메뉴 건너뛰기




Volumn 37, Issue 12, 2013, Pages 1970-1977

BACE2 degradation mediated by the macroautophagy-lysosome pathway

Author keywords

site APP cleaving enzyme 2; Alzheimer's disease; Down syndrome; Protein degradation

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 2;

EID: 84879232227     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/ejn.12204     Document Type: Article
Times cited : (22)

References (65)
  • 1
    • 0033970139 scopus 로고    scopus 로고
    • The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region
    • Acquati, F., Accarino, M., Nucci, C., Fumagalli, P., Jovine, L., Ottolenghi, S. & Taramelli, R. (2000) The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region. FEBS Lett., 468, 59-64.
    • (2000) FEBS Lett. , vol.468 , pp. 59-64
    • Acquati, F.1    Accarino, M.2    Nucci, C.3    Fumagalli, P.4    Jovine, L.5    Ottolenghi, S.6    Taramelli, R.7
  • 2
    • 0034721509 scopus 로고    scopus 로고
    • Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease
    • Adamec, E., Mohan, P.S., Cataldo, A.M., Vonsattel, J.P. & Nixon, R.A. (2000) Up-regulation of the lysosomal system in experimental models of neuronal injury: implications for Alzheimer's disease. Neuroscience, 100, 663-675.
    • (2000) Neuroscience , vol.100 , pp. 663-675
    • Adamec, E.1    Mohan, P.S.2    Cataldo, A.M.3    Vonsattel, J.P.4    Nixon, R.A.5
  • 5
    • 78449295431 scopus 로고    scopus 로고
    • In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model
    • Azkona, G., Levannon, D., Groner, Y. & Dierssen, M. (2010b) In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model. Amino Acids, 39, 1571-1580.
    • (2010) Amino Acids , vol.39 , pp. 1571-1580
    • Azkona, G.1    Levannon, D.2    Groner, Y.3    Dierssen, M.4
  • 7
    • 58149087894 scopus 로고    scopus 로고
    • Entering the lysosome through a transient gate by chaperone-mediated autophagy
    • Bandyopadhyay, U. & Cuervo, A.M. (2008) Entering the lysosome through a transient gate by chaperone-mediated autophagy. Autophagy, 4, 1101-1103.
    • (2008) Autophagy , vol.4 , pp. 1101-1103
    • Bandyopadhyay, U.1    Cuervo, A.M.2
  • 8
    • 51349130544 scopus 로고    scopus 로고
    • The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane
    • Bandyopadhyay, U., Kaushik, S., Varticovski, L. & Cuervo, A.M. (2008) The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol. Cell. Biol., 28, 5747-5763.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 5747-5763
    • Bandyopadhyay, U.1    Kaushik, S.2    Varticovski, L.3    Cuervo, A.M.4
  • 9
    • 80053561992 scopus 로고    scopus 로고
    • Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn)
    • Batelli, S., Peverelli, E., Rodilossi, S., Forloni, G. & Albani, D. (2011) Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn). Neuroscience, 195, 128-137.
    • (2011) Neuroscience , vol.195 , pp. 128-137
    • Batelli, S.1    Peverelli, E.2    Rodilossi, S.3    Forloni, G.4    Albani, D.5
  • 10
    • 0037989761 scopus 로고    scopus 로고
    • Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis-an approach for slowing Alzheimer disease?
    • Bendiske, J. & Bahr, B.A. (2003) Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis-an approach for slowing Alzheimer disease? J. Neuropath. Exp. Neur., 62, 451-463.
    • (2003) J. Neuropath. Exp. Neur. , vol.62 , pp. 451-463
    • Bendiske, J.1    Bahr, B.A.2
  • 13
    • 0030045552 scopus 로고    scopus 로고
    • Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease
    • Cataldo, A.M., Hamilton, D.J., Barnett, J.L., Paskevich, P.A. & Nixon, R.A. (1996) Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J. Neurosci., 16, 186-199.
