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Volumn 2, Issue 3, 2012, Pages 52-59

Expression of Ki 67 in hepatocellular carcinoma induced by diethylnitrosamine in mice and its correlation with histopathological alterations

Author keywords

DEN; HCC; Histopathology and immunohistochemistry; Ki 67

Indexed keywords


EID: 84875909501     PISSN: None     EISSN: 22313354     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (24)

References (55)
  • 1
    • 0035019334 scopus 로고    scopus 로고
    • Hepatic fibrosis. Pathogenesis and principles of therapy
    • Albanis E, Friedman SL. Hepatic fibrosis. Pathogenesis and principles of therapy. Clin Liver Dis. 2001; 5(2): 315-334.
    • (2001) Clin Liver Dis. , vol.5 , Issue.2 , pp. 315-334
    • Albanis, E.1    Friedman, S.L.2
  • 7
    • 26844540048 scopus 로고    scopus 로고
    • Proton-induced X-ray emission (PIXE) analysis and DNA-chain break study in rat hepatocarcinogenesis: A possible chemopreventive role by combined supplementation of vanadium and beta-carotene
    • Chattopadhyay MB, Mukherjee S, Kulkarni I, VijayanV, Doloi M, Kanjilal NB and Chatterjee M. Proton-induced X-ray emission (PIXE) analysis and DNA-chain break study in rat hepatocarcinogenesis: A possible chemopreventive role by combined supplementation of vanadium and beta-carotene. Cancer Cell International. 2005, 5:16-24.
    • (2005) Cancer Cell International. , vol.5 , pp. 16-24
    • Chattopadhyay, M.B.1    Mukherjee, S.2    Kulkarni, I.3    Vijayan, V.4    Doloi, M.5    Kanjilal, N.B.6    Chatterjee, M.7
  • 8
    • 16244416190 scopus 로고    scopus 로고
    • Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis
    • Clouston AD, Powell EE, Walsh MJ, Richardson MM, Demetris AJ, Jonsson JR. Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis. Hepatol. 2005; 41(4):809-818.
    • (2005) Hepatol , vol.41 , Issue.4 , pp. 809-818
    • Clouston, A.D.1    Powell, E.E.2    Walsh, M.J.3    Richardson, M.M.4    Demetris, A.J.5    Jonsson, J.R.6
  • 9
    • 0031708626 scopus 로고    scopus 로고
    • Clinical relevance of transforming growth factor alpha, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors
    • De-Jong KP, Stellema R, Karrenbeld A, Koudstaal J, Gouw AS, Sluiter WJ, Peeters PM, Slooff MJ, De-Vries EG.: Clinical relevance of transforming growth factor alpha, epidermal growth factor receptor, p53, and Ki67 in colorectal liver metastases and corresponding primary tumors. Hepatol. 1998; 28: 971-979.
    • (1998) Hepatol. , vol.28 , pp. 971-979
    • De-Jong, K.P.1    Stellema, R.2    Karrenbeld, A.3    Koudstaal, J.4    Gouw, A.S.5    Sluiter, W.J.6    Peeters, P.M.7    Slooff, M.J.8    De-Vries, E.G.9
  • 11
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterol. 2007; 132(7): 2557-2576.
    • (2007) Gastroenterol. , vol.132 , Issue.7 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 12
    • 58649100690 scopus 로고    scopus 로고
    • Membranous and cytoplasmic staining of Ki67 is associated with HER2 and ER status in invasive breast carcinoma
    • Faratian D, Munro A, Twelves C, Bartlett JM. Membranous and cytoplasmic staining of Ki67 is associated with HER2 and ER status in invasive breast carcinoma. Histopathology. 2009; 54(1): 254-257.
    • (2009) Histopathology. , vol.54 , Issue.1 , pp. 254-257
    • Faratian, D.1    Munro, A.2    Twelves, C.3    Bartlett, J.M.4
  • 13
    • 0032847564 scopus 로고    scopus 로고
    • Mouse liver tumorigenesis: models, mechanisms, and relevance to human disease
    • Fausto N. Mouse liver tumorigenesis: models, mechanisms, and relevance to human disease. Semin Liver Dis. 1999; 19: 243-252.
