메뉴 건너뛰기




Volumn 220, Issue 3, 2013, Pages 205-218

Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model

Author keywords

Chemoprevention; Diosmin; Hepatocellular carcinoma; Hyperproliferation

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CYCLOOXYGENASE 2; DIOSMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; KI 67 ANTIGEN; LACTATE DEHYDROGENASE; N (2 FLUORENYL)ACETAMIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84879487042     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.04.004     Document Type: Article
Times cited : (51)

References (84)
  • 2
    • 84867536275 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: molecular interactions between hepatitis C virus and p53 in hepatocarcinogenesis
    • Anzola M., Burgos J.J. Hepatocellular carcinoma: molecular interactions between hepatitis C virus and p53 in hepatocarcinogenesis. Expert Reviews in Molecular Medicine 2003, 5:1-16.
    • (2003) Expert Reviews in Molecular Medicine , vol.5 , pp. 1-16
    • Anzola, M.1    Burgos, J.J.2
  • 3
    • 0029785375 scopus 로고    scopus 로고
    • Coordination of copper polyamines complex with immidiozoles potentiates its superoxide dismutase mimicking activity and abolishes its interactions with albumin
    • Athar M., Sharma S.D., Iqbal M., Sultana S., Pandaya K.B., Tripathi I.P. Coordination of copper polyamines complex with immidiozoles potentiates its superoxide dismutase mimicking activity and abolishes its interactions with albumin. Biochemistry and Molecular Biology International 1996, 39:813-821.
    • (1996) Biochemistry and Molecular Biology International , vol.39 , pp. 813-821
    • Athar, M.1    Sharma, S.D.2    Iqbal, M.3    Sultana, S.4    Pandaya, K.B.5    Tripathi, I.P.6
  • 4
    • 0035984912 scopus 로고    scopus 로고
    • ROS, stress-activated kinases and stress signaling in cancer
    • Benhar M., Engelberg D., Levitzki A. ROS, stress-activated kinases and stress signaling in cancer. EMBO Reports 2002, 3:420-425.
    • (2002) EMBO Reports , vol.3 , pp. 420-425
    • Benhar, M.1    Engelberg, D.2    Levitzki, A.3
  • 6
    • 34247598318 scopus 로고    scopus 로고
    • Treatment with 2-AAF blocks the small hepatocyte-like progenitor cell response in retrorsine-exposed rats
    • Best D.H., Coleman W.B. Treatment with 2-AAF blocks the small hepatocyte-like progenitor cell response in retrorsine-exposed rats. Journal of Hepatology 2007, 46:1055-1063.
    • (2007) Journal of Hepatology , vol.46 , pp. 1055-1063
    • Best, D.H.1    Coleman, W.B.2
  • 7
    • 22844443613 scopus 로고    scopus 로고
    • Expression of Ki-67 and squamous intraepithelial lesions are related with HPV in endocervical adenocarcinoma
    • Cambruzzi E., Zettler C.G., Alexandre C.O. Expression of Ki-67 and squamous intraepithelial lesions are related with HPV in endocervical adenocarcinoma. Pathology Oncology Research 2005, 11(2):114-120.
    • (2005) Pathology Oncology Research , vol.11 , Issue.2 , pp. 114-120
    • Cambruzzi, E.1    Zettler, C.G.2    Alexandre, C.O.3
  • 9
    • 33750711341 scopus 로고    scopus 로고
    • Vanadium limits the expression of proliferating cell nuclear antigen and inhibits early DNA damage during diethylnitrosamine-induced hepatocellular preneoplasia in rats
    • Chakraborty T., Chatterjee A., Dhachinamoorthi D., Srivastava S., Panayappan L., Chatterjee M. Vanadium limits the expression of proliferating cell nuclear antigen and inhibits early DNA damage during diethylnitrosamine-induced hepatocellular preneoplasia in rats. Environmental and Molecular Mutagenesis 2006, 47:603-617.
