메뉴 건너뛰기




Volumn 30, Issue 23, 2011, Pages 4838-4849

PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β 2-catenin

Author keywords

Innate immunity; Interferon; Virus

Indexed keywords

BETA CATENIN; HISTONE DEACETYLASE 6; INTERFERON; PROTEIN KINASE C ALPHA;

EID: 82455175292     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.351     Document Type: Article
Times cited : (85)

References (61)
  • 2
    • 34547684065 scopus 로고    scopus 로고
    • HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination
    • Boyault C, Sadoul K, Pabion M, Khochbin S (2007) HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene 26: 5468-5476
    • (2007) Oncogene , vol.26 , pp. 5468-5476
    • Boyault, C.1    Sadoul, K.2    Pabion, M.3    Khochbin, S.4
  • 3
    • 78449239909 scopus 로고    scopus 로고
    • Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells
    • Bozym RA, Morosky SA, Kim KS, Cherry S, Coyne CB (2010) Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells. PLoS Pathog 6: e1001135
    • (2010) PLoS Pathog , vol.6
    • Bozym, R.A.1    Morosky, S.A.2    Kim, K.S.3    Cherry, S.4    Coyne, C.B.5
  • 4
    • 80052252539 scopus 로고    scopus 로고
    • Calcium signals and calpaindependent necrosis are essential for release of Coxsackievirus B from polarized intestinal epithelial cells
    • Bozym RA, Patel K, White C, Cheung KH, Bergelson JM, Morosky SA, Coyne CB (2011) Calcium signals and calpaindependent necrosis are essential for release of Coxsackievirus B from polarized intestinal epithelial cells. Mol Biol Cell 22: 3010-3021
    • (2011) Mol Biol Cell , vol.22 , pp. 3010-3021
    • Bozym, R.A.1    Patel, K.2    White, C.3    Cheung, K.H.4    Bergelson, J.M.5    Morosky, S.A.6    Coyne, C.B.7
  • 5
    • 0347298773 scopus 로고    scopus 로고
    • Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding
    • Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marie I (2002) Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. J Biol Chem 277: 49417-49421
    • (2002) J Biol Chem , vol.277 , pp. 49417-49421
    • Caillaud, A.1    Prakash, A.2    Smith, E.3    Masumi, A.4    Hovanessian, A.G.5    Levy, D.E.6    Marie, I.7
  • 6
    • 3042752799 scopus 로고    scopus 로고
    • Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
    • Chang HM, Paulson M, Holko M, Rice CM, Williams BR, Marie I, Levy DE (2004) Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. Proc Natl Acad Sci USA 101: 9578-9583
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9578-9583
    • Chang, H.M.1    Paulson, M.2    Holko, M.3    Rice, C.M.4    Williams, B.R.5    Marie, I.6    Levy, D.E.7
  • 7
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NFkappaB
    • Chen LF, Greene WC (2004) Shaping the nuclear action of NFkappaB. Nat Rev Mol Cell Biol 5: 392-401
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2
  • 8
    • 41949092999 scopus 로고    scopus 로고
    • Phosphorylation of IRF- 3 on ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association
    • Clement JF, Bibeau-Poirier A, Gravel SP, Grandvaux N, Bonneil E, Thibault P, Meloche S, Servant MJ (2008) Phosphorylation of IRF- 3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association. J Virol 82: 3984-3996
    • (2008) J Virol , vol.82 , pp. 3984-3996
    • Clement, J.F.1    Bibeau-Poirier, A.2    Gravel, S.P.3    Grandvaux, N.4    Bonneil, E.5    Thibault, P.6    Meloche, S.7    Servant, M.J.8
  • 10
    • 0842304532 scopus 로고    scopus 로고
    • Innate cellular response to virus particle entry requires IRF3 but not virus replication
    • Collins SE, Noyce RS, Mossman KL (2004) Innate cellular response to virus particle entry requires IRF3 but not virus replication. J Virol 78: 1706-1717
    • (2004) J Virol , vol.78 , pp. 1706-1717
    • Collins, S.E.1    Noyce, R.S.2    Mossman, K.L.3
