메뉴 건너뛰기




Volumn 13, Issue 14, 2012, Pages 1757-1771

Ascorbic acid in cancer chemoprevention: Translational perspectives and efficacy

Author keywords

Ascorbic acid; Chemoprevention; Phytochemicals

Indexed keywords

ALPHA TOCOPHEROL; ARSENIC TRIOXIDE; ASCORBIC ACID; ASPARAGINASE; BLEOMYCIN; BORTEZOMIB; CISPLATIN; CREATINE; CYCLOPHOSPHAMIDE; DOXORUBICIN; ERLOTINIB; ETHYLNITROSOUREA; FLUOROURACIL; GEMCITABINE; MELPHALAN; METHOTREXATE; METHYLGLYOXAL; PACLITAXEL; PLACEBO; PROCARBAZINE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VINBLASTINE; VINCRISTINE;

EID: 84879307951     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945012804545669     Document Type: Article
Times cited : (26)

References (172)
  • 1
    • 77954251791 scopus 로고    scopus 로고
    • World Health Organization, February, Accessed March 30, 2012
    • World Health Organization. Cancer fact sheet. February 2011. Accessed March 30, 2012. http://www.who.int/mediacentre/fact sheets/fs297/en/ index.html.
    • (2011) Cancer Fact Sheet
  • 2
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 0019829568 scopus 로고
    • The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today
    • Doll R, Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 1981; 66: 1191-1308.
    • (1981) J Natl Cancer Inst , vol.66 , pp. 1191-1308
    • Doll, R.1    Peto, R.2
  • 4
    • 0034331551 scopus 로고    scopus 로고
    • Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers
    • Michels KB, Givannucci E, Joshipura KJ, et al. Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. J Natl Cancer Inst 2000; 92: 1740-1752.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1740-1752
    • Michels, K.B.1    Givannucci, E.2    Joshipura, K.J.3
  • 5
    • 0033590959 scopus 로고    scopus 로고
    • Criteria and recommendations for vitamin C intake
    • Levine M, Rumsey SC, Daruwala R, Park JB, Wang Y. Criteria and recommendations for vitamin C intake. JAMA 1999; 281: 1415-1423.
    • (1999) JAMA , vol.281 , pp. 1415-1423
    • Levine, M.1    Rumsey, S.C.2    Daruwala, R.3    Park, J.B.4    Wang, Y.5
  • 6
    • 0021073686 scopus 로고
    • Protective effect of citrus fruit on esophageal cancer
    • Tuyns A. Protective effect of citrus fruit on esophageal cancer. Nutr Cancer 1983; 5: 195-200.
    • (1983) Nutr Cancer , vol.5 , pp. 195-200
    • Tuyns, A.1
  • 8
    • 0018669229 scopus 로고
    • Failure of high-dose Vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer: A controlled trial
    • Creagen ET, Moertal CG, O'Fallon JR, et al. Failure of high-dose Vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer: a controlled trial. New England J Med 1979; 301: 687-690.
    • (1979) New England J Med , vol.301 , pp. 687-690
    • Creagen, E.T.1    Moertal, C.G.2    O'Fallon, J.R.3
  • 9
    • 0021955675 scopus 로고
    • High-dose Vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy: A randomized double blind comparison
    • Moertal CG, Fleming TR, Creagen ET, Rubin AJ, O'Connell MJ, Ames MM. High-dose Vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy: a randomized double blind comparison. New England J Med 1985; 312: 137-141
    • (1985) New England J Med , vol.312 , pp. 137-141
    • Moertal, C.G.1    Fleming, T.R.2    Creagen, E.T.3    Rubin, A.J.4    O'Connell, M.J.5    Ames, M.M.6
  • 11
    • 0003535322 scopus 로고
    • A treatise of the scurvy
    • Reprinted. C. P. Stewart and D. Guthrie (eds.). Edinburgh: Edinburgh University Press
    • Lind J. A treatise of the scurvy. Edinburgh: Sands, Murray and Cochrane, 1753. Reprinted. C. P. Stewart and D. Guthrie (eds.). Edinburgh: Edinburgh University Press, 1953.
    • (1953) Edinburgh: Sands, Murray and Cochrane, 1753
    • Lind, J.1
  • 12
    • 0000645314 scopus 로고
    • Observations of the functions of peroxidase systems and the chemistry of the adrenal cortex
    • Szent-GyOrgyi, A. Observations of the functions of peroxidase systems and the chemistry of the adrenal cortex. Biochem J 1928; 22: 1387-1409.
    • (1928) Biochem J , vol.22 , pp. 1387-1409
    • Szent-Gyorgyi, A.1
  • 14
    • 84891421720 scopus 로고
    • Cancer: The preconditioning factor in pathogenesis
    • McCormick WJ. Cancer: the preconditioning factor in pathogenesis. Arch Pediatr 1954; 71: 313-322.
    • (1954) Arch Pediatr , vol.71 , pp. 313-322
    • McCormick, W.J.1
  • 15
    • 0008465610 scopus 로고
    • Cancer: A collagen disease, secondary to a nutritional deficiency?
    • McCormick WJ. Cancer: a collagen disease, secondary to a nutritional deficiency? Arch Pediatr 1959; 76: 166-171.
    • (1959) Arch Pediatr , vol.76 , pp. 166-171
    • McCormick, W.J.1
  • 16
    • 0018757414 scopus 로고
    • Linus Pauling and Brian Leibovitz. Ascorbic Acid and Cancer: A Review
    • Ewan Cameron, Linus Pauling and Brian Leibovitz. Ascorbic Acid and Cancer: A Review. Cancer Res 1979; 39: 663-681.
    • (1979) Cancer Res , vol.39 , pp. 663-681
    • Cameron, E.1
  • 17
    • 0026077980 scopus 로고
    • Vitamin C and cancer prevention: The epidemiologic evidence
    • Gladiis Block. Vitamin C and cancer prevention: the epidemiologic evidence. Am J Clin Nutr 1991; 53: 270S-82S.
    • (1991) Am J Clin Nutr , vol.53
    • Block, G.1
  • 18
    • 0032087594 scopus 로고    scopus 로고
    • Head. Ascorbic Acid in the Prevention and Treatment of Cancer
    • Kathleen A. Head. Ascorbic Acid in the Prevention and Treatment of Cancer. Altern Med Rev 1998; 3(3): 174-186
    • (1998) Altern Med Rev , vol.3 , Issue.3 , pp. 174-186
    • Kathleen, A.1
  • 19
    • 0035799105 scopus 로고    scopus 로고
    • Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: A prospective population study
    • Khaw KT, Bingham S, Welch A. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. Lancet 2001; 357: 657-663.
    • (2001) Lancet , vol.357 , pp. 657-663
    • Khaw, K.T.1    Bingham, S.2    Welch, A.3
  • 20
    • 0025977141 scopus 로고
    • Gastric juice ascorbic acid: Effects of disease and implications for gastric carcinogenesis
    • Schorah CJ, Sobala M, Collis N, Primrose JN. Gastric juice ascorbic acid: effects of disease and implications for gastric carcinogenesis. Am J Clin Nutr 1991; 53: 287S-293S.
    • (1991) Am J Clin Nutr , vol.53
    • Schorah, C.J.1    Sobala, M.2    Collis, N.3    Primrose, J.N.4
  • 21
    • 0025982018 scopus 로고
    • Levels of nitrite, nitrate, N-nitroso compounds, ascorbic acid in gastric juice of patients with and without precancerous conditions of the stomach
    • Sobala GM, Pignaetelli B, Schorah CJ, et al. Levels of nitrite, nitrate, N-nitroso compounds, ascorbic acid in gastric juice of patients with and without precancerous conditions of the stomach. Carcinogenesis 1991; 12: 193-18.
    • (1991) Carcinogenesis , vol.12 , pp. 193-218
    • Sobala, G.M.1    Pignaetelli, B.2    Schorah, C.J.3
  • 22
    • 0029983192 scopus 로고    scopus 로고
    • Ascorbic acid may protect against human gastric cancer by scavenging mucosal oxygen radicals
    • Drake IM, Davies MJ, Mapstone NP, et al. Ascorbic acid may protect against human gastric cancer by scavenging mucosal oxygen radicals. Carcinogenesis 1996; 17: 559-562.
    • (1996) Carcinogenesis , vol.17 , pp. 559-562
    • Drake, I.M.1    Davies, M.J.2    Mapstone, N.P.3
  • 23
    • 0028849839 scopus 로고
    • Ascorbic acid and gastrointestinal cancer
    • Cohen M, Bhagavan HN. Ascorbic acid and gastrointestinal cancer. J Am Coll Nutr 1995; 14: 565-578.
    • (1995) J Am Coll Nutr , vol.14 , pp. 565-578
    • Cohen, M.1    Bhagavan, H.N.2
  • 25
    • 0019841976 scopus 로고
    • Diet and cancer of the esophagus
    • Mettlin C, Graham S, Priore R, et al. Diet and cancer of the esophagus. Nutr Cancer 1981; 2: 143-147.
