Role of podocyte injury in IgA nephropathy

Contributions to Nephrology

Volumn 181, Issue , 2013, Pages 41-51

  Menon, Madhav C ^a   Chuang, Peter Y ^a   He, John Cijiang ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A;

CELL COMMUNICATION; COMPLEMENT ACTIVATION; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; MESANGIUM CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; PODOCYTE; REVIEW;

CELL COMMUNICATION; COMPLEMENT ACTIVATION; GLOMERULONEPHRITIS, IGA; HUMANS; IMMUNOGLOBULIN A; MESANGIAL CELLS; PODOCYTES;

EID: 84879087457     PISSN: 03025144     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000348461     Document Type: Review

References (64)

1. Berger J, Hinglais N: Intercapillary deposits of IgA-IgG (in French). J Urol Nephrol 1968; 74:694-695.
2. Donadio JV, Grande JP: IgA nephropathy. N Engl J Med 2002; 347:738-748. (Pubitemid 35203906)
3. Lai KN: Pathogenesis of IgA nephropathy. Nat Rev Nephrol 2012; 8:275-283.
4. Moura IC, Benhamou M, Launay P, Vrtovs-nik F, Blank U, Monteiro RC: The glomerular response to IgA deposition in IgA nephropa-thy. Semin Nephrol 2008; 28:88-95.
5. Barratt J, Feehally J, Smith AC: Pathogenesis of IgA nephropathy. Semin Nephrol 2004; 24: 197-217. (Pubitemid 38685990)
6. Floege J: The pathogenesis of IgA nephropa-thy: what is new and how does it change therapeutic approaches? Am J Kidney Dis 2011; 58:992-1004.
7. D'Amico G: The commonest glomerulone-phritis in the world: IgA nephropathy. Q J Med 1987; 64:709-727. (Pubitemid 18047151)
8. Li LS, Liu ZH: Epidemiologic data of renal diseases from a single unit in China: analysis based on 13, 519 renal biopsies. Kidney Int 2004; 66:920-923.
9. Simon P, Ramee MP, Boulahrouz R, Stanescu C, Charasse C, Ang KS, Leonetti F, Cam G, Laruelle E, Autuly V, Rioux N: Epidemiologic data of primary glomerular diseases in western France. Kidney Int 2004; 66:905-908. (Pubitemid 39120990)
10. Julian BA, Novak J: IgA nephropathy: an update. Curr Opin Nephrol Hypertens 2004; 13: 171-179. (Pubitemid 38373139)
11. D'Amico G: Natural history of idiopathic IgA nephropathy: role of clinical and histological prognostic factors. Am J Kidney Dis 2000; 36: 227-237. (Pubitemid 30485830)
12. Philibert D, Cattran D, Cook T: Clinicopath-ologic correlation in IgA nephropathy. Semin Nephrol 2008; 28:10-17.
13. Nachman PH, Jennette JC, Falk RJ: Brenner and Rector's the Kidney, ed 8. Philadelphia, Saunders, 2008.
14. Suzuki K, Honda K, Tanabe K, Toma H, Ni-hei H, Yamaguchi Y: Incidence of latent me-sangial IgA deposition in renal allograft donors in japan. Kidney Int 2003; 63:2286-2294. (Pubitemid 36605844)
15. Waldherr R, Rambausek M, Duncker WD, Ritz E: Frequency of mesangial IgA deposits in a non-selected autopsy series. Nephrol Dial Transplant 1989; 4:943-946. (Pubitemid 20050397)
16. Alamartine E, Sabatier JC, Guerin C, Berliet JM, Berthoux F: Prognostic factors in mesan-gial IgA glomerulonephritis: an extensive study with univariate and multivariate analyses. Am J Kidney Dis 1991; 18:12-19.
17. Rekola S, Bergstrand A, Bucht H: Deterioration of GFR in IgA nephropathy as measured by #sup#51#/sup# Cr-EDTA clearance. Kidney Int 1991; 40: 1050-1054.
18. Working Group of the International IgA Ne-phropathy Network and the Renal Pathology Society: Cattran DC, Coppo R, Cook HT, Feehally J, Roberts IS, Troyanov S, Alpers CE, Amore A, Barratt J, Berthoux F, Bonsib S, Bruijn JA, D'Agati V, D'Amico G, Emancipator S, Emma F, Ferrario F, Fervenza FC, Flo-rquin S, Fogo A, Geddes CC, Groene HJ, Haas M, Herzenberg AM, Hill PA, Hogg RJ, Hsu SI, Jennette JC, Joh K, Julian BA, Kawamura T, Lai FM, Leung CB, Li LS, Li PK, Liu ZH, Mackinnon B, Mezzano S, Sche-na FP, Tomino Y, Walker PD, Wang H, Weening JJ, Yoshikawa N, Zhang H: The Oxford classification of IgA nephropathy: rationale, clinicopathological correlations, and classification. Kidney Int 2009; 76:534-545.
