The Role of Secretory IgA and Complement in IgA Nephropathy

Seminars in Nephrology

Volumn 28, Issue 1, 2008, Pages 58-65

  Oortwijn, Beatrijs D ^a   Eijgenraam, Jan Willem ^a   Rastaldi, Maria Pia ^b   Roos, Anja ^a   Daha, Mohamed R ^a   van Kooten, Cees ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SAN CARLO BORROMEO HOSPITAL   (Italy)

Author keywords

antigen specific IgA; complement activation; IgA nephropathy; mannose binding lectin; Secretory IgA

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C3; MANNOSE BINDING LECTIN; SECRETORY IMMUNOGLOBULIN;

ARTICLE; BINDING AFFINITY; BIOPSY TECHNIQUE; CELL ACTIVATION; COMPLEMENT LECTIN PATHWAY; CONFOCAL MICROSCOPY; DISEASE ASSOCIATION; DISEASE COURSE; EPITHELIUM CELL; GLYCOSYLATION; HEMATURIA; HUMAN; IMMUNIZATION; IMMUNOGLOBULIN A DEPOSITION; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY INJURY; MESANGIUM CELL; MUCOSAL IMMUNITY; NEPHRITIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEINURIA; SEDIMENTATION; TONSIL; TONSILLECTOMY; TRANSCYTOSIS; UPPER RESPIRATORY TRACT INFECTION;

COMPLEMENT SYSTEM PROTEINS; GASTRIC MUCOSA; GLOMERULONEPHRITIS, IGA; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN A, SECRETORY; KIDNEY GLOMERULUS; MANNOSE-BINDING LECTIN;

EID: 38349134274     PISSN: 02709295     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2007.10.007     Document Type: Article

References (76)