    • (1981) Nutr Cancer , vol.2 , pp. 143-147
    • Mettlin, C.1    Graham, S.2    Priore, R.3
  • 26
    • 0020009511 scopus 로고
    • Study of blood vitamin C in lung and bladder cancer patients before and after treatment with ascorbic acid. A preliminary report
    • Greco AM, Gentile M, Di Filippo O, Coppola A. Study of blood vitamin C in lung and bladder cancer patients before and after treatment with ascorbic acid. A preliminary report. Acta Vitaminol Enzymol 1982; 4: 155-162.
    • (1982) Acta Vitaminol Enzymol , vol.4 , pp. 155-162
    • Greco, A.M.1    Gentile, M.2    Di Filippo, O.3    Coppola, A.4
  • 27
    • 0022616712 scopus 로고
    • Diet and cancer of the colon and rectum: A case-control study
    • Potter JD, McMichael AJ. Diet and cancer of the colon and rectum: A case-control study. J Natl Cancer Inst 1986; 76: 557-569.
    • (1986) J Natl Cancer Inst , vol.76 , pp. 557-569
    • Potter, J.D.1    McMichael, A.J.2
  • 29
    • 0026321353 scopus 로고
    • A case-control study of nutrient status and invasive cervical cancer
    • Herrero R, Potischman N, Brinton L, et al. A case-control study of nutrient status and invasive cervical cancer. Am J Epidemiol 1991; 134: 1347-1355.
    • (1991) Am J Epidemiol , vol.134 , pp. 1347-1355
    • Herrero, R.1    Potischman, N.2    Brinton, L.3
  • 31
    • 0027687827 scopus 로고
    • A case control study of nutritional factors and cervical dysplasia
    • Liu T, Soong SJ, Wilson NP, et al. A case control study of nutritional factors and cervical dysplasia. Cancer Epidemiol Biomarkers Prev 1993; 2: 525-530.
    • (1993) Cancer Epidemiol Biomarkers Prev , vol.2 , pp. 525-530
    • Liu, T.1    Soong, S.J.2    Wilson, N.P.3
  • 32
    • 1842281445 scopus 로고
    • Ascorbic acid in the plasma and blood cells of women with breast cancer. The effect of the consumption of food with an elevated content of this vitamin
    • Nunez MC, Ortiz de Apodaca y Ruiz A. Ascorbic acid in the plasma and blood cells of women with breast cancer. The effect of the consumption of food with an elevated content of this vitamin. Nutr Hosp 1995; 10: 368-372.
    • (1995) Nutr Hosp , vol.10 , pp. 368-372
    • Nunez, M.C.1    de Apodaca, O.2    Ruiz, A.3
  • 33
    • 0030018520 scopus 로고    scopus 로고
    • Intake of vitamins A, C and E and postmenopausal breast cancer. The Iowa Women's Health Study
    • Kushi LH, Fee RM, Sellers TA, et al. Intake of vitamins A, C and E and postmenopausal breast cancer. The Iowa Women's Health Study. Am J Epidemiol 1996; 144: 165-174.
    • (1996) Am J Epidemiol , vol.144 , pp. 165-174
    • Kushi, L.H.1    Fee, R.M.2    Sellers, T.A.3
  • 34
    • 79959937842 scopus 로고    scopus 로고
    • Ascorbic acid content in exotic fruits: A contribution; to produce quality data for food composition databases
    • Valente A, Albuquerque TG, Sanches-Silva A, Costa HS. Ascorbic acid content in exotic fruits: A contribution; to produce quality data for food composition databases. Food Res Internat 2011; 44: 2237-2242.
    • (2011) Food Res Internat , vol.44 , pp. 2237-2242
    • Valente, A.1    Albuquerque, T.G.2    Sanches-Silva, A.3    Costa, H.S.4
  • 35
    • 17144474622 scopus 로고    scopus 로고
    • Plant L-ascorbic acid: Chemistry, function, metabolism, bioavailability and effects of processing
    • Davey MW, Montagu MV, Inzé D, Sanmartin M, Kanellis A, Smirnoff N et al. Plant L-ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing. J Sci Food Agric 2000; 80: 825-860.
    • (2000) J Sci Food Agric , vol.80 , pp. 825-860
    • Davey, M.W.1    Montagu, M.V.2    Inzé, D.3    Sanmartin, M.4    Kanellis, A.5    Smirnoff, N.6
  • 36
    • 10044252598 scopus 로고    scopus 로고
    • Ascorbate biosynthesis: A diversity of pathways
    • H. Asard, J. M. May and N. Smirnoff, eds.), Bios Scientific Publishers, Oxford
    • Smirnoff N, Gatzek S. Ascorbate biosynthesis: A diversity of pathways. In Vitamin C. Function and Biochemistry in Animals and Plants, (H. Asard, J. M. May and N. Smirnoff, eds.), Bios Scientific Publishers, Oxford 2004 pp. 7-29.
    • (2004) Vitamin C. Function and Biochemistry In Animals and Plants , pp. 7-29
    • Smirnoff, N.1    Gatzek, S.2
  • 37
    • 0032574983 scopus 로고    scopus 로고
    • The biosynthetic pathway of vitamin C in higher plants
    • Wheeler GL, Jones MA, Smirnoff N. The biosynthetic pathway of vitamin C in higher plants. Nature 1998; 393: 365-369.
    • (1998) Nature , vol.393 , pp. 365-369
    • Wheeler, G.L.1    Jones, M.A.2    Smirnoff, N.3
  • 39
    • 0022315362 scopus 로고
    • Bioavailability of vitamins
    • Sauberlich HE, Bioavailability of vitamins. Prog Food Nutr Sci 1985; 9: 1-33.
    • (1985) Prog Food Nutr Sci , vol.9 , pp. 1-33
    • Sauberlich, H.E.1
  • 41
    • 0035057999 scopus 로고    scopus 로고
    • The new US dietary reference for vitamins C and E
    • Frei B, Traber M. The new US dietary reference for vitamins C and E. Redox Rep 2001; 6: 5-9
    • (2001) Redox Rep , vol.6 , pp. 5-9
    • Frei, B.1    Traber, M.2
  • 42
    • 9244219627 scopus 로고    scopus 로고
    • Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance
    • Levine M, Conry-Cantilena C, Wang Y, et al. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 1996; 93: 3704-3709.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3704-3709
    • Levine, M.1    Conry-Cantilena, C.2    Wang, Y.3
  • 43
    • 0035859936 scopus 로고    scopus 로고
    • A new recommended dietary allowance of vitamin C for healthy young women
    • Levine M, Wang Y, Padayatty S, Morrow J. A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci USA 2001; 98: 9842-9846.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9842-9846
    • Levine, M.1    Wang, Y.2    Padayatty, S.3    Morrow, J.4
  • 44
    • 0030765538 scopus 로고    scopus 로고
    • Pharmacokinetic model of ascorbic acid in healthy male volunteers during depletion and repletion
    • Graumlich JF, Ludden TM, Conry-Cantilena C, Cantilena Jr LR, Wang Y, Levine M. Pharmacokinetic model of ascorbic acid in healthy male volunteers during depletion and repletion. Pharm Res 1997; 14: 1133-1139.
    • (1997) Pharm Res , vol.14 , pp. 1133-1139
    • Graumlich, J.F.1    Ludden, T.M.2    Conry-Cantilena, C.3    Cantilena, L.R.4    Wang, Y.5    Levine, M.6
  • 45
    • 0031469362 scopus 로고    scopus 로고
    • Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters
    • Agus D, Gambhir S, Pardridge W, Spielholz C, Baselga J, Vera J, et al. Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J Clin Invest 1997; 100: 2842-2848.
    • (1997) J Clin Invest , vol.100 , pp. 2842-2848
    • Agus, D.1    Gambhir, S.2    Pardridge, W.3    Spielholz, C.4    Baselga, J.5    Vera, J.6
  • 46
    • 0027302594 scopus 로고
    • Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid
    • Vera J, Rivas C, Fischbarg J, Golde D. Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid. Nature 1993; 364: 79-82.
    • (1993) Nature , vol.364 , pp. 79-82
    • Vera, J.1    Rivas, C.2    Fischbarg, J.3    Golde, D.4
  • 47
    • 1242317668 scopus 로고    scopus 로고
    • Sodium-dependent ascorbic acid transporter family SLC23
    • Takanaga H, Mackenzie B, Hediger M. Sodium-dependent ascorbic acid transporter family SLC23. Pflugers Arch 2004; 447: 677-682.
    • (2004) Pflugers Arch , vol.447 , pp. 677-682
    • Takanaga, H.1    Mackenzie, B.2    Hediger, M.3
  • 48
    • 40849102818 scopus 로고    scopus 로고
    • Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin C
    • Montel-Hagen A, Kinet S, Manel N, et al. Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin C. Cell 2008; 132: 1039-1048.
