Impact of linker and conjugation chemistry on antigen binding, Fc receptor binding and thermal stability of model antibody-drug conjugates

mAbs

Volumn 4, Issue 3, 2012, Pages 362-372

  Acchione, Mauro ^a   Kwon, Hyewon ^a   Jochheim, Claudia M ^b   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b CMC Consulting   (United States)

Author keywords

Amine; Carbohydrate; CD32b; Conjugate; DSC; Fc; Linker; SPR; Thermostability; Thiol

Indexed keywords

AMINE; ANTIBODY CONJUGATE; BIOTIN; CARBOHYDRATE; FC RECEPTOR; FC RECEPTOR IIB; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; PROTEIN A; PROTEIN G; THIOL;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONJUGATION; DIFFERENTIAL SCANNING CALORIMETRY; MOLECULAR INTERACTION; RECEPTOR BINDING; SURFACE PLASMON RESONANCE; THERMOSTABILITY;

EID: 84860893742     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.19449     Document Type: Article

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