Innate instruction of CD4+ T cell immunity in respiratory bacterial infection

Journal of Immunology

Volumn 189, Issue 2, 2012, Pages 616-628

  Trunk, Gerhard ^a   Oxenius, Annette ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; MYELOID DIFFERENTIATION FACTOR 88; PATTERN RECOGNITION RECEPTOR;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELLULAR IMMUNITY; CONTROLLED STUDY; INNATE IMMUNITY; LEGIONELLA PNEUMOPHILA; LYMPH NODE; LYMPHOCYTE PROLIFERATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RESPIRATORY TRACT INFECTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; TH2 CELL;

ANIMALS; BACTERIAL PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; GENETIC VECTORS; IMMUNITY, INNATE; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; VIRULENCE;

EID: 84863615353     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1200924     Document Type: Article

References (61)

1. Eisenbarth, S. C., and R. A. Flavell. 2009. Innate instruction of adaptive immunity revisited: the inflammasome. EMBO Mol Med 1: 92-98.
2. Vance, R. E., R. R. Isberg, and D. A. Portnoy. 2009. Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe 6: 10-21.
3. McDade, J. E., C. C. Shepard, D. W. Fraser, T. R. Tsai, M. A. Redus, and W. R. Dowdle. 1977. Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N. Engl. J. Med. 297: 1197-1203. (Pubitemid 8226680)
4. Fraser, D. W., T. R. Tsai, W. Orenstein, W. E. Parkin, H. J. Beecham, R. G. Sharrar, J. Harris, G. F. Mallison, S. M. Martin, J. E. McDade, et al. 1977. Legionnaires' disease: description of an epidemic of pneumonia. N. Engl. J. Med. 297: 1189-1197. (Pubitemid 8226679)
5. Isberg, R. R., T. J. O'Connor, and M. Heidtman. 2009. The Legionella pneumophila replication vacuole: making a cosy niche inside host cells. Nat. Rev. Microbiol. 7: 13-24.
6. Coers, J., C. Monahan, and C. R. Roy. 1999. Modulation of phagosome biogenesis by Legionella pneumophila creates an organelle permissive for intracellular growth. Nat. Cell Biol. 1: 451-453. (Pubitemid 129502813)
7. Archer, K. A., and C. R. Roy. 2006. MyD88-dependent responses involving toll-like receptor 2 are important for protection and clearance of Legionella pneumophila in a mouse model of Legionnaires' disease. Infect. Immun. 74: 3325-3333. (Pubitemid 43794520)
8. Spörri, R., N. Joller, U. Albers, H. Hilbi, and A. Oxenius. 2006. MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection. J. Immunol. 176: 6162-6171.
9. Diez, E., S. H. Lee, S. Gauthier, Z. Yaraghi, M. Tremblay, S. Vidal, and P. Gros. 2003. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Nat. Genet. 33: 55-60. (Pubitemid 36068682)
10. Berrington, W. R., R. Iyer, R. D. Wells, K. D. Smith, S. J. Skerrett, and T. R. Hawn. 2010. NOD1 and NOD2 regulation of pulmonary innate immunity to Legionella pneumophila. Eur. J. Immunol. 40: 3519-3527.
11. Joller, N., R. Spörri, H. Hilbi, and A. Oxenius. 2007. Induction and protective role of antibodies in Legionella pneumophila infection. Eur. J. Immunol. 37: 3414-3423.
12. Brieland, J. K., L. A. Heath, G. B. Huffnagle, D. G. Remick, M. S. McClain, M. C. Hurley, R. K. Kunkel, J. C. Fantone, and C. Engleberg. 1996. Humoral immunity and regulation of intrapulmonary growth of Legionella pneumophila in the immunocompetent host. J. Immunol. 157: 5002-5008. (Pubitemid 126449579)
13. Susa, M., B. Ticac, T. Rukavina, M. Doric, and R. Marre. 1998. Legionella pneumophila infection in intratracheally inoculated T cell-depleted or -nondepleted A/J mice. J. Immunol. 160: 316-321. (Pubitemid 28116744)
