Unraveling hidden regulatory sites in structurally homologous metalloproteases

Journal of Molecular Biology

Volumn 425, Issue 13, 2013, Pages 2330-2346

  Udi, Yael ^a   Fragai, Marco ^b   Grossman, Moran ^a   Mitternacht, Simon ^c   Arad Yellin, Rina ^a   Calderone, Vito ^b   Melikian, Maxime ^b   Toccafondi, Mirco ^b   Berezovsky, Igor N ^a   Luchinat, Claudio ^b   Sagi, Irit ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

drug design; matrix metalloproteases; MMP inhibitors; structurally homologous

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; HOMOLOGOUS METALLOPROTEASE; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MATRILYSIN; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 16; METALLOPROTEINASE; NEUTROPHIL COLLAGENASE; STROMELYSIN; STROMELYSIN 2; STROMELYSIN 3; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; DISSOCIATION CONSTANT; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

EID: 84879114272     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.04.009     Document Type: Article

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