    • (1999) Semin Liver Dis. , vol.19 , pp. 243-252
    • Fausto, N.1
  • 15
    • 69249105411 scopus 로고    scopus 로고
    • Measuring Microenvironment mechanical stress of rat liver during diethylnitrosamine induced hepatocarcinogenesis by atomic force microscope
    • Gang Z, Qi Q, Jing C, Wang C,. Measuring Microenvironment mechanical stress of rat liver during diethylnitrosamine induced hepatocarcinogenesis by atomic force microscope. Microsc Res Tech. 2009; 72(9):672-678.
    • (2009) Microsc Res Tech. , vol.72 , Issue.9 , pp. 672-678
    • Gang, Z.1    Qi, Q.2    Jing, C.3    Wang, C.4
  • 16
    • 0030004852 scopus 로고    scopus 로고
    • Glycoprotein metabolism in dimethylnitrosamine induced hepatic fibrosis in rats
    • George J, Chandrakasan G. Glycoprotein metabolism in dimethylnitrosamine induced hepatic fibrosis in rats. Int J Biochem Cell Biol. 1996; 28(3): 353-361.
    • (1996) Int J Biochem Cell Biol. , vol.28 , Issue.3 , pp. 353-361
    • George, J.1    Chandrakasan, G.2
  • 17
    • 0036581372 scopus 로고    scopus 로고
    • MIB-1, p53, bcl-2, and WAF-1 expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas: correlation with clinical outcome
    • Graflund M, Sorbe B, Karlsson M: MIB-1, p53, bcl-2, and WAF-1 expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas: correlation with clinical outcome. Int J Oncol. 2002; 20: 1041-1047.
    • (2002) Int J Oncol. , vol.20 , pp. 1041-1047
    • Graflund, M.1    Sorbe, B.2    Karlsson, M.3
  • 18
    • 33745760839 scopus 로고    scopus 로고
    • Noninvasive biochemical markers of liver fibrosis
    • Grigorescu M. Noninvasive biochemical markers of liver fibrosis. J Gastrointestin Liver Dis.2006; 15(2):149-159.
    • (2006) J Gastrointestin Liver Dis. , vol.15 , Issue.2 , pp. 149-159
    • Grigorescu, M.1
  • 20
    • 34447284943 scopus 로고    scopus 로고
    • Liver regeneration is suppressed in alcoholic cirrhosis: Correlation with decreased STAT3 activation
    • Horiguchi N, Ishac EJ, Gao B: Liver regeneration is suppressed in alcoholic cirrhosis: Correlation with decreased STAT3 activation. Alcohol. 2007; 41(4):271-280.
    • (2007) Alcohol. , vol.41 , Issue.4 , pp. 271-280
    • Horiguchi, N.1    Ishac, E.J.2    Gao, B.3
  • 23
    • 27444435278 scopus 로고    scopus 로고
    • Hepatic expression of the proliferative marker Ki-67 and p53 protein in HBV or HCV cirrhosis in relation to dysplastic liver cell changes and hepatocellular carcinoma
    • Koskinas J, Petraki K, Kavantzas N, Rapti I, Kountouras D, Hadziyannis S. Hepatic expression of the proliferative marker Ki-67 and p53 protein in HBV or HCV cirrhosis in relation to dysplastic liver cell changes and hepatocellular carcinoma. J Viral Hepat.2005; 12(6): 635-641.
    • (2005) J Viral Hepat. , vol.12 , Issue.6 , pp. 635-641
    • Koskinas, J.1    Petraki, K.2    Kavantzas, N.3    Rapti, I.4    Kountouras, D.5    Hadziyannis, S.6
  • 24
    • 0043282657 scopus 로고    scopus 로고
    • Chemopreventive effect of garlic powder diet in diethylnitrosamine-induced rat hepatocarcinogenesis
    • Kweon S, Park KA, Choi H: Chemopreventive effect of garlic powder diet in diethylnitrosamine-induced rat hepatocarcinogenesis. Life Sci. 2003; 73: 2515-2526.