    • (2008) Cell , vol.132 , pp. 1039-1048
    • Montel-Hagen, A.1    Kinet, S.2    Manel, N.3
  • 49
    • 0022520696 scopus 로고
    • Jacob RA Plasma ascorbic acid in adult males: Effects of depletions and supplementation
    • Omaya TS, Scala JH, Jacob RA Plasma ascorbic acid in adult males: effects of depletions and supplementation. J Am Coll Nutr 1986; 44: 257-264.
    • (1986) J Am Coll Nutr , vol.44 , pp. 257-264
    • Omaya, T.S.1    Scala, J.H.2
  • 50
    • 0003452118 scopus 로고    scopus 로고
    • World Cancer Research Fund American Institute for Cancer Research, WCRF, AICR,Washington, DC
    • World Cancer Research Fund American Institute for Cancer Research, Food, nutrition and the prevention of cancer: a global perspective. WCRF, AICR,Washington, DC; 2007.
    • (2007) Food, Nutrition and The Prevention of Cancer: A Global Perspective
  • 52
    • 0035025124 scopus 로고    scopus 로고
    • Mechanisms of carcinogenesis: Focus on oxidative stress and electron transfer
    • Kovacic P, Jacintho JD. Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer. Curr Med Chem2001; 8: 773-796.
    • (2001) Curr Med Chem , vol.8 , pp. 773-796
    • Kovacic, P.1    Jacintho, J.D.2
  • 53
    • 0022635104 scopus 로고
    • New concepts in the biology and biochemistry of ascorbic acid
    • Levin M. New concepts in the biology and biochemistry of ascorbic acid. New Engl J Med 1986; 31: 892-902.
    • (1986) New Engl J Med , vol.31 , pp. 892-902
    • Levin, M.1
  • 54
    • 0029939394 scopus 로고    scopus 로고
    • Catalytic metals, ascorbate and free radicals: Combinations to avoid
    • Buettner GR, Jurkiewicz BA. Catalytic metals, ascorbate and free radicals: combinations to avoid. Radiat Res 1996; 145: 532-541.
    • (1996) Radiat Res , vol.145 , pp. 532-541
    • Buettner, G.R.1    Jurkiewicz, B.A.2
  • 55
    • 0027756851 scopus 로고
    • EPR spin trapping of free radicals produced by bleomycin and ascorbate
    • Buettner GR, Moseley PL. EPR spin trapping of free radicals produced by bleomycin and ascorbate. Free Radic Res Commun 1993; 19: S89-S93.
    • (1993) Free Radic Res Commun , vol.19
    • Buettner, G.R.1    Moseley, P.L.2
  • 56
    • 0027251053 scopus 로고
    • The pecking order of free radicals and antioxidants: Lipid peroxidation, a-tocopherol, and ascorbate
    • Buettner GR. The pecking order of free radicals and antioxidants: lipid peroxidation, a-tocopherol, and ascorbate. Arch Biochem Biophys 1993; 300: 535-543.
    • (1993) Arch Biochem Biophys , vol.300 , pp. 535-543
    • Buettner, G.R.1
  • 57
    • 12244289625 scopus 로고    scopus 로고
    • Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
    • Padayatty SJ, Katz A, Wang Y, et al. Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention. J Am Coll Nutr 2003; 22: 18-35
    • (2003) J Am Coll Nutr , vol.22 , pp. 18-35
    • Padayatty, S.J.1    Katz, A.2    Wang, Y.3
  • 59
    • 0029789043 scopus 로고    scopus 로고
    • NO-induced oxidative stress and glutathione metabolism in rodent and human cells
    • Luperchio S, Tamir S, Tannenbaum SR. NO-induced oxidative stress and glutathione metabolism in rodent and human cells. Free Radic Biol Med 1996; 21: 513-59.
    • (1996) Free Radic Biol Med , vol.21 , pp. 513-559
    • Luperchio, S.1    Tamir, S.2    Tannenbaum, S.R.3
  • 60
    • 0030894953 scopus 로고    scopus 로고
    • Vitamins as antimutagens: Advantages and some possible mechanisms of antimutagenic action
    • Odin AP. Vitamins as antimutagens: advantages and some possible mechanisms of antimutagenic action. Mutat Res 1997; 386: 39-67.
    • (1997) Mutat Res , vol.386 , pp. 39-67
    • Odin, A.P.1
  • 61
    • 0033040739 scopus 로고    scopus 로고
    • Does vitamin C act as pro-oxidant under physiological conditions?
    • Carr AC, Frei B. Does vitamin C act as pro-oxidant under physiological conditions? FASEB J 1999; 13: 1007-1024.
    • (1999) FASEB J , vol.13 , pp. 1007-1024
    • Carr, A.C.1    Frei, B.2
  • 62
    • 0029910233 scopus 로고    scopus 로고
    • Vitamin C: Antioxidant or pro-oxidant in vivo?
    • Halliwell B. Vitamin C: antioxidant or pro-oxidant in vivo? Free Rad Res 1996; 25: 439-454.
    • (1996) Free Rad Res , vol.25 , pp. 439-454
    • Halliwell, B.1
  • 63
    • 0026200339 scopus 로고
    • A spectrophotometric assay for chlorine-containing compounds
    • Chesney JA, Mahoney JR, Eaton JW. A spectrophotometric assay for chlorine-containing compounds. Anal. Biochem 1991; 196: 262-266.
    • (1991) Anal Biochem , vol.196 , pp. 262-266
    • Chesney, J.A.1    Mahoney, J.R.2    Eaton, J.W.3
  • 64
    • 0015111379 scopus 로고
    • Oxidation of biologically active reducing substances by ozone
    • Menzel DB. Oxidation of biologically active reducing substances by ozone. Arch Environ Health 1971; 23: 149-153.
    • (1971) Arch Environ Health , vol.23 , pp. 149-153
    • Menzel, D.B.1
  • 65
    • 0020572998 scopus 로고
    • L-Ascorbic acid quenching of singlet delta molecular oxygen in aqueous media: Generalized antioxidant property of vitamin C
    • Chou PT, Khan AU. L-Ascorbic acid quenching of singlet delta molecular oxygen in aqueous media: generalized antioxidant property of vitamin C. Biochem Biophys Res Commun 1983; 115: 932-97.
    • (1983) Biochem Biophys Res Commun , vol.115 , pp. 932-997
    • Chou, P.T.1    Khan, A.U.2
  • 66
    • 0022538236 scopus 로고
    • N-nitrosation and N-nitration of morpholine by nitrogen dioxide: Inhibition by ascorbate, glutathione and α-tocopherol
    • Cooney RV, Ross PD, Bartolini GL. N-nitrosation and N-nitration of morpholine by nitrogen dioxide: inhibition by ascorbate, glutathione and α-tocopherol. Cancer Lett 1986; 32: 83-90.
    • (1986) Cancer Lett , vol.32 , pp. 83-90
    • Cooney, R.V.1    Ross, P.D.2    Bartolini, G.L.3
  • 67
    • 0023851276 scopus 로고
    • Use of ascorbic acid to inhibit nitrosation: Kinetic and mass transfer considerations for an in vitro system
    • Licht WR, Tannenbaum SR, Deen WM. Use of ascorbic acid to inhibit nitrosation: kinetic and mass transfer considerations for an in vitro system. Carcinogenesis 1988; 9: 365-372.
    • (1988) Carcinogenesis , vol.9 , pp. 365-372
    • Licht, W.R.1    Tannenbaum, S.R.2    Deen, W.M.3
  • 70
    • 0031459669 scopus 로고    scopus 로고
    • Prooxidant and antioxidant reaction mechanisms of carotene and radical interactions with vitamins
    • Edge R, Truscott TG. Prooxidant and antioxidant reaction mechanisms of carotene and radical interactions with vitamins E and C. Nutrition 1997; 13: 992-994.
    • (1997) E and C. Nutrition , vol.13 , pp. 992-994
    • Edge, R.1    Truscott, T.G.2
  • 72
    • 0033981389 scopus 로고    scopus 로고
    • Free radicals, antioxidant enzymes and lipid peroxidation in different types of leukemia
    • Devi GS, Prasad MH, Saraswathi I, Rao DN, Reddy PP. Free radicals, antioxidant enzymes and lipid peroxidation in different types of leukemia. Clin Chim Acta 2000; 293: 53-62.
    • (2000) Clin Chim Acta , vol.293 , pp. 53-62
    • Devi, G.S.1    Prasad, M.H.2    Saraswathi, I.3    Rao, D.N.4    Reddy, P.P.5
  • 73
    • 58549089871 scopus 로고    scopus 로고
    • Elevated copper and oxidative stress in cancer cells as a target for cancer treatment
    • Gupte A, Mumper RG. Elevated copper and oxidative stress in cancer cells as a target for cancer treatment. Cancer Treat Rev 2008; 35: 32-46.
    • (2008) Cancer Treat Rev , vol.35 , pp. 32-46
    • Gupte, A.1    Mumper, R.G.2
  • 75
    • 0028966431 scopus 로고
    • A novel cancer therapy based on oxygen radicls
    • Yoshikawa T, Tainaka K, Naito Y, Kondo M. A novel cancer therapy based on oxygen radicls. Cancer Res 1995; 55: 1617-1620.