  • 11
    • 78149305588 scopus 로고    scopus 로고
    • The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis
    • Cureton DK, Massol RH, Whelan SP, Kirchhausen T (2010) The length of vesicular stomatitis virus particles dictates a need for actin assembly during clathrin-dependent endocytosis. PLoS Pathog 6: e1001127
    • (2010) PLoS Pathog , vol.6
    • Cureton, D.K.1    Massol, R.H.2    Whelan, S.P.3    Kirchhausen, T.4
  • 12
    • 33745260979 scopus 로고    scopus 로고
    • Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells
    • Das SC, Nayak D, Zhou Y, Pattnaik AK (2006) Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells. J Virol 80: 6368-6377
    • (2006) J Virol , vol.80 , pp. 6368-6377
    • Das, S.C.1    Nayak, D.2    Zhou, Y.3    Pattnaik, A.K.4
  • 13
    • 0031846233 scopus 로고    scopus 로고
    • Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid
    • Desai P, Person S (1998) Incorporation of the green fluorescent protein into the herpes simplex virus type 1 capsid. J Virol 72: 7563-7568
    • (1998) J Virol , vol.72 , pp. 7563-7568
    • Desai, P.1    Person, S.2
  • 14
    • 15244361975 scopus 로고    scopus 로고
    • Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-kappaB, and interferon but not toll-like receptor 3
    • Elco CP, Guenther JM,Williams BR, Sen GC (2005) Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-kappaB, and interferon but not toll-like receptor 3. J Virol 79: 3920-3929
    • (2005) J Virol , vol.79 , pp. 3920-3929
    • Elco, C.P.1    Guenther, J.M.2    Williams, B.R.3    Sen, G.C.4
  • 15
    • 78650637976 scopus 로고    scopus 로고
    • Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression
    • Feng D, Sangster-Guity N, Stone R, Korczeniewska J, Mancl ME, Fitzgerald-Bocarsly P, Barnes BJ (2010) Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression. J Immunol 185: 6003-6012
    • (2010) J Immunol , vol.185 , pp. 6003-6012
    • Feng, D.1    Sangster-Guity, N.2    Stone, R.3    Korczeniewska, J.4    Mancl, M.E.5    Fitzgerald-Bocarsly, P.6    Barnes, B.J.7
  • 19
    • 58149393201 scopus 로고    scopus 로고
    • Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding
    • Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat PS, Roberts TM, Gjoerup OV (2009) Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol 83: 117-127
    • (2009) J Virol , vol.83 , pp. 117-127
    • Hein, J.1    Boichuk, S.2    Wu, J.3    Cheng, Y.4    Freire, R.5    Jat, P.S.6    Roberts, T.M.7    Gjoerup, O.V.8
  • 20
    • 67849115954 scopus 로고    scopus 로고
    • Influenza A virus-induced caspase-3 cleaves the histone deacetylase 6 in infected epithelial cells
    • Husain M, Harrod KS (2009) Influenza A virus-induced caspase-3 cleaves the histone deacetylase 6 in infected epithelial cells. FEBS Lett 583: 2517-2520
    • (2009) FEBS Lett , vol.583 , pp. 2517-2520
    • Husain, M.1    Harrod, K.S.2
  • 21
    • 0037385662 scopus 로고    scopus 로고
    • PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1
    • Ivaska J, Bosca L, Parker PJ (2003) PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1. Nat Cell Biol 5: 363-369
    • (2003) Nat Cell Biol , vol.5 , pp. 363-369
    • Ivaska, J.1    Bosca, L.2    Parker, P.J.3
  • 23
    • 34447504038 scopus 로고    scopus 로고
    • Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type i interferon-beta synthesis
    • Johnson J, Albarani V, Nguyen M, Goldman M, Willems F, Aksoy E (2007) Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis. J Biol Chem 282: 15022-15032
    • (2007) J Biol Chem , vol.282 , pp. 15022-15032
    • Johnson, J.1    Albarani, V.2    Nguyen, M.3    Goldman, M.4    Willems, F.5    Aksoy, E.6
  • 24
    • 0029615509 scopus 로고
    • Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
