Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2

Genes, Brain and Behavior

Volumn 9, Issue 2, 2010, Pages 160-172

  Azkona, G ^a,b,c   Amador Arjona, A ^a,b   Obradors Tarrago C ^a,b   Varea, E ^d   Arque G ^a,b   Pinacho, R ^a   Fillat, C ^a,b   De La Luna, S ^a,b,e   Estivill, X ^a   Dierssen, M ^a,b  

^a Barcelona Biomedical Research Park   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^d MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^e INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Alzheimer disease; BACE2; Chromosome 21; Down syndrome; Locus coeruleus; Noradrenergic system

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE;

ANIMAL EXPERIMENT; ANXIETY DISORDER; ARTICLE; BEHAVIOR; CHOLINERGIC NERVE; COGNITIVE DEFECT; CONTROLLED STUDY; DEGENERATIVE DISEASE; GENE AMPLIFICATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENOTYPE; IMMUNOHISTOCHEMISTRY; LOCOMOTION; LOCUS CERULEUS; MAZE TEST; MOUSE; NERVE DEGENERATION; NEUROLOGIC EXAMINATION; NONHUMAN; NORADRENERGIC NERVE; NORADRENERGIC SYSTEM; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRANSGENIC MOUSE; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANXIETY; ASPARTIC ACID ENDOPEPTIDASES; DARKNESS; DOWN SYNDROME; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMMUNOHISTOCHEMISTRY; LOCUS COERULEUS; MAZE LEARNING; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MOTOR ACTIVITY; NEURONS; PHOTOSENSITIVITY DISORDERS; PROSENCEPHALON; RNA; TRANSCRIPTION, GENETIC;

ANIMALIA; MUS MUSCULUS;

EID: 77949385534     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2009.00538.x     Document Type: Article

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