Sett S, et al. (2003) Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling. Mol Cell Biol 23: 4649-4662.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 4649-4662
-
-
Sanchez, J.F.1
Sniderhan, L.F.2
Williamson, A.L.3
Fan, S.4
Chakraborty-Sett, S.5
-
52
-
-
4544341116
-
Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor
-
Takada Y, Fang X, Jamaluddin MS, Boyd DD, Aggarwal BB, (2004) Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J Biol Chem 279: 39541-39554.
-
(2004)
J Biol Chem
, vol.279
, pp. 39541-39554
-
-
Takada, Y.1
Fang, X.2
Jamaluddin, M.S.3
Boyd, D.D.4
Aggarwal, B.B.5
-
53
-
-
57749173844
-
Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity
-
Yuskaitis CJ, Jope RS, (2009) Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity. Cell Signal 21: 264-273.
-
(2009)
Cell Signal
, vol.21
, pp. 264-273
-
-
Yuskaitis, C.J.1
Jope, R.S.2
-
54
-
-
1542618320
-
Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway
-
Deng J, Xia W, Miller SA, Wen Y, Wang HY, et al. (2004) Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway. Mol Carcinog 39: 139-146.
-
(2004)
Mol Carcinog
, vol.39
, pp. 139-146
-
-
Deng, J.1
Xia, W.2
Miller, S.A.3
Wen, Y.4
Wang, H.Y.5
-
55
-
-
84860822029
-
Glycogen synthase kinase-3 beta inhibitor suppresses Porphyromonas gingivalis lipopolysaccharide-induced CD40 expression by inhibiting nuclear factor-kappa B activation in mouse osteoblasts
-
Die L, Yan P, Jun Jiang Z, Min Hua T, Cai W, et al. (2012) Glycogen synthase kinase-3 beta inhibitor suppresses Porphyromonas gingivalis lipopolysaccharide-induced CD40 expression by inhibiting nuclear factor-kappa B activation in mouse osteoblasts. Mol Immunol 52: 38-49.
-
(2012)
Mol Immunol
, vol.52
, pp. 38-49
-
-
Die, L.1
Yan, P.2
Jun Jiang, Z.3
Min Hua, T.4
Cai, W.5
-
56
-
-
34249034925
-
beta-Catenin activity negatively regulates bacteria-induced inflammation
-
Duan Y, Liao AP, Kuppireddi S, Ye Z, Ciancio MJ, et al. (2007) beta-Catenin activity negatively regulates bacteria-induced inflammation. Lab Invest 87: 613-624.
-
(2007)
Lab Invest
, vol.87
, pp. 613-624
-
-
Duan, Y.1
Liao, A.P.2
Kuppireddi, S.3
Ye, Z.4
Ciancio, M.J.5
-
57
-
-
84874454971
-
beta-Catenin regulates innate and adaptive immunity in mouse liver ischemia-reperfusion injury
-
Ke B, Shen XD, Kamo N, Ji H, Yue S, et al. (2012) beta-Catenin regulates innate and adaptive immunity in mouse liver ischemia-reperfusion injury. Hepatology 57: 1203-14.
-
(2012)
Hepatology
, vol.57
, pp. 1203-1214
-
-
Ke, B.1
Shen, X.D.2
Kamo, N.3
Ji, H.4
Yue, S.5
-
58
-
-
84866179288
-
The Akt1 isoform is required for optimal IFN-beta transcription through direct phosphorylation of beta-catenin
-
Gantner BN, Jin H, Qian F, Hay N, He B, et al. (2012) The Akt1 isoform is required for optimal IFN-beta transcription through direct phosphorylation of beta-catenin. J Immunol 189: 3104-3111.
-
(2012)
J Immunol
, vol.189
, pp. 3104-3111
-
-
Gantner, B.N.1
Jin, H.2
Qian, F.3
Hay, N.4
He, B.5
-
59
-
-
82455175292
-
PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and beta-catenin
-
Zhu J, Coyne CB, Sarkar SN, (2011) PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and beta-catenin. EMBO J 30: 4838-4849.
-
(2011)
EMBO J
, vol.30
, pp. 4838-4849
-
-
Zhu, J.1
Coyne, C.B.2
Sarkar, S.N.3
-
60
-
-
26444603837
-
GCF2/LRRFIP1 represses tumor necrosis factor alpha expression
-
Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, et al. (2005) GCF2/LRRFIP1 represses tumor necrosis factor alpha expression. Mol Cell Biol 25: 9073-9081.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 9073-9081
-
-
Suriano, A.R.1
Sanford, A.N.2
Kim, N.3
Oh, M.4
Kennedy, S.5
-
61
-
-
84875446466
-
RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling
-
Cruciat CM, Dolde C, de Groot RE, Ohkawara B, Reinhard C, et al. (2013) RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling. Science 339: 1436-1441.
-
(2013)
Science
, vol.339
, pp. 1436-1441
-
-
Cruciat, C.M.1
Dolde, C.2
de Groot, R.E.3
Ohkawara, B.4
Reinhard, C.5
-
62
-
-
78649828281
-
Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages
-
Neumann J, Schaale K, Farhat K, Endermann T, Ulmer AJ, et al. (2010) Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages. FASEB J 24: 4599-4612.