1. Berger J., and Hinglais N. Les depots intercapillaires d′IgA-IgG. J Urol Nephrol (Paris) 74 (1968) 694-695
2. Donadio J.V., and Grande J.P. IgA nephropathy. N Engl J Med 347 (2002) 738-748
3. Floege J., and Feehally J. IgA nephropathy: recent developments. J Am Soc Nephrol 11 (2000) 2395-2403
4. Silva F.G., Chander P., Pirani C.L., et al. Disappearance of glomerular mesangial IgA deposits after renal allograft transplantation. Transplantation 33 (1982) 241-246
5. Sanfilippo F., Croker B.P., and Bollinger R.R. Fate of four cadaveric donor renal allografts with mesangial IgA deposits. Transplantation 33 (1982) 370-376
6. Barratt J., Feehally J., and Smith A.C. Pathogenesis of IgA nephropathy. Semin Nephrol 24 (2004) 197-217
7. van der Boog P.J., van Kooten C., de Fijter J.W., et al. Role of macromolecular IgA in IgA nephropathy. Kidney Int 67 (2005) 813-821
8. Allen A.C., and Feehally J. IgA1 glycosylation and the pathogenesis of IgA nephropathy. Am J Kidney Dis 35 (2000) 551-556
9. van den Wall Bake A.W., Daha M.R., Haaijman J.J., et al. Elevated production of polymeric and monomeric IgA1 by the bone marrow in IgA nephropathy. Kidney Int 35 (1989) 1400-1404
10. Harper S.J., Allen A.C., Layward L., et al. Increased immunoglobulin A and immunoglobulin A1 cells in bone marrow trephine biopsy specimens in immunoglobulin A nephropathy. Am J Kidney Dis 24 (1994) 888-892
11. Harper S.J., Pringle J.H., Wicks A.C., et al. Expression of J chain mRNA in duodenal IgA plasma cells in IgA nephropathy. Kidney Int 45 (1994) 836-844
12. de Fijter J.W., Eijgenraam J.W., Braam C.A., et al. Deficient IgA1 immune response to nasal cholera toxin subunit B in primary IgA nephropathy. Kidney Int 50 (1996) 952-961
13. Brown T.A., Clements M.L., Murphy B.R., et al. Molecular form and subclass distribution of IgA antibodies after immunization with live and inactivated influenza A vaccines. Adv Exp Med Biol 216B (1987) 1691-1700
14. Mascart-Lemone F., Carlsson B., Jalil F., et al. Polymeric and monomeric IgA response in serum and milk after parenteral cholera and oral typhoid vaccination. Scand J Immunol 28 (1988) 443-448
15. van den Wall Bake A.W., Beyer W.E., Evers-Schouten J.H., et al. Humoral immune response to influenza vaccination in patients with primary immunoglobulin A nephropathy. An analysis of isotype distribution and size of the influenza-specific antibodies. J Clin Invest 84 (1989) 1070-1075
16. Layward L., Allen A.C., Harper S.J., et al. Increased and prolonged production of specific polymeric IgA after systemic immunization with tetanus toxoid in IgA nephropathy. Clin Exp Immunol 88 (1992) 394-398
17. Layward L., Finnemore A.M., Allen A.C., et al. Systemic and mucosal IgA responses to systemic antigen challenge in IgA nephropathy. Clin Immunol Immunopathol 69 (1993) 306-313
18. Kerr M.A. The structure and function of human IgA. Biochem J 271 (1990) 285-296
19. Kokubo T, Hiki Y, Iwase H, et al. Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins. J Am Soc Nephrol. 198;9:2048-54.
20. Thompson R.A., Asquith P., and Cooke W.T. Secretory IgA in the serum. Lancet 2 (1969) 517-519
21. Oortwijn B.D., van der Boog P.J., Roos A., et al. A pathogenic role for secretory IgA in IgA nephropathy. Kidney Int 69 (2006) 1131-1138
22. Bene M.C., and Faure G.C. Composition of mesangial deposits in IgA nephropathy: complement factors. Nephron 46 (1987) 219
23. Rauterberg E.W., Lieberknecht H.M., Wingen A.M., et al. Complement membrane attack (MAC) in idiopathic IgA-glomerulonephritis. Kidney Int 31 (1987) 820-829
24. Zwirner J., Burg M., Schulze M., et al. Activated complement C3: a potentially novel predictor of progressive IgA nephropathy. Kidney Int 51 (1997) 1257-1264
25. Hiemstra P.S., Gorter A., Stuurman M.E., et al. Activation of the alternative pathway of complement by human serum IgA. Eur J Immunol 17 (1987) 321-326
26. Stad R.K., Gijlswijk-Janssen D.J., Van Es L.A., et al. Complement depletion abolishes IgA-mediated glomerular inflammation in rats. Exp Nephrol 2 (1994) 182-189