    • (2003) Life Sci. , vol.73 , pp. 2515-2526
    • Kweon, S.1    Park, K.A.2    Choi, H.3
  • 25
    • 0034781449 scopus 로고    scopus 로고
    • Diethylnitrosamine causes pituitary damage, disturbs hormone levels, and reduces sexual dimorphism of certain liver functions in the rat
    • Liao DJ, Blanck A, Eneroth P, Gustafsson JÅ, Hällström IP: Diethylnitrosamine causes pituitary damage, disturbs hormone levels, and reduces sexual dimorphism of certain liver functions in the rat. Environ Health Perspect. 2001; 109 (9): 943-947.
    • (2001) Environ Health Perspect. , vol.109 , Issue.9 , pp. 943-947
    • Liao, D.J.1    Blanck, A.2    Eneroth, P.3    Gustafsson, J.Å.4    Hällström, I.P.5
  • 26
    • 34548493192 scopus 로고    scopus 로고
    • Effect of Qiprotecting powder (Huqi San) on expression of c-jun, c-fos and c-myc in diethylnitrosamine-mediated hepatocarcinogenesis
    • Li X, Shi ZM, Fing P, Wen ZY, Wang XJ. Effect of Qiprotecting powder (Huqi San) on expression of c-jun, c-fos and c-myc in diethylnitrosamine-mediated hepatocarcinogenesis. World J Gastroenterol. 2007; 13: 4192-4198.
    • (2007) World J Gastroenterol. , vol.13 , pp. 4192-4198
    • Li, X.1    Shi, Z.M.2    Fing, P.3    Wen, Z.Y.4    Wang, X.J.5
  • 27
    • 0033999201 scopus 로고    scopus 로고
    • Immunohistochemical stud y on p53, H-rasp21, c-erbB-2 protein and PCNA expression in HCC tissues of Han and minority ethnic patients
    • Lin GY, Chen ZL, Lu CM, Li Y, Ping XJ, Huang R Immunohistochemical stud y on p53, H-rasp21, c-erbB-2 protein and PCNA expression in HCC tissues of Han and minority ethnic patients. World J Gastroenterol. 2000; 6(2): 234-238.
    • (2000) World J Gastroenterol. , vol.6 , Issue.2 , pp. 234-238
    • Lin, G.Y.1    Chen, Z.L.2    Lu, C.M.3    Li, Y.4    Ping, X.J.5    Huang, R.6
  • 28
    • 33645960124 scopus 로고    scopus 로고
    • Therapeutic strategies against TGF beta signaling pathway in hepatic fibrosis
    • Liu X, Hu H, Yin JQ. Therapeutic strategies against TGF beta signaling pathway in hepatic fibrosis. Liver Int. 2006; 26(1):8-22.
    • (2006) Liver Int. , vol.26 , Issue.1 , pp. 8-22
    • Liu, X.1    Hu, H.2    Yin, J.Q.3
  • 29
    • 54449083925 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • Llovet JM, Bruix J. Molecular targeted therapies in hepatocellular carcinoma. Hepatology (Baltimore, Md) 2008; 48(4):1312-1327.
    • (2008) Hepatology (Baltimore, Md) , vol.48 , Issue.4 , pp. 1312-1327
    • Llovet, J.M.1    Bruix, J.2
  • 30
    • 0141491273 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003; 362(9399):1907-1917.
    • (2003) Lancet , vol.362 , Issue.9399 , pp. 1907-1917
    • Llovet, J.M.1    Burroughs, A.2    Bruix, J.3
  • 31
    • 20044380746 scopus 로고    scopus 로고
    • An inhibitor of cyclin-dependent kinase, stress-induced p21(Waf-1/Cip-1), mediates hepatocyte mito-inhibition during the evolution of cirrhosis
    • Lunz JG 3rd, Tsuji H, Nozaki I, Murase N, Demetris AJ An inhibitor of cyclin-dependent kinase, stress-induced p21(Waf-1/Cip-1), mediates hepatocyte mito-inhibition during the evolution of cirrhosis. Hepatol 2005; 41(6):1262-1271.
