Naturally derived factors and their role in the promotion of angiogenesis for the healing of chronic wounds

Angiogenesis

Volumn 16, Issue 3, 2013, Pages 493-502

  Morgan, Claire ^a   Nigam, Yamni ^a  

^a SWANSEA UNIVERSITY   (United Kingdom)

Author keywords

Angiogenesis; Chronic wounds; Growth factors; Maggots; Plants; VEGF

Indexed keywords

8 PRENYLNARINGENIN; ANT VENOM; ASIATICOSIDE; BECAPLERMIN; BEE VENOM; BLECHNUM ORIENTALE EXTRACT; CENTELLA ASIATICA EXTRACT; CHROMOLAENA ODORATA EXTRACT; CONNECTIVE TISSUE GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; FERULIC ACID; FIBROBLAST GROWTH FACTOR; GARLIC EXTRACT; GRAPE SEED EXTRACT; GROWTH FACTOR; ISOXANTHOHUMOL; NICOTIANA ALATA EXTRACT; NICOTINE; PLACEBO; PLANT EXTRACT; PLATELET DERIVED GROWTH FACTOR; POLYPHENOL; POUTERIA LUCUMA EXTRACT; PROANTHOCYANIDIN; RECOMBINANT BASIC FIBROBLAST GROWTH FACTOR; SPIDER VENOM; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; XANTHOHUMOL;

ANGIOGENESIS; ANTIOXIDANT ACTIVITY; ARTHRITIS; BLECHNUM ORIENTALE; BURN; CHROMOLAENA; CHROMOLAENA ODORATA; CHRONIC WOUND; DEBRIDEMENT; DRUG MECHANISM; GRANULATION TISSUE; HUMAN; INFLAMMATION; MACROPHAGE FUNCTION; MAGGOT THERAPY; MEDICINAL PLANT; NICOTIANA; NICOTIANA ALATA; NONHUMAN; PATHOPHYSIOLOGY; POUTERIA; POUTERIA LUCUMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SKIN INFECTION; SKIN INJURY; SOFT TISSUE INJURY; SOLID TUMOR; UPREGULATION; WOUND; WOUND CARE; WOUND FLUID; WOUND HEALING; WOUND HEALING IMPAIRMENT;

ANGIOGENESIS INDUCING AGENTS; ANIMALS; BIOLOGICAL AGENTS; CHRONIC DISEASE; HUMANS; INSECTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LARVA; MODELS, BIOLOGICAL; NEOVASCULARIZATION, PHYSIOLOGIC; PHENOLS; PLANT EXTRACTS; WOUND HEALING;

ANIMALIA;

EID: 84879236626     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-013-9341-1     Document Type: Review

References (115)