    • (1995) Cancer Res , vol.55 , pp. 1617-1620
    • Yoshikawa, T.1    Tainaka, K.2    Naito, Y.3    Kondo, M.4
  • 76
    • 26444521256 scopus 로고    scopus 로고
    • Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a prodrug to deliver hydrogen peroxide to tissues
    • Chen Q, Espey MG, Krishna MC, et al. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a prodrug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci USA 2005; 102: 13604-13609.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13604-13609
    • Chen, Q.1    Espey, M.G.2    Krishna, M.C.3
  • 79
    • 0030781092 scopus 로고    scopus 로고
    • Modulating factors of radical intensity and cytotoxic action of ascorbate
    • Saikagami H, Satoh K. Modulating factors of radical intensity and cytotoxic action of ascorbate. Anticancer Res 1997; 17: 3513-3520.
    • (1997) Anticancer Res , vol.17 , pp. 3513-3520
    • Saikagami, H.1    Satoh, K.2
  • 80
    • 0024438802 scopus 로고
    • Site-specific cleavage of supercoiled DNA by ascorbate/Cu(II)
    • Wang Y, Ness BR. Site-specific cleavage of supercoiled DNA by ascorbate/Cu(II). Nucleic Acid Res 1989; 17: 6915-6926.
    • (1989) Nucleic Acid Res , vol.17 , pp. 6915-6926
    • Wang, Y.1    Ness, B.R.2
  • 81
    • 0014982421 scopus 로고
    • DNA-Copper (II) complex and the DNA conformation
    • Zimmer C, Luck G, Fritzsche H, Triebel H. DNA-Copper (II) complex and the DNA conformation. Biopolymers 1971; 10: 441-463.
    • (1971) Biopolymers , vol.10 , pp. 441-463
    • Zimmer, C.1    Luck, G.2    Fritzsche, H.3    Triebel, H.4
  • 82
    • 77955547212 scopus 로고    scopus 로고
    • Catalytic therapy of cancer by ascorbate involves redox cycling of endogenous/ exogenous copper and generation of reactive oxygen species
    • Hadi SM, Ullah MF, Shamim U, Bhat SH, Azmi AS. Catalytic therapy of cancer by ascorbate involves redox cycling of endogenous/ exogenous copper and generation of reactive oxygen species. Chemotherapy 2010; 56: 280-284.
    • (2010) Chemotherapy , vol.56 , pp. 280-284
    • Hadi, S.M.1    Ullah, M.F.2    Shamim, U.3    Bhat, S.H.4    Azmi, A.S.5
  • 83
    • 78651068532 scopus 로고    scopus 로고
    • The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant cellular DNA breakage: Implications for chemopreventive action against cancer
    • Ullah MF, Khan HY, Zubair H, Shamim U, Hadi SM. The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant cellular DNA breakage: Implications for chemopreventive action against cancer. Cancer Chemother pharmacol 2011; 67: 103-110.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 103-110
    • Ullah, M.F.1    Khan, H.Y.2    Zubair, H.3    Shamim, U.4    Hadi, S.M.5
  • 84
    • 0023744891 scopus 로고
    • Why is hydroxyl radical the only radical that commonly binds to DNA? Hypothesis: It has rare combination of high electrophilicity, thermochemical reactivity and a mode of production near DNA
    • Pryor WA. Why is hydroxyl radical the only radical that commonly binds to DNA? Hypothesis: it has rare combination of high electrophilicity, thermochemical reactivity and a mode of production near DNA. Free Rad Biol Med 1988; 4: 219-233.
    • (1988) Free Rad Biol Med , vol.4 , pp. 219-233
    • Pryor, W.A.1
  • 85
    • 0006733083 scopus 로고    scopus 로고
    • Apoptosis- inducing activity of vitamin C and vitamin K
    • Sakagami H, Satoh K, Hakeda Y, Kumegawa M. Apoptosis- inducing activity of vitamin C and vitamin K. Cell Mol Biol 2000; 46: 129-143.
    • (2000) Cell Mol Biol , vol.46 , pp. 129-143
    • Sakagami, H.1    Satoh, K.2    Hakeda, Y.3    Kumegawa, M.4
  • 86
    • 0029670976 scopus 로고    scopus 로고
    • 1, 10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat liver nuclei by promoting redox activity of endogenous copper ions
    • Burkitt MJ, Milne L, Nicotera P, Orrenius S. 1, 10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat liver nuclei by promoting redox activity of endogenous copper ions. Biochem J 1996; 313: 163-169.
    • (1996) Biochem J , vol.313 , pp. 163-169
    • Burkitt, M.J.1    Milne, L.2    Nicotera, P.3    Orrenius, S.4
  • 87
    • 34248193253 scopus 로고    scopus 로고
    • Immune surveillance of tumors
    • Swann JB, Smyth MJ. Immune surveillance of tumors. J Clin Invest 2007; 117: 1137-1146.
    • (2007) J Clin Invest , vol.117 , pp. 1137-1146
    • Swann, J.B.1    Smyth, M.J.2
  • 88
    • 0015949733 scopus 로고
    • Enhancement of random migration and chemotactic response of human leukocytes by ascorbic acid
    • Goetzl EJ, Wasserman SI, Gigli I, et al. Enhancement of random migration and chemotactic response of human leukocytes by ascorbic acid. J Clin Invest 1974; 53: 813-818.
    • (1974) J Clin Invest , vol.53 , pp. 813-818
    • Goetzl, E.J.1    Wasserman, S.I.2    Gigli, I.3
  • 89
    • 0018717599 scopus 로고
    • Human macrophage and lymphocyte responses to mitogen stimulation after exposure to influenza virus, ascorbic acid, and hyperthermia
    • Manzella JP, Roberts NJ. Human macrophage and lymphocyte responses to mitogen stimulation after exposure to influenza virus, ascorbic acid, and hyperthermia. J Immunol 1979; 123: 1940-1944
    • (1979) J Immunol , vol.123 , pp. 1940-1944
    • Manzella, J.P.1    Roberts, N.J.2
  • 90
    • 0016687165 scopus 로고
    • Enhancement of interferon production by poly(rI). poly(rC) in mouse cell cultures by ascorbic acid
    • Siegel BV. Enhancement of interferon production by poly(rI). poly(rC) in mouse cell cultures by ascorbic acid. Nature 1975; 254: 531-532.
    • (1975) Nature , vol.254 , pp. 531-532
    • Siegel, B.V.1
  • 91
    • 0025008267 scopus 로고
    • Pauling L Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells
    • Harakeh S, Jariwalla RJ, Pauling L Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells. Proc Natl Acad Sci USA 1990; 87: 7245-7249.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7245-7249
    • Harakeh, S.1    Jariwalla, R.J.2
  • 92
    • 0027225609 scopus 로고
    • In vivo effect of ascorbic acid on enhancement of human natural killer cell activity
    • Aristo Vojdani, Mamdooh Ghoneum. In vivo effect of ascorbic acid on enhancement of human natural killer cell activity. Nutr Res 1993; 753-764.
    • (1993) Nutr Res , pp. 753-764
    • Vojdani, A.1    Ghoneum, M.2
  • 93
    • 73349127485 scopus 로고    scopus 로고
    • Plasma fibrinogen levels and prognosis in patients with ovarian cancer: A multicenter study
    • Polterauer S, Grimm C, Seebacher V, et al. Plasma fibrinogen levels and prognosis in patients with ovarian cancer: a multicenter study. Oncologist 2009; 14: 979-985.
    • (2009) Oncologist , vol.14 , pp. 979-985
    • Polterauer, S.1    Grimm, C.2    Seebacher, V.3
  • 94
    • 69249170029 scopus 로고    scopus 로고
    • Abnormal expression of fibrinogen gamma (FGG) and plasma level of fibrinogen in patients with hepatocellular carcinoma
    • Zhu WL, Fan BL, Liu DL, Zhu WX. Abnormal expression of fibrinogen gamma (FGG) and plasma level of fibrinogen in patients with hepatocellular carcinoma. Anticancer Res 2009; 29: 2531-2534.
    • (2009) Anticancer Res , vol.29 , pp. 2531-2534
    • Zhu, W.L.1    Fan, B.L.2    Liu, D.L.3    Zhu, W.X.4
  • 95
    • 78650952222 scopus 로고    scopus 로고
    • Thrombosis risk and survival in cancer patients with elevated C-reactive protein
    • Kanz R, Vukovich T, Vormittag R, et al. Thrombosis risk and survival in cancer patients with elevated C-reactive protein. J Thromb Haemost 2011; 9: 57-63.
    • (2011) J Thromb Haemost , vol.9 , pp. 57-63
    • Kanz, R.1    Vukovich, T.2    Vormittag, R.3
  • 96
    • 70449397951 scopus 로고    scopus 로고
    • C-reactive protein and malignancy: Clinicopathological association and therapeutic implication
    • Wang CS, Sun CF. C-reactive protein and malignancy: clinicopathological association and therapeutic implication. Chang Gung Med J 2009; 32: 471-482.
