In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica

Journal of Ethnopharmacology

Volumn 65, Issue 1, 1999, Pages 1-11

  Shukla, A ^a,b   Rasik, A M ^a   Jain, G K ^c   Shankar, R ^d   Kulshrestha, D K ^e   Dhawan, B N ^a  

^a Pharmacology Division   (India)

^b UNIVERSITY OF VERMONT   (United States)

^c Pharmaceutics Division   (India)

^d CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^e CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Angiogenesis; Asiaticoside; Centella asiatica; Wound healing

Indexed keywords

ASIATICOSIDE; COLLAGEN; HYDROXYPROLINE; PLANT EXTRACT; STREPTOZOCIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CHICKEN; CHORIOALLANTOIS; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOSE CALCULATION; DRUG EFFECT; DRUG STRUCTURE; EPITHELIZATION; ETHNOPHARMACOLOGY; FIBROBLAST; GUINEA PIG; INDIA; MALE; NONHUMAN; RAT; TENSILE STRENGTH; TOPICAL TREATMENT; WOUND HEALING;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFECTIVE AGENTS; CHICK EMBRYO; GUINEA PIGS; MALE; MODELS, BIOLOGICAL; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN; TIME FACTORS; TRITERPENES; WOUND HEALING; WOUNDS AND INJURIES;

EID: 0032938834     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(98)00141-X     Document Type: Article

References (18)

1. Boiteau, P., Batsimamanga, A.R., 1950. Asiaticoside extracted from Centella asiatica, Its therapeutic uses in the healing of experimental refractory wounds, leprosy, skin tuberculosis and lupus. Therapie 11, 125-149.
2. Burton, K., 1956. A study of the condition and mechanism of the diphenyleamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochemical Journal 62, 315-321.
3. Chopra, R.N., Nayar, S.L., Chopra, I.C., 1956. Glossary of Indian Medicinal Plants. CSIR, New Delhi, p. 58.
4. Clark, R.A.F., 1991. Cutaneous Wound Repair. Oxford University, New York, p. 576.
5. Ehrlich, H.P., Grislis, G., Hunt, T.K., 1972. Metabolic and circulatory contribution to oxygen gradient in wounds. Surgery 72, 576-583.
6. Ingold, W.M., 1993. Wound therapy: growth factors as agents to promote healing. Trends in Biotechnology 11, 387-392.
7. Lobb, R.R., Alderman, E.M., Fett, J.W., 1985. Induction of angiogenesis by bovine brain derived class 1 heparin binding growth factor. Biochemistry 24, 4970-4973.
8. Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., 1951. Protein measurement with folin phenol reagent. Journal of Biochemistry 193, 265-275.
9. Lupia, E., Montrucchio, G., Battaglia, E., Modena, V., Camussi, G., 1996. Role of tumor necrosis factor alpha and platelet-activating factor in neoangiogenesis induced by synovial fluids of patients with rheumatoid arthritis. Europian Journal of Immunology 26, 1690-1694.
10. Maquart, F.X., Bellon, G., Gillery, P., Wegrowski, Y., Borel, J.P., 1990. Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica. Connective Tissue Research 24, 107-120.
11. McManus, J.F.A., Mowry, R.W., 1965. Staining methods, histologic and histochemical. Harper 7 Raw, New York, Evanston, London.
12. Rasik, A.M., Shukla, A., Patnaik, G.K., Dhawan, B.N., Kulshrestha, D.K., Srivastava, S., 1996. Wound healing activity of latex of Euphorbia neriifolia linn. Indian Journal of Pharmacology 28, 107-109.
13. Rosen, H., Blumenthal, A., McCallum, J., 1967. Effect of asiaticoside on wound healing in rats. Experimental Medicine and Surgery 125, 279-280.
14. Schweigerer, L., 1988. Basic fibroblast growth factor as wound healing harmone. Trends in Pharmacology 9, 427-428.
15. Shukla, A., Rasik, A.M., Patnaik, G.K., 1997. Depletion of reduced glutathione, ascorbic acid, vitamin E and antioxidant defense enzymes in a healing cutaneous wounds. Free Radical Research 26, 93-101.
16. Veechai, A.D., Senmi, J., Gassan, G., Mohinaro, M., 1984. Effect of Centella asiatica on the biosynthetic activity of fibroblast in culture. Farmacie Edition 39, 355-364.
17. Woessner, J.F., 1961. The determination of hydroxyproline in tissue and protein samples containing small portion of this imino acid. Archives of Biochemistry and Biophysics 193, 440-447.
18. Yoshinori, A., Reiko, M., Tsumematsu, T., 1982. Mono and sesquiterpenoids from hydrocotyle and Centella species. Phytochemistry 21, 2590-2592.