1. Tonnesen MG, Feng X, Clark RA (2000) Angiogenesis in wound healing. J Investig Dermatol Symp Proc 5(1):40-46
2. Kajdaniuk D, et al. (2011) Vascular endothelial growth factor (VEGF) - part 1: in physiology and pathophysiology. Endokrynol Pol 62(5):444-455
3. Huang Z, Bao SD (2004) Roles of main pro- and anti-angiogenic factors in tumor angiogenesis. World J Gastroenterol 10(4):463-470
4. Slevin M, Krupinski J, Badimon L (2009) Controlling the angiogenic switch in developing atherosclerotic plaques: possible targets for therapeutic intervention. J Angiogenes Res 1:4
5. Libby P, Theroux P (2005) Pathophysiology of coronary artery disease. Circulation 111(25):3481-3488
6. Fan TP, Jaggar R, Bicknell R (1995) Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends Pharmacol Sci 16(2):57-66
7. Schultz GS, et al. (2003) Wound bed preparation: a systematic approach to wound management. Wound Repair Regen 11(Suppl 1):S1-S28
8. Li J, Zhang YP, Kirsner RS (2003) Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix. Microsc Res Tech 60(1):107-114
9. The management of pressure ulcers in primary and secondary care royal college of nursing (UK) (2005) London: Royal College of Nursing. NICE Clinical Guidelines, No. 29
10. Nugent R (2008) Chronic diseases in developing countries: health and economic burdens. Ann N Y Acad Sci 1136:70-79
11. Favia G, et al. (2008) Accelerated wound healing of oral soft tissues and angiogenic effect induced by a pool of aminoacids combined to sodium hyaluronate (AMINOGAM). J Biol Regul Homeost Agents 22(2):109-116
12. Cho CH, et al. (2006) COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model. Proc Natl Acad Sci USA 103(13):4946-4951
13. Kleinman HK, Malinda KM (2000) Role of angiogenesis in wound healing. Angiogenesis inhibitors and stimulators:potential therapeutic implications
14. Li WW, Li VW (2003) Angiogenesis: a control point for normal and delayed wound healing. Contemp Surg Supplement:5-11
15. Clark RA, Ghosh K, Tonnesen MG (2007) Tissue engineering for cutaneous wounds. J Invest Dermatol 127(5):1018-1029
16. Greenburg GB, Hunt TK (1978) The proliferative response in vitro of vascular endothelial and smooth muscle cells exposed to wound fluids and macrophages. J Cell Physiol 97(3 Pt 1):353-360
17. Banda MJ, et al. (1982) Isolation of a nonmitogenic angiogenesis factor from wound fluid. Proc Natl Acad Sci USA 79(24):7773-7777
18. Marikovsky M, et al. (1993) Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury. Proc Natl Acad Sci USA 90(9):3889-3893
19. Vogt PM, et al. (1998) Determination of endogenous growth factors in human wound fluid: temporal presence and profiles of secretion. Plast Reconstr Surg 102(1):117-123
20. Higley HR, et al. (1995) Extravasation of macromolecules and possible trapping of transforming growth factor-beta in venous ulceration. Br J Dermatol 132(1):79-85
21. Chen SM, et al. (1997) Ability of chronic wounds to degrade peptide growth factors is associated with increased levels of elastase activity and diminished levels of proteinase inhibitors. Wound Repair Regen 5:23-32
22. Shukla A, et al. (1999) In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol 65(1):1-11
23. Pradhan L, et al. (2007) Wound-healing abnormalities in diabetes and new therapeutic interventions. US Endocrinol (1):68-72
24. Smiell JM, et al. (1999) Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: a combined analysis of four randomized studies. Wound Repair Regen 7(5):335-346
25. Lee MJ, et al. (1998) In vitro angiogenic activity of Aloe vera gel on calf pulmonary artery endothelial (CPAE) cells. Arch Pharm Res 21(3):260-265
26. Morisaki N, et al. (1995) Mechanism of angiogenic effects of saponin from ginseng Radix rubra in human umbilical vein endothelial cells. Br J Pharmacol 115(7):1188-1193
27. Choi DY, et al. (2009) Stimulatory effect of Cinnamomum cassia and cinnamic acid on angiogenesis through up-regulation of VEGF and Flk-1/KDR expression. Int Immunopharmacol 9(7-8):959-967
28. Fan TP, et al. (2006) Angiogenesis: from plants to blood vessels. Trends Pharmacol Sci 27(6):297-309
29. Majewska I, Gendaszewska-Darmach E (2011) Proangiogenic activity of plant extracts in accelerating wound healing - a new face of old phytomedicines. Acta Biochim Pol 58(4):449-460