    • (2006) Environmental and Molecular Mutagenesis , vol.47 , pp. 603-617
    • Chakraborty, T.1    Chatterjee, A.2    Dhachinamoorthi, D.3    Srivastava, S.4    Panayappan, L.5    Chatterjee, M.6
  • 10
    • 33947412656 scopus 로고    scopus 로고
    • Inhibition of cell proliferation and induction of apoptosis by genistein in experimental hepatocellular carcinoma
    • Chodon D., Mumtaz Banu S., Padmavathi R., Sakthisekaran D. Inhibition of cell proliferation and induction of apoptosis by genistein in experimental hepatocellular carcinoma. Molecular and Cellular Biochemistry 2007, 297:73-80.
    • (2007) Molecular and Cellular Biochemistry , vol.297 , pp. 73-80
    • Chodon, D.1    Mumtaz Banu, S.2    Padmavathi, R.3    Sakthisekaran, D.4
  • 11
    • 34447532263 scopus 로고    scopus 로고
    • Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stagemouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B
    • Chung W.Y., Park J.H., Kim M.J., Kim H.O., Hwang J.K., Lee S.K., Park K.K. Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stagemouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B. Carcinogenesis 2007, 28:1224-1231.
    • (2007) Carcinogenesis , vol.28 , pp. 1224-1231
    • Chung, W.Y.1    Park, J.H.2    Kim, M.J.3    Kim, H.O.4    Hwang, J.K.5    Lee, S.K.6    Park, K.K.7
  • 13
    • 4544243747 scopus 로고    scopus 로고
    • At the crossroads of inflammation and cancer
    • Clevers H. At the crossroads of inflammation and cancer. Cell 2004, 118:671-674.
    • (2004) Cell , vol.118 , pp. 671-674
    • Clevers, H.1
  • 14
    • 0025168534 scopus 로고
    • Cell proliferation in carcinogenesis
    • Cohen S.M., Ellwin L.B. Cell proliferation in carcinogenesis. Science 1990, 249:1007-1011.
    • (1990) Science , vol.249 , pp. 1007-1011
    • Cohen, S.M.1    Ellwin, L.B.2
  • 15
    • 27644481208 scopus 로고    scopus 로고
    • The chemopreventive agent development research program in the division of cancer prevention of the US National Cancer Institute: an overview
    • Crowell J.A. The chemopreventive agent development research program in the division of cancer prevention of the US National Cancer Institute: an overview. European Journal of Cancer 2005, 41:1889-1910.
    • (2005) European Journal of Cancer , vol.41 , pp. 1889-1910
    • Crowell, J.A.1
  • 16
    • 5644283296 scopus 로고    scopus 로고
    • Role of chemopreventive agents in cancer therapy
    • Dorai T., Aggarwal B.B. Role of chemopreventive agents in cancer therapy. Cancer Letters 2004, 215:129-140.
    • (2004) Cancer Letters , vol.215 , pp. 129-140
    • Dorai, T.1    Aggarwal, B.B.2
  • 17
    • 84859364854 scopus 로고    scopus 로고
    • PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression
    • Dung T.D., Day C.H., Binh T.V., Lin C.H., Hsu H.H., Su C.C., Lin Y.M., Tsai F.J., Kuo W.W., Chen L.M., Huang C.Y. PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression. Food and Chemical Toxicology 2012, 50(5):1802-1810.
    • (2012) Food and Chemical Toxicology , vol.50 , Issue.5 , pp. 1802-1810
    • Dung, T.D.1    Day, C.H.2    Binh, T.V.3    Lin, C.H.4    Hsu, H.H.5    Su, C.C.6    Lin, Y.M.7    Tsai, F.J.8    Kuo, W.W.9    Chen, L.M.10    Huang, C.Y.11
  • 18
    • 0027818830 scopus 로고
    • Proliferating cell nuclear antigen: a marker for hepatocellular proliferation in rodents
    • Eldrige S.R., Butterworth B.E., Goldsworthy T.L. Proliferating cell nuclear antigen: a marker for hepatocellular proliferation in rodents. Environmental Health Perspectives 1993, 101:211-218.
    • (1993) Environmental Health Perspectives , vol.101 , pp. 211-218
    • Eldrige, S.R.1    Butterworth, B.E.2    Goldsworthy, T.L.3
  • 20
    • 0025370064 scopus 로고
    • Clonal adaptation during carcinogenesis
    • Farber E. Clonal adaptation during carcinogenesis. Biochemical Pharmacology 1990, 39:1837-1846.