    • (2005) Hepatol , vol.41 , Issue.6 , pp. 1262-1271
    • Lunz, J.G.1    Tsuji, H.2    Nozaki, I.3    Murase, N.4    Demetris, A.J.5
  • 32
    • 21244472975 scopus 로고    scopus 로고
    • IK K beta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IK K beta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell. 2005; 121(7): 977-990.
    • (2005) Cell. , vol.121 , Issue.7 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 34
    • 1642473193 scopus 로고    scopus 로고
    • The poor responsiveness of infiltrating lobular breast carcinomas to neoadjuvant chemotherapy can be explained by their biological profile
    • Mathieu MC: The poor responsiveness of infiltrating lobular breast carcinomas to neoadjuvant chemotherapy can be explained by their biological profile. Eur J Cancer. 2004; 40: 342-351.
    • (2004) Eur J Cancer. , vol.40 , pp. 342-351
    • Mathieu, M.C.1
  • 36
  • 37
    • 0027323616 scopus 로고
    • Navas-Palacios: Proliferating cell nuclear antigen expression in normal, regenerative, and neoplastic liver: a fine-needle aspiration
    • Ojanguren I, Ariza A, Llatjos M, Castellá E, Mate JI, Navas-Palacios: Proliferating cell nuclear antigen expression in normal, regenerative, and neoplastic liver: a fine-needle aspiration. Human Pathol. 1993; 24: 905-908.
    • (1993) Human Pathol. , vol.24 , pp. 905-908
    • Ojanguren, I.1    Ariza, A.2    Llatjos, M.3    Castellá, E.4    Mate, J.I.5
  • 39
    • 0034812370 scopus 로고    scopus 로고
    • Proliferative and apoptotic activity in hepatocellular carcinoma and surrounding nonneoplastic liver tissue Pflugers
    • Pizem J, Marolt VF, Luzar B, Cor A. Proliferative and apoptotic activity in hepatocellular carcinoma and surrounding nonneoplastic liver tissue Pflugers Arch. 2001; 442(6): 174-176.
    • (2001) Arch , vol.442 , Issue.6 , pp. 174-176
    • Pizem, J.1    Marolt, V.F.2    Luzar, B.3    Cor, A.4
  • 40
    • 0028030221 scopus 로고
    • DNA adduct measurements and tumor incidence during chronic carcinogen exposure in rodents
    • Poirier MC, Beland FA: DNA adduct measurements and tumor incidence during chronic carcinogen exposure in rodents. Environ Health Perspect. 1994; 102: 161-165.
    • (1994) Environ Health Perspect. , vol.102 , pp. 161-165
    • Poirier, M.C.1    Beland, F.A.2
  • 41
    • 0036280651 scopus 로고    scopus 로고
    • The prognostic molecular markers in hepatocellular carcinoma
    • Qin LX, Tang ZY. The prognostic molecular markers in hepatocellular carcinoma. World J Gastroenterol. 2002; 8: 385-392.
    • (2002) World J Gastroenterol. , vol.8 , pp. 385-392
    • Qin, L.X.1    Tang, Z.Y.2
  • 42
    • 33646828371 scopus 로고    scopus 로고
    • Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats
    • Ramakrishnan G, Raghavendran HR, Vinodhkumar R, Devaki T: Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chem Biol Interact. 2006; 161: 104-114.
    • (2006) Chem Biol Interact. , vol.161 , pp. 104-114
    • Ramakrishnan, G.1    Raghavendran, H.R.2    Vinodhkumar, R.3    Devaki, T.4
  • 44
    • 84855474176 scopus 로고    scopus 로고
    • Diethylnitrosamineinduced hepatocarcinogenesis in rats: possible chemoprevention by blueberries
    • Sadik NA, El-Maraghy SA, Ismail MF. Diethylnitrosamineinduced hepatocarcinogenesis in rats: possible chemoprevention by blueberries. African Journal of Biochemistry. 2008; 2(3): 81-87.