30. Gupta A, et al. (2008) A poly-herbal formulation accelerates normal and impaired diabetic wound healing. Wound Repair Regen 16(6):784-790
31. Gupta A, et al. (2005) A preclinical study of the effects of seabuckthorn (Hippophae rhamnoides L.) leaf extract on cutaneous wound healing in albino rats. Int J Low Extrem Wounds 4(2):88-92
32. Seven B, et al. (2009) Hippophae rhamnoides L. and dexpanthenol- bepanthene on blood flow after experimental skin burns in rats using 133Xe clearance technique. Hell J Nucl Med 12(1):55-58
33. Upadhyay NK, et al. (2009) Safety and healing efficacy of Sea buckthorn (Hippophae rhamnoides L.) seed oil on burn wounds in rats. Food Chem Toxicol 47(6):1146-1153
34. Atiba A, et al. (2011) Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-beta and fibroblast growth factor production. Am J Surg 201(6):809-818
35. Davies RH, et al. (1989) Wound healing:oral and topcial activity of Aloe Vera. J Am Podiatr Med Assoc. 79(11):559-562
36. Rodriguez-Bigas M, Cruz NI, Suarez A (1988) Comparative evaluation of aloe vera in the management of burn wounds in guinea pigs. Plast Reconstr Surg 81(3):386-389
37. Cock MJW, Holloway JD (1982) The history of, and prospects for, the biological control of Chromolaena odorata (Compositae) by Pareuchaetes pseudoinsulata Rego Barros and allies (Lepidoptera: Arctiidae). Bull Entomol Res 72:193-205
38. Suksamrarn A, et al. (2004) Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata. Arch Pharm Res 27(5):507-511
39. Owoyele VB, Adediji JO, Soladoye AO (2005) Anti-inflammatory activity of aqueous leaf extract of Chromolaena odorata. Inflammopharmacology 13(5-6):479-484
40. Rao KS, Chaudhury PK, Pradhan A (2010) Evaluation of anti-oxidant activities and total phenolic content of Chromolaena odorata. Food Chem Toxicol 48(2):729-732
41. Phan TT, Hughes MA, Cherry GW (2001) Effects of an aqueous extract from the leaves of Chromolaena odorata (Eupolin) on the proliferation of human keratinocytes and on their migration in an in vitro model of reepithelialization. Wound Repair Regen 9(4):305-313
42. Phan TT, Hughes MA, Cherry GW (1998) Enhanced proliferation of fibroblasts and endothelial cells treated with an extract of the leaves of Chromolaena odorata (Eupolin), an herbal remedy for treating wounds. Plast Reconstr Surg 101(3):756-765
43. Chander R, Kapoor NK, Dhawan BN (1992) Picroliv, picroside-I and kutkoside from Picrorhiza kurrooa are scavengers of superoxide anions. Biochem Pharmacol 44(1):180-183
44. Singh AK, et al. (2007) Picroliv accelerates epithelialization and angiogenesis in rat wounds. Planta Med 73(3):251-256
45. Gohil KJ, Patel JA, Gajjar AK (2010) Pharmacological review on Centella asiatica: a potential herbal cure-all. Indian J Pharm Sci 72(5):546-556
46. Abou Shousha ES, Khalil HA (1967) Effect of asiaticoside (Madecassol) on the healing process in cataract surgical wounds and retinal detachment operations (clinical and experimental study). Bull Ophthalmol Soc Egypt 60(64):451-470
47. Lawrence JC (1967) The morphological and pharmacological effects of asiaticoside upon skin in vitro and in vivo. Eur J Pharmacol 1(5):414-424
48. Rosen H, Blumenthal A, McCallum J (1967) Effect of asiaticoside on wound healing in the rat. Proc Soc Exp Biol Med 125(1):279-280
49. Shukla A, Rasik AM, Dhawan BN (1999) Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytother Res 13(1):50-54
50. Maquart FX, et al. (1999) Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur J Dermatol 9(4):289-296
51. Maquart FX, et al. (1990) Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica. Connect Tissue Res 24(2):107-120
52. Lu L, et al. (2004) Dermal fibroblast-associated gene induction by asiaticoside shown in vitro by DNA microarray analysis. Br J Dermatol 151(3):571-578
53. Kimura Y, et al. (2008) Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism. Eur J Pharmacol 584(2-3):415-423
54. Ejaz S, et al. (2009) Effect of aged garlic extract on wound healing: a new frontier in wound management. Drug Chem Toxicol 32(3):191-203
55. Schuller HM (2009) Is cancer triggered by altered signalling of nicotinic acetylcholine receptors? Nat Rev Cancer 9(3):195-205
56. Silverstein P (1992) Smoking and wound healing. Am J Med 93(1A):22S-24S