    • (1990) Biochemical Pharmacology , vol.39 , pp. 1837-1846
    • Farber, E.1
  • 21
    • 0025775739 scopus 로고
    • Hepatocyte proliferation in stepwise development of experimental liver cell cancer
    • Farber E. Hepatocyte proliferation in stepwise development of experimental liver cell cancer. Digestive Diseases and Sciences 1991, 36:973-978.
    • (1991) Digestive Diseases and Sciences , vol.36 , pp. 973-978
    • Farber, E.1
  • 22
    • 0018873482 scopus 로고
    • The sequential analysis of cancer development
    • Farber E., Cameron R. The sequential analysis of cancer development. Advances in Cancer Research 1980, 35:125-226.
    • (1980) Advances in Cancer Research , vol.35 , pp. 125-226
    • Farber, E.1    Cameron, R.2
  • 23
    • 0023736832 scopus 로고
    • Analysis of DNA adducts in putative premalignant hepatic nodules and non-target tissues of rats during 2-acetylaminofluorene carcinogenesis
    • Gupta R.C., Earley K., Becker F.F. Analysis of DNA adducts in putative premalignant hepatic nodules and non-target tissues of rats during 2-acetylaminofluorene carcinogenesis. Cancer Research 1988, 48:5270-5274.
    • (1988) Cancer Research , vol.48 , pp. 5270-5274
    • Gupta, R.C.1    Earley, K.2    Becker, F.F.3
  • 25
    • 0027489384 scopus 로고
    • Clinical implications of the p53 tumor-suppressor gene
    • Harris C.C., Hollstein M. Clinical implications of the p53 tumor-suppressor gene. New England Journal of Medicine 1993, 329:1318-1327.
    • (1993) New England Journal of Medicine , vol.329 , pp. 1318-1327
    • Harris, C.C.1    Hollstein, M.2
  • 26
    • 0035342562 scopus 로고    scopus 로고
    • Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation
    • Hirahu Y., Yamashita N., Nishiguchi M., Kawanishi S. Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation. International Journal of Cancer 2001, 92:333-337.
    • (2001) International Journal of Cancer , vol.92 , pp. 333-337
    • Hirahu, Y.1    Yamashita, N.2    Nishiguchi, M.3    Kawanishi, S.4
  • 27
    • 33847281886 scopus 로고    scopus 로고
    • DNA damage, a biomarker of carcinogenesis: its measurement and modulation by diet and environment
    • Hwang E.S., Bowen P.E. DNA damage, a biomarker of carcinogenesis: its measurement and modulation by diet and environment. Critical Reviews in Food Science and Nutrition 2007, 47:27-50.
    • (2007) Critical Reviews in Food Science and Nutrition , vol.47 , pp. 27-50
    • Hwang, E.S.1    Bowen, P.E.2
  • 29
    • 33644629050 scopus 로고    scopus 로고
    • Immunohistochemistry of p53, Bcl-2, and Ki-67 as predictors of chemosensitivity
    • Itaya M., Yoshimoto J., Kojima K., Kawasaki S. Immunohistochemistry of p53, Bcl-2, and Ki-67 as predictors of chemosensitivity. Methods in Molecular Medicine 2005, 110:213-227.
    • (2005) Methods in Molecular Medicine , vol.110 , pp. 213-227
    • Itaya, M.1    Yoshimoto, J.2    Kojima, K.3    Kawasaki, S.4
  • 31
    • 0016151122 scopus 로고
    • Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4, bromobenzene oxide as the hepatotoxic intermediate
    • Jollow D.J., Mitchell J.R., Zampaglione N., Gillete J.R. Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4, bromobenzene oxide as the hepatotoxic intermediate. Pharmocology 1974, 11:151-169.
    • (1974) Pharmocology , vol.11 , pp. 151-169
    • Jollow, D.J.1    Mitchell, J.R.2    Zampaglione, N.3    Gillete, J.R.4
  • 33
    • 0026318356 scopus 로고
    • Participation of p53 protein in the cellular response to DNA damage
    • Kastan M.B., Onyekwere O., Sidransky D., et al. Participation of p53 protein in the cellular response to DNA damage. Cancer Research 1991, 51:6304-6311.