19. Hill GS, Karoui KE, Karras A, Mandet C, Duong Van Huyen JP, Nochy D, Bruneval P: Focal segmental glomerulosclerosis plays a major role in the progression of IgA ne-phropathy. I. Immunohistochemical studies. Kidney Int 2011; 79:635-642.
20. El Karoui K, Hill GS, Karras A, Moulonguet L, Caudwell V, Loupy A, Bruneval P, Jacquot C, Nochy D: Focal segmental glomeruloscle-rosis plays a major role in the progression of IgA nephropathy. II. Light microscopic and clinical studies. Kidney Int 2011; 79:643-654.
21. Cook HT: Focal segmental glomerulosclero-sis in IgA nephropathy: a result of primary podocyte injury? Kidney Int 2011; 79:581-583.
22. Berger J: Recurrence of IgA nephropathy in renal allografts. Am J Kidney Dis 1988; 12: 371-372.
23. Suzuki H, Fan R, Zhang Z, Brown R, Hall S, Julian BA, Chatham WW, Suzuki Y, Wyatt RJ, Moldoveanu Z, Lee JY, Robinson J, Tomana M, Tomino Y, Mestecky J, Novak J: Aberrantly glycosylated IgA1 in IgA ne-phropathy patients is recognized by IgG antibodies with restricted heterogeneity. J Clin Invest 2009; 119:1668-1677.
24. Tomana M, Novak J, Julian BA, Matousovic K, Konecny K, Mestecky J: Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J Clin Invest 1999; 104:73-81. (Pubitemid 29534347)
25. Schena FP, Pastore A, Ludovico N, Sinico RA, Benuzzi S, Montinaro V: Increased serum levels of IgA1-IgG immune complexes and anti-F(ab ′)#inf#2#/inf# antibodies in patients with primary IgA nephropathy. Clin Exp Immunol 1989; 77:15-20. (Pubitemid 19198805)
26. Leung JC, Poon PY, Lai KN: Increased si-alylation of polymeric immunoglobulin A1: mechanism of selective glomerular deposition in immunoglobulin A nephropathy? J Lab Clin Med 1999; 133:152-160. (Pubitemid 29073239)
27. Suzuki H, Moldoveanu Z, Hall S, Brown R, Vu HL, Novak L, Julian BA, Tomana M, Wyatt RJ, Edberg JC, Alarcon GS, Kimberly RP, Tomino Y, Mestecky J, Novak J: IgA1-secreting cell lines from patients with IgA nephrop-athy produce aberrantly glycosylated IgA1. J Clin Invest 2008; 118:629-639. (Pubitemid 351206552)
28. Narita I, Gejyo F: Pathogenetic significance of aberrant glycosylation of IgA1 in IgA ne-phropathy. Clin Exp Nephrol 2008; 12:332-338.
29. Hisano S, Matsushita M, Fujita T, Endo Y, Takebayashi S: Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis. Am J Kidney Dis 2001; 38:1082-1088. (Pubitemid 33022187)
30. Roos A, Rastaldi MP, Calvaresi N, Oortwijn BD, Schlagwein N, van Gijlswijk-Janssen DJ, Stahl GL, Matsushita M, Fujita T, van Kooten C, Daha MR: Glomerular activation of the lectin pathway of complement in IgA ne-phropathy is associated with more severe renal disease. J Am Soc Nephrol 2006; 17:1724-1734. (Pubitemid 43794676)
31. Oortwijn BD, Eijgenraam JW, Rastaldi MP, Roos A, Daha MR, van Kooten C: The role of secretory IgA and complement in IgA ne-phropathy. Semin Nephrol 2008; 28:58-65.
32. Arima S, Nakayama M, Naito M, Sato T, Takahashi K: Significance of mononuclear phagocytes in IgA nephropathy. Kidney Int 1991; 39:684-692.
33. Falk MC, Ng G, Zhang GY, Fanning GC, Roy LP, Bannister KM, Thomas AC, Clarkson AR, Woodroffe AJ, Knight JF: Infiltration of the kidney by αβ and γδ T cells: effect on progression in IgA nephropathy. Kidney Int 1995; 47:177-185.