    • Keranen LM, Dutil EM, Newton AC (1995) Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol 5: 1394-1403
    • (1995) Curr Biol , vol.5 , pp. 1394-1403
    • Keranen, L.M.1    Dutil, E.M.2    Newton, A.C.3
  • 25
    • 3142721913 scopus 로고    scopus 로고
    • Requirement of histone deacetylase activity for signaling by STAT1
    • Klampfer L, Huang J, Swaby LA, Augenlicht L (2004) Requirement of histone deacetylase activity for signaling by STAT1. J Biol Chem 279: 30358-30368
    • (2004) J Biol Chem , vol.279 , pp. 30358-30368
    • Klampfer, L.1    Huang, J.2    Swaby, L.A.3    Augenlicht, L.4
  • 26
    • 72749088774 scopus 로고    scopus 로고
    • Protein kinase Calpha: Disease regulator and therapeutic target
    • Konopatskaya O, Poole AW (2010) Protein kinase Calpha: disease regulator and therapeutic target. Trends Pharmacol Sci 31: 8-14
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 8-14
    • Konopatskaya, O.1    Poole, A.W.2
  • 28
    • 49449113465 scopus 로고    scopus 로고
    • Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6
    • Kozikowski AP, Tapadar S, Luchini DN, Kim KH, Billadeau DD (2008) Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem 51: 4370-4373
    • (2008) J Med Chem , vol.51 , pp. 4370-4373
    • Kozikowski, A.P.1    Tapadar, S.2    Luchini, D.N.3    Kim, K.H.4    Billadeau, D.D.5
  • 29
    • 78650177936 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1
    • Lei CQ, Zhong B, Zhang Y, Zhang J, Wang S, Shu HB (2010) Glycogen synthase kinase 3beta regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity 33: 878-889
    • (2010) Immunity , vol.33 , pp. 878-889
    • Lei, C.Q.1    Zhong, B.2    Zhang, Y.3    Zhang, J.4    Wang, S.5    Shu, H.B.6
  • 30
    • 45149089913 scopus 로고    scopus 로고
    • HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization
    • Li Y, Zhang X, Polakiewicz RD, Yao TP, Comb MJ (2008) HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J Biol Chem 283: 12686-12690
    • (2008) J Biol Chem , vol.283 , pp. 12686-12690
    • Li, Y.1    Zhang, X.2    Polakiewicz, R.D.3    Yao, T.P.4    Comb, M.J.5
  • 31
    • 79956314622 scopus 로고    scopus 로고
    • Immune signaling by RIG-I-like receptors
    • Loo YM, Gale Jr M. (2011) Immune signaling by RIG-I-like receptors. Immunity 34: 680-692
    • (2011) Immunity , vol.34 , pp. 680-692
    • Loo, Y.M.1    Gale Jr., M.2
  • 32
    • 0035877666 scopus 로고    scopus 로고
    • Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment
    • Masumi A, Ozato K (2001) Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment. J Biol Chem 276: 20973-20980
    • (2001) J Biol Chem , vol.276 , pp. 20973-20980
    • Masumi, A.1    Ozato, K.2
  • 33
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-catenin, and cadherin pathways
    • Nelson WJ, Nusse R (2004) Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303: 1483-1487
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 34
    • 0037337159 scopus 로고    scopus 로고
    • Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm
    • Newton AC (2003) Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 370: 361-371
    • (2003) Biochem J , vol.370 , pp. 361-371
    • Newton, A.C.1
  • 35
    • 66149083542 scopus 로고    scopus 로고
    • Differential modification of interferon regulatory factor 3 following virus particle entry
    • Noyce RS, Collins SE, Mossman KL (2009) Differential modification of interferon regulatory factor 3 following virus particle entry. J Virol 83: 4013-4022
    • (2009) J Virol , vol.83 , pp. 4013-4022
    • Noyce, R.S.1    Collins, S.E.2    Mossman, K.L.3
  • 36
    • 0344304443 scopus 로고    scopus 로고
    • Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1
    • Nusinzon I, Horvath CM (2003) Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc Natl Acad Sci USA 100: 14742-14747