    • (1991) Cancer Research , vol.51 , pp. 6304-6311
    • Kastan, M.B.1    Onyekwere, O.2    Sidransky, D.3
  • 34
    • 0031427096 scopus 로고    scopus 로고
    • Benzoapyrene up-regulates cyclooxygenase-2 gene expression in oral epithelial cells
    • Kelley D.J., Mestre J.R., Subbaramaiah K., et al. Benzoapyrene up-regulates cyclooxygenase-2 gene expression in oral epithelial cells. Carcinogenesis 1997, 18:795-799.
    • (1997) Carcinogenesis , vol.18 , pp. 795-799
    • Kelley, D.J.1    Mestre, J.R.2    Subbaramaiah, K.3
  • 35
    • 0031045565 scopus 로고    scopus 로고
    • PCNA: structure, functions and interactions
    • Kelman Z. PCNA: structure, functions and interactions. Oncogene 1997, 14:629-640.
    • (1997) Oncogene , vol.14 , pp. 629-640
    • Kelman, Z.1
  • 37
    • 79958203399 scopus 로고    scopus 로고
    • Effect of Aegle marmelos on DEN initiated and 2-AAF promoted hepatocarcinogenesis: a chemopreventive study
    • Khan T.H., Sultana S. Effect of Aegle marmelos on DEN initiated and 2-AAF promoted hepatocarcinogenesis: a chemopreventive study. Toxicology Mechanisms and Methods 2011, 21(6):453-462.
    • (2011) Toxicology Mechanisms and Methods , vol.21 , Issue.6 , pp. 453-462
    • Khan, T.H.1    Sultana, S.2
  • 38
    • 34548015679 scopus 로고    scopus 로고
    • Protective effects of Cuscutae semen against diethylnitrosamine-induced acute liver injury in Sprague-Dawley rats
    • Kim E.Y., Kim E.K., Lee H.S., Sohn Y., Soh Y., Jung H.S., et al. Protective effects of Cuscutae semen against diethylnitrosamine-induced acute liver injury in Sprague-Dawley rats. Biological and Pharmaceutical Bulletin 2007, 30:1427-1431.
    • (2007) Biological and Pharmaceutical Bulletin , vol.30 , pp. 1427-1431
    • Kim, E.Y.1    Kim, E.K.2    Lee, H.S.3    Sohn, Y.4    Soh, Y.5    Jung, H.S.6
  • 40
    • 0029061367 scopus 로고
    • A metabolite of carcinogen 2-acetyl aminofluorene induces redox cycling in mitochondria
    • Klohn P.C., Massalha H., Neumann H.G. A metabolite of carcinogen 2-acetyl aminofluorene induces redox cycling in mitochondria. Biochimica et Biophysica Acta 1995, 1229:363-372.
    • (1995) Biochimica et Biophysica Acta , vol.1229 , pp. 363-372
    • Klohn, P.C.1    Massalha, H.2    Neumann, H.G.3
  • 41
    • 50649098449 scopus 로고    scopus 로고
    • Promotion of hepatocarcinogenesis in humans and animal models
    • Kohle C., Schwarz M., Bock K.W. Promotion of hepatocarcinogenesis in humans and animal models. Archives of Toxicology 2008, 82:623-631.
    • (2008) Archives of Toxicology , vol.82 , pp. 623-631
    • Kohle, C.1    Schwarz, M.2    Bock, K.W.3
  • 42
    • 77957003298 scopus 로고
    • Lactic dehydrogenase of muscle
    • Academic Press, New York
    • Korenberg A. Lactic dehydrogenase of muscle. Methods in Enzymology 1955, vol. I:441-443. Academic Press, New York.
    • (1955) Methods in Enzymology , vol.1 , pp. 441-443
    • Korenberg, A.1
  • 43
    • 0039728235 scopus 로고    scopus 로고
    • P53 represses CAAT enhancer-binding protein (C/EBP)-dependent transcription of the albumin gene. A molecular mechanism involved in viral liver infection with implications for hepatocarcinogenesis
    • Kubicka S., Kühnel F., Zender L., Rudolph K.L., Plümpe J., Manns M., Trautwein C. p53 represses CAAT enhancer-binding protein (C/EBP)-dependent transcription of the albumin gene. A molecular mechanism involved in viral liver infection with implications for hepatocarcinogenesis. Journal of Biological Chemistry 1999, 274:32137-32144.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 32137-32144
    • Kubicka, S.1    Kühnel, F.2    Zender, L.3    Rudolph, K.L.4    Plümpe, J.5    Manns, M.6    Trautwein, C.7
  • 44
    • 40949159866 scopus 로고    scopus 로고
    • Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype
    • Kumar B., Koul S., Khandrika L., Meacham R.B., Koul H.K. Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Research 2008, 68:1777-1785.