    • (2009) Chang Gung Med J , vol.32 , pp. 471-482
    • Wang, C.S.1    Sun, C.F.2
  • 97
    • 0026625812 scopus 로고
    • Serum level of interleukin 6 as a prognosis factor in metastatic renal cell carcinoma
    • Blay JY, Negrier S, Combaret V, et al. Serum level of interleukin 6 as a prognosis factor in metastatic renal cell carcinoma. Cancer Res 1992; 52: 3317-3322.
    • (1992) Cancer Res , vol.52 , pp. 3317-3322
    • Blay, J.Y.1    Negrier, S.2    Combaret, V.3
  • 98
    • 1942534028 scopus 로고    scopus 로고
    • Micronutrient concentrations in patients with malignant disease: Effect of the inflammatory response
    • Mayland C, Allen KR, Degg TJ, Bennet M. Micronutrient concentrations in patients with malignant disease: effect of the inflammatory response. Ann Clin Biochem 2004; 41: 138-141.
    • (2004) Ann Clin Biochem , vol.41 , pp. 138-141
    • Mayland, C.1    Allen, K.R.2    Degg, T.J.3    Bennet, M.4
  • 99
    • 57449100455 scopus 로고    scopus 로고
    • Vitamin C treatment reduces elevated C-reactive protein
    • Block G, Jensen CD, Dalvi TB, et al. Vitamin C treatment reduces elevated C-reactive protein. Free Radic Biol Med 2009; 46: 70-77.
    • (2009) Free Radic Biol Med , vol.46 , pp. 70-77
    • Block, G.1    Jensen, C.D.2    Dalvi, T.B.3
  • 100
    • 77953288713 scopus 로고    scopus 로고
    • Pharmacologic concentrations of ascorbic acid cause diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines
    • Lin ZY, Chuang WL. Pharmacologic concentrations of ascorbic acid cause diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines. Biomed Pharmacother 2010; 64: 348-351.
    • (2010) Biomed Pharmacother , vol.64 , pp. 348-351
    • Lin, Z.Y.1    Chuang, W.L.2
  • 101
    • 0034671636 scopus 로고    scopus 로고
    • Vitamin C inhibits NF-kB activation by TNF via the activation of p38 mitogen-activated protein kinase
    • Bowie AG, O'Neill LAJ. Vitamin C inhibits NF-kB activation by TNF via the activation of p38 mitogen-activated protein kinase. J Immunol 2000; 165: 7180-7388.
    • (2000) J Immunol , vol.165 , pp. 7180-7388
    • Bowie, A.G.1    O'Neill, L.A.J.2
  • 102
    • 0022357068 scopus 로고
    • Ethoxy-penthoxy and benzyloxyphexazones and homologues: A series of substrates to different induced cytochromes P450
    • Burke MD, Thompson S, Elcombe CR, Halpert J, Haaparanta T, Mayer RT. Ethoxy-penthoxy and benzyloxyphexazones and homologues: A series of substrates to different induced cytochromes P450. Biochem Pharmacol 1985; 34: 3337-3345.
    • (1985) Biochem Pharmacol , vol.34 , pp. 3337-3345
    • Burke, M.D.1    Thompson, S.2    Elcombe, C.R.3    Halpert, J.4    Haaparanta, T.5    Mayer, R.T.6
  • 103
    • 11844304365 scopus 로고    scopus 로고
    • Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid
    • Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005; 155: 411-420.
    • (2005) Toxicol Lett , vol.155 , pp. 411-420
    • Wang, Y.P.1    Yan, J.2    Fu, P.P.3    Chou, M.W.4
  • 104
    • 9644281228 scopus 로고    scopus 로고
    • A method for determination of volatile N-nitrosamines in food by HS-SPME-GC-TEA
    • Andrade R, Reyes FGR, Rath SA. A method for determination of volatile N-nitrosamines in food by HS-SPME-GC-TEA. Food Chem Toxicol 2005; 91: 173-179.
    • (2005) Food Chem Toxicol , vol.91 , pp. 173-179
    • Andrade, R.1    Reyes, F.G.R.2    Rath, S.A.3
  • 106
    • 0037328394 scopus 로고    scopus 로고
    • Comparative metabolism of Nnitrosopiperidine and N nitrosopyrrolidine by rat liver and esophageal microsomes and cythocrome P450 2A3
    • Wong HL, Murphy SE, Hecht SS. Comparative metabolism of Nnitrosopiperidine and N nitrosopyrrolidine by rat liver and esophageal microsomes and cythocrome P450 2A3. Carcinogenesis 2003; 24: 291-300.
    • (2003) Carcinogenesis , vol.24 , pp. 291-300
    • Wong, H.L.1    Murphy, S.E.2    Hecht, S.S.3
  • 107
    • 0034961045 scopus 로고    scopus 로고
    • Screening of organosulfur compounds as inhibitors of human CYP2A6
    • Fujita K, Kamataki T. Screening of organosulfur compounds as inhibitors of human CYP2A6. Drug Metabol Dispos 2001; 29: 983-989.
    • (2001) Drug Metabol Dispos , vol.29 , pp. 983-989
    • Fujita, K.1    Kamataki, T.2
  • 108
    • 35648994838 scopus 로고    scopus 로고
    • Protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. Toxicol
    • Arranz N, Haza AI, Garcia A, Rafter J, Morales P. Protective effect of vitamin C towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. Toxicol in vitro 2007; 21: 1311-137.
    • (2007) In Vitro , vol.21 , pp. 1311-1337
    • Arranz, N.1    Haza, A.I.2    Garcia, A.3    Rafter, J.4    Morales, P.5
  • 109
    • 0034059998 scopus 로고    scopus 로고
    • Inhibition of 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD)-stimulated Cyp1a1 promoter activity by hypoxic agents
    • Kim JE, Sheen YY. Inhibition of 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD)-stimulated Cyp1a1 promoter activity by hypoxic agents. Biochem Pharmacol 2000; 59: 1549-1556.
    • (2000) Biochem Pharmacol , vol.59 , pp. 1549-1556
    • Kim, J.E.1    Sheen, Y.Y.2
  • 110
    • 0028174982 scopus 로고
    • Carcinogenicity of TCDD: Experimental, mechanistic and epidermiology evidence
    • Huff J, Lucier G, Tritscher A. Carcinogenicity of TCDD: experimental, mechanistic and epidermiology evidence. Ann Rev Pharmacol Toxicol 1994; 34: 343-372.
    • (1994) Ann Rev Pharmacol Toxicol , vol.34 , pp. 343-372
    • Huff, J.1    Lucier, G.2    Tritscher, A.3
  • 111
    • 0003217385 scopus 로고    scopus 로고
    • Polychlorinated Dibenzo-p-dioxins and Polychlorinated dibenzofurans
    • IARC (International Agency for Research on Cancer) Monographs on the evaluation of carcinogenesis risks humans, Lyon France
    • IARC (International Agency for Research on Cancer) Monographs on the evaluation of carcinogenesis risks humans. Polychlorinated Dibenzo-p-dioxins and Polychlorinated dibenzofurans. IARC Scientific Publication 69, 1997;Lyon France, pp. 1-631.
    • (1997) IARC Scientific Publication , vol.69 , pp. 1-631
  • 112
    • 67349085177 scopus 로고    scopus 로고
    • Ascorbic acid suppresses the 2,3,7,8-tetrachloridibenxo-p-dioxin (TCDD)-induced CYP1A1 expression in human HepG2 cells
    • Chang HJ, Park JS, Lee EK, et al. Ascorbic acid suppresses the 2,3,7,8-tetrachloridibenxo-p-dioxin (TCDD)-induced CYP1A1 expression in human HepG2 cells. Toxicol in vitro 2009; 23: 622-626.
    • (2009) Toxicol In Vitro , vol.23 , pp. 622-626
    • Chang, H.J.1    Park, J.S.2    Lee, E.K.3
  • 113
    • 0034162822 scopus 로고    scopus 로고
    • Sulphorane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells
    • Gamet-Payrastre L, Li P, Lumeau S, et al. Sulphorane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res 2000; 60: 1426-1433.
    • (2000) Cancer Res , vol.60 , pp. 1426-1433
    • Gamet-Payrastre, L.1    Li, P.2    Lumeau, S.3
  • 114
    • 0028786534 scopus 로고
    • Induction of NAD(P)H: Q uinine reductase by vitamins A, E and C in Colo205 colon cancer cells
    • Wang W, Higuchi CM. Induction of NAD(P)H: q uinine reductase by vitamins A, E and C in Colo205 colon cancer cells. Cancer Lett 1995; 98: 63-69.
    • (1995) Cancer Lett , vol.98 , pp. 63-69
    • Wang, W.1    Higuchi, C.M.2
  • 115
    • 0031888158 scopus 로고    scopus 로고
    • Modulation of drug metabolizing enzymes in guinea pig liver by high intakes of ascorbic acid
    • Roomi MW, Netke S, Tsao C. Modulation of drug metabolizing enzymes in guinea pig liver by high intakes of ascorbic acid. Internat J Vit Nutr Res 1998; 68: 42-47.
