Berry fruits modulated endothelial cell migration and angiogenesis via phosphoinositide-3 kinase/protein kinase B pathway in vitro in endothelial cells

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 23, 2012, Pages 5803-5812

  Tulio, Artemio Z ^a   Chang, Claire ^a   Edirisinghe, Indika ^b   White, Kevin D ^a   Jablonski, Joseph E ^a   Banaszewski, Katarzyna ^b   Kangath, Archana ^b   Tadapaneni, Ravi K ^b   Burton Freeman, Britt ^b   Jackson, Lauren S ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b ILLINOIS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

anthocyanins; cell migration; cranberry; p Akt; polyphenolic compounds; strawberry; tube formation; wild blueberry

Indexed keywords

CELL MIGRATION; CRANBERRY; P-AKT; POLYPHENOLIC COMPOUND; STRAWBERRY; TUBE FORMATION; WILD BLUEBERRIES;

ACTIVATION ANALYSIS; ANTHOCYANINS; ENDOTHELIAL CELLS; ENZYMES;

FRUITS;

ANTHOCYANIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; POLYPHENOL; PROTEIN KINASE B;

ARTICLE; CELL MOTION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIUM CELL; FRUIT; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANTHOCYANINS; CELL MOVEMENT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; FRUIT; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT EXTRACTS; POLYPHENOLS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

FRAGARIA X ANANASSA; VACCINIUM; VACCINIUM MACROCARPON;

EID: 84862165580     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf3001636     Document Type: Article

References (37)