27. Holmskov U., Thiel S., and Jensenius J.C. Collections and ficolins: humoral lectins of the innate immune defense. Annu Rev Immunol 21 (2003) 547-578
28. Matsushita M., Endo Y., and Fujita T. Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease. J Immunol 164 (2000) 2281-2284
29. Neth O., Jack D.L., Dodds A.W., et al. Mannose-binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun 68 (2000) 688-693
30. Garred P., Pressler T., Madsen H.O., et al. Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis. J Clin Invest 104 (1999) 431-437
31. Endo M., Ohi H., Ohsawa I., et al. Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy. Nephrol Dial Transplant 13 (1998) 1984-1990
32. Matsuda M., Shikata K., Wada J., et al. Deposition of mannan binding protein and mannan binding protein-mediated complement activation in the glomeruli of patients with IgA nephropathy. Nephron 80 (1998) 408-413
33. Malhotra R., Wormald M.R., Rudd P.M., et al. Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nat Med 1 (1995) 237-243
34. Roos A., Bouwman L.H., Gijlswijk-Janssen D.J., et al. Human IgA activates the complement system via the mannan-binding lectin pathway. J Immunol 167 (2001) 2861-2868
35. Oortwijn B.D., Roos A., Royle L., et al. Differential glycosylation of polymeric and monomeric IgA: a possible role in glomerular inflammation in IgA nephropathy. J Am Soc Nephrol 17 (2006) 3529-3539
36. Hisano S., Matsushita M., Fujita T., et al. Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis. Am J Kidney Dis 38 (2001) 1082-1088
37. Lhotta K., Wurzner R., and Konig P. Glomerular deposition of mannose-binding lectin in human glomerulonephritis. Nephrol Dial Transplant 14 (1999) 881-886
38. Roos A., Rastaldi M.P., Calvaresi N., et al. Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease. J Am Soc Nephrol 17 (2006) 1724-1734
39. Coppo R., and Amore A. Aberrant glycosylation in IgA nephropathy (IgAN). Kidney Int 65 (2004) 1544-1547
40. Nicholls K.M., Fairley K.F., Dowling J.P., et al. The clinical course of mesangial IgA associated nephropathy in adults. QJM 53 (1984) 227-250
41. Mostov K.E. Transepithelial transport of immunoglobulins. Annu Rev Immunol 12 (1994) 63-84
42. Corthesy B. Roundtrip ticket for secretory IgA: role in mucosal homeostasis?. J Immunol 178 (2007) 27-32
43. Heystek H.C., Moulon C., Woltman A.M., et al. Human immature dendritic cells efficiently bind and take up secretory IgA without the induction of maturation. J Immunol 168 (2002) 102-107
44. Delacroix D.L., and Vaerman J.P. A solid phase, direct competition, radioimmunoassay for quantitation of secretory IgA in human serum. J Immunol Methods 40 (1981) 345-358
45. Mole C.M., Renoult E., Bene M.C., et al. Serum secretory IgA and IgM and free secretory component in IgA nephropathy. Nephron 71 (1995) 75-78
46. Rostoker G., Terzidis H., Petit-Phar M., et al. Secretory IgA are elevated in both saliva and serum of patients with various types of primary glomerulonephritis. Clin Exp Immunol 90 (1992) 305-311
47. Seilles E., Rossel M., Vuitton D.A., et al. Serum secretory IgA and secretory component in patients with non-cirrhotic alcoholic liver diseases. J Hepatol 22 (1995) 278-285
48. Yamabe H., Ozawa K., Fukushi K., et al. Elevated serum secretory IgA in patients with IgA nephropathy. Nephron 51 (1989) 499-501
49. Roccatello D., Picciotto G., Coppo R., et al. Clearance of polymeric IgA aggregates in humans. Am J Kidney Dis 14 (1989) 354-360
50. Hiki Y., Odani H., Takahashi M., et al. Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy. Kidney Int 59 (2001) 1077-1085
51. Allen A.C., Bailey E.M., Brenchley P.E., et al. Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients. Kidney Int 60 (2001) 969-973
52. Tomana M., Matousovic K., Julian B.A., et al. Galactose-deficient IgA1 in sera of IgA nephropathy patients is present in complexes with IgG. Kidney Int 52 (1997) 509-516
53. Monteiro R.C., Halbwachs-Mecarelli L., Roque-Barreira M.C., et al. Charge and size of mesangial IgA in IgA nephropathy. Kidney Int 28 (1985) 666-671
