Innate and adaptive effects of inflammasomes on T cell responses

Current Opinion in Immunology

Volumn 25, Issue 3, 2013, Pages 359-365

  Dostert, Catherine ^a   Ludigs, Kristina ^b   Guarda, Greta ^b  

^a UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^b Department of Biochemistry ^*  (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM POTASSIUM SULFATE; CRYOPYRIN; GAMMA INTERFERON; INFLAMMASOME; INTERLEUKIN 17; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR;

ADAPTIVE IMMUNITY; ADJUVANT THERAPY; CD8+ T LYMPHOCYTE; CINCA SYNDROME; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HELPER CELL; HUMAN; INFECTION; INNATE IMMUNITY; LYMPHOCYTE ACTIVATION; MEMORY T LYMPHOCYTE; MULTIPLE SCLEROSIS; NONHUMAN; PROTEIN DEGRADATION; REVIEW; T LYMPHOCYTE; TH1 CELL; TH17 CELL;

ADAPTIVE IMMUNITY; ANIMALS; CASPASE 1; CYTOKINES; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; T-LYMPHOCYTES;

EID: 84879195120     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2013.02.008     Document Type: Review

References (55)

1. Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140:821-832.
2. Rathinam V.A., Vanaja S.K., Fitzgerald K.A. Regulation of inflammasome signaling. Nat Immunol 2012, 13:333-342.
3. Keller M., Ruegg A., Werner S., Beer H.D. Active caspase-1 is a regulator of unconventional protein secretion. Cell 2008, 132:818-831.
4. Lamkanfi M., Sarkar A., Vande Walle L., Vitari A.C., Amer A.O., Wewers M.D., Tracey K.J., Kanneganti T.D., Dixit V.M. Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol 2010, 185:4385-4392.
5. Bergsbaken T., Fink S.L., Cookson B.T. Pyroptosis: host cell death and inflammation. Nat Rev Microbiol 2009, 7:99-109.
6. Dinarello C.A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011, 117:3720-3732.
7. Yazdi A.S., Guarda G., Riteau N., Drexler S.K., Tardivel A., Couillin I., Tschopp J. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1alpha and IL-1beta. Proc Natl Acad Sci USA 2010, 107:19449-19454.
8. Gross O., Yazdi A.S., Thomas C.J., Masin M., Heinz L.X., Guarda G., Quadroni M., Drexler S.K., Tschopp J. Inflammasome activators induce interleukin-1alpha secretion via distinct pathways with differential requirement for the protease function of caspase-1. Immunity 2012, 36:388-400.
9. Arend W.P., Palmer G., Gabay C. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev 2008, 223:20-38.
10. Wu C., Orozco C., Boyer J., Leglise M., Goodale J., Batalov S., Hodge C.L., Haase J., Janes J., Huss J.W., et al. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol 2009, 10:R130.
11. Nakanishi K., Yoshimoto T., Tsutsui H., Okamura H. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 2001, 12:53-72.
12. Nagai T., Devergne O., Mueller T.F., Perkins D.L., van Seventer J.M., van Seventer G.A. Timing of IFN-beta exposure during human dendritic cell maturation and naive Th cell stimulation has contrasting effects on Th1 subset generation: a role for IFN-beta-mediated regulation of IL-12 family cytokines and IL-18 in naive Th cell differentiation. J Immunol 2003, 171:5233-5243.
13. Guarda G., Braun M., Staehli F., Tardivel A., Mattmann C., Forster I., Farlik M., Decker T., Du Pasquier R.A., Romero P., et al. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 2011, 34:213-223.
14. Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006, 24:179-189.
15. Acosta-Rodriguez E.V., Napolitani G., Lanzavecchia A., Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007, 8:942-949.
16. Kryczek I., Wei S., Vatan L., Escara-Wilke J., Szeliga W., Keller E.T., Zou W. Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression. J Immunol 2007, 179:1423-1426.
17. Blom L., Poulsen L.K. IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures. J Immunol 2012, 189:4331-4337.
18. Yoshimoto T., Mizutani H., Tsutsui H., Noben-Trauth N., Yamanaka K., Tanaka M., Izumi S., Okamura H., Paul W.E., Nakanishi K. IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. Nat Immunol 2000, 1:132-137.
19. Shi Y., Evans J.E., Rock K.L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 2003, 425:516-521.
20. Conforti-Andreoni C., Spreafico R., Qian H.L., Riteau N., Ryffel B., Ricciardi-Castagnoli P., Mortellaro A. Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. J Immunol 2011, 187:5842-5850.
21. Kool M., Willart M.A., van Nimwegen M., Bergen I., Pouliot P., Virchow J.C., Rogers N., Osorio F., Reis e Sousa C., Hammad H., et al. An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity 2011, 34:527-540.
22. Eisenbarth S.C., Colegio O.R., O'Connor W., Sutterwala F.S., Flavell R.A. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 2008, 453:1122-1126.
23. Li H., Willingham S.B., Ting J.P., Re F. Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. J Immunol 2008, 181:17-21.
24. Franchi L., Nunez G. The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur J Immunol 2008, 38:2085-2089.
25. McKee A.S., Munks M.W., MacLeod M.K., Fleenor C.J., Van Rooijen N., Kappler J.W., Marrack P. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol 2009, 183:4403-4414.
26. Kool M., Fierens K., Lambrecht B.N. Alum adjuvant: some of the tricks of the oldest adjuvant. J Med Microbiol 2012, 61:927-934.
27. Krause K., Metz M., Makris M., Zuberbier T., Maurer M. The role of interleukin-1 in allergy-related disorders. Curr Opin Allergy Clin Immunol 2012, 12:477-484.
