Effects of spider Macrothele raven venom on cell proliferation and cytotoxicity in HeLa cells

Acta Pharmacologica Sinica

Volumn 26, Issue 3, 2005, Pages 369-376

  Gao, Li ^a,b   Shan, Bao En ^c   Chen, Jing ^d   Liu, Jiang Hui ^e   Song, Da Xiang ^a   Zhu, Bao Cheng ^a,f  

^a HEBEI UNIVERSITY   (China)

^b HEBEI NORMAL UNIVERSITY   (China)

^c HEBEI MEDICAL UNIVERSITY   (China)

^d BETHUNE INTERNATIONAL PEACE HOSPITAL   (China)

^e Hebei Provincial Institute for Drug Control   (China)

^f AGRICULTURAL UNIVERSITY OF HEBEI   (China)

Author keywords

Caspase 3 expression; Cell cycle; Cell proliferation; Cytotoxicity; HeLa cells; Spider venom

Indexed keywords

ACRIDINE ORANGE; CASPASE 3; DNA FRAGMENT; ETHIDIUM BROMIDE; LACTATE DEHYDROGENASE; SPIDER VENOM;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; DOSE TIME EFFECT RELATION; ENZYME ASSAY; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; NONHUMAN; SPIDER; TRANSMISSION ELECTRON MICROSCOPY; TUMOR VOLUME; UTERINE CERVIX CARCINOMA; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CELL CYCLE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HELA CELLS; HUMANS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; SPIDER VENOMS; UTERINE CERVICAL NEOPLASMS;

EID: 15244359951     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2005.00052.x     Document Type: Article

References (32)