    • (1998) Internat J Vit Nutr Res , vol.68 , pp. 42-47
    • Roomi, M.W.1    Netke, S.2    Tsao, C.3
  • 116
    • 0015489358 scopus 로고
    • Polysaccharides in cancer: Glycoproteins and glycolipids
    • Nigam VN, Cantero A. Polysaccharides in cancer: glycoproteins and glycolipids. Adv. Cancer Res 1973; 17: 1-80.
    • (1973) Adv. Cancer Res , vol.17 , pp. 1-80
    • Nigam, V.N.1    Cantero, A.2
  • 117
    • 0014452874 scopus 로고
    • Collagen proteinpolysaccharide interactions in human intervertebral disc
    • Steven FS, Knott J, Jackson DS, Podrazky V. Collagen proteinpolysaccharide interactions in human intervertebral disc. Biochim Biophys Acta 1969; 188: 307-13.
    • (1969) Biochim Biophys Acta , vol.188 , pp. 307-313
    • Steven, F.S.1    Knott, J.2    Jackson, D.S.3    Podrazky, V.4
  • 118
    • 0035061652 scopus 로고    scopus 로고
    • Commentary: Is the concept of "tumor promotion" a useful paradigm?
    • Trosko JE. Commentary: is the concept of "tumor promotion" a useful paradigm? Mol Carcinog 2001; 30: 131-137.
    • (2001) Mol Carcinog , vol.30 , pp. 131-137
    • Trosko, J.E.1
  • 119
    • 0034494960 scopus 로고    scopus 로고
    • Modulation of cell-cell communication in the cause and chemoprevention/chemotherapy of cancer
    • Trosko JE, Chang CC. Modulation of cell-cell communication in the cause and chemoprevention/chemotherapy of cancer. Biofactors 2000; 12: 259-263.
    • (2000) Biofactors , vol.12 , pp. 259-263
    • Trosko, J.E.1    Chang, C.C.2
  • 120
    • 0034019784 scopus 로고    scopus 로고
    • Exploring the relationship between the inhibition of gap junctional intercellular communication and other biological phenomena
    • Rosenkranz HS, Pollack N, Cunningham AR. Exploring the relationship between the inhibition of gap junctional intercellular communication and other biological phenomena. Carcinogenesis 2000; 21: 1007-1011.
    • (2000) Carcinogenesis , vol.21 , pp. 1007-1011
    • Rosenkranz, H.S.1    Pollack, N.2    Cunningham, A.R.3
  • 121
    • 33845472110 scopus 로고    scopus 로고
    • Preventive effects of vitamin C on carcinogenesis
    • Lee KW, Lee HJ, Kang KS, Lee CY. Preventive effects of vitamin C on carcinogenesis. Lancet 2002; 359: 172
    • (2002) Lancet , vol.359 , pp. 172
    • Lee, K.W.1    Lee, H.J.2    Kang, K.S.3    Lee, C.Y.4
  • 122
    • 0642276600 scopus 로고    scopus 로고
    • Vitamin C and cancer chemoprevention: Reappraisal
    • Ki Won Lee, Hyong Joo Lee, Young-Joon Surh, Chang Yong Lee. Vitamin C and cancer chemoprevention: reappraisal. Am J Clin Nutr 2003; 78: 1074-1078.
    • (2003) Am J Clin Nutr , vol.78 , pp. 1074-1078
    • Ki, W.L.1    Lee, H.J.2    Young-Joon, S.3    Lee, C.Y.4
  • 123
    • 0022349214 scopus 로고
    • Peptides and blood brain barrier: Lipophilicity as predictor of permeability
    • Banks WA, Kastin AJ: Peptides and blood brain barrier: lipophilicity as predictor of permeability. Brain Res Bull 1985; 15: 287-292.
    • (1985) Brain Res Bull , vol.15 , pp. 287-292
    • Banks, W.A.1    Kastin, A.J.2
  • 124
    • 0035184401 scopus 로고    scopus 로고
    • Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cell: Modulation of insulin- like growth factor-I receptor (IGF-IR) expression
    • Naidu KA, Tang JL, Naidu KA, Prockop LD, Nicosia SV, Coppola D. Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cell: Modulation of insulin- like growth factor-I receptor (IGF-IR) expression. J Neuro- Oncol 2001; 54: 15-22.
    • (2001) J Neuro- Oncol , vol.54 , pp. 15-22
    • Naidu, K.A.1    Tang, J.L.2    Naidu, K.A.3    Prockop, L.D.4    Nicosia, S.V.5    Coppola, D.6
  • 125
    • 0026667730 scopus 로고
    • AKT2 a putative oncogene encoding a member of a subfamily of proteinserine/ threonine kinase is amplified in human ovarian carcinomas
    • Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, et al. AKT2 a putative oncogene encoding a member of a subfamily of proteinserine/ threonine kinase is amplified in human ovarian carcinomas. Proc Natl Acad Sci USA 1992; 89: 9267-9271.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9267-9271
    • Cheng, J.Q.1    Godwin, A.K.2    Bellacosa, A.3    Taguchi, T.4
  • 126
    • 0001582482 scopus 로고
    • Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2; amplification of AKT1 in a primary human gastric adenocarcinoma
    • Staal SP. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2; amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA 1987; 84: 5034-5037.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 5034-5037
    • Staal, S.P.1
  • 127
    • 32144454061 scopus 로고    scopus 로고
    • Ascorbyl Stearate Inhibits Cell Proliferation and Tumor Growth in Human Ovarian Carcinoma Cells by Targeting the PI3K/AKT Pathway
    • Fang Q, Naidu KA, Naidu KA, et al. Ascorbyl Stearate Inhibits Cell Proliferation and Tumor Growth in Human Ovarian Carcinoma Cells by Targeting the PI3K/AKT Pathway. Anticancer Res 2006; 26: 203-210.
    • (2006) Anticancer Res , vol.26 , pp. 203-210
    • Fang, Q.1    Naidu, K.A.2    Naidu, K.A.3
  • 128
    • 61849142251 scopus 로고    scopus 로고
    • High concentrations of ascorbic acid induces apoptosis of human gastric cancer cell by p38-MAP kinase-dependent up-regulation of transferrin receptor
    • Ha YM, Park MK, Kim HJ, Seo HG, Lee JH, Chang KC. High concentrations of ascorbic acid induces apoptosis of human gastric cancer cell by p38-MAP kinase-dependent up-regulation of transferrin receptor. Cancer Lett 2009; 277: 48-54.
    • (2009) Cancer Lett , vol.277 , pp. 48-54
    • Ha, Y.M.1    Park, M.K.2    Kim, H.J.3    Seo, H.G.4    Lee, J.H.5    Chang, K.C.6
  • 129
    • 40949142209 scopus 로고    scopus 로고
    • The role of hypoxia-inducible factors in tumorigenesis
    • Rankin E, Giaccia A. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ 2008; 15: 678-685.
    • (2008) Cell Death Differ , vol.15 , pp. 678-685
    • Rankin, E.1    Giaccia, A.2
  • 130
    • 56749160108 scopus 로고    scopus 로고
    • The controversial place of vitamin C in cancer treatment
    • Verrax J, Calderon BP. The controversial place of vitamin C in cancer treatment. Biochem Pharmacol 2008; 76; 1644-1652.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1644-1652
    • Verrax, J.1    Calderon, B.P.2
  • 131
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza G. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-32.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.1
  • 132
    • 23844461100 scopus 로고    scopus 로고
    • Evaluating hypoxiainducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo
    • Li L, Lin X, Staver M, Shoemaker A, et al. Evaluating hypoxiainducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo. Cancer Res 2005; 65: 7249-7258.
    • (2005) Cancer Res , vol.65 , pp. 7249-7258
    • Li, L.1    Lin, X.2    Staver, M.3    Shoemaker, A.4
  • 133
    • 38749106115 scopus 로고    scopus 로고
    • Hypoxiainducible factor-1{alpha} stabilization in nonhypoxic conditions: Role of oxidation and intracellular ascorbate depletion
    • Page E, Chan D, Giaccia A, Levine M, Richard D. Hypoxiainducible factor-1{alpha} stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol Biol Cell 2008; 19: 86-94.
    • (2008) Mol Biol Cell , vol.19 , pp. 86-94
    • Page, E.1    Chan, D.2    Giaccia, A.3    Levine, M.4    Richard, D.5
  • 134
    • 33847051180 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate
    • Vissers M, Gunningham S, Morrison M, Dachs G, Currie M. Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate. Free Radic Biol Med 2007; 42: 765-772.
    • (2007) Free Radic Biol Med , vol.42 , pp. 765-772
    • Vissers, M.1    Gunningham, S.2    Morrison, M.3    Dachs, G.4    Currie, M.5
  • 135
    • 0016275402 scopus 로고
    • The ortho molecular treatment of cancer II. Clinical trial of high-dose ascorbic supplements in advanced human cancers
    • Cameron E, Campbell A. The ortho molecular treatment of cancer II. Clinical trial of high-dose ascorbic supplements in advanced human cancers. Chem Biol Interact 1974; 9: 285-315.