    • (2008) Cancer Research , vol.68 , pp. 1777-1785
    • Kumar, B.1    Koul, S.2    Khandrika, L.3    Meacham, R.B.4    Koul, H.K.5
  • 45
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane D.P. Cancer. p53, guardian of the genome. Nature 1992, 358:15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 46
    • 9644254191 scopus 로고    scopus 로고
    • Application of comparative functional genomics to identify best-fit mouse models to study human cancer
    • Lee J.S., Chu I.S., Mikaelyan A., Calvisi D.F., Heo J., Reddy J.K., et al. Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nature Genetics 2004, 36:1306-1311.
    • (2004) Nature Genetics , vol.36 , pp. 1306-1311
    • Lee, J.S.1    Chu, I.S.2    Mikaelyan, A.3    Calvisi, D.F.4    Heo, J.5    Reddy, J.K.6
  • 47
    • 34547838415 scopus 로고    scopus 로고
    • Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets
    • Lee J.C., Kundu J.K., Hwang D.M., Na H.K., Surh Y.J. Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. Carcinogenesis 2007, 28:1491-1498.
    • (2007) Carcinogenesis , vol.28 , pp. 1491-1498
    • Lee, J.C.1    Kundu, J.K.2    Hwang, D.M.3    Na, H.K.4    Surh, Y.J.5
  • 50
    • 1542507176 scopus 로고    scopus 로고
    • Expression and significance proliferating cell nuclear antigen in resistance of lithium carbonate to aflatoxins B1 induced hepatocarcinogenesis in rats
    • Lu S., Zhan A.H., Huang X.X., Ren Y.J. Expression and significance proliferating cell nuclear antigen in resistance of lithium carbonate to aflatoxins B1 induced hepatocarcinogenesis in rats. Alibian Jibian Tubian 2002, 14:84-86.
    • (2002) Alibian Jibian Tubian , vol.14 , pp. 84-86
    • Lu, S.1    Zhan, A.H.2    Huang, X.X.3    Ren, Y.J.4
  • 51
    • 0021752183 scopus 로고
    • Differential distribution of glutathione and glutathione related enzymes in rabbit kidney
    • Mohandas J., Marshall J.J., Duggin G.G., Horvath J.S., Tiller D. Differential distribution of glutathione and glutathione related enzymes in rabbit kidney. Cancer Research 1984, 44:5086-5091.
    • (1984) Cancer Research , vol.44 , pp. 5086-5091
    • Mohandas, J.1    Marshall, J.J.2    Duggin, G.G.3    Horvath, J.S.4    Tiller, D.5
  • 52
    • 50849132549 scopus 로고    scopus 로고
    • E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage
    • Moon N.S., Di Stefano L., Morris E.J., Patel R., White K., Dyson N.J. E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genetics 2008, 4:e1000153.
    • (2008) PLoS Genetics , vol.4
    • Moon, N.S.1    Di Stefano, L.2    Morris, E.J.3    Patel, R.4    White, K.5    Dyson, N.J.6
  • 53
    • 0037310736 scopus 로고    scopus 로고
    • Immunohisto-chemical studies on the expression of P-glycoprotein and p53 in relation to histological differentiation and cell proliferation in hepatocellular carcinoma
    • Nakano A., Watanabe N., Nishizaki Y., Takashimizu S., Matsuzaki S. Immunohisto-chemical studies on the expression of P-glycoprotein and p53 in relation to histological differentiation and cell proliferation in hepatocellular carcinoma. Hepatology Research 2003, 25:158-165.
