Synthesis and biological characterization of synthetic analogs of Huwentoxin-IV (Mu-theraphotoxin-Hh2a), a neuronal tetrodotoxin-sensitive sodium channel inhibitor

Toxicon

Volumn 71, Issue , 2013, Pages 57-65

  Deng, Meichun ^a   Luo, Xuan ^b   Jiang, Liping ^c   Chen, Hanchun ^a   Wang, Jun ^a   He, Hailun ^a   Liang, Songping ^b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b HUNAN NORMAL UNIVERSITY   (China)

^c Central South University   (China)

Author keywords

HWTX IV; Mutant; Patch clamp; Protein folding; Solid phase peptide synthesis; Voltage gated sodium channel

Indexed keywords

ARGININE; GLYCINE; HUWENTOXIN IV; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN SENSITIVE SODIUM CHANNEL; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG SYNTHESIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PURIFICATION; RAT; SEQUENCE HOMOLOGY; SODIUM CURRENT; SPINAL GANGLION; STRUCTURE ACTIVITY RELATION;

DORSAL ROOT GANGLION; DRG; HIGH PRESSURE LIQUID CHROMATOGRAPHY; HPLC; HUWENTOXIN; HWTX; HWTX-IV; IC(50); ICK; INHIBITOR CYSTINE KNOT; KV CHANNEL; MALDI-TOF; MATRIX ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT; MEDIAN INHIBITORY CONCENTRATION; MUTANT; PATCH-CLAMP; PROTEIN FOLDING; SOLID-PHASE PEPTIDE SYNTHESIS; TETRODOTOXIN; TTX; TTX-R; TTX-RESISTANT; TTX-S; TTX-SENSITIVE; VGSC; VOLTAGE-GATED POTASSIUM CHANNEL; VOLTAGE-GATED SODIUM CHANNEL;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; FEMALE; GANGLIA, SPINAL; MOLECULAR SEQUENCE DATA; NEURONS; NEUROTOXINS; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPIDER VENOMS; SPIDERS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRODOTOXIN;

MAMMALIA; ORNITHOCTONUS HUWENA; RATTUS; TARANTULA;

EID: 84879525993     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2013.05.015     Document Type: Article

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