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14742-14747
    • Nusinzon, I.1    Horvath, C.M.2
  • 37
    • 30344447505 scopus 로고    scopus 로고
    • Unexpected roles for deacetylation in interferon- and cytokine-induced transcription
    • Nusinzon I, Horvath CM (2005) Unexpected roles for deacetylation in interferon- and cytokine-induced transcription. J Interferon Cytokine Res 25: 745-748
    • (2005) J Interferon Cytokine Res , vol.25 , pp. 745-748
    • Nusinzon, I.1    Horvath, C.M.2
  • 38
    • 33645812740 scopus 로고    scopus 로고
    • Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation
    • Nusinzon I, Horvath CM (2006) Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Mol Cell Biol 26: 3106-3113
    • (2006) Mol Cell Biol , vol.26 , pp. 3106-3113
    • Nusinzon, I.1    Horvath, C.M.2
  • 40
    • 0036170183 scopus 로고    scopus 로고
    • IFNStimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff
    • Paulson M, Press C, Smith E, Tanese N, Levy DE (2002) IFNStimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff. Nat Cell Biol 4: 140-147
    • (2002) Nat Cell Biol , vol.4 , pp. 140-147
    • Paulson, M.1    Press, C.2    Smith, E.3    Tanese, N.4    Levy, D.E.5
  • 41
    • 41149143076 scopus 로고    scopus 로고
    • IRF-3 activation by Sendai virus infection is required for cellular apoptosis and avoidance of persistence
    • Peters K, Chattopadhyay S, Sen GC (2008) IRF-3 activation by Sendai virus infection is required for cellular apoptosis and avoidance of persistence. J Virol 82: 3500-3508
    • (2008) J Virol , vol.82 , pp. 3500-3508
    • Peters, K.1    Chattopadhyay, S.2    Sen, G.C.3
  • 43
    • 34250758641 scopus 로고    scopus 로고
    • HEF1-dependent Aurora A activation induces disassembly of the primary cilium
    • Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA (2007) HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 129: 1351-1363
    • (2007) Cell , vol.129 , pp. 1351-1363
    • Pugacheva, E.N.1    Jablonski, S.A.2    Hartman, T.R.3    Henske, E.P.4    Golemis, E.A.5
  • 44
    • 35448978754 scopus 로고    scopus 로고
    • The protein kinase C (PKC) family of proteins in cytokine signaling in hematopoiesis
    • Redig AJ, Platanias LC (2007) The protein kinase C (PKC) family of proteins in cytokine signaling in hematopoiesis. J Interferon Cytokine Res 27: 623-636
    • (2007) J Interferon Cytokine Res , vol.27 , pp. 623-636
    • Redig, A.J.1    Platanias, L.C.2
  • 46
    • 4644366536 scopus 로고    scopus 로고
    • Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes
    • Sakamoto S, Potla R, Larner AC (2004) Histone deacetylase activity is required to recruit RNA polymerase II to the promoters of selected interferon-stimulated early response genes. J Biol Chem 279: 40362-40367
    • (2004) J Biol Chem , vol.279 , pp. 40362-40367
    • Sakamoto, S.1    Potla, R.2    Larner, A.C.3
  • 47
    • 7544225495 scopus 로고    scopus 로고
    • Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
    • Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC (2004) Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol 11: 1060-1067
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 1060-1067
    • Sarkar, S.N.1    Peters, K.L.2    Elco, C.P.3    Sakamoto, S.4    Pal, S.5    Sen, G.C.6
  • 48
    • 4644295390 scopus 로고    scopus 로고
    • Novel functions of proteins encoded by viral stress-inducible genes
    • Sarkar SN, Sen GC (2004) Novel functions of proteins encoded by viral stress-inducible genes. Pharmacol Ther 103: 245-259
    • (2004) Pharmacol Ther , vol.103 , pp. 245-259
    • Sarkar, S.N.1    Sen, G.C.2
  • 49
    • 77956630038 scopus 로고    scopus 로고
    • 2+ influx extends survival of west nile virus-infected cells
    • 2+ influx extends survival of west nile virus-infected cells. J Virol 84: 8721-8731