    • (2003) Hepatology Research , vol.25 , pp. 158-165
    • Nakano, A.1    Watanabe, N.2    Nishizaki, Y.3    Takashimizu, S.4    Matsuzaki, S.5
  • 54
    • 0028271583 scopus 로고
    • Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma
    • Ng I.O., Lai E.C., Fan S.T., Ng M., Chan A.S., So M.K. Prognostic significance of proliferating cell nuclear antigen expression in hepatocellular carcinoma. Cancer 1994, 73:2268-2274.
    • (1994) Cancer , vol.73 , pp. 2268-2274
    • Ng, I.O.1    Lai, E.C.2    Fan, S.T.3    Ng, M.4    Chan, A.S.5    So, M.K.6
  • 55
    • 0028346995 scopus 로고
    • High performance liquid chromatographic determination of naturally occurring flavonoids in Citrus with a photodiode-ray detector
    • Nogata Y., Ohta H., Yoza K., Berhow M., Hasegawa S. High performance liquid chromatographic determination of naturally occurring flavonoids in Citrus with a photodiode-ray detector. Journal of Chromatography 1994, 667:59-66.
    • (1994) Journal of Chromatography , vol.667 , pp. 59-66
    • Nogata, Y.1    Ohta, H.2    Yoza, K.3    Berhow, M.4    Hasegawa, S.5
  • 56
    • 0016804041 scopus 로고
    • Induction of the polyamine biosynthetic enzymes in mouse epidermis by tumor promoting agents
    • O'Brien T.G., Simsiman R.C., Boutwell R.K. Induction of the polyamine biosynthetic enzymes in mouse epidermis by tumor promoting agents. Cancer Research 1975, 35:1662-1670.
    • (1975) Cancer Research , vol.35 , pp. 1662-1670
    • O'Brien, T.G.1    Simsiman, R.C.2    Boutwell, R.K.3
  • 57
    • 0036262191 scopus 로고    scopus 로고
    • Reduction of hepatocarcinogenesis by ursodeoxycholic acid in rats
    • Oyama K., Shiota G., Ito H., Murawaki Y., Kawasaki H. Reduction of hepatocarcinogenesis by ursodeoxycholic acid in rats. Carcinogenesis 2002, 23(5):885-892.
    • (2002) Carcinogenesis , vol.23 , Issue.5 , pp. 885-892
    • Oyama, K.1    Shiota, G.2    Ito, H.3    Murawaki, Y.4    Kawasaki, H.5
  • 59
    • 0033203308 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 protein, proliferation and apoptosis of oval cells in acetylaminofluorene induced rat liver regeneration
    • Park D.Y., Suh K.S. Transforming growth factor-beta1 protein, proliferation and apoptosis of oval cells in acetylaminofluorene induced rat liver regeneration. Journal of Korean Medical Science 1999, 14:531-538.
    • (1999) Journal of Korean Medical Science , vol.14 , pp. 531-538
    • Park, D.Y.1    Suh, K.S.2
  • 60
    • 0026353166 scopus 로고
    • Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine
    • Peto R., Gary R., Brantom P., Grasso P. Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine. Cancer Research 1991, 51:6452-6469.
    • (1991) Cancer Research , vol.51 , pp. 6452-6469
    • Peto, R.1    Gary, R.2    Brantom, P.3    Grasso, P.4
  • 61
    • 0019504929 scopus 로고
    • 2 production by chemically elicited peritoneal macrophages-induction by multiple non-phagocytic stimulus
    • 2 production by chemically elicited peritoneal macrophages-induction by multiple non-phagocytic stimulus. Cellular Immunology 1981, 59:301-308.
    • (1981) Cellular Immunology , vol.59 , pp. 301-308
    • Pick, A.1    Keisari, Y.2
  • 63
    • 66349129125 scopus 로고
    • Colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases
    • Reitman S., Frankel S.A. Colorimetric method for determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. American Journal of Clinical Pathology 1957, 28:56-63.
    • (1957) American Journal of Clinical Pathology , vol.28 , pp. 56-63
    • Reitman, S.1    Frankel, S.A.2
  • 65
    • 0033984235 scopus 로고    scopus 로고
    • The Ki-67 protein: from the known and the unknown
    • Scholzen T., Gerdes J. The Ki-67 protein: from the known and the unknown. Journal of Cellular Physiology 2000, 182:311-322.
