In vivo assessment of toxicity and pharmacokinetics of methylglyoxal: Augmentation of the curative effect of methylglyoxal on cancer-bearing mice by ascorbic acid and creatine

Toxicology and Applied Pharmacology

Volumn 212, Issue 1, 2006, Pages 45-58

  Ghosh, Manju ^a   Talukdar, Dipa ^a   Ghosh, Swapna ^a   Bhattacharyya, Nivedita ^a   Ray, Manju ^a   Ray, Subhankar ^b  

^a DEPARTMENT OF MATERIALS SCIENCE   (India)

^b UNIVERSITY OF CALCUTTA   (India)

Author keywords

Ascorbic acid; Cancer treatment; Creatine; Methylglyoxal; Pharmacokinetics; Toxicity

Indexed keywords

ASCORBIC ACID; CREATINE; METHYLGLYOXAL;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BEHAVIOR; BODY WEIGHT; CANCER; CHEMICAL ANALYSIS; CHRONIC TOXICITY; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; FERTILITY; GENITAL SYSTEM; GROWTH INHIBITION; HEMATOLOGICAL PARAMETERS; HISTOPATHOLOGY; IN VIVO STUDY; LIFESPAN; MALE; MAXIMUM ALLOWABLE CONCENTRATION; MOUSE; NONHUMAN; ORGAN; PERITONEAL CAVITY; PROGENY; RABBIT; RAT; TERATOGENICITY; TOXICITY TESTING; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; ASCORBIC ACID; BODY WEIGHT; CARCINOMA, EHRLICH TUMOR; CREATINE; DOGS; DRUG SYNERGISM; ENZYMES; FEMALE; FERTILITY; LONGEVITY; MALE; MICE; NEOPLASM TRANSPLANTATION; PYRUVALDEHYDE; RABBITS; RATS; REPRODUCTION; SPECIES SPECIFICITY; SURVIVAL ANALYSIS; TERATOGENS; VITAMINS;

ANIMALIA; CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS; RODENTIA;

EID: 33644963032     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.07.003     Document Type: Article

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