    • (1996) J. Neurosci. , vol.16 , pp. 186-199
    • Cataldo, A.M.1    Hamilton, D.J.2    Barnett, J.L.3    Paskevich, P.A.4    Nixon, R.A.5
  • 14
    • 84856428468 scopus 로고    scopus 로고
    • Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease
    • Chen, C.H., Zhou, W., Liu, S., Deng, Y., Cai, F., Tone, M., Tone, Y., Tong, Y. & Song, W. (2012) Increased NF-kappaB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. Int. J. Neuropsychop., 15, 77-90.
    • (2012) Int. J. Neuropsychop. , vol.15 , pp. 77-90
    • Chen, C.H.1    Zhou, W.2    Liu, S.3    Deng, Y.4    Cai, F.5    Tone, M.6    Tone, Y.7    Tong, Y.8    Song, W.9
  • 15
    • 0347356360 scopus 로고    scopus 로고
    • Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1
    • Christensen, M.A., Zhou, W., Qing, H., Lehman, A., Philipsen, S. & Song, W. (2004) Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1. Mol. Cell. Biol., 24, 865-874.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 865-874
    • Christensen, M.A.1    Zhou, W.2    Qing, H.3    Lehman, A.4    Philipsen, S.5    Song, W.6
  • 16
    • 11244309014 scopus 로고    scopus 로고
    • Proteolysis: from the lysosome to ubiquitin and the proteasome
    • Ciechanover, A. (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat. Rev. Mol. Cell Bio., 6, 79-87.
    • (2005) Nat. Rev. Mol. Cell Bio. , vol.6 , pp. 79-87
    • Ciechanover, A.1
  • 18
    • 80054026084 scopus 로고    scopus 로고
    • Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of alpha-synuclein
    • Ebrahimi-Fakhari, D., Cantuti-Castelvetri, I., Fan, Z., Rockenstein, E., Masliah, E., Hyman, B.T., McLean, P.J. & Unni, V.K. (2011) Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of alpha-synuclein. J. Neurosci., 31, 14508-14520.
    • (2011) J. Neurosci. , vol.31 , pp. 14508-14520
    • Ebrahimi-Fakhari, D.1    Cantuti-Castelvetri, I.2    Fan, Z.3    Rockenstein, E.4    Masliah, E.5    Hyman, B.T.6    McLean, P.J.7    Unni, V.K.8
  • 19
    • 0034662929 scopus 로고    scopus 로고
    • BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein
    • Farzan, M., Schnitzler, C.E., Vasilieva, N., Leung, D. & Choe, H. (2000) BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc. Natl. Acad. Sci. USA, 97, 9712-9717.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 9712-9717
    • Farzan, M.1    Schnitzler, C.E.2    Vasilieva, N.3    Leung, D.4    Choe, H.5
  • 20
  • 21
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner, G.G. & Wong, C.W. (1984a) Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Bioph. Res. Co., 122, 1131-1135.
    • (1984) Biochem. Bioph. Res. Co. , vol.122 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 22
    • 0021572660 scopus 로고
    • The amyloid deposits in Alzheimer's disease: their nature and pathogenesis
    • Glenner, G.G., Wong, C.W., Quaranta, V. & Eanes, E.D. (1984b) The amyloid deposits in Alzheimer's disease: their nature and pathogenesis. Appl. Pathol., 2, 357-369.
    • (1984) Appl. Pathol. , vol.2 , pp. 357-369
    • Glenner, G.G.1    Wong, C.W.2    Quaranta, V.3    Eanes, E.D.4
  • 23
    • 84857058225 scopus 로고    scopus 로고
    • Control of autophagy as a therapy for neurodegenerative disease. Nature reviews
    • Harris, H. & Rubinsztein, D.C. (2012) Control of autophagy as a therapy for neurodegenerative disease. Nature reviews. Neurology, 8, 108-117.
    • (2012) Neurology , vol.8 , pp. 108-117
    • Harris, H.1    Rubinsztein, D.C.2
  • 24
    • 0036260892 scopus 로고    scopus 로고
    • Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease
    • Holsinger, R.M., McLean, C.A., Beyreuther, K., Masters, C.L. & Evin, G. (2002) Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease. Ann. Neurol., 51, 783-786.