14. Neild, A. L., and C. R. Roy. 2003. Legionella reveal dendritic cell functions that facilitate selection of antigens for MHC class II presentation. Immunity 18: 813-823. (Pubitemid 36776430)
15. Adachi, O., T. Kawai, K. Takeda, M. Matsumoto, H. Tsutsui, M. Sakagami, K. Nakanishi, and S. Akira. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9: 143-150. (Pubitemid 28361303)
16. Labow, M., D. Shuster, M. Zetterstrom, P. Nunes, R. Terry, E. B. Cullinan, T. Bartfai, C. Solorzano, L. L. Moldawer, R. Chizzonite, and K. W. McIntyre. 1997. Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J. Immunol. 159: 2452-2461. (Pubitemid 127681040)
17. Takeda, K., H. Tsutsui, T. Yoshimoto, O. Adachi, N. Yoshida, T. Kishimoto, H. Okamura, K. Nakanishi, and S. Akira. 1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity 8: 383-390. (Pubitemid 28188898)
18. Li, P., H. Allen, S. Banerjee, S. Franklin, L. Herzog, C. Johnston, J. McDowell, M. Paskind, L. Rodman, J. Salfeld, et al. 1995. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80: 401-411.
19. Sadosky, A. B., L. A. Wiater, and H. A. Shuman. 1993. Identification of Legionella pneumophila genes required for growth within and killing of human macrophages. Infect. Immun. 61: 5361-5373. (Pubitemid 23353920)
20. Tiaden, A., T. Spirig, S. S. Weber, H. Brüggemann, R. Bosshard, C. Buchrieser, and H. Hilbi. 2007. The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA. Cell. Microbiol. 9: 2903-2920. (Pubitemid 350066574)
21. Segal, G., M. Purcell, and H. A. Shuman. 1998. Host cell killing and bacterial conjugation require overlapping sets of genes within a 22-kb region of the Legionella pneumophila genome. Proc. Natl. Acad. Sci. USA 95: 1669-1674. (Pubitemid 28103451)
22. Horwitz, M. A. 1983. Cell-mediated immunity in Legionnaires' disease. J. Clin. Invest. 71: 1686-1697. (Pubitemid 13056772)
23. Blander, S. J., R. F. Breiman, and M. A. Horwitz. 1989. A live avirulent mutant Legionella pneumophila vaccine induces protective immunity against lethal aerosol challenge. J. Clin. Invest. 83: 810-815. (Pubitemid 19080610)
24. Blander, S. J., and M. A. Horwitz. 1989. Vaccination with the major secretory protein of Legionella pneumophila induces cell-mediated and protective immunity in a guinea pig model of Legionnaires' disease. J. Exp. Med. 169: 691-705. (Pubitemid 19085814)
25. Blander, S. J., and M. A. Horwitz. 1991. Vaccination with the major secretory protein of Legionella induces humoral and cell-mediated immune responses and protective immunity across different serogroups of Legionella pneumophila and different species of Legionella. J. Immunol. 147: 285-291.
26. Blander, S. J., and M. A. Horwitz. 1991. Vaccination with Legionella pneumophila membranes induces cell-mediated and protective immunity in a guinea pig model of Legionnaires' disease. Protective immunity independent of the major secretory protein of Legionella pneumophila. J. Clin. Invest. 87: 1054-1059.
27. Weeratna, R., D. A. Stamler, P. H. Edelstein, M. Ripley, T. Marrie, D. Hoskin, and P. S. Hoffman. 1994. Human and guinea pig immune responses to Legionella pneumophila protein antigens OmpS and Hsp60. Infect. Immun. 62: 3454-3462. (Pubitemid 24232133)
28. Marra, A., S. J. Blander, M. A. Horwitz, and H. A. Shuman. 1992. Identification of a Legionella pneumophila locus required for intracellular multiplication in human macrophages. Proc. Natl. Acad. Sci. USA 89: 9607-9611.
29. Horwitz, M. A. 1987. Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes. J. Exp. Med. 166: 1310-1328. (Pubitemid 18051425)