34. Kanamaru Y, Arcos-Fajardo M, Moura IC, Tsuge T, Cohen H, Essig M, Vrtovsnik F, Loi-rat C, Peuchmaur M, Beaudoin L, Launay P, Lehuen A, Blank U, Monteiro RC: Fc-α receptor I activation induces leukocyte recruitment and promotes aggravation of glomeru-lonephritis through the Fcr-γ adaptor. Eur J Immunol 2007; 37:1116-1128. (Pubitemid 46925347)
35. Pavenstadt H, Kriz W, Kretzler M: Cell biology of the glomerular podocyte. Physiol Rev 2003; 83:253-307. (Pubitemid 36459882)
36. Menon MC, Chuang PY, He CJ: The glomer-ular filtration barrier: components and crosstalk. Int J Nephrol 2012; 2012:749010.
37. Lai KN, Leung JC, Chan LY, Saleem MA, Ma-thieson PW, Lai FM, Tang SC: Activation of podocytes by mesangial-derived TNF-α: Glo-merulo-podocytic communication in IgA nephropathy. Am J Physiol Renal Physiol 2008; 294:F945-F955.
38. Haddad E, Moura IC, Arcos-Fajardo M, Macher MA, Baudouin V, Alberti C, Loirat C, Monteiro RC, Peuchmaur M: Enhanced expression of the CD71 mesangial IgA1 receptor in Berger disease and Henoch-Schönlein nephritis: association between CD71 expression and IgA deposits. J Am Soc Nephrol 2003; 14:327-337. (Pubitemid 36150856)
39. Gomez-Guerrero C, Duque N, Egido J: Me-sangial cells possess an asialoglycoprotein receptor with affinity for human immuno-globulin A. J Am Soc Nephrol 1998; 9:568-576. (Pubitemid 28186044)
40. Launay P, Grossetete B, Arcos-Fajardo M, Gaudin E, Torres SP, Beaudoin L, Patey-Mar-iaud de Serre N, Lehuen A, Monteiro RC: Fc-α receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropa-thy (Berger's disease). Evidence for pathogenic soluble receptor-IgA complexes in patients and CD89 transgenic mice. J Exp Med 2000; 191:1999-2009. (Pubitemid 30390361)
41. Leung JC, Tsang AW, Chan DT, Lai KN: Absence of CD89, polymeric immunoglobulin receptor, and asialoglycoprotein receptor on human mesangial cells. J Am Soc Nephrol 2000; 11:241-249. (Pubitemid 30064847)
42. Wang C, Liu X, Ye Z, Zhang J, Tang H, Chen Z, Zhang H, Lou T: Mesangial medium with IgA1 from IgA nephropathy inhibits nephrin expression in mouse podocytes. Eur J Clin Invest 2009; 39:561-567.
43. Lai KN, Tang SC, Guh JY, Chuang TD, Lam MF, Chan LY, Tsang AW, Leung JC: Polymeric IgA1 from patients with IgA nephropa-thy upregulates transforming growth factor-β synthesis and signal transduction in human mesangial cells via the renin-angiotensin system. J Am Soc Nephrol 2003; 14:3127-3137. (Pubitemid 37509290)
44. Chan LY, Leung JC, Tsang AW, Tang SC, Lai KN: Activation of tubular epithelial cells by mesangial-derived TNF-α: glomerulotubular communication in IgA nephropathy. Kidney Int 2005; 67:602-612. (Pubitemid 40139851)
45. Lai KN, Leung JC, Chan LY, Saleem MA, Ma-thieson PW, Tam KY, Xiao J, Lai FM, Tang SC: Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy. Nephrol Dial Transplant 2009; 24:62-72.
46. Lopez-Armada MJ, Gomez-Guerrero C, Egi-do J: Receptors for immune complexes activate gene expression and synthesis of matrix proteins in cultured rat and human mesan-gial cells: Role of TGF-β. J Immunol 1996; 157:2136-2142. (Pubitemid 126449692)
47. Kang YS, Li Y, Dai C, Kiss LP, Wu C, Liu Y: Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria. Kidney Int 2010; 78:363-373.
48. El-Aouni C, Herbach N, Blattner SM, Henger A, Rastaldi MP, Jarad G, Miner JH, Moeller MJ, St-Arnaud R, Dedhar S, Holzman LB, Wanke R, Kretzler M: Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis. J Am Soc Nephrol 2006; 17:1334-1344. (Pubitemid 43673413)