54. Novak J., Vu H.L., Novak L., et al. Interactions of human mesangial cells with IgA and IgA-containing immune complexes. Kidney Int 62 (2002) 465-475
55. Duque N., Gomez-Guerrero C., and Egido J. Interaction of IgA with Fc alpha receptors of human mesangial cells activates transcription factor nuclear factor-kappa B and induces expression and synthesis of monocyte chemoattractant protein-1, IL-8, and IFN-inducible protein 10. J Immunol 159 (1997) 3474-3482
56. Fujii K., Muller K.D., Clarkson A.R., et al. The effect of IgA immune complexes on the proliferation of cultured human mesangial cells. Am J Kidney Dis 16 (1990) 207-210
57. Chen A., Chen W.P., Sheu L.F., et al. Pathogenesis of IgA nephropathy: in vitro activation of human mesangial cells by IgA immune complex leads to cytokine secretion. J Pathol 173 (1994) 119-126
58. Lai K.N., Tang S.C., Guh J.Y., et al. Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesangial cells via the renin-angiotensin system. J Am Soc Nephrol 14 (2003) 3127-3137
59. Gomez-Guerrero C., Lopez-Armada M.J., Gonzalez E., et al. Soluble IgA and IgG aggregates are catabolized by cultured rat mesangial cells and induce production of TNF-alpha and IL-6, and proliferation. J Immunol 153 (1994) 5247-5255
60. Royle L., Roos A., Harvey D.J., et al. Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems. J Biol Chem 278 (2003) 20140-20153
61. Oortwijn B.D., Rastaldi M.P., Roos A., et al. Demonstration of secretory IgA in kidneys of patients with IgA nephropathy. Nephrol Dial Transplant 22 (2007) 3191-3195
62. Suzuki S., Kobayashi H., Sato H., et al. Immunohistochemical characterization of glomerular IgA deposits in IgA nephropathy. Clin Nephrol 33 (1990) 66-71
63. Obara W., Iida A., Suzuki Y., et al. Association of single-nucleotide polymorphisms in the polymeric immunoglobulin receptor gene with immunoglobulin A nephropathy (IgAN) in Japanese patients. J Hum Genet 48 (2003) 293-299
64. Harper S.J., Allen A.C., Pringle J.H., et al. Increased dimeric IgA producing B cells in the bone marrow in IgA nephropathy determined by in situ hybridisation for J chain mRNA. J Clin Pathol 49 (1996) 38-42
65. Nagy J., and Brandtzaeg P. Tonsillar distribution of IgA and IgG immunocytes and production of IgA subclasses and J chain in tonsillitis vary with the presence or absence of IgA nephropathy. Scand J Immunol 27 (1988) 393-399
66. Itoh A., Iwase H., Takatani T., et al. Tonsillar IgA1 as a possible source of hypoglycosylated IgA1 in the serum of IgA nephropathy patients. Nephrol Dial Transplant 18 (2003) 1108-1114
67. Horie A., Hiki Y., Odani H., et al. IgA1 molecules produced by tonsillar lymphocytes are under-O-glycosylated in IgA nephropathy. Am J Kidney Dis 42 (2003) 486-496
68. Yamabe H., Sugawara T., Nakamura M., et al. Involvement of tonsils in IgA nephropathy. Acta Otolaryngol Suppl 555 (2004) 54-57
69. Akagi H., Kosaka M., Hattori K., et al. Long-term results of tonsillectomy as a treatment for IgA nephropathy. Acta Otolaryngol Suppl 555 (2004) 38-42
70. Bene M.C., Faure G.C., de Ligny B.H., et al. Clinical involvement of the tonsillar immune system in IgA nephropathy. Acta Otolaryngol Suppl 555 (2004) 10-14
71. Xie Y., Nishi S., Ueno M., et al. The efficacy of tonsillectomy on long-term renal survival in patients with IgA nephropathy. Kidney Int 63 (2003) 1861-1867
72. Waldo F.B. Systemic immune response after mucosal immunization in patients with IgA nephropathy. J Clin Immunol 12 (1992) 21-26
73. Leinikki P.O., Mustonen J., and Pasternack A. Immune response to oral polio vaccine in patients with IgA glomerulonephritis. Clin Exp Immunol 68 (1987) 33-38
74. Endoh M., Suga T., Miura M., et al. In vivo alteration of antibody production in patients with IgA nephropathy. Clin Exp Immunol 57 (1984) 564-570
75. Waldo F.B., and Cochran A.M. Systemic immune response to oral polio immunization in patients with IgA nephropathy. J Clin Lab Immunol 28 (1989) 109-114
76. Smith A.C., Molyneux K., Feehally J., et al. O-glycosylation of serum IgA1 antibodies against mucosal and systemic antigens in IgA nephropathy. J Am Soc Nephrol 17 (2006) 3520-3528