1. Stoclet, J. C.; Chataigneau, T.; Ndiaye, M.; Oak, M. H.; ElBedoui, J.; Chataigneau, M.; Schini-Kerth, V. B. Vascular protection by dietary polyphenols Eur. J. Pharmacol. 2004, 500, 299-313
2. Pandey, K. B.; Rizvi, S. I. Plant polyphenols as dietary antioxidants inhuman health and disease Oxid. Med. Cell Longev. 2009, 2, 270-278
3. Manach, C.; Mazur, A.; Scalbert, A. Polyphenols and prevention of cardiovascular diseases Curr. Opin. Lipidol. 2005, 16, 77-84
4. Hirata, Y.; Nagata, D.; Suzuki, E.; Nishimatsu, H.; Suzuki, J.; Nagai, R. Diagnosis and treatment of endothelial dysfunction in cardiovascular disease Int. Heart J. 2010, 51, 1-6
5. Vanhoutte, P. M.; Shimokawa, H.; Tang, E. H.; Feletou, M. Endothelial dysfunction and vascular disease Acta Physiol. 2009, 196, 193-222
6. Olsson, A. K.; Dimberg, A.; Kreuger, J.; Claesson-Welsh, L. VEGF receptor signaling - in control of vascular function Nat. Rev. Mol. Cell. Biol. 2006, 7, 359-371
7. Edirisinghe, I.; Yang, S. R.; Yao, H.; Rajendrasozhan, S.; Caito, S; Adenuga, D.; Wong, C.; Rahman, A.; Phipps, R. P.; Jin, Z. G.; Rahman, I. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction FASEB J. 2008, 22, 2297-2310
8. Edirisinghe, I.; Banaszewski, K.; Cappozzo, J.; Sandhya, K.; Ellis, C. L.; Tadapaneni, R.; Kappagoda, C. T.; Burton-Freeman, B. M. Strawberry anthocyanin and its association with postprandial inflammation and insulin Br. J. Nutr. 2011, 106, 913-922
9. Auger, C.; Kim, J. H.; Trinh, S.; Chataigneau, T.; Popken, A. M.; Schini-Kerth, V. B. Fruit juice-induced endothelium-dependent relaxations in isolated porcine coronary arteries: evaluation of different fruit juices and purees and optimization of a red fruit juice blend Food Funct. 2011, 2, 245-250
10. Edirisinghe, I.; Burton-Freeman, B.; Varelis, P.; Kappagoda, T. Strawberry extract caused endothelium-dependent relaxation through the activation of PI3 kinase/Akt J. Agric. Food Chem. 2008, 56, 9383-9390
11. Edirisinghe, I.; Banaszewski, K.; Cappozzo, J.; McCarthy, D.; Burton-Freeman, B. M. Effect of black currant anthocyanins on the activation of endothelial nitric oxide synthase (eNOS) in vitro in human endothelial cells J. Agric. Food Chem. 2011, 59, 8616-8624
12. Edirisinghe, I.; Burton-Freeman, B; Tissa Kappagoda, C. Mechanism of the endothelium-dependent relaxation evoked by a grape seed extract Clin. Sci. 2008, 114, 331-337
13. Asami, D. K.; Hong, Y.-J.; Barrett, D. M.; Mitchell, A. E. Comparison of the total phenolic and ascorbic acid content of freeze-dried and Air-dried marionberry, strawberry, and corn grown using conventional, organic, and sustainable agricultural practices J. Agric. Food Chem. 2003, 51, 1237-1241
14. Mullen, W.; Larcombe, S.; Arnold, K.; Welchman, H.; Crozier, A. Use of accurate mass full scan mass spectrometry for the analysis of anthocyanins in berries and berry-fed tissues J. Agric. Food Chem. 2010, 58, 3910-3915
15. Slinkard, K.; Singleton, V. L. Total phenol analysis: automation and comparison with manual methods Am. J. Enol. Vitic. 1977, 28, 49-55
16. Sanchez-Mata, M. C.; Camara-Hurtado, M.; Diez-Marques, C.; Torija-Isasa, M. E. Comparison of high-performance liquid chromatography and spectrofluorimetry for vitamin C analysis of green beans (Phaseolus vulgaris L.) Eur. Food Res. Technol. 2000, 210, 220-225
17. FL) of plasma and other biological and food samples J. Agric. Food Chem. 2003, 51, 3273-3279
18. Celermajer, D. S. Endothelial dysfunction: does it matter? Is it reversible? J. Am. Coll. Cardiol. 1997, 30, 325-333
19. Lamalice, L.; Le Beouf, F.; Hout, J. Endothelial cell migration during angiogenesis Circ. Res. 2007, 100, 782-794
20. Kalt, W.; McDonald, J. E.; Ricker, R. D.; Lu, X. Anthocyanin content and profile within and among blueberry species Can. J. Plant Sci. 1999, 79, 617-623
21. Sapers, G. M.; Hargrave, D. L. Proportion of individual anthocyanins in fruits of cranberry cultivars J. Am. Soc. Hortic. Sci. 1987, 112, 104-108
22. Pappas, E.; Schaich, K. M. Phytochemicals of cranberries and cranberry products: characterization, potential health effects, and processing stability Crit. Rev. Food Sci. Nutr. 2009, 49, 741-781
23. Vorsa, N.; Welker, W. V. Relationship between fruit size and extractable anthocyanin content in cranberry HortScience 1985, 20, 402-403
24. Ucuzian, A. A.; Greisler, H. P. In vitro models of angiogenesis World J. Surg. 2007, 31, 654-663
25. Schini-Kerth, V. B.; Etienne-Selloum, N.; Chataigneau, T.; Auger, C. Planta Med. 2011, 77, 1161-1167
26. Lekakis, J.; Rallidis, L. S.; Andreadou, I.; Vamvakou, G.; Kazantzoglou, G.; Magiatis, P.; Skaltsounis, A. L.; Kremastinos, D. T. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease Eur. J. Cardiovasc. Prev. Rehabil. 2005, 12, 596-600
27. Dohadwala, M. M.; Holbrook, M.; Hamburg, N. M.; Shenouda, S. M.; Chung, W. B.; Titas, M.; Kluge, M. A.; Wang, N.; Palmisano, J.; Milbury, P. E.; Blumberg, J. B.; Vita, J. A. Effects of cranberry juice consumption on vascular function in patients with coronary artery disease Am. J. Clin. Nutr. 2011, 93, 934-940
28. Dal-Ros, S.; Zoll, J.; Lang, A. L.; Auger, C.; Keller, N.; Bronner, C.; Geny, B.; Schini-Kerth, V. B. Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase Biochem. Biophys. Res. Commun. 2011, 404, 743-749
29. Kolluru, G. P.; Bir, S. C.; Kevil, C. G. Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing. Int. J. Vasc. Med. 2012, 2012, DOI: 10.1155/2012/918267.
30. Ohga, N.; Hida, K.; Hida, Y.; Muraki, C.; Tsuchiya, K.; Matsuda, K.; Ohiro, Y.; Totsuka, Y.; Shindoh, M. Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells Cancer Sci. 2009, 100, 1963-1970
31. Seeram, N. P.; Adams, L. S.; Zhang, Y.; Lee, R.; Sand, D.; Scheuller, H. S.; Heber, D. Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro J. Agric. Food Chem. 2006, 54, 9329-9339
32. Kim, K. K.; Singh, A. P.; Singh, R. K.; Demartino, A.; Brard, L.; Vorsa, N.; Lange, T. S.; Moore, R. G. Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells Int. J. Oncol. 2012, 40, 227-335
33. Chen, C.-H.; Li, S.-C.; Chen, C.-Y. O.; Au, H.-K.; Shih, C.-K.; Hsu, C.-Y.; Liu, J.-F. Constituents in purple sweet potato leaves inhibit in vitro angiogenesis with opposite effects ex vivo Nutr. 2011, 27, 1177-1182
34. Wang, L.; Morris, M. E. Liquid chromatography tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine J. Chromatogr., B 2005, 821, 194-201
35. Kay, C. D.; Mazza, G.; Holub, B. J.; Wang, J. Anthocyanin metabolites in human urine and serum Br. J. Nutr. 2004, 91, 933-942
36. Felgines, C.; Talavéra, S.; Gonthier, M.-P.; Texier, O.; Scalbert, A.; Lamaison, J.-L.; Rémésy, C. Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugated in humans J. Nutr. 2003, 133, 1296-1301
37. Keppler, K.; Humpf, H.-U. Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora Bioorg. Med. Chem. 2005, 13, 5195-5205