49. Wang C, Liu X, Ke Z, Tang Y, Li CC, Li CM, Ye Z, Zhang J, Lou T: Mesangial medium from IgA nephropathy patients induces podocyte epithelial-to-mesenchymal transition through activation of the phosphatidyl inositol-3-kinase/Akt signaling pathway. Cell Physiol Biochem 2012; 29:743-752.
50. Ye ZC, Wang C, Tang Y, Liu X, Peng H, Zhang H, Lou TQ: Serum IgA1 from patients with IgA nephropathy upregulates integrin-linked kinase synthesis and inhibits adhesive capacity in podocytes through indirect pathways. Clin Invest Med 2009; 32:E20-E27.
51. Wajant H: Death receptors. Essays Biochem 2003; 39:53-71. (Pubitemid 37457071)
52. Schiffer M, Bitzer M, Roberts IS, Kopp JB, ten Dijke P, Mundel P, Bottinger EP: Apoptosis in podocytes induced by TGF-β and Smad7. J Clin Invest 2001; 108:807-816. (Pubitemid 32880291)
53. Wu DT, Bitzer M, Ju W, Mundel P, Bottinger EP: TGF-β concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes. J Am Soc Nephrol 2005; 16:3211-3221. (Pubitemid 46179327)
54. Wang C, Peng H, Tang H, Liu X, Chen Z, Lou T, Yu X: Serum IgA1 from IgA nephrop-athy patients induces apoptosis in podocytes through direct and indirect pathways. Clin Invest Med 2007; 30:E240-E249. (Pubitemid 350248524)
55. Asanuma K, Akiba-Takagi M, Kodama F, Asao R, Nagai Y, Lydia A, Fukuda H, Tanaka E, Shibata T, Takahara H, Hidaka T, Asanu-ma E, Kominami E, Ueno T, Tomino Y: Den-drin location in podocytes is associated with disease progression in animal and human glomerulopathy. Am J Nephrol 2011; 33:537-549.
56. Asanuma K, Campbell KN, Kim K, Faul C, Mundel P: Nuclear relocation of the nephrin and CD2AP-binding protein dendrin promotes apoptosis of podocytes. Proc Natl Acad Sci USA 2007; 104:10134-10139. (Pubitemid 47175275)
57. Tian J, Wang HP, Mao YY, Jin J, Chen JH: Reduced glomerular epithelial protein 1 expression and podocyte injury in immuno-globulin A nephropathy. J Int Med Res 2007; 35:338-345. (Pubitemid 46971354)
58. Lemley KV, Lafayette RA, Safai M, Derby G, Blouch K, Squarer A, Myers BD: Podocytope-nia and disease severity in IgA nephropathy. Kidney Int 2002; 61:1475-1485. (Pubitemid 34304509)
59. Xu L, Yang HC, Hao CM, Lin ST, Gu Y, Ma J: Podocyte number predicts progression of proteinuria in IgA nephropathy. Mod Pathol 2010; 23:1241-1250.
60. Hara M, Yanagihara T, Kihara I: Cumulative excretion of urinary podocytes reflects disease progression in IgA nephropathy and Schönlein-Henoch purpura nephritis. Clin J Am Soc Nephrol 2007; 2:231-238.
61. Asao R, Asanuma K, Kodama F, Akiba-Taka-gi M, Nagai-Hosoe Y, Seki T, Takeda Y, Oh-sawa I, Mano S, Matsuoka K, Kurosawa H, Ogasawara S, Hirayama Y, Sekine S, Horiko-shi S, Hara M, Tomino Y: Relationships between levels of urinary podocalyxin, number of urinary podocytes, and histologic injury in adult patients with IgA nephropathy. Clin J Am Soc Nephrol 2012; 7:1385-1393.
62. Qiu LQ, Sinniah R, I-Hong Hsu S: Downreg-ulation of Bcl-2 by podocytes is associated with progressive glomerular injury and clinical indices of poor renal prognosis in human IgA nephropathy. J Am Soc Nephrol 2004; 15: 79-90. (Pubitemid 38020700)
63. Praga M, Gutierrez E, Gonzalez E, Morales E, Hernandez E: Treatment of IgA nephropathy with ACE inhibitors: a randomized and controlled trial. J Am Soc Nephrol 2003; 14:1578-1583. (Pubitemid 36687059)
64. Campbell R, Sangalli F, Perticucci E, Aros C, Viscarra C, Perna A, Remuzzi A, Bertocchi F, Fagiani L, Remuzzi G, Ruggenenti P: Effects of combined ACE inhibitor and angiotensin II antagonist treatment in human chronic nephropathies. Kidney Int 2003; 63:1094-1103. (Pubitemid 36315589)