1. Schanbacher FL, Lee CK, Hall JE, Wilson IB, Howell DE, Odell GV. Composition and properties of tarantula Dugesiella hentzi (Girard) venom. Toxicon 1973; 11: 21-4.
2. Jackson H, Parks TN. Spider toxins: recent applications in neurobiology. Annu Rev Neurosci 1989; 12: 405-14.
3. Ori M, Ikeda H. Spider venoms and spider toxins. J Toxicol 1998; 17: 405-26.
4. Rash LD, Hodgson WC. Pharmacology and biochemistry of spider venoms. Toxicon 2002; 40: 225-54.
5. Abu-Sinna G, Esmat AY, Al-Zahaby AA, Soliman NA, Ibrahim TM. Fractionation and characterization of Cerastes cerastes snake venom and the antitumor action of its lethal and non-lethal fractions. Toxicon 2003; 42: 207-15.
6. Swenson S, Costa F, Minea R, Sherwin RP, Ernst W, Fujii G, et al Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression. Mol Cancer Ther 2004; 3: 499-511.
7. Correa MC Jr, Maria DA, Moura-da-Silva AM, Pizzocaro KF, Ruiz IR. Inhibition of melanoma cell tumorigenicity by the snake venom toxin jararhagin. Toxicon 2002; 40: 739-48.
8. de Carvalho DD, Schmitmeier S, Novelle JC, Markland FS. Effect of BJcuL (a lectin from the venom of the snake Bothrops jararacussu) on adhesion and growth of tumor and endothelial cells. Toxicon 2001; 39: 1471-6.
9. Schmitmeier S, Markland FS, Chen TC. Anti-invasive effect of contortrostatin, a snake venom disintegrin, and TNF-alpha on malignant glioma cells. Anticancer Res 2000; 20: 4227-33.
10. Orsolic N, Sver L, Verstovsek S, Terzic S, Basic I. Inhibition of mammary carcinoma cell proliferation in vitro and tumor growth in vivo by bee venom. Toxicon 2003; 41: 861-70.
11. Shaposhnikova VV, Kublik LN, Narimanov AA, Levitman MKh, Orlova OE, Kudriavtsev AA, et al. Growth inhibition and induction of tumor cell death by phospholipase A2 and lipoxygenase inhibitors. Izv Akad Nauk Ser Biol 2001; (2): 249-52.
12. Liu X, Chen D, Xie L, Zhang R. Effect of honey bee venom on proliferation of K1735M2 mouse melanoma cells in-vitro and growth of murine B16 melanomas in-vivo. J Pharm Pharmacol 2002; 54: 1083-9.
13. Liu YF, Ma RL, Wang SL, Duan ZY, Zhang JH, Wu LJ, et al. Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii karsch in Escherichia coli. Protein Expr Purif 2003; 27: 253-8.
14. Szeto TH, Birinyi-Strachan LC, Smith R, Connor M, Christie MJ, King GF, et al. Isolation and pharmacological characterisation of delta-atracotoxin-Hv1b, a vertebrate- selective sodium channel toxin. FEBS Lett 2000; 470: 293-9.
15. Stotz SC. Block of voltage-dependent calcium channel by the green mamba toxin calcicludine. J Membrane Biol 2000; 174: 157-65.
16. Marvin L, De E, Cosette P, Gagnon J, Molle G, Lange C. Isolation, amino acid sequence and functional assays of SGTx1. The first toxin purified from the venom of the spider Scodra griseipes. Eur J Biochem 1999; 265: 572-9.
17. Corzo G, Gilles N, Satake H, Villegas E, Dai L, Nakajima T, et al. Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel. FEBS Lett 2003; 547: 43-50.
18. Satake H, Villegas E, Oshiro N, Terada K, Shinada T, Corzo G. Rapid and efficient identification of cysteine-rich peptides by random screening of a venom gland cDNA library from the hexathelid spider Macrothele gigas. Toxicon 2004; 44: 149-56.
19. Zhu MS, Li TH, Song DX. A species of genus macrothele (araneae: hexathekidae) from China. J Hebei Univ (Natural Science Edition) 2000; 4: 358-61.
20. Zheng XZ, Liang SP. Purification and preliminary toxin research of raventoxin-II, a neurotoxic peptide from the venom of the spider Macrothele raveni. Life Sci Res 2001; 3: 217-20.
21. Zeng XZ, Xiao QB, Liang SP. Purification and characterization of raventoxin-I and raventoxin-III, two neurotoxic peptides from the venom of the spider Macrothele raveni. Toxicon 2003; 41: 651-6.
22. Friedel T, Nentwig W. Immobilizing and lethal effects of spider venoms on the cockroach and the common mealbeetle. Toxicon 1989; 27: 305-16.
23. Giuliano M, Lauricella M, Vassallo E, Carabillò M, Vento R, Tesoriere G. Induction of apoptosis in human retinoblastoma cells by topoisomerase inhibitors. Invest Ophthalmol Vis Sci 1998; 39: 1300-11.
24. Zhang Y, Wu LJ, Tashiro S, Onodera S, Ikejima T. Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis. Acta Pharmacol Sin 2004; 25: 83-9.
25. i homeostasis underlying desipramine-induced C6 glioma cell apoptosis. Acta Pharmacol Sin 2002; 23: 803-7.
26. Lan H, Lu YY. Allitridi induces apoptosis by affecting Bcl-2 expression and caspase-3 activity in human gastric cancer cells. Acta Pharmacol Sin 2004; 25: 219-25.
27. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, et al. Human ICE/CED-3 protease nomenclature. Cell 1996; 87: 171.
28. Chae HJ, Park KM, Lee GY, Jeong GS, Park HR, Kim HM, et al. Je-chun-jun induced apoptosis of human cervical carcinoma HeLa cells. Acta Pharmacol Sin 2004; 25: 1372-9.
29. Liu DC, Zang CB, Liu HY, Possinger K, Fan SG, Elstner E. A novel PPAR alpha/gamma dual agonist inhibits cell growth and induces apoptosis in human glioblastoma T98G cells. Acta Pharmacol Sin 2004; 25: 1312-19.
30. Hou R, Zhou QL, Wang BX, Tashiro S, Onodera S, Ikejima T. Diosgenin induces apoptosis in HeLa cells via activation of caspase pathway. Acta Pharmacol Sin 2004; 25: 1077-82.
31. Salvesen GS, Dixit VM. Caspases: intracellular signaling by proteolysis. Cell 1997; 91: 443-6.
32. An WW, Gong XF, Wang MW, Tashiro S, Onodera S, Ikejima T. Norcantharidin induces apoptosis in HeLa cells through caspase, MAPK, and mitochondrial pathways. Acta Pharmacol Sin 2004; 25: 1502-8.