28. Corazza N., Kaufmann T. Novel insights into mechanisms of food allergy and allergic airway inflammation using experimental mouse models. Allergy 2012, 67:1483-1490.
29. Ghiringhelli F., Apetoh L., Tesniere A., Aymeric L., Ma Y., Ortiz C., Vermaelen K., Panaretakis T., Mignot G., Ullrich E., et al. Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med 2009, 15:1170-1178.
30. Sutton C., Brereton C., Keogh B., Mills K.H., Lavelle E.C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 2006, 203:1685-1691.
31. Matsuki T., Nakae S., Sudo K., Horai R., Iwakura Y. Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis. Int Immunol 2006, 18:399-407.
32. Ludigs K., Parfenov V., Du Pasquier R.A., Guarda G. Type I IFN-mediated regulation of IL-1 production in inflammatory disorders. Cell Mol Life Sci 2012, 69:3395-3418.
33. Furlan R., Martino G., Galbiati F., Poliani P.L., Smiroldo S., Bergami A., Desina G., Comi G., Flavell R., Su M.S., et al. Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. J Immunol 1999, 163:2403-2409.
34. Gris D., Ye Z., Iocca H.A., Wen H., Craven R.R., Gris P., Huang M., Schneider M., Miller S.D., Ting J.P. NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses. J Immunol 2010, 185:974-981.
35. Shaw P.J., Lukens J.R., Burns S., Chi H., McGargill M.A., Kanneganti T.D. Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. J Immunol 2010, 184:4610-4614.
36. Inoue M., Williams K.L., Oliver T., Vandenabeele P., Rajan J.V., Miao E.A., Shinohara M.L. Interferon-beta therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. Sci Signal 2012, 5:ra38.
37. Goldbach-Mansky R. Current status of understanding the pathogenesis and management of patients with NOMID/CINCA. Curr Rheumatol Rep 2011, 13:123-131.
38. Meng G., Zhang F., Fuss I., Kitani A., Strober W. A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity 2009, 30:860-874.
39. Brydges S.D., Mueller J.L., McGeough M.D., Pena C.A., Misaghi A., Gandhi C., Putnam C.D., Boyle D.L., Firestein G.S., Horner A.A., et al. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 2009, 30:875-887.
40. Lasiglie D., Traggiai E., Federici S., Alessio M., Buoncompagni A., Accogli A., Chiesa S., Penco F., Martini A., Gattorno M. Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients. PLoS ONE 2011, 6:e20014.
41. Hitzler I., Sayi A., Kohler E., Engler D.B., Koch K.N., Hardt W.D., Muller A. Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1beta and IL-18. J Immunol 2012, 188:3594-3602.
42. van de Veerdonk F.L., Joosten L.A., Shaw P.J., Smeekens S.P., Malireddi R.K., van der Meer J.W., Kullberg B.J., Netea M.G., Kanneganti T.D. The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis. Eur J Immunol 2011, 41:2260-2268.
43. Dunne A., Ross P.J., Pospisilova E., Masin J., Meaney A., Sutton C.E., Iwakura Y., Tschopp J., Sebo P., Mills K.H. Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis. J Immunol 2010, 185:1711-1719.
44. Ritter M., Gross O., Kays S., Ruland J., Nimmerjahn F., Saijo S., Tschopp J., Layland L.E., Prazeres da Costa C. Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Proc Natl Acad Sci USA 2010, 107:20459-20464.
45. Trunk G., Oxenius A. Innate instruction of CD4+ T cell immunity in respiratory bacterial infection. J Immunol 2012, 189:616-628.
46. Saiga H., Kitada S., Shimada Y., Kamiyama N., Okuyama M., Makino M., Yamamoto M., Takeda K. Critical role of AIM2 in Mycobacterium tuberculosis infection. Int Immunol 2012, 24:637-644.
47. Zielinski C.E., Mele F., Aschenbrenner D., Jarrossay D., Ronchi F., Gattorno M., Monticelli S., Lanzavecchia A., Sallusto F. Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Nature 2012, 484:514-518.
48. O'Sullivan B.J., Thomas H.E., Pai S., Santamaria P., Iwakura Y., Steptoe R.J., Kay T.W., Thomas R. IL-1 beta breaks tolerance through expansion of CD25+ effector T cells. J Immunol 2006, 176:7278-7287.
49. Pang I.K., Ichinohe T., Iwasaki A. IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8(+) T cell responses to influenza A virus. Nature immunology 2013, 14:246-253.
50. Takeda K., Tsutsui H., Yoshimoto T., Adachi O., Yoshida N., Kishimoto T., Okamura H., Nakanishi K., Akira S. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 1998, 8:383-390.
51. Kupz A., Guarda G., Gebhardt T., Sander L.E., Short K.R., Diavatopoulos D.A., Wijburg O.L., Cao H., Waithman J.C., Chen W., et al. NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8(+) T cells. Nat Immunol 2012, 13:162-169.
52. Soudja S.M., Ruiz A.L., Marie J.C., Lauvau G. Inflammatory monocytes activate memory CD8(+) T and innate NK lymphocytes independent of cognate antigen during microbial pathogen invasion. Immunity 2012, 37:549-562.
53. Kastenmuller W., Torabi-Parizi P., Subramanian N., Lammermann T., Germain R.N. A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread. Cell 2012, 150:1235-1248.
54. Lalor S.J., Dungan L.S., Sutton C.E., Basdeo S.A., Fletcher J.M., Mills K.H. Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity. J Immunol 2011, 186:5738-5748.
55. Hernandez-Cuellar E., Tsuchiya K., Hara H., Fang R., Sakai S., Kawamura I., Akira S., Mitsuyama M. Cutting edge: nitric oxide inhibits the NLRP3 inflammasome. J Immunol 2012, 189:5113-5117.