30. Shin, S., C. L. Case, K. A. Archer, C. V. Nogueira, K. S. Kobayashi, R. A. Flavell, C. R. Roy, and D. S. Zamboni. 2008. Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. PLoS Pathog. 4: e1000220.
31. Didierlaurent, A., I. Ferrero, L. A. Otten, B. Dubois, M. Reinhardt, H. Carlsen, R. Blomhoff, S. Akira, J. P. Kraehenbuhl, and J. C. Sirard. 2004. Flagellin promotes myeloid differentiation factor 88-dependent development of Th2-type response. J. Immunol. 172: 6922-6930. (Pubitemid 38669131)
32. Hegazy, A. N., M. Peine, C. Helmstetter, I. Panse, A. Fröhlich, A. Bergthaler, L. Flatz, D. D. Pinschewer, A. Radbruch, and M. Löhning. 2010. Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions. Immunity 32: 116-128.
33. Ruedl, C., M. F. Bachmann, and M. Kopf. 2000. The antigen dose determines T helper subset development by regulation of CD40 ligand. Eur. J. Immunol. 30: 2056-2064. (Pubitemid 30456202)
34. Eisenbarth, S. C., D. A. Piggott, J. W. Huleatt, I. Visintin, C. A. Herrick, and K. Bottomly. 2002. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J. Exp. Med. 196: 1645-1651. (Pubitemid 36026476)
35. Lightfield, K. L., J. Persson, S. W. Brubaker, C. E. Witte, J. von Moltke, E. A. Dunipace, T. Henry, Y. H. Sun, D. Cado, W. F. Dietrich, et al. 2008. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat. Immunol. 9: 1171-1178.
36. Zhao, Y., J. Yang, J. Shi, Y. N. Gong, Q. Lu, H. Xu, L. Liu, and F. Shao. 2011. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477: 596-600.
37. Lightfield, K. L., J. Persson, N. J. Trinidad, S. W. Brubaker, E. M. Kofoed, J. D. Sauer, E. A. Dunipace, S. E. Warren, E. A. Miao, and R. E. Vance. 2011. Differential requirements for NAIP5 in activation of the NLRC4 inflammasome. Infect. Immun. 79: 1606-1614.
38. Guo, L., G. Wei, J. Zhu, W. Liao, W. J. Leonard, K. Zhao, and W. Paul. 2009. IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. USA 106: 13463-13468.
39. Chung, Y., S. H. Chang, G. J. Martinez, X. O. Yang, R. Nurieva, H. S. Kang, L. Ma, S. S. Watowich, A. M. Jetten, Q. Tian, and C. Dong. 2009. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30: 576-587.
40. Sutton, C., C. Brereton, B. Keogh, K. H. Mills, and E. C. Lavelle. 2006. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203: 1685-1691. (Pubitemid 44036274)
41. Veldhoen, M., R. J. Hocking, C. J. Atkins, R. M. Locksley, and B. Stockinger. 2006. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24: 179-189. (Pubitemid 43214587)
42. Tateda, K., T. A. Moore, J. C. Deng, M. W. Newstead, X. Zeng, A. Matsukawa, M. S. Swanson, K. Yamaguchi, and T. J. Standiford. 2001. Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of Legionella pneumophila pneumonia. J. Immunol. 166: 3355-3361. (Pubitemid 33117336)
43. Tateda, K., T. Matsumoto, Y. Ishii, N. Furuya, A. Ohno, S. Miyazaki, and K. Yamaguchi. 1998. Serum cytokines in patients with Legionella pneumonia: relative predominance of Th1-type cytokines. Clin. Diagn. Lab. Immunol. 5: 401-403. (Pubitemid 28246466)
44. Wright, E. K., S. A. Goodart, J. D. Growney, V. Hadinoto, M. G. Endrizzi, E. M. Long, K. Sadigh, A. L. Abney, I. Bernstein-Hanley, and W. F. Dietrich. 2003. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Curr. Biol. 13: 27-36. (Pubitemid 36080619)
45. Sutton, C. E., S. J. Lalor, C. M. Sweeney, C. F. Brereton, E. C. Lavelle, and K. H. Mills. 2009. Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity 31: 331-341.