57. Wong LS, et al. (2004) Effects of "second-hand" smoke on structure and function of fibroblasts, cells that are critical for tissue repair and remodeling. BMC Cell Biol 5:13
58. Wong LS, Martins-Green M (2004) Firsthand cigarette smoke alters fibroblast migration and survival: implications for impaired healing. Wound Repair Regen 12(4):471-484
59. Martin JW, et al. (2009) The multiple faces of nicotine and its implications in tissue and wound repair. Exp Dermatol 18(6):497-505
60. Siegmund B, Leitner E, Pfannhauser W (1999) Determination of the nicotine content of various edible nightshades (Solanaceae) and their products and estimation of the associated dietary nicotine intake. J Agric Food Chem 47(8):3113-3120
61. Heeschen C, et al. (2001) Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nat Med 7(7):833-839
62. Villablanca AC (1998) Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. J Appl Physiol 84(6):2089-2098
63. Heeschen C, et al. (2006) Endothelial progenitor cells participate in nicotine-mediated angiogenesis. J Am Coll Cardiol 48(12):2553-2560
64. Jacobi J, et al. (2002) Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice. Am J Pathol 161(1):97-104
65. Morimoto N, et al. (2008) Nicotine at a low concentration promotes wound healing. J Surg Res 145(2):199-204
66. Rojo LE, et al. (2010) Wound-healing properties of nut oil from Pouteria lucuma. J Cosmet Dermatol 9(3):185-195
67. Guo S, Dipietro LA (2010) Factors affecting wound healing. J Dent Res 89(3):219-229
68. Rodriguez PG, et al. (2008) The role of oxygen in wound healing: a review of the literature. Dermatol Surg 34(9):1159-1169
69. Bagchi M, et al. (1999) Smokeless tobacco, oxidative stress, apoptosis, and antioxidants in human oral keratinocytes. Free Radic Biol Med 26(7-8):992-1000
70. Bagchi D, et al. (1997) Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95(2):179-189
71. Gu L, et al. (2004) Concentrations of proanthocyanidins in common foods and estimations of normal consumption. J Nutr 134(3):613-617
72. Hupkens P, Boxma H, Dokter J (1995) Tannic acid as a topical agent in burns: historical considerations and implications for new developments. Burns 21(1):57-61
73. Khanna S, et al. (2002) Dermal wound healing properties of redox-active grape seed proanthocyanidins. Free Radic Biol Med 33(8):1089-1096
74. Khanna S, et al. (2001) Upregulation of oxidant-induced VEGF expression in cultured keratinocytes by a grape seed proanthocyanidin extract. Free Radic Biol Med 31(1):38-42
75. Dufresne CJ, Farnworth ER (2001) A review of the latest research findings on the health promotion properties of tea. J Nutr Biochem 12:404-421
76. Cao Y, Cao R (1999) Angiogenesis inhibited by drinking tea. Nature 398:381
77. Jung YD, et al. (2001) Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea. Br J Cancer 84(6):844-850
78. Toi M, et al. (2003) Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo. Angiogenesis 6(2):121-128
79. Lin C, et al. (2010) Ferulic acid augments angiogenesis via VEGF, PDGF and HIF-1. J Nutr Biochem 21:627-633
80. Tulio Az, et al. (2012) Berry fruits modulate endothelial cell migration and angiogenesis via phosphoinositide-3 kinase/protein kinase B pathway in vitro in endothelial cells. J Agric Food Chem 60:5803-5812
81. Negrao R, et al. (2010) Angiogenesis and inflammation signalling are targets of beer polyphenols on vascular cells. J Cell Biochem 111(5):1207-1209
82. Rates SMK (2001) Plants as sources of drugs. Toxicon 39(5):603-613
83. Altman RD, et al. (1984) The effects of a partially purified fraction of an ant venom in rheumatoid arthritis. Arthritis Rheum 27(3):277-284
84. Lee JY, et al. (2005) Inhibitory effect of whole bee venom in adjuvant-induced arthritis. In Vivo 19(4):801-805
85. Kang SS, Pak SC, Choi SH (2002) The effect of whole bee venom on arthritis. Am J Chin Med 30(1):73-80
86. Saad Rached IC, et al. (2010) Anti-inflammatory effect of bee venom on antigen-induced arthritis in rabbits: influence of endogenous glucocorticoids. J Ethnopharmacol 130(1):175-178
87. Ip SW, et al. (2012) Bee venom induces apoptosis through intracellular Ca2+-modulated intrinsic death pathway in human bladder cancer cells. Int J Urol 19(1):61-70
88. Park MH, et al. (2011) Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-kappaB. Prostate 71(8):801-812