    • (1974) Chem Biol Interact , vol.9 , pp. 285-315
    • Cameron, E.1    Campbell, A.2
  • 136
    • 0012375577 scopus 로고
    • Pauling L Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancers
    • Cameron E, Pauling L Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancers. Proc Natl Acad Sci USA 1978; 75: 4538-4542.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 4538-4542
    • Cameron, E.1
  • 137
    • 0018220437 scopus 로고
    • Prolongation of survival times in terminal human cancer by administration of supplemental ascorbate
    • Morishige F, Murata A. Prolongation of survival times in terminal human cancer by administration of supplemental ascorbate. J Interntl Acad Prev Med 1979; 5: 47-52.
    • (1979) J Interntl Acad Prev Med , vol.5 , pp. 47-52
    • Morishige, F.1    Murata, A.2
  • 138
    • 0020006414 scopus 로고
    • Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate
    • Murata A, Morishige F, Yamaguchi H. Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate. Int J Vitam Nutr Res Suppl 1982; 23: 103-113.
    • (1982) Int J Vitam Nutr Res Suppl , vol.23 , pp. 103-113
    • Murata, A.1    Morishige, F.2    Yamaguchi, H.3
  • 139
    • 77952133915 scopus 로고    scopus 로고
    • Catalytic therapy of cancer with ascorbate and extracts of medicinal herbs
    • Rozanova N, Zhang JZ, and Heck DE. Catalytic therapy of cancer with ascorbate and extracts of medicinal herbs. Evid Based Complement Alternat Med 2007; 7: 203-212.
    • (2007) Evid Based Complement Alternat Med , vol.7 , pp. 203-212
    • Rozanova, N.1    Zhang, J.Z.2    Heck, D.E.3
  • 140
    • 0020696383 scopus 로고
    • Enhancement of anti-tumor activity of ascorbate against Ehrlich ascites tumor cells by copper:Glycylglycyl complex
    • Kimoto EH, Tanaka K, Gytoku P, Morishige F, Pauling L. Enhancement of anti-tumor activity of ascorbate against Ehrlich ascites tumor cells by copper:glycylglycyl complex. Cancer Res 1983; 43: 824-828.
    • (1983) Cancer Res , vol.43 , pp. 824-828
    • Kimoto, E.H.1    Tanaka, K.2    Gytoku, P.3    Morishige, F.4    Pauling, L.5
  • 141
    • 0027944149 scopus 로고
    • Ascorbic acid (vitamin C) modulates the mutagenic effects produced by an alkylating agent in vivo
    • Aidoo A, Lyn-Cook LE, Lensing S, Wamer W. Ascorbic acid (vitamin C) modulates the mutagenic effects produced by an alkylating agent in vivo. Environ Mol Mutagen 1994; 24: 220-228.
    • (1994) Environ Mol Mutagen , vol.24 , pp. 220-228
    • Aidoo, A.1    Lyn-Cook, L.E.2    Lensing, S.3    Wamer, W.4
  • 142
  • 143
    • 79960008207 scopus 로고    scopus 로고
    • Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models
    • Ping Chen, Jennifer Stone, Garrett Sullivan, Jeanne A. Drisko, Qi Chen. Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models. Free Rad Biol Med 2011; 51: 681-687.
    • (2011) Free Rad Biol Med , vol.51 , pp. 681-687
    • Chen, P.1    Stone, J.2    Sullivan, G.3    Drisko, J.A.4    Qi, C.5
  • 144
    • 0030891065 scopus 로고    scopus 로고
    • Selective inhibition of mitochondrial respiration and glycolysis in human leukemic leukocytes by methylglyoxal
    • Biswas S, Ray M, Misra S, Dutta DP, Ray S. Selective inhibition of mitochondrial respiration and glycolysis in human leukemic leukocytes by methylglyoxal. Biochem J 1997; 323: 343-348.
    • (1997) Biochem J , vol.323 , pp. 343-348
    • Biswas, S.1    Ray, M.2    Misra, S.3    Dutta, D.P.4    Ray, S.5
  • 145
    • 33644963032 scopus 로고    scopus 로고
    • In vivo assessment of toxicity and pharmacokinetics of methylglyoxal Augmentation of the curative effect of methylglyoxal on cancer-bearing mice by ascorbic acid and creatine
    • Ghosh M, Talukdar D, Ghosh S, Bhattacharyya N, Ray M, Ray S. In vivo assessment of toxicity and pharmacokinetics of methylglyoxal Augmentation of the curative effect of methylglyoxal on cancer-bearing mice by ascorbic acid and creatine. Toxicol Appl Pharmacol 2006; 212: 45-58.
    • (2006) Toxicol Appl Pharmacol , vol.212 , pp. 45-58
    • Ghosh, M.1    Talukdar, D.2    Ghosh, S.3    Bhattacharyya, N.4    Ray, M.5    Ray, S.6
  • 146
    • 0011404932 scopus 로고
    • Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture
    • Prasad K, Sinha P, Ramanujam M, Sakamoto A. Sodium ascorbate potentiates the growth inhibitory effect of certain agents on neuroblastoma cells in culture. Proc Natl Acad Sci USA 1979; 76: 829-832.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 829-832
    • Prasad, K.1    Sinha, P.2    Ramanujam, M.3    Sakamoto, A.4
  • 148
    • 0029986515 scopus 로고    scopus 로고
    • Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro
    • Kurbacher C, Wagner U, Kolster B, Andreotti P, Krebs D, Bruckner H. Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro. Cancer Lett 1996; 103: 183-19.
    • (1996) Cancer Lett , vol.103 , pp. 183-219
    • Kurbacher, C.1    Wagner, U.2    Kolster, B.3    Andreotti, P.4    Krebs, D.5    Bruckner, H.6
  • 149
    • 0030005062 scopus 로고    scopus 로고
    • Potentiation of radiotherapy by nontoxic pretreatment with combined vitamins C and K3 in mice bearing solid transplantable tumor
    • Taper H, Keyeux A, Roberfroid M. Potentiation of radiotherapy by nontoxic pretreatment with combined vitamins C and K3 in mice bearing solid transplantable tumor. Anticancer Res 1996; 16: 499-503.
    • (1996) Anticancer Res , vol.16 , pp. 499-503
    • Taper, H.1    Keyeux, A.2    Roberfroid, M.3
  • 150
    • 0023618556 scopus 로고
    • Non-toxic potentiation of cancer chemotherapy by combined C and K3 vitamin pretreatment
    • Taper H, de Gerlache J, Lans M, Roberfroid M. Non-toxic potentiation of cancer chemotherapy by combined C and K3 vitamin pretreatment. Int J Cancer 1987; 40: 575-579.
    • (1987) Int J Cancer , vol.40 , pp. 575-579
    • Taper, H.1    de Gerlache, J.2    Lans, M.3    Roberfroid, M.4
  • 151
    • 0034806033 scopus 로고    scopus 로고
    • Vitamin. C augments chemotherapeutic response of cervical carcinoma HeLa cells by stabilizing P53
    • Reddy V, Khanna N, Singh N, Vitamin. C augments chemotherapeutic response of cervical carcinoma HeLa cells by stabilizing P53. Biochem Biophys Res Commun 2001; 282: 409-415.
    • (2001) Biochem Biophys Res Commun , vol.282 , pp. 409-415
    • Reddy, V.1    Khanna, N.2    Singh, N.3
  • 152
    • 0028131244 scopus 로고
    • Ascorbic acid increases drug accumulation and reverses vincristine resistance of human nonsmall- cell lung-cancer cells
    • Chiang C, Song E, Yang V, Chao C. Ascorbic acid increases drug accumulation and reverses vincristine resistance of human nonsmall- cell lung-cancer cells. Biochem J 1994; 301: 759-764.
    • (1994) Biochem J , vol.301 , pp. 759-764
    • Chiang, C.1    Song, E.2    Yang, V.3    Chao, C.4
  • 153
    • 0028983518 scopus 로고
    • Potentiation of growth inhibition due to vincristine by ascorbic acid in a resistant human nonsmall cell lung cancer cell line
    • Song E, Yang V, Chiang C, Chao C. Potentiation of growth inhibition due to vincristine by ascorbic acid in a resistant human nonsmall cell lung cancer cell line. Eur J Pharmacol 1995; 292: 119-125.
    • (1995) Eur J Pharmacol , vol.292 , pp. 119-125
    • Song, E.1    Yang, V.2    Chiang, C.3    Chao, C.4
  • 154
    • 0036896388 scopus 로고    scopus 로고
    • Feasibility and correlates of arsenic trioxide combined with ascorbic acidmediated depletion of intracellular glutathione for the treatment of relapsed/refractory multiple myeloma
    • Bahlis N, McCafferty-Grad J, Jordan-McMurry I, et al. Feasibility and correlates of arsenic trioxide combined with ascorbic acidmediated depletion of intracellular glutathione for the treatment of relapsed/refractory multiple myeloma. Clin Cancer Res 2002; 8: 3658-3668.