    • (2000) Journal of Cellular Physiology , vol.182 , pp. 311-322
    • Scholzen, T.1    Gerdes, J.2
  • 66
    • 33747506594 scopus 로고    scopus 로고
    • Evaluation of possible mechanisms of protective role of Tamarix gallica against DEN initiated and 2-AAF promoted hepatocarcinogenesis in male Wistar rats
    • Sehrawat A., Sultana S. Evaluation of possible mechanisms of protective role of Tamarix gallica against DEN initiated and 2-AAF promoted hepatocarcinogenesis in male Wistar rats. Life Sciences 2006, 79(15):1456-1465.
    • (2006) Life Sciences , vol.79 , Issue.15 , pp. 1456-1465
    • Sehrawat, A.1    Sultana, S.2
  • 67
    • 33745228128 scopus 로고    scopus 로고
    • Chemoprevention by Butea monosperma of hepatic carcinogenesis and oxidative damage in male wistar rats
    • Sehrawat A., Sultana S. Chemoprevention by Butea monosperma of hepatic carcinogenesis and oxidative damage in male wistar rats. Asian Pacific Journal of Cancer Prevention: APJCP 2006, 7(1):140-148.
    • (2006) Asian Pacific Journal of Cancer Prevention: APJCP , vol.7 , Issue.1 , pp. 140-148
    • Sehrawat, A.1    Sultana, S.2
  • 68
    • 84857791346 scopus 로고    scopus 로고
    • Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats
    • Silambarasan T., Raja B. Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats. European Journal of Pharmacology 2012, 679(1-3):81-89.
    • (2012) European Journal of Pharmacology , vol.679 , Issue.1-3 , pp. 81-89
    • Silambarasan, T.1    Raja, B.2
  • 69
    • 0017166164 scopus 로고
    • A new principle for the analysis of chemical carcinogenesis
    • Solt D.B., Farber E. A new principle for the analysis of chemical carcinogenesis. Nature 1976, 263:701-703.
    • (1976) Nature , vol.263 , pp. 701-703
    • Solt, D.B.1    Farber, E.2
  • 70
    • 82055194290 scopus 로고    scopus 로고
    • Ameliorative effect of diosmin, a Citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats
    • Srinivasan S., Pari L. Ameliorative effect of diosmin, a Citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. Chemico-Biological Interactions 2012, 195(1):43-51.
    • (2012) Chemico-Biological Interactions , vol.195 , Issue.1 , pp. 43-51
    • Srinivasan, S.1    Pari, L.2
  • 71
    • 0029783253 scopus 로고    scopus 로고
    • Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells
    • Subbaramaiah K., Telang N., Ramonetti J.T., et al. Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells. Cancer Research 1996, 56:4424-4429.
    • (1996) Cancer Research , vol.56 , pp. 4424-4429
    • Subbaramaiah, K.1    Telang, N.2    Ramonetti, J.T.3
  • 72
    • 44149108886 scopus 로고    scopus 로고
    • Emblica officinalis and hepatocarcinogenesis: a chemopreventive study in Wistar rats
    • Sultana S., Ahmed S., Jahangir T. Emblica officinalis and hepatocarcinogenesis: a chemopreventive study in Wistar rats. Journal of Ethnopharmacology 2008, 118(1):1-6.
    • (2008) Journal of Ethnopharmacology , vol.118 , Issue.1 , pp. 1-6
    • Sultana, S.1    Ahmed, S.2    Jahangir, T.3
  • 73
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh Y.J. Cancer chemoprevention with dietary phytochemicals. Nature Reviews. Cancer 2003, 3:768-780.
    • (2003) Nature Reviews. Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 74
    • 0035651290 scopus 로고    scopus 로고
    • Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer
    • Surh Y.J., Na H.K., Lee J.Y., Keum Y.S. Molecular mechanisms underlying anti-tumor promoting activities of heat-processed Panax ginseng C.A. Meyer. Journal of Korean Medical Science 2001, 16:S38-S41.