-
(2010)
FASEB J
, vol.24
, pp. 4599-4612
-
-
Neumann, J.1
Schaale, K.2
Farhat, K.3
Endermann, T.4
Ulmer, A.J.5
-
63
-
-
68849085894
-
A cell biological view of Toll-like receptor function: regulation through compartmentalization
-
Barton GM, Kagan JC, (2009) A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol 9: 535-542.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 535-542
-
-
Barton, G.M.1
Kagan, J.C.2
-
64
-
-
33751318469
-
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion
-
Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, et al. (2006) Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev Cell 11: 791-801.
-
(2006)
Dev Cell
, vol.11
, pp. 791-801
-
-
Takada, R.1
Satomi, Y.2
Kurata, T.3
Ueno, N.4
Norioka, S.5
-
65
-
-
0037737726
-
Wnt proteins are lipid-modified and can act as stem cell growth factors
-
Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, et al. (2003) Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423: 448-452.
-
(2003)
Nature
, vol.423
, pp. 448-452
-
-
Willert, K.1
Brown, J.D.2
Danenberg, E.3
Duncan, A.W.4
Weissman, I.L.5
-
66
-
-
67049096677
-
Primary cultures of human hepatocytes isolated from hepatitis C virus-infected cirrhotic livers as a model to study hepatitis C infection
-
Raymond VA, Selliah S, Ethier C, Houle R, Jouan L, et al. (2009) Primary cultures of human hepatocytes isolated from hepatitis C virus-infected cirrhotic livers as a model to study hepatitis C infection. Liver Int 29: 942-949.
-
(2009)
Liver Int
, vol.29
, pp. 942-949
-
-
Raymond, V.A.1
Selliah, S.2
Ethier, C.3
Houle, R.4
Jouan, L.5
-
67
-
-
59749085907
-
MAVS dimer is a crucial signaling component of innate immunity and the target of hepatitis C virus NS3/4A protease
-
Baril M, Racine ME, Penin F, Lamarre D, (2009) MAVS dimer is a crucial signaling component of innate immunity and the target of hepatitis C virus NS3/4A protease. J Virol 83: 1299-1311.
-
(2009)
J Virol
, vol.83
, pp. 1299-1311
-
-
Baril, M.1
Racine, M.E.2
Penin, F.3
Lamarre, D.4
-
68
-
-
0029949810
-
Repression of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule
-
Berube P, Barbeau B, Cantin R, Sekaly RP, Tremblay M, (1996) Repression of human immunodeficiency virus type 1 long terminal repeat-driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule. J Virol 70: 4009-4016.
-
(1996)
J Virol
, vol.70
, pp. 4009-4016
-
-
Berube, P.1
Barbeau, B.2
Cantin, R.3
Sekaly, R.P.4
Tremblay, M.5
-
69
-
-
0034602156
-
Multiple regulatory domains control IRF-7 activity in response to virus infection
-
Lin R, Mamane Y, Hiscott J, (2000) Multiple regulatory domains control IRF-7 activity in response to virus infection. J Biol Chem 275: 34320-34327.
-
(2000)
J Biol Chem
, vol.275
, pp. 34320-34327
-
-
Lin, R.1
Mamane, Y.2
Hiscott, J.3
-
70
-
-
0038363463
-
Triggering the interferon antiviral response through an IKK-related pathway
-
Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, et al. (2003) Triggering the interferon antiviral response through an IKK-related pathway. Science 300: 1148-1151.
-
(2003)
Science
, vol.300
, pp. 1148-1151
-
-
Sharma, S.1
tenOever, B.R.2
Grandvaux, N.3
Zhou, G.P.4
Lin, R.5
-
71
-
-
34247586514
-
Production of infectious hepatitis C virus of various genotypes in cell cultures
-
Kato T, Matsumura T, Heller T, Saito S, Sapp RK, et al. (2007) Production of infectious hepatitis C virus of various genotypes in cell cultures. J Virol 81: 4405-4411.
-
(2007)
J Virol
, vol.81
, pp. 4405-4411
-
-
Kato, T.1
Matsumura, T.2
Heller, T.3
Saito, S.4
Sapp, R.K.5
-
72
-
-
34547734952
-
Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus
-
Jones CT, Murray CL, Eastman DK, Tassello J, Rice CM, (2007) Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus. J Virol 81: 8374-8383.
-
(2007)
J Virol
, vol.81
, pp. 8374-8383
-
-
Jones, C.T.1
Murray, C.L.2
Eastman, D.K.3
Tassello, J.4
Rice, C.M.5
-
73
-
-
0031710033
-
A third-generation lentivirus vector with a conditional packaging system
-
Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, et al. (1998) A third-generation lentivirus vector with a conditional packaging system. J Virol 72: 8463-8471.
-
(1998)
J Virol
, vol.72
, pp. 8463-8471
-
-
Dull, T.1
Zufferey, R.2
Kelly, M.3
Mandel, R.J.4
Nguyen, M.5
-
74
-
-
0033604281
-
Impaired antiviral response in human hepatoma cells
-
Keskinen P, Nyqvist M, Sareneva T, Pirhonen J, Melen K, et al. (1999) Impaired antiviral response in human hepatoma cells. Virology 263: 364-375.
-
(1999)
Virology
, vol.263
, pp. 364-375
-
-
Keskinen, P.1
Nyqvist, M.2
Sareneva, T.3
Pirhonen, J.4
Melen, K.5
-
75
-
-
79955542915
-
A diverse range of gene products are effectors of the type I interferon antiviral response
-
Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, et al. (2011) A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472: 481-485.
-
(2011)
Nature
, vol.472
, pp. 481-485
-
-
Schoggins, J.W.1
Wilson, S.J.2
Panis, M.3
Murphy, M.Y.4
Jones, C.T.5
|