    • (2002) Ann. Neurol. , vol.51 , pp. 783-786
    • Holsinger, R.M.1    McLean, C.A.2    Beyreuther, K.3    Masters, C.L.4    Evin, G.5
  • 26
    • 84864318195 scopus 로고    scopus 로고
    • Chaperone-mediated autophagy: a unique way to enter the lysosome world
    • Kaushik, S. & Cuervo, A.M. (2012) Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol., 22, 407-417.
    • (2012) Trends Cell Biol. , vol.22 , pp. 407-417
    • Kaushik, S.1    Cuervo, A.M.2
  • 27
    • 33748374920 scopus 로고    scopus 로고
    • Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy
    • Kaushik, S., Massey, A.C. & Cuervo, A.M. (2006) Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy. EMBO J., 25, 3921-3933.
    • (2006) EMBO J. , vol.25 , pp. 3921-3933
    • Kaushik, S.1    Massey, A.C.2    Cuervo, A.M.3
  • 29
    • 4344681535 scopus 로고    scopus 로고
    • Expression of the Alzheimer protease BACE1 is suppressed via its 5′-untranslated region
    • Lammich, S., Schobel, S., Zimmer, A.K., Lichtenthaler, S.F. & Haass, C. (2004) Expression of the Alzheimer protease BACE1 is suppressed via its 5′-untranslated region. EMBO Rep., 5, 620-625.
    • (2004) EMBO Rep. , vol.5 , pp. 620-625
    • Lammich, S.1    Schobel, S.2    Zimmer, A.K.3    Lichtenthaler, S.F.4    Haass, C.5
  • 30
    • 33644920657 scopus 로고    scopus 로고
    • Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription
    • Li, Y., Zhou, W., Tong, Y., He, G. & Song, W. (2006) Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription. FASEB J., 20, 285-292.
    • (2006) FASEB J. , vol.20 , pp. 285-292
    • Li, Y.1    Zhou, W.2    Tong, Y.3    He, G.4    Song, W.5
  • 31
    • 0034652309 scopus 로고    scopus 로고
    • Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
    • Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A. & Tang, J. (2000) Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc. Natl. Acad. Sci. USA, 97, 1456-1460.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1456-1460
    • Lin, X.1    Koelsch, G.2    Wu, S.3    Downs, D.4    Dashti, A.5    Tang, J.6
  • 32
    • 70349666552 scopus 로고    scopus 로고
    • Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways
    • Liu, H., Wang, P., Song, W. & Sun, X. (2009) Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways. FASEB J., 23, 3383-3392.
    • (2009) FASEB J. , vol.23 , pp. 3383-3392
    • Liu, H.1    Wang, P.2    Song, W.3    Sun, X.4
  • 35
    • 0033793248 scopus 로고    scopus 로고
    • Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain
    • Marcinkiewicz, M. & Seidah, N.G. (2000) Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain. J. Neurochem., 75, 2133-2143.
    • (2000) J. Neurochem. , vol.75 , pp. 2133-2143
    • Marcinkiewicz, M.1    Seidah, N.G.2
  • 37
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: process and function
    • Mizushima, N. (2007) Autophagy: process and function. Gene. Dev., 21, 2861-2873.
    • (2007) Gene. Dev. , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 39
    • 33747388358 scopus 로고    scopus 로고
    • Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease
    • Nixon, R.A. & Cataldo, A.M. (2006) Lysosomal system pathways: genes to neurodegeneration in Alzheimer's disease. J. Alzheimers Dis., 9, 277-289.
    • (2006) J. Alzheimers Dis. , vol.9 , pp. 277-289
    • Nixon, R.A.1    Cataldo, A.M.2
  • 40
    • 0034304390 scopus 로고    scopus 로고
    • The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review
    • Nixon, R.A., Cataldo, A.M. & Mathews, P.M. (2000) The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review. Neurochem. Res., 25, 1161-1172.
