The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function

Biochemistry

Volumn 49, Issue 29, 2010, Pages 6184-6192

  Grossman, Moran ^a   Tworowski, Dmitry ^a   Dym, Orly ^a   Lee, Meng Huee ^b   Levy, Yaakov ^a   Murphy, Gillian ^b   Sagi, Irit ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY AFFINITY; ASSOCIATION CONSTANT; BINDING CONFORMATIONS; BINDING INTERFACE; BIOLOGICAL PROCESS; CATALYTIC SITES; CLINICAL TARGETS; CONFORMATIONAL DYNAMICS; ENDOGENOUS INHIBITOR; ENTROPY COST; ENZYME CATALYSIS; HIGH RESOLUTION; HYDROGEN BOND NETWORKS; LIMITED INFORMATION; MEMBRANE TYPE-1 MATRIX METALLOPROTEINASE; METALLOPROTEINASES; MOLECULAR DYNAMICS SIMULATIONS; NOVEL PROTEINS; PROTEASE INHIBITOR; PROTEIN DYNAMICS; PROTEIN FLEXIBILITY; SINGLE-POINT MUTATION; TISSUE INHIBITOR; X-RAY STRUCTURE;

COMPUTER SIMULATION; ENZYME INHIBITION; ENZYMES; HYDROGEN BONDS; MOLECULAR DYNAMICS; SIGNAL TRANSDUCTION;

DYNAMICS;

TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANTIBODY AFFINITY; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENTROPY; ENZYME ACTIVE SITE; ENZYME MECHANISM; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; X RAY ANALYSIS;

CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MATRIX METALLOPROTEINASE 14; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN FOLDING; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 77954827231     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi902141x     Document Type: Article

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