    • (2008) African Journal of Biochemistry. , vol.2 , Issue.3 , pp. 81-87
    • Sadik, N.A.1    El-Maraghy, S.A.2    Ismail, M.F.3
  • 47
    • 0033984235 scopus 로고    scopus 로고
    • The Ki-67 protein: from the known and the unknown
    • Scholzen T, Gerdes J: The Ki-67 protein: from the known and the unknown. J Cell Physiol. 2000; 182: 311-322.
    • (2000) J Cell Physiol. , vol.182 , pp. 311-322
    • Scholzen, T.1    Gerdes, J.2
  • 49
    • 0242329867 scopus 로고    scopus 로고
    • Analysis of Ki-67 antigen expression, DNA proliferative fraction, and survival in resected cancer of the pancreas
    • Stanton KJ, Sidner RA, Miller GA: Analysis of Ki-67 antigen expression, DNA proliferative fraction, and survival in resected cancer of the pancreas Am J Surg. 2003; 186: 486-492.
    • (2003) Am J Surg. , vol.186 , pp. 486-492
    • Stanton, K.J.1    Sidner, R.A.2    Miller, G.A.3
  • 51
    • 0026634766 scopus 로고
    • Kuni:Development of hepatocellular carcinoma associated increases in DNA synthesis in the surrounding cirrhosis
    • Tarao K, Shimizu A, Ohkawa S, Harada M, Ito Y, Tamai S, Kuni: Development of hepatocellular carcinoma associated increases in DNA synthesis in the surrounding cirrhosis. Gastroenterology. 1992; 103: 595-600.
    • (1992) Gastroenterology. , vol.103 , pp. 595-600
    • Tarao, K.1    Shimizu, A.2    Ohkawa, S.3    Harada, M.4    Ito, Y.5    Tamai, S.6
  • 52
    • 0038687703 scopus 로고    scopus 로고
    • Prevention of dual promoting effects of pentachlorophenol, an environmental pollutant, on diethylnitrosamineinduced hepato-and cholangio carcinogenesis in mice by green teainfusion
    • Umemura, T, Kai S, Hasegawa R, Keita K, Kitamura Y, Nishikawa A, Hirose M Prevention of dual promoting effects of pentachlorophenol, an environmental pollutant, on diethylnitrosamineinduced hepato-and cholangio carcinogenesis in mice by green teainfusion. Carcinogenesis, 2003; 24(6): 1105-1109.
    • (2003) Carcinogenesis , vol.24 , Issue.6 , pp. 1105-1109
    • Umemura, T.1    Kai, S.2    Hasegawa, R.3    Keita, K.4    Kitamura, Y.5    Nishikawa, A.6    Hirose, M.7
  • 53
    • 0029780653 scopus 로고
    • N-nitrosodiethylamine mechanistic data and risk asseessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation
    • Verna L, Whysner J, Williams GM: N-nitrosodiethylamine mechanistic data and risk asseessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther. 1994; 71: 57-58.
    • (1994) Pharmacol Ther. , vol.71 , pp. 57-58
    • Verna, L.1    Whysner, J.2    Williams, G.M.3
  • 54
    • 34548354613 scopus 로고    scopus 로고
    • Chemo-preventive effect of star anise in N-nitrosodiethylamine initiated and phenobarbital promoted hepatocarcinogenesis
    • Yadav AS, Bhatnagar D: Chemo-preventive effect of star anise in N-nitrosodiethylamine initiated and phenobarbital promoted hepatocarcinogenesis. Chem Biol Interact. 2007; 169: 207-214.
    • (2007) Chem Biol Interact. , vol.169 , pp. 207-214
    • Yadav, A.S.1    Bhatnagar, D.2
  • 55
    • 0033755731 scopus 로고    scopus 로고
    • Dedifferentiation of human hepatocellular carcinoma up-regulates telomerase and Ki-67 expression
    • Yeh TS, Chen TC, Chen MF. Dedifferentiation of human hepatocellular carcinoma up-regulates telomerase and Ki-67 expression. Arch Surg. 2000; 135(11):1334-1339.
    • (2000) Arch Surg. , vol.135 , Issue.11 , pp. 1334-1339
    • Yeh, T.S.1    Chen, T.C.2    Chen, M.F.3


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