    • (2000) Neurochem. Res. , vol.25 , pp. 1161-1172
    • Nixon, R.A.1    Cataldo, A.M.2    Mathews, P.M.3
  • 41
    • 0242330370 scopus 로고    scopus 로고
    • Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein
    • Nunan, J., Williamson, N.A., Hill, A.F., Sernee, M.F., Masters, C.L. & Small, D.H. (2003) Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein. J. Neurosci. Res., 74, 378-385.
    • (2003) J. Neurosci. Res. , vol.74 , pp. 378-385
    • Nunan, J.1    Williamson, N.A.2    Hill, A.F.3    Sernee, M.F.4    Masters, C.L.5    Small, D.H.6
  • 42
    • 2642714342 scopus 로고
    • Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents
    • Ohkuma, S. & Poole, B. (1978) Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc. Natl. Acad. Sci. USA, 75, 3327-3331.
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 3327-3331
    • Ohkuma, S.1    Poole, B.2
  • 43
    • 0842303313 scopus 로고    scopus 로고
    • Back to the future with ubiquitin
    • Pickart, C.M. (2004) Back to the future with ubiquitin. Cell, 116, 181-190.
    • (2004) Cell , vol.116 , pp. 181-190
    • Pickart, C.M.1
  • 44
    • 7444250507 scopus 로고    scopus 로고
    • Degradation of BACE by the ubiquitin-proteasome pathway
    • Qing, H., Zhou, W., Christensen, M.A., Sun, X., Tong, Y. & Song, W. (2004) Degradation of BACE by the ubiquitin-proteasome pathway. FASEB J., 18, 1571-1573.
    • (2004) FASEB J. , vol.18 , pp. 1571-1573
    • Qing, H.1    Zhou, W.2    Christensen, M.A.3    Sun, X.4    Tong, Y.5    Song, W.6
  • 45
    • 1542357687 scopus 로고    scopus 로고
    • Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation
    • Rogers, G.W. Jr., Edelman, G.M. & Mauro, V.P. (2004) Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation. Proc. Natl. Acad. Sci. USA, 101, 2794-2799.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 2794-2799
    • Rogers Jr., G.W.1    Edelman, G.M.2    Mauro, V.P.3
  • 47
    • 79957881200 scopus 로고    scopus 로고
    • Chasing the elusive mammalian microautophagy
    • Santambrogio, L. & Cuervo, A.M. (2011) Chasing the elusive mammalian microautophagy. Autophagy, 7, 652-654.
    • (2011) Autophagy , vol.7 , pp. 652-654
    • Santambrogio, L.1    Cuervo, A.M.2
  • 48
    • 0033819772 scopus 로고    scopus 로고
    • A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase
    • Solans, A., Estivill, X. & de La Luna, S. (2000) A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase. Cytogenet. Cell Genet., 89, 177-184.
    • (2000) Cytogenet. Cell Genet. , vol.89 , pp. 177-184
    • Solans, A.1    Estivill, X.2    de La Luna, S.3
  • 49
  • 52
    • 33746549926 scopus 로고    scopus 로고
    • BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome
    • Sun, X., He, G. & Song, W. (2006b) BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome. FASEB J., 20, 1369-1376.
    • (2006) FASEB J. , vol.20 , pp. 1369-1376
    • Sun, X.1    He, G.2    Song, W.3
  • 53
    • 33746572249 scopus 로고    scopus 로고
    • Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome
    • Sun, X., Tong, Y., Qing, H., Chen, C.H. & Song, W. (2006c) Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome. FASEB J., 20, 1361-1368.
    • (2006) FASEB J. , vol.20 , pp. 1361-1368
    • Sun, X.1    Tong, Y.2    Qing, H.3    Chen, C.H.4    Song, W.5
  • 55
    • 84655166491 scopus 로고    scopus 로고
    • Regulation of beta-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer's disease
    • Sun, X., Bromley-Brits, K. & Song, W. (2012) Regulation of beta-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer's disease. J. Neurochem., 120(Suppl 1), 62-70.