46. Hawn, T. R., W. R. Berrington, I. A. Smith, S. Uematsu, S. Akira, A. Aderem, K. D. Smith, and S. J. Skerrett. 2007. Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila. J. Immunol. 179: 6981-6987.
47. Amer, A., L. Franchi, T. D. Kanneganti, M. Body-Malapel, N. Ozören, G. Brady, S. Meshinchi, R. Jagirdar, A. Gewirtz, S. Akira, and G. Núñez. 2006. Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J. Biol. Chem. 281: 35217-35223. (Pubitemid 46043249)
48. Fink, S. L., and B. T. Cookson. 2006. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell. Microbiol. 8: 1812-1825. (Pubitemid 44530672)
49. Rivera, A., G. Ro, H. L. Van Epps, T. Simpson, I. Leiner, D. B. Sant'Angelo, and E. G. Pamer. 2006. Innate immune activation and CD4+ T cell priming during respiratory fungal infection. Immunity 25: 665-675. (Pubitemid 44529034)
50. Schnare, M., G. M. Barton, A. C. Holt, K. Takeda, S. Akira, and R. Medzhitov. 2001. Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2: 947-950. (Pubitemid 32976167)
51. Jankovic, D., M. C. Kullberg, S. Hieny, P. Caspar, C. M. Collazo, and A. Sher. 2002. In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting. Immunity 16: 429-439. (Pubitemid 34260920)
52. Fritz, J. H., L. Le Bourhis, G. Sellge, J. G. Magalhaes, H. Fsihi, T. A. Kufer, C. Collins, J. Viala, R. L. Ferrero, S. E. Girardin, and D. J. Philpott. 2007. Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity 26: 445-459. (Pubitemid 46604867)
53. Magalhaes, J. G., J. H. Fritz, L. Le Bourhis, G. Sellge, L. H. Travassos, T. Selvanantham, S. E. Girardin, J. L. Gommerman, and D. J. Philpott. 2008. Nod2-dependent Th2 polarization of antigen-specific immunity. J. Immunol. 181: 7925-7935.
54. Frutuoso, M. S., J. I. Hori, M. S. Pereira, D. S. Junior, F. Sônego, K. S. Kobayashi, R. A. Flavell, F. Q. Cunha, and D. S. Zamboni. 2010. The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila. Microbes Infect. 12: 819-827.
55. Iweala, O. I., D. W. Smith, K. S. Matharu, I. Sada-Ovalle, D. D. Nguyen, R. H. Dekruyff, D. T. Umetsu, S. M. Behar, and C. R. Nagler. 2009. Vaccine-induced antibody isotypes are skewed by impaired CD4 T cell and invariant NKT cell effector responses inMyD88-deficient mice. J. Immunol. 183: 2252-2260.
56. Chen, L., L. Lei, X. Chang, Z. Li, C. Lu, X. Zhang, Y. Wu, I. T. Yeh, and G. Zhong. 2010. Mice deficient in MyD88 Develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection. J. Immunol. 184: 2602-2610.
57. McCoy, A. J., and A. T. Maurelli. 2006. Building the invisible wall: updating the chlamydial peptidoglycan anomaly. Trends Microbiol. 14: 70-77. (Pubitemid 43190736)
58. Muraille, E., C. De Trez, M. Brait, P. De Baetselier, O. Leo, and Y. Carlier. 2003. Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response. J. Immunol. 170: 4237-4241. (Pubitemid 36428190)
59. Rittig, M. G., J. C. Jagoda, B. Wilske, R. Murgia, M. Cinco, R. Repp, G. R. Burmester, and A. Krause. 1998. Coiling phagocytosis discriminates between different spirochetes and is enhanced by phorbol myristate acetate and granulocyte-macrophage colony-stimulating factor. Infect. Immun. 66: 627-635. (Pubitemid 28074205)
60. Akamine, M., F. Higa, N. Arakaki, K. Kawakami, K. Takeda, S. Akira, and A. Saito. 2005. Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila. Infect. Immun. 73: 352-361. (Pubitemid 40041127)
61. Lettinga, K. D., S. Florquin, P. Speelman, R. van Ketel, T. van der Poll, and A. Verbon. 2002. Toll-like receptor 4 is not involved in host defense against pulmonary Legionella pneumophila infection in a mouse model. J. Infect. Dis. 186: 570-573. (Pubitemid 34876270)