    • (2002) Clin Cancer Res , vol.8 , pp. 3658-3668
    • Bahlis, N.1    McCafferty-Grad, J.2    Jordan-McMurry, I.3
  • 155
    • 0035437189 scopus 로고    scopus 로고
    • Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells
    • Grad J, Bahlis N, Reis I, Oshiro M, Dalton W, Boise L. Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells. Blood 2001; 98: 805-813.
    • (2001) Blood , vol.98 , pp. 805-813
    • Grad, J.1    Bahlis, N.2    Reis, I.3    Oshiro, M.4    Dalton, W.5    Boise, L.6
  • 156
    • 0032933610 scopus 로고    scopus 로고
    • Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system
    • Dai J, Weinberg R, Waxman S, Jing Y. Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system. Blood 1999; 93: 268-277.
    • (1999) Blood , vol.93 , pp. 268-277
    • Dai, J.1    Weinberg, R.2    Waxman, S.3    Jing, Y.4
  • 157
    • 18544376266 scopus 로고    scopus 로고
    • Vitamin C protects HL60 and U266 cells from arsenic toxicity
    • Karasavvas N, Cárcamo J, Stratis G, Golde D. Vitamin C protects HL60 and U266 cells from arsenic toxicity. Blood 2005; 105: 4004-4012.
    • (2005) Blood , vol.105 , pp. 4004-4012
    • Karasavvas, N.1    Cárcamo, J.2    Stratis, G.3    Golde, D.4
  • 158
    • 33845762723 scopus 로고    scopus 로고
    • Caspase-8 dependent TRAILinduced apoptosis in cancer cell lines is inhibited by vitamin C and catalase
    • Perez-Cruz I, Cárcamo J, Golde D. Caspase-8 dependent TRAILinduced apoptosis in cancer cell lines is inhibited by vitamin C and catalase. Apoptosis 2007; 12: 225-234.
    • (2007) Apoptosis , vol.12 , pp. 225-234
    • Perez-Cruz, I.1    Cárcamo, J.2    Golde, D.3
  • 159
    • 31544446367 scopus 로고    scopus 로고
    • Vitamin C inactivates the proteasome inhibitor PS-341 in human cancer cells
    • Zou W, Yue P, Lin N, He M, Zhou Z, Lonial S, et al. Vitamin C inactivates the proteasome inhibitor PS-341 in human cancer cells. Clin Cancer Res 2006; 12: 273-280.
    • (2006) Clin Cancer Res , vol.12 , pp. 273-280
    • Zou, W.1    Yue, P.2    Lin, N.3    He, M.4    Zhou, Z.5    Lonial, S.6
  • 160
    • 84864322154 scopus 로고    scopus 로고
    • Depletion of ascorbic acid impairs NK cell activity against ovarian cancer in a mouse model
    • Kim JE, Cho HS, Yang HS, et al. Depletion of ascorbic acid impairs NK cell activity against ovarian cancer in a mouse model. Immunobiol 2012; 217: 873-881.
    • (2012) Immunobiol , vol.217 , pp. 873-881
    • Kim, J.E.1    Cho, H.S.2    Yang, H.S.3
  • 161
    • 66749118481 scopus 로고    scopus 로고
    • Genetic variation in sodium-dependent ascorbic acid transporters and risk of gastric cancer in Poland
    • Wright ME, Andreotti G, Lissowska J, et al. Genetic variation in sodium-dependent ascorbic acid transporters and risk of gastric cancer in Poland. Eur J Cancer 2009; 45: 1824-1830.
    • (2009) Eur J Cancer , vol.45 , pp. 1824-1830
    • Wright, M.E.1    Andreotti, G.2    Lissowska, J.3
  • 162
    • 0025977141 scopus 로고
    • Gastric juice ascorbic acid: Effects of disease and implications for gastric carcinogenesis
    • Schorah CJ, Sobala GM, Sanderson M, Collis N, Primrose JN. Gastric juice ascorbic acid: effects of disease and implications for gastric carcinogenesis. Am J Clin Nutr 1991; 53: 287S-293S.
    • (1991) Am J Clin Nutr , vol.53
    • Schorah, C.J.1    Sobala, G.M.2    Sanderson, M.3    Collis, N.4    Primrose, J.N.5
  • 163
    • 0016758739 scopus 로고
    • The orthomolecular treatment of cancer: III. Reticulum cell sarcoma: Double complete regression induced by high-dose ascorbic acid therapy
    • Cameron E, Campbel A, Jack T. The orthomolecular treatment of cancer: III. Reticulum cell sarcoma: Double complete regression induced by high-dose ascorbic acid therapy. Chemico-Biol Interact 1975; 11: 387-393.
    • (1975) Chemico-Biol Interact , vol.11 , pp. 387-393
    • Cameron, E.1    Campbel, A.2    Jack, T.3
  • 164
    • 0025265387 scopus 로고
    • Case Study: High-dose intravenous vitamin C in the treatment of a patient with adenocarcinoma of the kidney
    • Riordan HD, Jackson JA, Schultz M: Case Study: High-dose intravenous vitamin C in the treatment of a patient with adenocarcinoma of the kidney. J Orthomol Med 1990; 5: 5-7.
    • (1990) J Orthomol Med , vol.5 , pp. 5-7
    • Riordan, H.D.1    Jackson, J.A.2    Schultz, M.3
  • 165
    • 33645555541 scopus 로고    scopus 로고
    • Intravenously administered vitamin C as cancer therapy: Three cases
    • Sebastian J. Padayatty, Hugh D, et al. Intravenously administered vitamin C as cancer therapy: three cases. CMAJ 2006; 174: 937-942.
    • (2006) CMAJ , vol.174 , pp. 937-942
    • Padayatty, S.J.1    Hugh, D.2
  • 166
    • 0025746287 scopus 로고
    • Ascorbic acid and in situ kinetics: A new approach to vitamin requirements
    • Levine M, Dhariwal KR, Washko PW, et al. Ascorbic acid and in situ kinetics: a new approach to vitamin requirements. Am J Clin Nutr 1991; 54: 1157S-1162S.
    • (1991) Am J Clin Nutr , vol.54
    • Levine, M.1    Dhariwal, K.R.2    Washko, P.W.3
  • 167
    • 69349096333 scopus 로고    scopus 로고
    • High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/Cmice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis
    • Yeom CH, Lee G, Park JH, Yu J, Park S, et al. High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/Cmice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis. J Transl Med 2009; 7: 70-74.
    • (2009) J Transl Med , vol.7 , pp. 70-74
    • Yeom, C.H.1    Lee, G.2    Park, J.H.3    Yu, J.4    Park, S.5
  • 168
    • 67349235547 scopus 로고    scopus 로고
    • Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects
    • Verrax J, Calderon PB. Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects. Free Radic Biol Med 2009; 47: 32-40.
    • (2009) Free Radic Biol Med , vol.47 , pp. 32-40
    • Verrax, J.1    Calderon, P.B.2
  • 169
    • 84855858767 scopus 로고    scopus 로고
    • Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer
    • Montil DA, Mitchell E, Bazzan AJ, et al. Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer. PLOS ONE 2012; 7: e29794.
    • (2012) PLOS ONE , vol.7
    • Montil, D.A.1    Mitchell, E.2    Bazzan, A.J.3
  • 170
    • 79955603438 scopus 로고    scopus 로고
    • Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer
    • Espey MG, Chen P, Chalmers B, Drisko J, Sun AY, et al. Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer. Free Radic Biol Med 2011; 50: 1610-1619.
    • (2011) Free Radic Biol Med , vol.50 , pp. 1610-1619
    • Espey, M.G.1    Chen, P.2    Chalmers, B.3    Drisko, J.4    Sun, A.Y.5
  • 171
    • 65349193958 scopus 로고    scopus 로고
    • Bortezomib, ascorbic acid and melphalan (BAM) therapy for patients with newly diagnosed multiple myeloma: An effective and well-tolerated frontline regimen
    • Berenson JR, Yellin O, Woytowitz D, et al. Bortezomib, ascorbic acid and melphalan (BAM) therapy for patients with newly diagnosed multiple myeloma: an effective and well-tolerated frontline regimen. Eur J Haematol 2009; 82: 433-49.
    • (2009) Eur J Haematol , vol.82 , pp. 433-449
    • Berenson, J.R.1    Yellin, O.2    Woytowitz, D.3
  • 172
    • 84863408900 scopus 로고    scopus 로고
    • Effect of vitamins C and E on antioxidant status of breast-cancer patients undergoing chemotherapy
    • Suhail N, Bilal N, Khan HY, et al. Effect of vitamins C and E on antioxidant status of breast-cancer patients undergoing chemotherapy. J Clin Pharm Ther 2012; 37: 22-26.
    • (2012) J Clin Pharm Ther , vol.37 , pp. 22-26
    • Suhail, N.1    Bilal, N.2    Khan, H.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.