    • (2012) J. Neurochem. , vol.120 , Issue.SUPPL. 1 , pp. 62-70
    • Sun, X.1    Bromley-Brits, K.2    Song, W.3
  • 56
    • 0035292759 scopus 로고    scopus 로고
    • Themes and variations on ubiquitylation
    • Weissman, A.M. (2001) Themes and variations on ubiquitylation. Nat. Rev. Mol. Cell Bio., 2, 169-178.
    • (2001) Nat. Rev. Mol. Cell Bio. , vol.2 , pp. 169-178
    • Weissman, A.M.1
  • 57
    • 79952585579 scopus 로고    scopus 로고
    • Integration of clearance mechanisms: the proteasome and autophagy
    • Wong, E. & Cuervo, A.M. (2010) Integration of clearance mechanisms: the proteasome and autophagy. Cold Spring Harb. Perspect. Biol., 2, a006734.
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2
    • Wong, E.1    Cuervo, A.M.2
  • 58
    • 84871901624 scopus 로고    scopus 로고
    • Regulation of RCAN1 translation and its role in oxidative stress-induced apoptosis
    • Wu, Y. & Song, W. (2013) Regulation of RCAN1 translation and its role in oxidative stress-induced apoptosis. FASEB J., 27, 208-221.
    • (2013) FASEB J. , vol.27 , pp. 208-221
    • Wu, Y.1    Song, W.2
  • 60
    • 27644484061 scopus 로고    scopus 로고
    • Autophagy: molecular machinery for self-eating
    • Yorimitsu, T. & Klionsky, D.J. (2005) Autophagy: molecular machinery for self-eating. Cell Death Differ., 12(Suppl 2), 1542-1552.
    • (2005) Cell Death Differ. , vol.12 , Issue.SUPPL. 2 , pp. 1542-1552
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 62
    • 84857920499 scopus 로고    scopus 로고
    • Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1
    • Zhang, M., Deng, Y., Luo, Y., Zhang, S., Zou, H., Cai, F., Wada, K. & Song, W. (2012) Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1. J. Neurochem., 120, 1129-1138.
    • (2012) J. Neurochem. , vol.120 , pp. 1129-1138
    • Zhang, M.1    Deng, Y.2    Luo, Y.3    Zhang, S.4    Zou, H.5    Cai, F.6    Wada, K.7    Song, W.8
  • 63
    • 82855181494 scopus 로고    scopus 로고
    • Macroautophagy-generated increase of lysosomal amyloid beta-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells
    • Zheng, L., Terman, A., Hallbeck, M., Dehvari, N., Cowburn, R.F., Benedikz, E., Kagedal, K., Cedazo-Minguez, A. & Marcusson, J. (2011a) Macroautophagy-generated increase of lysosomal amyloid beta-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells. Autophagy, 7, 1528-1545.
    • (2011) Autophagy , vol.7 , pp. 1528-1545
    • Zheng, L.1    Terman, A.2    Hallbeck, M.3    Dehvari, N.4    Cowburn, R.F.5    Benedikz, E.6    Kagedal, K.7    Cedazo-Minguez, A.8    Marcusson, J.9
  • 64
    • 82855181806 scopus 로고    scopus 로고
    • Proteasome malfunction activates macroautophagy in the heart
    • Zheng, Q., Su, H., Tian, Z. & Wang, X. (2011b) Proteasome malfunction activates macroautophagy in the heart. Am. J. Cardiovasc. Dis., 1, 214-226.
    • (2011) Am. J. Cardiovasc. Dis. , vol.1 , pp. 214-226
    • Zheng, Q.1    Su, H.2    Tian, Z.3    Wang, X.4
  • 65
    • 33646244775 scopus 로고    scopus 로고
    • Leaky scanning and reinitiation regulate BACE1 gene expression
    • Zhou, W. & Song, W. (2006) Leaky scanning and reinitiation regulate BACE1 gene expression. Mol. Cell Bio., 26, 3353-3364.
    • (2006) Mol. Cell Bio. , vol.26 , pp. 3353-3364
    • Zhou, W.1    Song, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.