    • (2001) Journal of Korean Medical Science , vol.16
    • Surh, Y.J.1    Na, H.K.2    Lee, J.Y.3    Keum, Y.S.4
  • 75
    • 31544441350 scopus 로고    scopus 로고
    • Redox-sensitive transcription factors asprime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals
    • Surh Y.J., Kundu J.K., Na H.K., Lee J.S. Redox-sensitive transcription factors asprime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals. Journal of Nutrition 2005, 135:2993-3001.
    • (2005) Journal of Nutrition , vol.135 , pp. 2993-3001
    • Surh, Y.J.1    Kundu, J.K.2    Na, H.K.3    Lee, J.S.4
  • 76
    • 77954427466 scopus 로고    scopus 로고
    • Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet)
    • Taha M.M., Abdul A.B., Abdullah R., Ibrahim T.A., Abdelwahab S.I., Mohan S. Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chemico-Biological Interactions 2010, 186(3):295-305.
    • (2010) Chemico-Biological Interactions , vol.186 , Issue.3 , pp. 295-305
    • Taha, M.M.1    Abdul, A.B.2    Abdullah, R.3    Ibrahim, T.A.4    Abdelwahab, S.I.5    Mohan, S.6
  • 78
    • 0029780653 scopus 로고    scopus 로고
    • N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation. DNA-adduct formation, mutagenicity, and tumor initiation
    • Verna L., Whysner J., Williams G.M. N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation. DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacology and Therapeutics 1996, 71:57-81.
    • (1996) Pharmacology and Therapeutics , vol.71 , pp. 57-81
    • Verna, L.1    Whysner, J.2    Williams, G.M.3
  • 79
    • 0026601982 scopus 로고
    • Carcinogens leave fingerprints
    • Vogelstein B., Kinzler K.W. Carcinogens leave fingerprints. Nature 1992, 355:209-210.
    • (1992) Nature , vol.355 , pp. 209-210
    • Vogelstein, B.1    Kinzler, K.W.2
  • 80
    • 33745441439 scopus 로고    scopus 로고
    • Arabidopsis ribonucleotide reductases are critical for cell cycle progression. DNA damage repair, and plant development
    • Wang C., Liu Z. Arabidopsis ribonucleotide reductases are critical for cell cycle progression. DNA damage repair, and plant development. Plant Cell 2006, 18:350-365.
    • (2006) Plant Cell , vol.18 , pp. 350-365
    • Wang, C.1    Liu, Z.2
  • 81
    • 0034113808 scopus 로고    scopus 로고
    • Primary prevention of hepatocellular carcinoma in developing countries
    • Wild C.P., Hall A.J. Primary prevention of hepatocellular carcinoma in developing countries. Mutation Research 2000, 462:381-393.
    • (2000) Mutation Research , vol.462 , pp. 381-393
    • Wild, C.P.1    Hall, A.J.2
  • 82
    • 0019475281 scopus 로고
    • Cytosolic factors that affect microsomal lipid peroxidation in lung and liver
    • Wright J.R., Colby H.D., Miles P.R. Cytosolic factors that affect microsomal lipid peroxidation in lung and liver. Archives of Biochemistry and Biophysics 1981, 206:296-304.
    • (1981) Archives of Biochemistry and Biophysics , vol.206 , pp. 296-304
    • Wright, J.R.1    Colby, H.D.2    Miles, P.R.3
  • 83
    • 84875909501 scopus 로고    scopus 로고
    • Expression of Ki 67 in hepatocellular carcinoma induced by diethylnitrosamine in mice and its correlation with histopathological alterations
    • Youssef M.I., Maghraby H., Youssef E.A., El-Sayed M.M. Expression of Ki 67 in hepatocellular carcinoma induced by diethylnitrosamine in mice and its correlation with histopathological alterations. Journal of Applied Pharmaceutical Science 2012, 2(3):52-59.
    • (2012) Journal of Applied Pharmaceutical Science , vol.2 , Issue.3 , pp. 52-59
    • Youssef, M.I.1    Maghraby, H.2    Youssef, E.A.3    El-Sayed, M.M.4
  • 84
    • 0347997608 scopus 로고    scopus 로고
    • MAPK signal pathways in the regulation of cell proliferation in mammalian cells
    • Zhang W., Liu H.T. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Research 2002, 12(1):9-18.
    • (2002) Cell Research , vol.12 , Issue.1 , pp. 9-18
    • Zhang, W.1    Liu, H.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.