    • (2010) J Virol , vol.84 , pp. 8721-8731
    • Scherbik, S.V.1    Brinton, M.A.2
  • 51
    • 57149118021 scopus 로고    scopus 로고
    • HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomereassociated promyelocytic leukemia bodies
    • Spardy N, Duensing A, Hoskins EE, Wells SI, Duensing S (2008) HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomereassociated promyelocytic leukemia bodies. Cancer Res 68: 9954-9963
    • (2008) Cancer Res , vol.68 , pp. 9954-9963
    • Spardy, N.1    Duensing, A.2    Hoskins, E.E.3    Wells, S.I.4    Duensing, S.5
  • 52
    • 0037151040 scopus 로고    scopus 로고
    • Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex
    • Suhara W, Yoneyama M, Kitabayashi I, Fujita T (2002) Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex. J Biol Chem 277: 22304-22313
    • (2002) J Biol Chem , vol.277 , pp. 22304-22313
    • Suhara, W.1    Yoneyama, M.2    Kitabayashi, I.3    Fujita, T.4
  • 53
    • 39149107423 scopus 로고    scopus 로고
    • MDA5/RIG-I and virus recognition
    • Takeuchi O, Akira S (2008) MDA5/RIG-I and virus recognition. CurrOpin Immunol 20: 17-22
    • (2008) CurrOpin Immunol , vol.20 , pp. 17-22
    • Takeuchi, O.1    Akira, S.2
  • 54
    • 0141669117 scopus 로고    scopus 로고
    • Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes
    • Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV (2003) Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. Mol Cell Biol 23: 7068-7081
    • (2003) Mol Cell Biol , vol.23 , pp. 7068-7081
    • Trushin, S.A.1    Pennington, K.N.2    Carmona, E.M.3    Asin, S.4    Savoy, D.N.5    Billadeau, D.D.6    Paya, C.V.7
  • 57
    • 77952566304 scopus 로고    scopus 로고
    • The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type i interferon via a beta-catenin-dependent pathway
    • Yang P, An H, Liu X, Wen M, Zheng Y, Rui Y, Cao X (2010) The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol 11: 487-494
    • (2010) Nat Immunol , vol.11 , pp. 487-494
    • Yang, P.1    An, H.2    Liu, X.3    Wen, M.4    Zheng, Y.5    Rui, Y.6    Cao, X.7
  • 58
    • 16244366803 scopus 로고    scopus 로고
    • Class II histone deacetylases: From sequence to function, regulation, and clinical implication
    • Yang XJ, Gregoire S (2005) Class II histone deacetylases: from sequence to function, regulation, and clinical implication. Mol Cell Biol 25: 2873-2884
    • (2005) Mol Cell Biol , vol.25 , pp. 2873-2884
    • Yang, X.J.1    Gregoire, S.2
  • 60
    • 33845973015 scopus 로고    scopus 로고
    • Ca2± and protein kinase C-dependent signaling pathway for nuclear factor-kappaB activation, inducible nitric-oxide synthase expression, and tumor necrosis factor-alpha production in lipopolysaccharide-stimulated rat peritoneal macrophages
    • Zhou X, Yang W, Li J (2006) Ca2± and protein kinase C-dependent signaling pathway for nuclear factor-kappaB activation, inducible nitric-oxide synthase expression, and tumor necrosis factor-alpha production in lipopolysaccharide-stimulated rat peritoneal macrophages. J Biol Chem 281: 31337-31347
    • (2006) J Biol Chem , vol.281 , pp. 31337-31347
    • Zhou, X.1    Yang, W.2    Li, J.3
  • 61
    • 77954725890 scopus 로고    scopus 로고
    • High-throughput screening for TLR3-IFN regulatory factor 3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors
    • Zhu J, Smith K, Hsieh PN, Mburu YK, Chattopadhyay S, Sen GC, Sarkar SN (2010) High-throughput screening for TLR3-IFN regulatory factor 3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors. J Immunol 184: 5768-5776
    • (2010) J Immunol , vol.184 , pp. 5768-5776
    • Zhu, J.1    Smith, K.2    Hsieh, P.N.3    Mburu, Y.K.4    Chattopadhyay, S.5    Sen, G.C.6    Sarkar, S.N.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.