89. Putz T, et al. (2007) Bee venom secretory phospholipase A2 and phosphatidylinositol-homologues cooperatively disrupt membrane integrity, abrogate signal transduction and inhibit proliferation of renal cancer cells. Cancer Immunol Immunother 56(5):627-640
90. D'Suze G, et al. (2010) Apoptogenic peptides from Tityus discrepans scorpion venom acting against the SKBR3 breast cancer cell line. Toxicon 56(8):1497-1505
91. Gao L, et al. (2005) Effects of spider Macrothele raven venom on cell proliferation and cytotoxicity in HeLa cells. Acta Pharmacol Sin 26(3):369-376
92. Gao L, et al. (2007) Effect of spider venom on cell apoptosis and necrosis rates in MCF-7 cells. DNA Cell Biol 26(7):485-489
93. Zargan J, et al. (2011) Scorpion venom (Odontobuthus doriae) induces apoptosis by depolarization of mitochondria and reduces S-phase population in human breast cancer cells (MCF-7). Toxicol In Vitro 25(8):1748-1756
94. Zhang YY, et al. (2009) Anti-proliferation Effect of Polypeptide Extracted from Scorpion Venom on Human Prostate Cancer Cells in vitro. J Clin Med Res 1(1):24-31
95. Cherniack EP (2010) Bugs and drugs, Part1: insects. The "New" alternative medicine for the 21st Century? Altern Med Rev 15(2):124-135
96. Chan DC, et al. (2007) Maggot debridement therapy in chronic wound care. Hong Kong Med J 13(5):382-386
97. Dossey L (2002) Maggots and leeches: when science and aesthetics collide. Altern Ther Health Med 8(4):12-6, 106-7
98. Dunn C, Raghavan U, Pfleiderer AG (2002) The use of maggots in head and neck necrotizing fasciitis. J Laryngol Otol 116(1):70-72
99. Namias N, et al. (2000) Biodebridement: a case report of maggot therapy for limb salvage after fourth-degree burns. J Burn Care Rehabil 21(3):254-257
100. Sherman RA (2003) Maggot therapy for treating diabetic foot ulcers unresponsive to conventional therapy. Diabetes Care 26(2):446-451
101. Sherman RA, Tran JM, Sullivan R (1996) Maggot therapy for venous stasis ulcers. Arch Dermatol 132(3):254-256
102. Steenvoorde P, et al. (2007) Maggot debridement therapy in necrotising fasciitis. Methods Wounds 19:73-78
103. Tantawi TI, et al. (2007) Clinical and microbiological efficacy of MDT in the treatment of diabetic foot ulcers. J Wound Care 16(9):379-383
104. Wayman J, et al. (2000) The cost effectiveness of larval therapy in venous ulcers. J Tissue Viability 10(3):91-94
105. Sherman RA (2002) Maggot versus conservative debridement therapy for the treatment of pressure ulcers. Wound Repair Regen 10(4):208-214
106. Courtenay M, Church JC, Ryan TJ (2000) Larva therapy in wound management. J R Soc Med 93(2):72-74
107. Wollina U, et al. (2002) Biosurgery supports granulation and debridement in chronic wounds - clinical data and remittance spectroscopy measurement. Int J Dermatol 41(10):635-639
108. Horobin AJ, Shakesheff KM, Pritchard DI (2005) Maggots and wound healing: an investigation of the effects of secretions from Lucilia sericata larvae upon the migration of human dermal fibroblasts over a fibronectin-coated surface. Wound Repair Regen 13(4):422-433
109. Horobin AJ, Shakesheff KM, Pritchard DI (2006) Promotion of human dermal fibroblast migration, matrix remodelling and modification of fibroblast morphology within a novel 3D model by Lucilia sericata larval secretions. J Invest Dermatol 126(6):1410-1418
110. Horobin AJ, et al. (2003) Maggots and wound healing: an investigation of the effects of secretions from Lucilia sericata larvae upon interactions between human dermal fibroblasts and extracellular matrix components. Br J Dermatol 148(5):923-933
111. Bexfield A, et al. (2010) Amino acid derivatives from Lucilia sericata excretions/secretions may contribute to the beneficial effects of maggot therapy via increased angiogenesis. Br J Dermatol 162(3):554-562
112. Zhang Z, et al. (2010) Fatty acid extracts from Lucilia sericata larvae promote murine cutaneous wound healing by angiogenic activity. Lipids Health Dis 9:24
113. rd edn:Moseby. Missouri
114. van der Plas MJ, van Dissel JT, Nibbering PH (2009) Maggot secretions skew monocyte-macrophage differentiation away from a pro-inflammatory to a pro-angiogenic type. PLoS ONE 4(11):e8071
115. Wang SY, et al. (2010) Maggot excretions/secretions induces human microvascular endothelial cell migration through AKT1. Mol Biol Rep 37(6):2719-2725